Motif ID: Zic3
Z-value: 0.986
Transcription factors associated with Zic3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zic3 | ENSMUSG00000067860.5 | Zic3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zic3 | mm10_v2_chrX_+_58030622_58030643 | 0.73 | 5.5e-14 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 4.0 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
| 3.4 | 13.4 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 2.7 | 16.1 | GO:0003383 | apical constriction(GO:0003383) |
| 2.5 | 7.4 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 1.9 | 5.6 | GO:0060023 | soft palate development(GO:0060023) |
| 1.9 | 7.5 | GO:0060032 | notochord regression(GO:0060032) |
| 1.6 | 4.7 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 1.5 | 10.7 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 1.5 | 9.1 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 1.5 | 5.9 | GO:0033326 | cerebrospinal fluid secretion(GO:0033326) |
| 1.3 | 5.2 | GO:0046210 | nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346) |
| 1.2 | 4.9 | GO:2000195 | negative regulation of female gonad development(GO:2000195) |
| 1.1 | 3.4 | GO:0046671 | negative regulation of retinal cell programmed cell death(GO:0046671) |
| 0.9 | 11.7 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.9 | 2.7 | GO:0071649 | regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) |
| 0.9 | 3.5 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
| 0.9 | 4.3 | GO:0060022 | hard palate development(GO:0060022) |
| 0.7 | 3.7 | GO:0032901 | positive regulation of neurotrophin production(GO:0032901) |
| 0.7 | 2.2 | GO:0070103 | regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104) |
| 0.7 | 3.6 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.7 | 2.8 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.7 | 4.2 | GO:0002934 | desmosome organization(GO:0002934) |
| 0.7 | 6.7 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 0.7 | 3.3 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.7 | 5.9 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.7 | 3.3 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.6 | 4.8 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.6 | 2.3 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.6 | 2.2 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.6 | 7.2 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.6 | 4.4 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.5 | 7.6 | GO:0060579 | ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581) |
| 0.5 | 1.6 | GO:0035621 | ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627) |
| 0.5 | 0.5 | GO:2000224 | regulation of testosterone biosynthetic process(GO:2000224) |
| 0.5 | 2.1 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.5 | 1.6 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
| 0.5 | 2.6 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.5 | 3.9 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.5 | 0.5 | GO:0048859 | formation of anatomical boundary(GO:0048859) |
| 0.5 | 1.9 | GO:0010288 | response to lead ion(GO:0010288) |
| 0.4 | 6.2 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.4 | 2.7 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.4 | 1.3 | GO:0014916 | regulation of lung blood pressure(GO:0014916) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137) cell proliferation involved in heart valve development(GO:2000793) |
| 0.4 | 2.6 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.4 | 4.3 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.4 | 1.7 | GO:1902608 | regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608) |
| 0.4 | 2.1 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.4 | 0.4 | GO:0007521 | muscle cell fate determination(GO:0007521) |
| 0.4 | 1.2 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 0.4 | 1.7 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.4 | 3.7 | GO:1900194 | negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194) |
| 0.4 | 7.2 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.4 | 1.2 | GO:0071579 | regulation of zinc ion transport(GO:0071579) |
| 0.4 | 2.3 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
| 0.4 | 9.5 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.4 | 1.5 | GO:0006545 | glycine biosynthetic process(GO:0006545) |
| 0.4 | 7.0 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.4 | 1.4 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.4 | 1.4 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.4 | 3.9 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.3 | 3.1 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.3 | 0.9 | GO:1902162 | regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) |
| 0.3 | 2.4 | GO:2000301 | myeloid progenitor cell differentiation(GO:0002318) negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.3 | 3.7 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.3 | 1.1 | GO:2000383 | regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384) |
| 0.3 | 2.7 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
| 0.3 | 1.3 | GO:0060178 | regulation of exocyst localization(GO:0060178) |
| 0.3 | 0.8 | GO:0097402 | neuroblast migration(GO:0097402) |
| 0.2 | 1.2 | GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013) |
| 0.2 | 1.0 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.2 | 1.6 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.2 | 1.4 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.2 | 0.9 | GO:0015744 | succinate transport(GO:0015744) |
| 0.2 | 0.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 0.6 | GO:0070375 | ERK5 cascade(GO:0070375) |
| 0.2 | 4.2 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.2 | 2.4 | GO:2000288 | positive regulation of myoblast proliferation(GO:2000288) |
| 0.2 | 3.8 | GO:0030220 | platelet formation(GO:0030220) platelet morphogenesis(GO:0036344) |
| 0.2 | 0.8 | GO:0032289 | central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912) |
| 0.2 | 0.6 | GO:1901355 | response to rapamycin(GO:1901355) |
| 0.2 | 0.6 | GO:0035519 | protein K29-linked ubiquitination(GO:0035519) |
| 0.2 | 0.7 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.2 | 0.9 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.2 | 1.4 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.2 | 1.7 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
| 0.2 | 0.9 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.2 | 0.6 | GO:0038108 | negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) |
| 0.1 | 0.4 | GO:2001016 | heparan sulfate proteoglycan catabolic process(GO:0030200) positive regulation of skeletal muscle cell differentiation(GO:2001016) |
| 0.1 | 9.8 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.1 | 1.0 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.1 | 2.8 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
| 0.1 | 1.8 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 0.9 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.1 | 6.4 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 5.3 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.1 | 5.0 | GO:0030517 | negative regulation of axon extension(GO:0030517) |
| 0.1 | 1.9 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.1 | 2.8 | GO:0048266 | behavioral response to pain(GO:0048266) |
| 0.1 | 1.1 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
| 0.1 | 3.2 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.1 | 1.2 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 2.3 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.1 | 1.4 | GO:0015697 | quaternary ammonium group transport(GO:0015697) |
| 0.1 | 3.9 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.1 | 0.7 | GO:1905244 | regulation of modification of synaptic structure(GO:1905244) |
| 0.1 | 0.9 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.1 | 1.6 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.1 | 1.3 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.1 | 5.5 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.1 | 0.7 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 1.3 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 0.7 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 0.1 | 1.6 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.1 | 7.8 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.1 | 1.4 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.1 | 1.3 | GO:0001553 | luteinization(GO:0001553) |
| 0.1 | 0.9 | GO:0061525 | hindgut development(GO:0061525) |
| 0.1 | 2.9 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.1 | 0.4 | GO:1904938 | dopaminergic neuron axon guidance(GO:0036514) serotonergic neuron axon guidance(GO:0036515) planar cell polarity pathway involved in axon guidance(GO:1904938) |
| 0.1 | 1.2 | GO:0032957 | inositol trisphosphate metabolic process(GO:0032957) |
| 0.1 | 2.6 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.1 | 3.3 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.1 | 0.8 | GO:1901620 | regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620) |
| 0.1 | 0.5 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.1 | 3.0 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.1 | 0.4 | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511) |
| 0.1 | 0.9 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.1 | 0.4 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.1 | 0.3 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) pyroptosis(GO:0070269) |
| 0.1 | 0.1 | GO:0006167 | AMP biosynthetic process(GO:0006167) |
| 0.1 | 1.3 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 1.6 | GO:0051353 | positive regulation of oxidoreductase activity(GO:0051353) |
| 0.1 | 0.9 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 0.3 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.1 | 1.7 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.1 | 1.0 | GO:0014898 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898) |
| 0.1 | 0.2 | GO:1903977 | positive regulation of Schwann cell migration(GO:1900149) positive regulation of glial cell migration(GO:1903977) |
| 0.1 | 0.7 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.1 | 3.5 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity(GO:0032088) |
| 0.0 | 0.4 | GO:2000254 | regulation of male germ cell proliferation(GO:2000254) |
| 0.0 | 1.0 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.0 | 1.2 | GO:0048873 | homeostasis of number of cells within a tissue(GO:0048873) |
| 0.0 | 0.2 | GO:0032691 | negative regulation of interleukin-1 beta production(GO:0032691) negative regulation of interleukin-1 production(GO:0032692) |
| 0.0 | 1.1 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 2.8 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 1.6 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 0.1 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.0 | 3.6 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 1.7 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.0 | 2.7 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
| 0.0 | 6.3 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 1.5 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.1 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 0.0 | 0.6 | GO:0006767 | water-soluble vitamin metabolic process(GO:0006767) |
| 0.0 | 0.7 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.0 | 0.2 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 0.1 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 0.0 | 0.2 | GO:1900112 | regulation of histone H3-K9 trimethylation(GO:1900112) negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.0 | 0.1 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.0 | 1.7 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 0.0 | 0.5 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 0.8 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.0 | 0.6 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.8 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 1.3 | GO:0000271 | polysaccharide biosynthetic process(GO:0000271) |
| 0.0 | 2.1 | GO:0006413 | translational initiation(GO:0006413) |
| 0.0 | 0.1 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.0 | 0.1 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.0 | 1.5 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.0 | 1.1 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.0 | 2.2 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 0.4 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.0 | 0.1 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.0 | 0.5 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.0 | 1.0 | GO:0030641 | regulation of cellular pH(GO:0030641) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 16.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.8 | 3.3 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
| 0.8 | 4.0 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.8 | 5.4 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.7 | 6.7 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.6 | 3.7 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.6 | 7.5 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.5 | 9.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.5 | 6.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.5 | 4.8 | GO:0000796 | condensin complex(GO:0000796) |
| 0.5 | 1.9 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.5 | 2.3 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.4 | 1.5 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.3 | 8.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.3 | 3.9 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.3 | 3.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.3 | 1.6 | GO:0098536 | deuterosome(GO:0098536) |
| 0.2 | 1.4 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.2 | 1.4 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.2 | 0.8 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.2 | 1.6 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.2 | 3.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.2 | 1.9 | GO:0032982 | myosin filament(GO:0032982) |
| 0.2 | 0.7 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.2 | 2.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 1.4 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.1 | 0.9 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.1 | 7.2 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 1.7 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.1 | 0.9 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.1 | 1.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 1.7 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.1 | 1.1 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.1 | 1.2 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 0.9 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 1.9 | GO:0030117 | membrane coat(GO:0030117) coated membrane(GO:0048475) |
| 0.1 | 0.7 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 0.1 | 1.8 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.1 | 1.2 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 1.4 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.1 | 6.0 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 0.7 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.1 | 0.2 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.1 | 0.6 | GO:0034464 | BBSome(GO:0034464) |
| 0.1 | 3.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 5.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 3.0 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.9 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 1.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 2.5 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 2.1 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.1 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.0 | 1.4 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 1.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 4.6 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 3.2 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.0 | 1.0 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.4 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 0.4 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 3.5 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.2 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 0.1 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.0 | 1.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.3 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 1.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 0.8 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 1.4 | GO:0032993 | protein-DNA complex(GO:0032993) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.3 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 1.8 | 10.7 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 1.3 | 5.2 | GO:0016708 | nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726) |
| 1.2 | 6.2 | GO:0043515 | kinetochore binding(GO:0043515) |
| 1.0 | 7.2 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.8 | 3.8 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.7 | 9.5 | GO:0005522 | profilin binding(GO:0005522) |
| 0.7 | 3.7 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.7 | 9.4 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.7 | 2.2 | GO:0097677 | STAT family protein binding(GO:0097677) |
| 0.7 | 7.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.6 | 3.1 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.6 | 3.7 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.6 | 3.9 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.5 | 2.7 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.5 | 2.7 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.5 | 4.1 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.5 | 1.5 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.5 | 1.5 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.5 | 1.4 | GO:0001565 | phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566) |
| 0.5 | 6.1 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.5 | 3.7 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
| 0.5 | 1.4 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 0.4 | 1.7 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.4 | 3.0 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.4 | 3.8 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.4 | 1.7 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.4 | 3.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 1.2 | GO:0051765 | inositol tetrakisphosphate kinase activity(GO:0051765) |
| 0.4 | 1.6 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.4 | 6.1 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.4 | 3.3 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.3 | 16.1 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.3 | 2.3 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.3 | 1.0 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.3 | 2.6 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 0.3 | 1.3 | GO:0070513 | death domain binding(GO:0070513) |
| 0.3 | 0.9 | GO:0008504 | monoamine transmembrane transporter activity(GO:0008504) |
| 0.3 | 4.6 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.3 | 0.9 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.3 | 3.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.3 | 2.7 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.3 | 1.6 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.2 | 0.7 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.2 | 0.4 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.2 | 1.3 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.2 | 3.3 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.2 | 7.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.2 | 7.3 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.2 | 1.0 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.2 | 1.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 1.3 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.2 | 4.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 0.9 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.2 | 0.9 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.2 | 4.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.2 | 5.1 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.2 | 20.4 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.2 | 1.6 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.2 | 2.3 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 0.7 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 2.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 1.4 | GO:0048531 | beta-1,3-galactosyltransferase activity(GO:0048531) |
| 0.1 | 1.7 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 0.7 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.1 | 1.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 2.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 22.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 2.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 1.4 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.1 | 3.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 1.9 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.1 | 11.8 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.1 | 0.9 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 3.3 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.1 | 1.1 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.1 | 2.1 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 2.0 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.1 | 0.8 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 1.4 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.1 | 0.2 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 0.1 | 5.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 2.7 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.1 | 1.4 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 2.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 2.1 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 2.3 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 10.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 1.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.9 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 1.4 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.2 | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) |
| 0.0 | 0.6 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 0.1 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 0.0 | 0.1 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.0 | 5.9 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 1.6 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 0.5 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.7 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.0 | 0.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 1.0 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 1.1 | GO:0008235 | metalloexopeptidase activity(GO:0008235) |
| 0.0 | 0.2 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 0.2 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.0 | 1.2 | GO:0016879 | ligase activity, forming carbon-nitrogen bonds(GO:0016879) |
| 0.0 | 0.4 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 1.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.1 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.0 | 0.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 0.4 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 2.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 2.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.6 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 1.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.7 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.5 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.0 | 1.2 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 1.2 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.5 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.3 | 7.5 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.3 | 16.1 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.3 | 9.8 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.3 | 2.8 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.2 | 15.1 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 2.4 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 7.9 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 14.7 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.2 | 9.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 6.2 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 2.8 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.1 | 2.2 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 4.8 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 4.1 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.1 | 2.4 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 3.6 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.8 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.1 | 0.6 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.1 | 0.9 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.2 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 3.0 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 2.5 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.7 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 3.8 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.3 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.7 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 1.5 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.2 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 1.8 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.9 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.8 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 1.8 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.5 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.7 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.6 | PID_AP1_PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 10.7 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.8 | 9.1 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.7 | 9.3 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.7 | 16.1 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.6 | 14.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 4.1 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.3 | 9.5 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.3 | 4.0 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.2 | 2.3 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.2 | 6.2 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 3.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 2.2 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.2 | 2.4 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.2 | 0.9 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 3.3 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 0.9 | REACTOME_SIGNALING_BY_NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.1 | 3.2 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 0.9 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 1.1 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 0.6 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 2.9 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 0.6 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 1.2 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.1 | 2.9 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 1.9 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 0.9 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 1.4 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 1.2 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 4.4 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.5 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 1.3 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.1 | 1.9 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 0.8 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 6.0 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 4.8 | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 1.0 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 1.7 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 2.5 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.4 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 0.9 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.6 | REACTOME_ELONGATION_ARREST_AND_RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 1.8 | REACTOME_DNA_REPAIR | Genes involved in DNA Repair |
| 0.0 | 0.3 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 1.2 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.5 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
