Motif ID: Zic4
Z-value: 0.968
Transcription factors associated with Zic4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zic4 | ENSMUSG00000036972.8 | Zic4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zic4 | mm10_v2_chr9_+_91368811_91368828 | -0.18 | 1.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 11.1 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 2.2 | 6.6 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 1.9 | 9.7 | GO:2001025 | positive regulation of response to drug(GO:2001025) |
| 1.6 | 11.1 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 1.4 | 11.5 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 1.2 | 3.7 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 1.1 | 3.3 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 1.1 | 3.3 | GO:0097491 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) |
| 0.9 | 4.4 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 0.9 | 2.6 | GO:1900738 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
| 0.8 | 2.3 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.7 | 3.0 | GO:0002924 | negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
| 0.7 | 10.3 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.7 | 4.0 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.6 | 5.8 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.6 | 0.6 | GO:0061317 | canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of heart induction(GO:0090381) |
| 0.6 | 2.5 | GO:0097374 | sensory neuron axon guidance(GO:0097374) |
| 0.6 | 1.7 | GO:0097274 | urea homeostasis(GO:0097274) |
| 0.5 | 6.6 | GO:0048484 | enteric nervous system development(GO:0048484) |
| 0.5 | 3.0 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.5 | 2.5 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.5 | 2.8 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.4 | 1.7 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.4 | 1.6 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
| 0.4 | 1.2 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144) |
| 0.4 | 3.0 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.3 | 0.3 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 0.3 | 2.1 | GO:0002317 | plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.3 | 2.4 | GO:0070458 | detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458) |
| 0.3 | 1.7 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.3 | 3.0 | GO:0031424 | keratinization(GO:0031424) |
| 0.3 | 1.0 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.3 | 1.3 | GO:0061743 | motor learning(GO:0061743) |
| 0.3 | 0.9 | GO:0015920 | regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920) |
| 0.3 | 0.9 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 0.3 | 5.7 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.3 | 0.9 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) |
| 0.3 | 0.6 | GO:0097168 | mesenchymal stem cell proliferation(GO:0097168) |
| 0.3 | 0.8 | GO:0002159 | desmosome assembly(GO:0002159) adherens junction maintenance(GO:0034334) intermediate filament bundle assembly(GO:0045110) maintenance of organ identity(GO:0048496) |
| 0.3 | 6.3 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.3 | 1.0 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.2 | 0.7 | GO:0002030 | inhibitory G-protein coupled receptor phosphorylation(GO:0002030) |
| 0.2 | 2.7 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.2 | 1.7 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
| 0.2 | 1.9 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.2 | 1.7 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.2 | 5.8 | GO:2000811 | negative regulation of anoikis(GO:2000811) |
| 0.2 | 1.3 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 1.8 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.2 | 3.5 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.2 | 1.1 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.2 | 1.4 | GO:0044336 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336) |
| 0.1 | 7.4 | GO:0048713 | regulation of oligodendrocyte differentiation(GO:0048713) |
| 0.1 | 3.8 | GO:1900452 | regulation of long term synaptic depression(GO:1900452) |
| 0.1 | 0.5 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.1 | 0.9 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 0.3 | GO:2001160 | regulation of histone H3-K79 methylation(GO:2001160) |
| 0.1 | 1.8 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 5.1 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.1 | 0.6 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.1 | 1.4 | GO:0035646 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 0.1 | 0.3 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
| 0.1 | 1.4 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.1 | 0.5 | GO:1904923 | regulation of mitophagy in response to mitochondrial depolarization(GO:1904923) |
| 0.1 | 0.3 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
| 0.1 | 3.5 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.1 | 0.6 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 0.2 | GO:0008582 | regulation of synaptic growth at neuromuscular junction(GO:0008582) regulation of sodium:potassium-exchanging ATPase activity(GO:1903406) |
| 0.1 | 0.6 | GO:2000766 | negative regulation of translational elongation(GO:0045900) negative regulation of cytoplasmic translation(GO:2000766) |
| 0.1 | 1.3 | GO:0042711 | maternal behavior(GO:0042711) |
| 0.1 | 0.9 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
| 0.1 | 0.4 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.1 | 0.2 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.1 | 1.2 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 1.6 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.1 | 0.7 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.1 | 2.9 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 0.1 | 1.7 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.0 | 0.9 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
| 0.0 | 1.5 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.0 | 1.0 | GO:0035115 | embryonic forelimb morphogenesis(GO:0035115) |
| 0.0 | 1.5 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 1.2 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.0 | 6.1 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.0 | 0.9 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.0 | 1.4 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.8 | GO:0009299 | mRNA transcription(GO:0009299) |
| 0.0 | 0.8 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.3 | GO:0048563 | post-embryonic organ morphogenesis(GO:0048563) |
| 0.0 | 0.2 | GO:0007202 | activation of phospholipase C activity(GO:0007202) positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.0 | 0.1 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.0 | 0.2 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.0 | 3.1 | GO:0001666 | response to hypoxia(GO:0001666) |
| 0.0 | 2.2 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 0.0 | 0.1 | GO:0070234 | positive regulation of T cell apoptotic process(GO:0070234) |
| 0.0 | 1.1 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 11.1 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.6 | 9.7 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.6 | 13.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.6 | 2.8 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.5 | 1.4 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.4 | 2.9 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.3 | 1.7 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.3 | 3.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.3 | 1.3 | GO:0044301 | climbing fiber(GO:0044301) |
| 0.3 | 3.0 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.2 | 8.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.2 | 0.6 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.2 | 0.6 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.2 | 0.9 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.1 | 5.8 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 9.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 4.0 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 0.8 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 0.9 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 1.0 | GO:0090543 | Flemming body(GO:0090543) |
| 0.1 | 7.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 0.3 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.1 | 10.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 0.6 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 0.6 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.1 | 0.8 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 1.7 | GO:0001741 | XY body(GO:0001741) |
| 0.1 | 4.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 0.9 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 1.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.4 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.5 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 0.9 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.6 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 1.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.3 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 1.3 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.2 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.0 | 2.6 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.9 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 9.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 1.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 4.0 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.0 | 1.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 9.7 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 2.9 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 0.6 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 1.9 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 11.1 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 2.2 | 6.6 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
| 1.1 | 3.2 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.6 | 4.4 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.6 | 6.4 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.6 | 11.1 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.6 | 1.7 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) |
| 0.6 | 2.8 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.4 | 2.9 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.4 | 1.2 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.3 | 2.9 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.3 | 0.9 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.3 | 1.7 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.3 | 1.1 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.3 | 3.3 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.3 | 1.0 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.3 | 3.3 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.2 | 0.9 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903) |
| 0.2 | 9.8 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.2 | 2.5 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 0.2 | 3.0 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.2 | 1.7 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.2 | 0.6 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.2 | 5.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 2.3 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.2 | 3.0 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.2 | 0.7 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.2 | 1.7 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.2 | 5.8 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 6.3 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 1.7 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 7.2 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 2.7 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.1 | 5.0 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.1 | 0.6 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.1 | 1.8 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 0.3 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
| 0.1 | 2.4 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.1 | 6.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 0.9 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.1 | 0.3 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.1 | 3.7 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.1 | 1.2 | GO:0004890 | GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917) |
| 0.1 | 0.3 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 0.8 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.1 | 1.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 1.1 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 1.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 3.0 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.2 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 2.1 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.2 | GO:0042030 | chondroitin sulfate binding(GO:0035374) ATPase inhibitor activity(GO:0042030) |
| 0.0 | 3.6 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 0.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.8 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.5 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 1.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 1.4 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 2.9 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 1.6 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 6.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 2.2 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.6 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.6 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.6 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.2 | 9.3 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 6.6 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 6.0 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 3.1 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 5.2 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 3.0 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.5 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.7 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 1.8 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.7 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.1 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.9 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.4 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.2 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 1.8 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 4.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 4.2 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.6 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.6 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.7 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.7 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.7 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.4 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 0.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 0.8 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.9 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.0 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.7 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 6.6 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 3.1 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 11.9 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.7 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 3.0 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 2.8 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 9.8 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 5.1 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.4 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 1.6 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 6.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 6.9 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 2.8 | REACTOME_SIGNALING_BY_NOTCH1 | Genes involved in Signaling by NOTCH1 |
| 0.1 | 1.2 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 0.9 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 0.3 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 0.9 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 5.4 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 2.2 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.5 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 1.0 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.7 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 1.4 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 1.7 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.9 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.0 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 2.2 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.9 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.9 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
