Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.107

Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

NameEntrezDescription
Adnp 11538 activity-dependent neuroprotective protein
Irx4 50916 Iroquois related homeobox 4 (Drosophila)
Irx5 54352 Iroquois related homeobox 5 (Drosophila)
Six2 20472 sine oculis-related homeobox 2 homolog (Drosophila)
Six5 20475 sine oculis-related homeobox 5 homolog (Drosophila)
Zhx1 22770 zinc fingers and homeoboxes 1
Zhx2 387609 zinc fingers and homeoboxes 2
Zhx3 320799 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Irx4chr13_+_73397944-0.473.5e-03Click!
Irx5chr8_+_94881694-0.316.7e-02Click!
Six5chr7_+_19679892-0.251.4e-01Click!
Zhx1chr15_-_57907735-0.222.1e-01Click!
Six2chr17_-_86087586-0.144.2e-01Click!
Zhx3chr2_-_1606987050.124.9e-01Click!
Zhx2chr15_+_575262120.096.0e-01Click!
Adnpchr2_-_1680325610.029.3e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr8_-_87297283 13.916 Nfix
nuclear factor I/X
chr5_+_90889913 6.997 NM_009654
Alb
albumin
chrM_+_13543 6.117


chrX_-_163645313 5.904 Tmsb4x
thymosin, beta 4, X chromosome
chr1_+_6720087 5.238 NM_173868
St18
suppression of tumorigenicity 18
chr9_-_91255831 5.165 Zic1
zinc finger protein of the cerebellum 1
chr1_+_6720153 5.116 St18
suppression of tumorigenicity 18
chr18_-_32109233 4.756 NM_001025381
Gpr17
G protein-coupled receptor 17
chr7_-_20284370 4.610 Apoe
apolipoprotein E
chr18_+_20823908 4.568 Ttr
transthyretin
chrM_+_13998 3.989


chr1_-_134603848 3.938 NM_001160318
Nfasc
neurofascin
chr1_-_137064124 3.772 NM_134438
Gpr37l1
G protein-coupled receptor 37-like 1
chr10_+_96942181 3.697 Dcn
decorin
chr3_+_84756090 3.598 NM_080428
Fbxw7
F-box and WD-40 domain protein 7
chr6_-_51416921 3.338 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chrM_+_13320 3.314


chr8_+_48072271 3.311 NM_177304
Enpp6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chrM_+_1550 3.032


chr5_-_89886732 2.974 NM_008096
Gc
group specific component
chrM_+_11027 2.953


chr10_+_96942263 2.921 Dcn
decorin
chr2_-_7002344 2.869 NM_001110229
NM_001110230
NM_001160292
Celf2


CUGBP, Elav-like family member 2


chr3_+_136598485 2.835 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr10_+_87321789 2.695 NM_001111275
NM_010512
Igf1

insulin-like growth factor 1

chrM_+_3320 2.674


chrM_+_9875 2.585 ND4L
NADH dehydrogenase subunit 4L
chr3_+_55265811 2.554 Dclk1
doublecortin-like kinase 1
chrM_+_14143 2.484


chr1_-_156731538 2.466 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr5_+_22988226 2.447


chr2_+_174171525 2.292 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chrM_+_11741 2.274 ND5
NADH dehydrogenase subunit 5
chrM_+_2750 2.256


chr19_+_29999596 2.249 NM_133775
Il33
interleukin 33
chr15_-_96861590 2.243 Slc38a4
solute carrier family 38, member 4
chrM_-_13886 2.203


chr2_+_125860377 2.186 NM_008008
Fgf7
fibroblast growth factor 7
chrM_+_5398 2.145


chrM_+_409 2.118


chr2_-_147011990 2.114 NM_001077632
NM_010919
Nkx2-2

NK2 transcription factor related, locus 2 (Drosophila)

chr19_+_26679649 2.070 NM_011416
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr18_+_69753035 2.020 Tcf4
transcription factor 4
chr13_-_58228079 1.994 Hnrnpa0
heterogeneous nuclear ribonucleoprotein A0
chrM_+_6139 1.988


chr11_-_62206116 1.959 Ncor1
nuclear receptor co-repressor 1
chr2_-_164268672 1.891 NM_011521
Sdc4
syndecan 4
chr8_+_56040445 1.854 Gpm6a
glycoprotein m6a
chr6_+_134874663 1.828 Cdkn1b
cyclin-dependent kinase inhibitor 1B
chr1_-_180259336 1.815 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr15_+_78757148 1.801 NM_008495
Lgals1
lectin, galactose binding, soluble 1
chr6_-_87793459 1.755 Cnbp
cellular nucleic acid binding protein
chrX_+_133371611 1.741 Plp1
proteolipid protein (myelin) 1
chr5_+_90889937 1.726 Alb
albumin
chrM_+_5462 1.687


chr17_-_90487479 1.651 Nrxn1
neurexin I
chr2_-_37502738 1.630 NM_009261
Strbp
spermatid perinuclear RNA binding protein
chrM_-_14069 1.584 ND6
NADH dehydrogenase subunit 6
chr8_-_89996474 1.581 NM_019626
Cbln1
cerebellin 1 precursor protein
chr3_+_90341208 1.567 S100a16
S100 calcium binding protein A16
chr6_-_51413182 1.563 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr2_+_181501718 1.533 NM_001171616
NM_008665
Myt1

myelin transcription factor 1

chr14_-_104215770 1.523 Ednrb
endothelin receptor type B
chr8_+_56040553 1.518 Gpm6a
glycoprotein m6a
chr18_+_36441115 1.473 Pura
purine rich element binding protein A
chr6_+_125045998 1.429 NM_145979
Chd4
chromodomain helicase DNA binding protein 4
chr18_+_78017198 1.423


chr10_-_63552994 1.413 NM_178678
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr18_-_77870871 1.407 2310007O11Rik
RIKEN cDNA 2310007O11 gene
chr18_+_36440748 1.386 NM_008989
Pura
purine rich element binding protein A
chr14_+_122879276 1.381 Zic2
zinc finger protein of the cerebellum 2
chr10_-_6980199 1.368 NM_133485
Ppp1r14c
protein phosphatase 1, regulatory (inhibitor) subunit 14c
chr7_-_148196526 1.365 Ifitm3
interferon induced transmembrane protein 3
chr11_+_108256590 1.343 NM_013475
Apoh
apolipoprotein H
chr17_+_12571455 1.286 NM_008877
Plg
plasminogen
chr16_-_85120798 1.282 App
amyloid beta (A4) precursor protein
chr8_-_89996089 1.282 Cbln1
cerebellin 1 precursor protein
chr2_+_174171943 1.269


chr11_+_77744280 1.259 NM_021286
Sez6
seizure related gene 6
chr15_+_3220999 1.210 Sepp1
selenoprotein P, plasma, 1
chr6_-_87793898 1.210 Cnbp
cellular nucleic acid binding protein
chr2_-_7002287 1.208 Celf2
CUGBP, Elav-like family member 2
chr2_+_55288297 1.184 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr17_+_12571494 1.183 Plg
plasminogen
chrM_+_11812 1.169


chr19_+_4711220 1.140 NM_021287
Spnb3
spectrin beta 3
chr5_-_33590505 1.140


chr1_+_67169588 1.131 NM_001080809
Cps1
carbamoyl-phosphate synthetase 1
chr8_+_89996742 1.099 Gm2694
predicted gene 2694
chr11_-_58768012 1.097 NM_206882
Hist3h2bb-ps
histone cluster 3, H2bb, pseudogene
chr3_+_98084352 1.045 NM_008256
Hmgcs2
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
chr11_-_75841236 1.014 NM_029658
Fam101b
family with sequence similarity 101, member B
chr19_+_20567199 1.013 E030003E18Rik
RIKEN cDNA E030003E18 gene
chr17_-_45705824 1.007 Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr19_+_5493612 1.001 Cfl1
cofilin 1, non-muscle
chrM_+_12383 0.992


chr1_+_179374783 0.992 NM_001012330
Zfp238
zinc finger protein 238
chrM_+_9458 0.988 ND3
NADH dehydrogenase subunit 3
chr16_-_84955488 0.987 App
amyloid beta (A4) precursor protein
chr15_+_3220994 0.981 Sepp1
selenoprotein P, plasma, 1
chr16_-_31314534 0.979 NM_007470
Apod
apolipoprotein D
chr6_+_141578016 0.973 NM_020495
Slco1b2
solute carrier organic anion transporter family, member 1b2
chr2_+_69708777 0.972 Ssb
Sjogren syndrome antigen B
chr7_-_148196606 0.952 Ifitm3
interferon induced transmembrane protein 3
chr11_-_69229653 0.937 Kdm6b
KDM1 lysine (K)-specific demethylase 6B
chr11_+_115891591 0.936 NM_172569
Unk
unkempt homolog (Drosophila)
chr5_-_146691425 0.916 NM_007818
Cyp3a11
cytochrome P450, family 3, subfamily a, polypeptide 11
chr12_+_37968225 0.898 NM_178767
Tmem195
transmembrane protein 195
chr1_+_34364633 0.896 Dst
dystonin
chr11_-_42134548 0.895 NM_001099641
NM_008068
Gabra6

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6

chr7_-_123182257 0.881 NM_001025559
Sox6
SRY-box containing gene 6
chr10_+_98486068 0.879 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr11_-_42134509 0.869 Gabra6
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
chr9_+_75623153 0.867 NM_007555
Bmp5
bone morphogenetic protein 5
chr2_+_14310024 0.862 NM_001012305
Slc39a12
solute carrier family 39 (zinc transporter), member 12
chr19_-_5799376 0.861 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chrM_+_67 0.842


chr10_-_20444654 0.839 NM_013875
Pde7b
phosphodiesterase 7B
chr5_-_122907269 0.838 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr16_+_22951183 0.838 Hrg
histidine-rich glycoprotein
chr12_+_39510297 0.830 NM_001163154
Etv1
ets variant gene 1
chr6_+_71149869 0.828 NM_017399
Fabp1
fatty acid binding protein 1, liver
chr7_-_53176582 0.823 NM_010129
Emp3
epithelial membrane protein 3
chr3_-_27795287 0.822 NM_001164437
Tmem212
transmembrane protein 212
chr9_+_53149188 0.820 Exph5
exophilin 5
chr6_-_136890189 0.812 NM_007486
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_109739389 0.804 Lin7c
lin-7 homolog C (C. elegans)
chr3_+_136598184 0.793 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr8_+_89996675 0.791 Gm2694
predicted gene 2694
chr7_+_27904968 0.782 NM_007817
Cyp2f2
cytochrome P450, family 2, subfamily f, polypeptide 2
chr2_+_44967779 0.780 NM_001177395
Gm13476
predicted gene 13476
chr19_-_40261753 0.771 NM_145499
Cyp2c70
cytochrome P450, family 2, subfamily c, polypeptide 70
chr6_+_121250304 0.761 NM_144512
Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr10_-_94786634 0.757 NM_009950
Cradd
CASP2 and RIPK1 domain containing adaptor with death domain
chr5_-_122906470 0.753 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chrM_-_16187 0.733


chr11_-_120441272 0.723 Arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr17_-_35971913 0.715 Tubb5
tubulin, beta 5
chr4_-_49562319 0.713 NM_144903
Aldob
aldolase B, fructose-bisphosphate
chr14_-_34195326 0.712 Mapk8
mitogen-activated protein kinase 8
chr12_+_109572514 0.710 NM_010010
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr11_-_83880574 0.706 Dusp14
dual specificity phosphatase 14
chr3_-_81779636 0.692 NM_019911
Tdo2
tryptophan 2,3-dioxygenase
chr9_-_55983967 0.691 Tspan3
tetraspanin 3
chr10_-_90616085 0.688 Tmpo
thymopoietin
chr4_-_118954780 0.682 Ybx1
Y box protein 1
chrM_-_622 0.680


chr5_+_32794685 0.680 Ppp1cb
protein phosphatase 1, catalytic subunit, beta isoform
chr19_-_5797749 0.678 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chrX_-_133267605 0.678


chr11_-_83391984 0.675 Ccl9
chemokine (C-C motif) ligand 9
chr12_-_100801791 0.668 Foxn3
forkhead box N3
chr7_+_29573191 0.668 Sirt2
sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
chr15_+_31154176 0.666 Dap
death-associated protein
chr1_-_180264067 0.656 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr2_+_162760505 0.656


chr9_-_78329444 0.636 NM_010106
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr3_+_28162135 0.629 NM_001163007
NM_001163008
NM_001163009
NM_026910
Tnik



TRAF2 and NCK interacting kinase



chr5_+_75548337 0.629 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr10_-_42722514 0.627 Sobp
sine oculis-binding protein homolog (Drosophila)
chr11_+_115891682 0.622 Unk
unkempt homolog (Drosophila)
chr6_+_124254668 0.606 NM_001170395
NM_053094
Cd163

CD163 antigen

chr8_+_91115856 0.603 Nkd1
naked cuticle 1 homolog (Drosophila)
chr8_-_96496001 0.600 Amfr
autocrine motility factor receptor
chr11_+_75570317 0.582 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr11_+_98626169 0.578 Thra
thyroid hormone receptor alpha
chrM_+_7714 0.568 Gm10925
ATP6
predicted gene 10925
ATP synthase F0 subunit 6
chr6_-_39760868 0.566 NM_001010930
NM_010270
Mrps33

mitochondrial ribosomal protein S33

chr11_-_6375845 0.564 NM_011221
Purb
purine rich element binding protein B
chrM_+_1091 0.563


chr11_-_120486280 0.562 NM_153056
Sirt7
sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)
chr1_-_165243777 0.558 NM_001025570
NM_011127
NM_175686
Prrx1


paired related homeobox 1


chr11_-_51414597 0.556 Hnrnpab
heterogeneous nuclear ribonucleoprotein A/B
chr8_-_87956665 0.548 NM_025722
4921524J17Rik
RIKEN cDNA 4921524J17 gene
chr7_+_19705202 0.546 NM_175530
Fbxo46
F-box protein 46
chr17_-_35973192 0.545 Tubb5
tubulin, beta 5
chr4_+_119486921 0.544 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chrM_+_5322 0.542 COX1
cytochrome c oxidase subunit I
chr2_-_84490666 0.539 NM_001085453
Ctnnd1
catenin (cadherin associated protein), delta 1
chr3_-_8923789 0.537 NM_025434
Mrps28
mitochondrial ribosomal protein S28
chr5_-_144267802 0.535 Rac1
RAS-related C3 botulinum substrate 1
chr2_+_84574217 0.534 NM_001005342
Ypel4
yippee-like 4 (Drosophila)
chr7_-_86887995 0.531 Pex11a
peroxisomal biogenesis factor 11 alpha
chr2_+_21289168 0.531 NM_001004761
Gpr158
G protein-coupled receptor 158
chr2_-_119980243 0.528 NM_133838
Ehd4
EH-domain containing 4
chr5_-_100391613 0.528 Hnrnpd
heterogeneous nuclear ribonucleoprotein D
chr14_-_31981780 0.524 Stab1
stabilin 1
chr15_+_31154178 0.521 Dap
death-associated protein
chr1_+_21230683 0.513 Gsta3
glutathione S-transferase, alpha 3
chr4_+_97444494 0.510 Nfia
nuclear factor I/A
chr15_+_78757171 0.507 Lgals1
lectin, galactose binding, soluble 1
chr15_+_34167908 0.503 Laptm4b
lysosomal-associated protein transmembrane 4B
chr12_+_105316152 0.499 Serpina4-ps1
serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1
chr16_-_75909440 0.497 NM_023380
Samsn1
SAM domain, SH3 domain and nuclear localization signals, 1
chr3_-_108707417 0.497 Prpf38b
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr1_-_20608010 0.496 NM_153179
Pkhd1
polycystic kidney and hepatic disease 1
chr9_+_92502908 0.496 Plod2
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
chr11_-_106642684 0.489 Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr3_-_146433544 0.489 NM_001164199
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr2_-_34956162 0.486 NM_178885
AI182371
expressed sequence AI182371

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
4.12 4.82e-06 GO:0065008 regulation of biological quality
3.50 7.04e-06 GO:0048731 system development
3.27 1.22e-05 GO:0048856 anatomical structure development
4.27 4.70e-05 GO:0051239 regulation of multicellular organismal process
4.77 6.65e-05 GO:0007399 nervous system development
2.96 8.62e-05 GO:0007275 multicellular organismal development
3.03 1.14e-04 GO:0048518 positive regulation of biological process
2.73 4.49e-04 GO:0032502 developmental process
5.13 5.73e-04 GO:0042592 homeostatic process
3.26 5.85e-04 GO:0048523 negative regulation of cellular process
6.23 6.97e-04 GO:0048878 chemical homeostasis
2.98 2.48e-03 GO:0048519 negative regulation of biological process
4.43 2.96e-03 GO:0032879 regulation of localization
12.67 4.59e-03 GO:0050678 regulation of epithelial cell proliferation
2.81 5.96e-03 GO:0048522 positive regulation of cellular process
7.19 8.40e-03 GO:0007610 behavior
7.17 8.57e-03 GO:0090066 regulation of anatomical structure size
61.72 8.93e-03 GO:0030195 negative regulation of blood coagulation
61.72 8.93e-03 GO:0045445 myoblast differentiation
8.68 9.13e-03 GO:0040007 growth
3.18 1.36e-02 GO:0048513 organ development
4.54 1.43e-02 GO:0048468 cell development
4.39 1.94e-02 GO:2000026 regulation of multicellular organismal development
2.42 1.99e-02 GO:0051179 localization
47.03 2.10e-02 GO:0050819 negative regulation of coagulation
13.18 2.32e-02 GO:0010638 positive regulation of organelle organization
6.21 2.40e-02 GO:0007417 central nervous system development
7.42 2.49e-02 GO:0051270 regulation of cellular component movement
5.24 2.87e-02 GO:0040011 locomotion
1.63 2.91e-02 GO:0065007 biological regulation
7.08 3.35e-02 GO:0019226 transmission of nerve impulse
7.08 3.35e-02 GO:0035637 multicellular organismal signaling
164.56 3.39e-02 GO:0034392 negative regulation of smooth muscle cell apoptosis
2.87 4.80e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

enrichment p-value GO term description
5.67 9.22e-05 GO:0005615 extracellular space
3.28 7.68e-04 GO:0005576 extracellular region
4.29 1.65e-03 GO:0044421 extracellular region part
164.56 5.52e-03 GO:0031232 extrinsic to external side of plasma membrane
5.71 7.04e-03 GO:0009986 cell surface
59.85 4.99e-02 GO:0042627 chylomicron

Gene overrepresentation in function category:

enrichment p-value GO term description
2.27 2.03e-06 GO:0005515 protein binding
12.11 5.61e-03 GO:0005539 glycosaminoglycan binding
10.84 9.51e-03 GO:0001871 pattern binding
10.84 9.51e-03 GO:0030247 polysaccharide binding
109.71 1.36e-02 GO:0033130 acetylcholine receptor binding
12.92 2.57e-02 GO:0008201 heparin binding
23.52 2.80e-02 GO:0043498 cell surface binding
2.73 4.01e-02 GO:0003677 DNA binding
19.76 4.69e-02 GO:0003697 single-stranded DNA binding