Motif ID: Zkscan3

Z-value: 0.296


Transcription factors associated with Zkscan3:

Gene SymbolEntrez IDGene Name
Zkscan3 ENSMUSG00000021327.12 Zkscan3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zkscan3mm10_v2_chr13_-_21402688_21402755-0.103.8e-01Click!


Activity profile for motif Zkscan3.

activity profile for motif Zkscan3


Sorted Z-values histogram for motif Zkscan3

Sorted Z-values for motif Zkscan3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zkscan3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_24985840 0.994 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr11_-_75422586 0.732 ENSMUST00000138661.1
ENSMUST00000000769.7
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr13_-_100786402 0.685 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr18_+_61105844 0.624 ENSMUST00000115268.3
 Csf1r
colony stimulating factor 1 receptor
chr11_-_75422524 0.578 ENSMUST00000125982.1
ENSMUST00000137103.1
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr2_+_104095796 0.570 ENSMUST00000040423.5
ENSMUST00000168176.1
 Cd59a

CD59a antigen

chr3_+_146500071 0.511 ENSMUST00000119130.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr6_-_122856151 0.490 ENSMUST00000042081.8
 C3ar1
complement component 3a receptor 1
chr8_+_31091593 0.396 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr13_-_19395728 0.393 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like
chr3_+_146499850 0.373 ENSMUST00000118280.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr1_+_180942452 0.355 ENSMUST00000027800.8
 Tmem63a
transmembrane protein 63a
chr2_-_66634952 0.350 ENSMUST00000100064.2
ENSMUST00000100063.2
 Scn9a

sodium channel, voltage-gated, type IX, alpha

chr3_+_79629074 0.340 ENSMUST00000029388.8
 4930579G24Rik
RIKEN cDNA 4930579G24 gene
chr11_-_102365111 0.325 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr7_+_101896340 0.319 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
 Anapc15


anaphase prompoting complex C subunit 15


chr5_-_88675613 0.317 ENSMUST00000113234.1
ENSMUST00000153565.1
 Grsf1

G-rich RNA sequence binding factor 1

chr13_-_32851176 0.314 ENSMUST00000091668.5
ENSMUST00000076352.6
 Serpinb1a

serine (or cysteine) peptidase inhibitor, clade B, member 1a

chr8_+_70616816 0.314 ENSMUST00000052437.3
 Lrrc25
leucine rich repeat containing 25
chr8_+_94810446 0.301 ENSMUST00000034232.1
 Ccl17
chemokine (C-C motif) ligand 17
chr13_-_38658991 0.293 ENSMUST00000001757.7
 Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr3_-_95687846 0.291 ENSMUST00000015994.3
ENSMUST00000148854.1
ENSMUST00000117782.1
 Adamtsl4


ADAMTS-like 4


chr18_+_82554463 0.284 ENSMUST00000062446.7
ENSMUST00000102812.4
ENSMUST00000075372.5
ENSMUST00000080658.4
ENSMUST00000152071.1
ENSMUST00000114674.3
ENSMUST00000142850.1
ENSMUST00000133193.1
ENSMUST00000123251.1
ENSMUST00000153478.1
ENSMUST00000132369.1
 Mbp










myelin basic protein










chr7_-_81345189 0.280 ENSMUST00000080813.4
 Rps17
ribosomal protein S17
chr2_+_121295437 0.256 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chrX_-_75874536 0.247 ENSMUST00000033547.7
 Pls3
plastin 3 (T-isoform)
chr8_-_105758570 0.232 ENSMUST00000155038.2
ENSMUST00000013294.9
 Gfod2

glucose-fructose oxidoreductase domain containing 2

chr4_+_139192899 0.229 ENSMUST00000102508.3
ENSMUST00000131912.1
ENSMUST00000102507.3
 Capzb


capping protein (actin filament) muscle Z-line, beta


chr8_+_33732237 0.219 ENSMUST00000171010.1
 Gtf2e2
general transcription factor II E, polypeptide 2 (beta subunit)
chr5_-_88675190 0.217 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chrX_-_17571563 0.214 ENSMUST00000177213.1
 Fundc1
FUN14 domain containing 1
chr15_-_3979432 0.208 ENSMUST00000022791.8
 Fbxo4
F-box protein 4
chr8_-_116978908 0.202 ENSMUST00000070577.5
 1700030J22Rik
RIKEN cDNA 1700030J22 gene
chr8_+_106893616 0.201 ENSMUST00000047629.5
 Cirh1a
cirrhosis, autosomal recessive 1A (human)
chr4_+_63544747 0.199 ENSMUST00000035301.6
 Atp6v1g1
ATPase, H+ transporting, lysosomal V1 subunit G1
chr8_-_106893581 0.175 ENSMUST00000176437.1
ENSMUST00000177068.1
ENSMUST00000169312.1
ENSMUST00000176515.1
 Chtf8



CTF8, chromosome transmission fidelity factor 8



chr2_+_156613664 0.166 ENSMUST00000169464.2
ENSMUST00000109567.3
 Dlgap4

discs, large homolog-associated protein 4 (Drosophila)

chr14_+_51893610 0.163 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr1_+_132298606 0.158 ENSMUST00000046071.4
 Klhdc8a
kelch domain containing 8A
chr9_+_114688782 0.154 ENSMUST00000047404.6
 Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr2_+_104069819 0.152 ENSMUST00000111131.2
ENSMUST00000111132.1
ENSMUST00000129749.1
 Cd59b


CD59b antigen


chr12_+_76533540 0.150 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chrX_-_17572241 0.148 ENSMUST00000176638.1
ENSMUST00000026016.6
 Fundc1

FUN14 domain containing 1

chr10_-_33951190 0.135 ENSMUST00000048222.4
 Zufsp
zinc finger with UFM1-specific peptidase domain
chr6_+_125552948 0.131 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr7_+_126759601 0.127 ENSMUST00000050201.4
ENSMUST00000057669.9
 Mapk3

mitogen-activated protein kinase 3

chr17_-_35673517 0.125 ENSMUST00000162266.1
ENSMUST00000160734.1
ENSMUST00000159852.1
ENSMUST00000160039.1
 Gtf2h4



general transcription factor II H, polypeptide 4



chr4_+_156026120 0.120 ENSMUST00000103173.3
 Tnfrsf18
tumor necrosis factor receptor superfamily, member 18
chr13_+_104109737 0.117 ENSMUST00000044385.7
 Sgtb
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr17_-_35673738 0.116 ENSMUST00000001565.8
 Gtf2h4
general transcription factor II H, polypeptide 4
chr2_+_31670714 0.102 ENSMUST00000038474.7
ENSMUST00000137156.1
 Exosc2

exosome component 2

chr2_+_32646586 0.101 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr14_+_57424054 0.098 ENSMUST00000122063.1
 Ift88
intraflagellar transport 88
chr7_-_127020321 0.086 ENSMUST00000032918.2
 Pagr1a
PAXIP1 associated glutamate rich protein 1A
chr19_+_6276725 0.080 ENSMUST00000025684.3
 Ehd1
EH-domain containing 1
chr1_+_58795371 0.078 ENSMUST00000027189.8
 Casp8
caspase 8
chr8_-_124897685 0.075 ENSMUST00000098312.2
 Exoc8
exocyst complex component 8
chr8_+_71396853 0.074 ENSMUST00000002473.8
 Babam1
BRISC and BRCA1 A complex member 1
chr11_-_102218923 0.074 ENSMUST00000131254.1
 Hdac5
histone deacetylase 5
chr1_+_135232045 0.071 ENSMUST00000110798.3
 Gm4204
predicted gene 4204
chr8_-_106893515 0.070 ENSMUST00000176090.1
 Chtf8
CTF8, chromosome transmission fidelity factor 8
chr2_+_121171155 0.070 ENSMUST00000110658.1
 Tubgcp4
tubulin, gamma complex associated protein 4
chr13_+_44730726 0.057 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
 Jarid2


jumonji, AT rich interactive domain 2


chr17_+_46110982 0.051 ENSMUST00000024763.3
ENSMUST00000123646.1
 Mrps18a

mitochondrial ribosomal protein S18A

chr5_+_117976761 0.044 ENSMUST00000035579.6
 Fbxo21
F-box protein 21
chr1_-_39651165 0.038 ENSMUST00000053355.4
 Creg2
cellular repressor of E1A-stimulated genes 2
chr13_+_104109752 0.027 ENSMUST00000160322.1
ENSMUST00000159574.1
 Sgtb

small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

chr11_-_100650693 0.026 ENSMUST00000103119.3
 Zfp385c
zinc finger protein 385C
chr9_+_108648720 0.009 ENSMUST00000098384.2
 Gm10621
predicted gene 10621
chr2_-_30194112 0.002 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.2 0.5 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.2 0.6 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.1 0.9 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 1.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.4 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.6 GO:0090272 negative regulation of fibroblast growth factor production(GO:0090272)
0.1 0.3 GO:1904207 chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.3 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.5 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:1905072 detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
0.0 0.1 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.0 0.1 GO:0000189 MAPK import into nucleus(GO:0000189)
0.0 0.2 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.0 0.2 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033) CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.3 GO:0006968 cellular defense response(GO:0006968)
0.0 0.2 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 0.1 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.1 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304) histone H3-K27 demethylation(GO:0071557)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 0.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 0.7 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 1.3 GO:0043203 axon hillock(GO:0043203)
0.1 0.2 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.1 0.2 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.1 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.0 0.4 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0060091 kinocilium(GO:0060091)
0.0 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 0.5 GO:0004875 complement receptor activity(GO:0004875)
0.1 0.4 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.7 GO:0001848 complement binding(GO:0001848)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0035877 death effector domain binding(GO:0035877)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:0048020 CCR chemokine receptor binding(GO:0048020)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.1 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.2 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease