Motif ID: Zscan4c

Z-value: 0.901


Transcription factors associated with Zscan4c:

Gene SymbolEntrez IDGene Name
Zscan4c ENSMUSG00000054272.5 Zscan4c



Activity profile for motif Zscan4c.

activity profile for motif Zscan4c


Sorted Z-values histogram for motif Zscan4c

Sorted Z-values for motif Zscan4c



Network of associatons between targets according to the STRING database.



First level regulatory network of Zscan4c

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_58807884 16.250 ENSMUST00000079828.5
 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr8_+_118283719 15.692 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr4_-_46991842 13.390 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr5_-_44799643 13.309 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr7_-_119184374 10.878 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr9_+_26733728 10.195 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr4_+_123183722 9.768 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr15_-_37458523 9.670 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr8_-_48555846 9.355 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr5_-_128953303 9.040 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr9_-_49798729 8.702 ENSMUST00000166811.2
 Ncam1
neural cell adhesion molecule 1
chr9_-_49798905 8.623 ENSMUST00000114476.2
 Ncam1
neural cell adhesion molecule 1
chr15_-_78718113 7.958 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr9_+_26733845 7.749 ENSMUST00000115269.2
 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr19_+_8664005 7.183 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr7_-_98178254 6.226 ENSMUST00000040971.7
 Capn5
calpain 5
chr3_-_158562199 6.168 ENSMUST00000106044.1
 Lrrc7
leucine rich repeat containing 7
chr13_-_56296551 6.074 ENSMUST00000021970.9
 Cxcl14
chemokine (C-X-C motif) ligand 14
chr14_-_70627008 6.059 ENSMUST00000110984.2
 Dmtn
dematin actin binding protein
chr9_+_89909775 5.856 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 17.9 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
5.8 17.3 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 17.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
2.0 16.3 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
3.1 15.7 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.5 13.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 10.9 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.1 9.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
1.2 9.4 GO:0097264 self proteolysis(GO:0097264)
1.4 7.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
2.0 6.1 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
2.0 6.1 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
1.5 6.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 5.9 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.9 5.6 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.9 5.6 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.1 5.5 GO:2001025 positive regulation of response to drug(GO:2001025)
0.9 5.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.3 5.2 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 5.0 GO:0010976 positive regulation of neuron projection development(GO:0010976)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 35.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 28.3 GO:0005615 extracellular space(GO:0005615)
0.1 17.9 GO:0000139 Golgi membrane(GO:0000139)
0.3 16.3 GO:0048786 presynaptic active zone(GO:0048786)
2.7 13.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.3 7.2 GO:0032279 asymmetric synapse(GO:0032279)
0.2 6.2 GO:0043194 axon initial segment(GO:0043194)
1.5 6.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 5.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
1.1 5.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 5.5 GO:1990635 proximal dendrite(GO:1990635)
0.5 5.2 GO:0005915 zonula adherens(GO:0005915)
0.0 4.9 GO:0005925 focal adhesion(GO:0005925)
0.0 4.4 GO:0043209 myelin sheath(GO:0043209)
0.4 4.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 4.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 3.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 2.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 17.9 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.9 17.3 GO:0030275 LRR domain binding(GO:0030275)
3.3 16.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
3.1 15.7 GO:0055100 adiponectin binding(GO:0055100)
0.3 14.3 GO:0005246 calcium channel regulator activity(GO:0005246)
2.2 13.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 11.4 GO:0035254 glutamate receptor binding(GO:0035254)
0.5 10.9 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.3 9.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 9.4 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.2 8.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
1.4 7.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.3 6.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 6.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.2 6.1 GO:0008009 chemokine activity(GO:0008009)
0.1 6.1 GO:0030507 spectrin binding(GO:0030507)
1.2 6.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
1.9 5.6 GO:0016901 glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.3 5.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.6 5.2 GO:0030274 LIM domain binding(GO:0030274)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 22.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 17.3 PID_FGF_PATHWAY FGF signaling pathway
0.1 11.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 10.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 10.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 5.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.4 PID_LKB1_PATHWAY LKB1 signaling events
0.0 3.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.3 2.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 2.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.0 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 1.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 0.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 17.9 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.4 17.3 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.4 15.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
1.0 13.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.5 9.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.6 8.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.6 7.2 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 6.6 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 5.2 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 4.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 4.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.4 4.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.2 3.5 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 3.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.2 2.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.5 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 2.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 2.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.1 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 1.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis