• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities
• All promoters sorted by FOV

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: Zscan4c

Z-value: 0.901

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr13_+_58807884	16.250	ENSMUST00000079828.5	Ntrk2	neurotrophic tyrosine kinase, receptor, type 2
chr8_+_118283719	15.692	ENSMUST00000117160.1	Cdh13	cadherin 13
chr4_-_46991842	13.390	ENSMUST00000107749.2	Gabbr2	gamma-aminobutyric acid (GABA) B receptor, 2
chr5_-_44799643	13.309	ENSMUST00000070748.5	Ldb2	LIM domain binding 2
chr7_-_119184374	10.878	ENSMUST00000084650.4	Gpr139	G protein-coupled receptor 139
chr9_+_26733728	10.195	ENSMUST00000160899.1 ENSMUST00000161431.1 ENSMUST00000159799.1	B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr4_+_123183722	9.768	ENSMUST00000152194.1	Hpcal4	hippocalcin-like 4
chr15_-_37458523	9.670	ENSMUST00000116445.2	Ncald	neurocalcin delta
chr8_-_48555846	9.355	ENSMUST00000110345.1 ENSMUST00000110343.1	Tenm3	teneurin transmembrane protein 3
chr5_-_128953303	9.040	ENSMUST00000111346.1	Rimbp2	RIMS binding protein 2
chr9_-_49798729	8.702	ENSMUST00000166811.2	Ncam1	neural cell adhesion molecule 1
chr9_-_49798905	8.623	ENSMUST00000114476.2	Ncam1	neural cell adhesion molecule 1
chr15_-_78718113	7.958	ENSMUST00000088592.4	Elfn2	leucine rich repeat and fibronectin type III, extracellular 2
chr9_+_26733845	7.749	ENSMUST00000115269.2	B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr19_+_8664005	7.183	ENSMUST00000035444.3 ENSMUST00000163785.1	Chrm1	cholinergic receptor, muscarinic 1, CNS
chr7_-_98178254	6.226	ENSMUST00000040971.7	Capn5	calpain 5
chr3_-_158562199	6.168	ENSMUST00000106044.1	Lrrc7	leucine rich repeat containing 7
chr13_-_56296551	6.074	ENSMUST00000021970.9	Cxcl14	chemokine (C-X-C motif) ligand 14
chr14_-_70627008	6.059	ENSMUST00000110984.2	Dmtn	dematin actin binding protein
chr9_+_89909775	5.856	ENSMUST00000034912.4 ENSMUST00000034909.4	Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1
chr2_+_57238297	5.620	ENSMUST00000112618.2 ENSMUST00000028167.2	Gpd2	glycerol phosphate dehydrogenase 2, mitochondrial
chr7_+_130936172	5.565	ENSMUST00000006367.7	Htra1	HtrA serine peptidase 1
chr7_-_47132698	5.516	ENSMUST00000033142.5	Ptpn5	protein tyrosine phosphatase, non-receptor type 5
chr8_-_95142477	5.192	ENSMUST00000034240.7 ENSMUST00000169748.1	Kifc3	kinesin family member C3
chr14_-_60177482	4.870	ENSMUST00000140924.1	Atp8a2	ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr4_+_123183456	4.533	ENSMUST00000126995.1	Hpcal4	hippocalcin-like 4
chr3_-_108017806	4.425	ENSMUST00000126593.1	Gstm1	glutathione S-transferase, mu 1
chr11_-_101785252	4.403	ENSMUST00000164750.1 ENSMUST00000107176.1 ENSMUST00000017868.6	Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)
chr2_-_36105271	4.393	ENSMUST00000112960.1 ENSMUST00000112967.5 ENSMUST00000112963.1	Lhx6	LIM homeobox protein 6
chr10_+_43579161	4.205	ENSMUST00000058714.8	Cd24a	CD24a antigen
chr19_-_21472552	4.174	ENSMUST00000087600.3	Gda	guanine deaminase
chr16_+_45094036	4.089	ENSMUST00000061050.5	Ccdc80	coiled-coil domain containing 80
chr6_-_55681257	4.081	ENSMUST00000044767.8	Neurod6	neurogenic differentiation 6
chr5_+_27261916	4.046	ENSMUST00000101471.3	Dpp6	dipeptidylpeptidase 6
chr2_-_166155624	3.668	ENSMUST00000109249.2	Sulf2	sulfatase 2
chr7_+_46841475	3.460	ENSMUST00000147535.1	Ldha	lactate dehydrogenase A
chr1_-_174921813	3.262	ENSMUST00000055294.3	Grem2	gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr11_+_16257706	3.167	ENSMUST00000109645.2 ENSMUST00000109647.2	Vstm2a	V-set and transmembrane domain containing 2A
chr1_+_132191436	2.977	ENSMUST00000112357.2	Lemd1	LEM domain containing 1
chr10_+_81292961	2.846	ENSMUST00000163075.1 ENSMUST00000105327.3 ENSMUST00000045469.8	Pip5k1c	phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
chr9_+_21936986	2.835	ENSMUST00000046371.6	BC018242	cDNA sequence BC018242
chr16_-_9994921	2.687	ENSMUST00000115835.1	Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)
chr2_+_169633517	2.583	ENSMUST00000109157.1	Tshz2	teashirt zinc finger family member 2
chr19_+_28963892	2.551	ENSMUST00000045674.2	Ppapdc2	phosphatidic acid phosphatase type 2 domain containing 2
chr10_+_74967164	2.498	ENSMUST00000037813.4	Gnaz	guanine nucleotide binding protein, alpha z subunit
chr9_+_57940104	2.441	ENSMUST00000043059.7	Sema7a	sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr2_-_166155272	2.284	ENSMUST00000088086.3	Sulf2	sulfatase 2
chr12_-_112929415	2.240	ENSMUST00000075827.3	Jag2	jagged 2
chr15_+_80173642	2.055	ENSMUST00000044970.6	Mgat3	mannoside acetylglucosaminyltransferase 3
chr12_-_69892989	2.023	ENSMUST00000110567.1 ENSMUST00000171211.1	Map4k5	mitogen-activated protein kinase kinase kinase kinase 5
chr19_+_47228804	1.791	ENSMUST00000111807.3	Neurl1a	neuralized homolog 1A (Drosophila)
chr19_-_6067785	1.678	ENSMUST00000162575.1 ENSMUST00000159084.1 ENSMUST00000161718.1 ENSMUST00000162810.1 ENSMUST00000025713.5 ENSMUST00000113543.2 ENSMUST00000161528.1	Tm7sf2	transmembrane 7 superfamily member 2
chr8_+_117257019	1.636	ENSMUST00000166750.1	Cmip	c-Maf inducing protein
chr9_-_44799179	1.550	ENSMUST00000114705.1 ENSMUST00000002100.7	Tmem25	transmembrane protein 25
chr5_+_114896936	1.547	ENSMUST00000031542.9 ENSMUST00000146072.1 ENSMUST00000150361.1	Oasl2	2'-5' oligoadenylate synthetase-like 2
chr4_+_49059256	1.507	ENSMUST00000076670.2	E130309F12Rik	RIKEN cDNA E130309F12 gene
chr9_+_36832684	1.479	ENSMUST00000034630.8	Fez1	fasciculation and elongation protein zeta 1 (zygin I)
chr2_-_91182848	1.463	ENSMUST00000111370.2 ENSMUST00000111376.1 ENSMUST00000099723.2	Madd	MAP-kinase activating death domain
chrX_-_64276937	1.258	ENSMUST00000114679.1 ENSMUST00000069926.7	Slitrk4	SLIT and NTRK-like family, member 4
chrX_+_48519245	1.126	ENSMUST00000033430.2	Rab33a	RAB33A, member of RAS oncogene family
chr11_-_70237638	1.048	ENSMUST00000100950.3	0610010K14Rik	RIKEN cDNA 0610010K14 gene
chr8_+_82863351	1.011	ENSMUST00000078525.5	Rnf150	ring finger protein 150
chr10_-_78295394	1.010	ENSMUST00000105387.1	Agpat3	1-acylglycerol-3-phosphate O-acyltransferase 3
chr5_+_64970069	0.927	ENSMUST00000031080.8	Fam114a1	family with sequence similarity 114, member A1
chr4_-_116464151	0.861	ENSMUST00000106486.1 ENSMUST00000106485.1	Mast2	microtubule associated serine/threonine kinase 2
chr4_+_115057683	0.811	ENSMUST00000161601.1	Tal1	T cell acute lymphocytic leukemia 1
chr11_+_52098681	0.802	ENSMUST00000020608.2	Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
chr2_+_169632996	0.775	ENSMUST00000109159.2	Tshz2	teashirt zinc finger family member 2
chr2_+_30364262	0.749	ENSMUST00000142801.1 ENSMUST00000100214.3	Fam73b	family with sequence similarity 73, member B
chr2_+_30364227	0.699	ENSMUST00000077977.7 ENSMUST00000140075.2	Fam73b	family with sequence similarity 73, member B
chr3_-_107760221	0.528	ENSMUST00000153114.1 ENSMUST00000118593.1 ENSMUST00000120243.1	Csf1	colony stimulating factor 1 (macrophage)
chr10_-_128645784	0.486	ENSMUST00000065334.3	Ikzf4	IKAROS family zinc finger 4
chr16_-_38713235	0.268	ENSMUST00000023487.4	Arhgap31	Rho GTPase activating protein 31
chr11_-_109473220	0.262	ENSMUST00000070872.6	Slc16a6	solute carrier family 16 (monocarboxylic acid transporters), member 6
chr5_-_145201829	0.194	ENSMUST00000162220.1 ENSMUST00000031632.8	Zkscan14	zinc finger with KRAB and SCAN domains 14
chr11_-_70237886	0.130	ENSMUST00000108577.1 ENSMUST00000108579.1 ENSMUST00000021181.6 ENSMUST00000108578.2 ENSMUST00000102569.3	0610010K14Rik	RIKEN cDNA 0610010K14 gene
chr11_-_70237761	0.127	ENSMUST00000108576.3	0610010K14Rik	RIKEN cDNA 0610010K14 gene
chr8_+_62951361	0.101	ENSMUST00000119068.1	Spock3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr3_+_134236483	0.067	ENSMUST00000181904.1 ENSMUST00000053048.9	Cxxc4	CXXC finger 4
chr2_-_158146385	0.054	ENSMUST00000103122.3	Tgm2	transglutaminase 2, C polypeptide
chr18_-_42262053	0.022	ENSMUST00000097590.3	Lars	leucyl-tRNA synthetase
chr18_-_39489776	0.004	ENSMUST00000025300.6	Nr3c1	nuclear receptor subfamily 3, group C, member 1
chr15_-_79403248	0.004	ENSMUST00000074991.2	Tmem184b	transmembrane protein 184b

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.8	17.3	GO:0001928	regulation of exocyst assembly(GO:0001928)
3.1	15.7	GO:0055095	lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
2.0	16.3	GO:0099550	trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
2.0	6.1	GO:2000501	natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
2.0	6.1	GO:0035585	calcium-mediated signaling using extracellular calcium source(GO:0035585)
1.5	6.0	GO:0014846	esophagus smooth muscle contraction(GO:0014846)
1.4	7.2	GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
1.4	4.2	GO:0002842	positive regulation of T cell mediated immune response to tumor cell(GO:0002842) positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.4	4.2	GO:0046098	guanine metabolic process(GO:0046098)
1.2	9.4	GO:0097264	self proteolysis(GO:0097264)
1.1	5.5	GO:2001025	positive regulation of response to drug(GO:2001025)
1.1	3.2	GO:0070343	white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.9	5.6	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.9	5.6	GO:0060718	chorionic trophoblast cell differentiation(GO:0060718)
0.9	17.9	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.9	5.2	GO:0045218	zonula adherens maintenance(GO:0045218)
0.7	4.4	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.7	4.4	GO:1904936	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.7	4.9	GO:0061092	involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.7	3.5	GO:0019659	fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.5	1.5	GO:1902277	negative regulation of pancreatic amylase secretion(GO:1902277)
0.5	13.4	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.5	3.3	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.4	2.4	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.4	2.7	GO:0071294	cellular response to zinc ion(GO:0071294)
0.4	2.8	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.3	5.9	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.3	1.8	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.3	2.2	GO:0060120	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.3	5.2	GO:0010669	epithelial structure maintenance(GO:0010669)
0.3	4.4	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.2	17.0	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.2	4.1	GO:0021542	dentate gyrus development(GO:0021542)
0.2	10.9	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.2	0.5	GO:1904139	microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1	2.5	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.1	9.7	GO:0003073	regulation of systemic arterial blood pressure(GO:0003073)
0.1	1.5	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
0.1	2.1	GO:0006044	N-acetylglucosamine metabolic process(GO:0006044)
0.1	4.0	GO:1901381	positive regulation of potassium ion transmembrane transport(GO:1901381)
0.1	0.2	GO:0060217	hemangioblast cell differentiation(GO:0060217)
0.1	0.8	GO:1901020	negative regulation of calcium ion transmembrane transporter activity(GO:1901020)
0.0	1.1	GO:2000785	regulation of autophagosome assembly(GO:2000785)
0.0	1.7	GO:1902653	cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0	2.3	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	5.0	GO:0010976	positive regulation of neuron projection development(GO:0010976)
0.0	1.3	GO:0051965	positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.7	13.4	GO:0038039	G-protein coupled receptor heterodimeric complex(GO:0038039)
1.5	6.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
1.1	5.6	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.5	5.2	GO:0005915	zonula adherens(GO:0005915)
0.4	4.2	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.3	5.5	GO:1990635	proximal dendrite(GO:1990635)
0.3	7.2	GO:0032279	asymmetric synapse(GO:0032279)
0.3	16.3	GO:0048786	presynaptic active zone(GO:0048786)
0.3	35.5	GO:0031225	anchored component of membrane(GO:0031225)
0.3	5.9	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.2	3.5	GO:0035686	sperm fibrous sheath(GO:0035686)
0.2	6.2	GO:0043194	axon initial segment(GO:0043194)
0.2	0.5	GO:1990682	CSF1-CSF1R complex(GO:1990682)
0.2	2.7	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	2.3	GO:0005614	interstitial matrix(GO:0005614)
0.1	1.1	GO:0016589	NURF complex(GO:0016589)
0.1	0.2	GO:0033193	Lsd1/2 complex(GO:0033193)
0.1	2.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	17.9	GO:0000139	Golgi membrane(GO:0000139)
0.0	1.8	GO:0097440	apical dendrite(GO:0097440)
0.0	4.0	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	0.8	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	28.3	GO:0005615	extracellular space(GO:0005615)
0.0	4.4	GO:0043209	myelin sheath(GO:0043209)
0.0	1.7	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	4.9	GO:0005925	focal adhesion(GO:0005925)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.3	16.3	GO:0005030	neurotrophin receptor activity(GO:0005030)
3.1	15.7	GO:0055100	adiponectin binding(GO:0055100)
3.0	17.9	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
2.2	13.4	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
1.9	5.6	GO:0016901	glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
1.4	7.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
1.2	6.0	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.9	17.3	GO:0030275	LRR domain binding(GO:0030275)
0.9	3.5	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.6	5.2	GO:0030274	LIM domain binding(GO:0030274)
0.5	10.9	GO:0008188	neuropeptide receptor activity(GO:0008188)
0.4	4.4	GO:0016151	nickel cation binding(GO:0016151)
0.4	5.2	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.4	3.3	GO:0036122	BMP binding(GO:0036122)
0.4	2.5	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.4	2.8	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.4	4.2	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.3	6.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3	14.3	GO:0005246	calcium channel regulator activity(GO:0005246)
0.3	9.7	GO:0043014	alpha-tubulin binding(GO:0043014)
0.3	2.7	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.3	5.6	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.2	4.1	GO:0001968	fibronectin binding(GO:0001968)
0.2	6.1	GO:0008009	chemokine activity(GO:0008009)
0.2	4.9	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.2	2.4	GO:0038191	neuropilin binding(GO:0038191)
0.2	8.0	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.1	2.0	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.1	0.8	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.1	11.4	GO:0035254	glutamate receptor binding(GO:0035254)
0.1	4.2	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1	6.1	GO:0030507	spectrin binding(GO:0030507)
0.1	4.0	GO:0015459	potassium channel regulator activity(GO:0015459)
0.1	1.7	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1	1.5	GO:0070566	adenylyltransferase activity(GO:0070566)
0.1	2.2	GO:0005112	Notch binding(GO:0005112)
0.0	1.0	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	1.8	GO:0045182	translation regulator activity(GO:0045182)
0.0	1.5	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	6.2	GO:0008022	protein C-terminus binding(GO:0008022)
0.0	9.4	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.0	0.5	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	1.5	GO:0047485	protein N-terminus binding(GO:0047485)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.5	PID_S1P_S1P4_PATHWAY	S1P4 pathway
0.3	17.3	PID_FGF_PATHWAY	FGF signaling pathway
0.3	22.1	PID_TRKR_PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.2	10.1	PID_ECADHERIN_STABILIZATION_PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	10.4	NABA_ECM_AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	11.6	NABA_ECM_REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	2.0	PID_TNF_PATHWAY	TNF receptor signaling pathway
0.1	4.4	PID_LKB1_PATHWAY	LKB1 signaling events
0.1	2.7	PID_REELIN_PATHWAY	Reelin signaling pathway
0.1	0.5	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	3.5	PID_HIF1_TFPATHWAY	HIF-1-alpha transcription factor network
0.0	2.2	PID_NOTCH_PATHWAY	Notch signaling pathway
0.0	5.7	NABA_SECRETED_FACTORS	Genes encoding secreted soluble factors
0.0	0.8	PID_IL8_CXCR2_PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	1.5	PID_CASPASE_PATHWAY	Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	13.4	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.6	8.5	REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.6	7.2	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	Genes involved in Amine ligand-binding receptors
0.5	17.9	REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.5	9.7	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.4	15.7	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	Genes involved in Adherens junctions interactions
0.4	4.2	REACTOME_PURINE_CATABOLISM	Genes involved in Purine catabolism
0.4	17.3	REACTOME_INTERFERON_GAMMA_SIGNALING	Genes involved in Interferon gamma signaling
0.2	2.8	REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2	4.4	REACTOME_GLUTATHIONE_CONJUGATION	Genes involved in Glutathione conjugation
0.2	2.2	REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2	3.5	REACTOME_PYRUVATE_METABOLISM	Genes involved in Pyruvate metabolism
0.1	4.9	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	5.2	REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1	3.3	REACTOME_SIGNALING_BY_BMP	Genes involved in Signaling by BMP
0.1	2.4	REACTOME_OTHER_SEMAPHORIN_INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	2.1	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1	1.7	REACTOME_CHOLESTEROL_BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.1	2.5	REACTOME_G_PROTEIN_ACTIVATION	Genes involved in G-protein activation
0.1	0.8	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	6.6	REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM	Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism

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