Motif ID: Zkscan1

Z-value: 0.588


Transcription factors associated with Zkscan1:

Gene SymbolEntrez IDGene Name
Zkscan1 ENSMUSG00000029729.6 Zkscan1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zkscan1mm10_v2_chr5_+_138085083_138085147-0.234.7e-02Click!


Activity profile for motif Zkscan1.

activity profile for motif Zkscan1


Sorted Z-values histogram for motif Zkscan1

Sorted Z-values for motif Zkscan1



Network of associatons between targets according to the STRING database.



First level regulatory network of Zkscan1

PNG image of the network

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Top targets:


Showing 1 to 20 of 110 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56969864 10.236 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr15_+_83779999 10.051 ENSMUST00000046168.5
 Mpped1
metallophosphoesterase domain containing 1
chr1_-_56969827 8.589 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr19_-_61228396 7.230 ENSMUST00000076046.6
 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr12_+_73997749 6.758 ENSMUST00000110451.2
 Syt16
synaptotagmin XVI
chr7_+_112225856 5.336 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr4_+_129960760 5.179 ENSMUST00000139884.1
 1700003M07Rik
RIKEN cDNA 1700003M07 gene
chr14_-_30353468 4.661 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr15_-_75048837 4.533 ENSMUST00000179762.1
ENSMUST00000065408.9
 Ly6c1

lymphocyte antigen 6 complex, locus C1

chr4_+_42922253 4.370 ENSMUST00000139100.1
 N28178
expressed sequence N28178
chr4_+_103619580 3.746 ENSMUST00000106827.1
 Dab1
disabled 1
chr17_+_28575718 3.425 ENSMUST00000080780.6
 Lhfpl5
lipoma HMGIC fusion partner-like 5
chr11_-_61453992 3.382 ENSMUST00000060255.7
ENSMUST00000054927.7
ENSMUST00000102661.3
 Rnf112


ring finger protein 112


chr3_+_62338344 3.268 ENSMUST00000079300.6
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr15_-_79164477 3.193 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr4_+_74013442 3.160 ENSMUST00000098006.2
ENSMUST00000084474.5
 Frmd3

FERM domain containing 3

chr12_-_76818374 3.118 ENSMUST00000118604.1
 Rab15
RAB15, member RAS oncogene family
chr7_+_44310213 3.044 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr11_+_19924403 2.985 ENSMUST00000093298.5
 Spred2
sprouty-related, EVH1 domain containing 2
chr10_-_83337845 2.951 ENSMUST00000039956.5
 Slc41a2
solute carrier family 41, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 18.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 7.2 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.0 6.8 GO:0006906 vesicle fusion(GO:0006906)
0.4 5.9 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
1.1 5.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
1.2 4.7 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 4.4 GO:0031032 actomyosin structure organization(GO:0031032)
0.3 4.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
1.2 3.7 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 3.6 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.2 3.4 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.2 3.3 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.6 3.2 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.1 3.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.3 3.0 GO:0046959 habituation(GO:0046959)
0.1 2.8 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.7 2.7 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.1 2.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 2.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.6 1.8 GO:2001180 negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 6.8 GO:0031225 anchored component of membrane(GO:0031225)
0.5 4.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 4.7 GO:0005903 brush border(GO:0005903)
0.0 3.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 3.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 3.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 2.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 2.1 GO:0032426 stereocilium tip(GO:0032426)
0.0 2.1 GO:0042641 actomyosin(GO:0042641)
0.4 1.6 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.5 1.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 1.4 GO:0031143 pseudopodium(GO:0031143)
0.1 1.4 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.3 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 1.0 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 0.9 GO:0034464 BBSome(GO:0034464)
0.0 0.7 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.2 GO:0003682 chromatin binding(GO:0003682)
0.1 7.2 GO:0004896 cytokine receptor activity(GO:0004896)
0.2 6.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 6.8 GO:0003924 GTPase activity(GO:0003924)
1.0 5.9 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 5.3 GO:0071949 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) FAD binding(GO:0071949)
0.6 4.7 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 4.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 3.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 3.6 GO:0072509 divalent inorganic cation transmembrane transporter activity(GO:0072509)
0.1 3.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 3.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.8 3.0 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 2.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 2.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.9 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.5 1.6 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 1.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 1.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.4 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 5.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 3.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.8 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 1.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 0.9 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.6 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.3 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.2 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 3.0 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 2.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 1.2 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 1.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 0.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions