Motif ID: AIRE.p2

Z-value: 1.209

Transcription factors associated with AIRE.p2:

NameEntrezDescription
Aire 11634 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal



Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr1_-_42749940 15.948 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chrX_+_108009728 8.239 NM_008901
Pou3f4
POU domain, class 3, transcription factor 4
chr2_-_91771882 7.964 Mdk
midkine
chr19_-_36994088 6.620 NM_028263
Fgfbp3
fibroblast growth factor binding protein 3
chr3_+_5218545 5.636 NM_030708
Zfhx4
zinc finger homeodomain 4
chr5_-_5265981 5.252 Cdk14
cyclin-dependent kinase 14
chr9_+_96159123 5.053 NM_001184709
Tfdp2
transcription factor Dp 2
chrX_+_104115963 5.028 NM_175271
Lpar4
lysophosphatidic acid receptor 4
chr1_-_128634766 4.951 Nckap5
NCK-associated protein 5
chr9_+_85739048 4.696 Tpbg
trophoblast glycoprotein
chr6_-_12699189 4.636 NM_001164805
Thsd7a
thrombospondin, type I, domain containing 7A
chr6_-_49214015 4.501 NM_198102
Tra2a
transformer 2 alpha homolog (Drosophila)
chr11_-_54601133 4.287 Cdc42se2
CDC42 small effector 2
chr9_+_96159666 4.276 NM_001184710
NM_001184711
Tfdp2

transcription factor Dp 2

chr14_+_67254087 4.046 NM_013461
Adra1a
adrenergic receptor, alpha 1a
chrX_+_166317553 3.865 NM_183151
Mid1
midline 1
chr13_-_4608352 3.735 NM_018859
Akr1e1
aldo-keto reductase family 1, member E1
chr11_-_54601093 3.696 Cdc42se2
CDC42 small effector 2
chr12_+_16817772 3.640 E2f6
E2F transcription factor 6
chr8_+_86239131 3.467 Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr2_-_91771919 3.246 NM_001012336
Mdk
midkine
chr17_+_17539908 3.201 Lix1
limb expression 1 homolog (chicken)
chr3_+_63780058 3.200 NM_001033300
Gmps
guanine monophosphate synthetase
chr11_-_107050573 2.942 NM_001161329
NM_133702
Nol11

nucleolar protein 11

chr6_-_49164469 2.918 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr3_+_66023884 2.905 Ptx3
pentraxin related gene
chr18_-_46372017 2.889 NM_178872
Trim36
tripartite motif-containing 36
chr4_+_134420419 2.766 NM_011270
Rhd
Rh blood group, D antigen
chr6_-_127075853 2.766 Ccnd2
cyclin D2
chr1_-_180267913 2.661 NM_016805
Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr5_-_21290971 2.521 NM_009584
Dnajc2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr1_+_19202046 2.368 NM_001025305
Tcfap2b
transcription factor AP-2 beta
chr17_-_15963372 2.362 NM_178615
Rgmb
RGM domain family, member B
chr5_+_147656646 2.250 NM_026864
Rasl11a
RAS-like, family 11, member A
chr13_+_14705508 2.244 NM_008944
Psma2
proteasome (prosome, macropain) subunit, alpha type 2
chr18_-_16966954 2.214 Cdh2
cadherin 2
chr5_-_138596915 2.212 NM_019747
Zfp113
zinc finger protein 113
chr5_+_130505154 2.155 NM_007761
Crcp
calcitonin gene-related peptide-receptor component protein
chr8_-_26707934 2.117 NM_173012
Letm2
leucine zipper-EF-hand containing transmembrane protein 2
chr11_+_3863948 2.085 NM_022889
Pes1
pescadillo homolog 1, containing BRCT domain (zebrafish)
chr3_+_133899454 2.069 Cxxc4
CXXC finger 4
chr1_+_168184269 2.061 NM_001164528
Ildr2
immunoglobulin-like domain containing receptor 2
chr5_+_89012547 2.035 Rufy3
RUN and FYVE domain containing 3
chr7_+_130267661 2.019 Tnrc6a
trinucleotide repeat containing 6a
chr3_+_66023808 2.019 NM_008987
Ptx3
pentraxin related gene
chr17_+_17539832 1.986 Lix1
limb expression 1 homolog (chicken)
chr2_+_44966657 1.974 NM_001177394
Gm13476
predicted gene 13476
chr4_-_94223435 1.946 NM_026368
5830433M19Rik
RIKEN cDNA 5830433M19 gene
chr5_-_135727086 1.939 Fzd9
frizzled homolog 9 (Drosophila)
chr5_-_67490295 1.937 NM_008888
Phox2b
paired-like homeobox 2b
chr12_-_86113816 1.922 Npc2
Niemann Pick type C2
chr8_+_108583449 1.909 NM_010901
Nfatc3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr14_-_52780511 1.853 Supt16h
suppressor of Ty 16 homolog (S. cerevisiae)
chr17_-_37095372 1.852 NM_023162
Znrd1
zinc ribbon domain containing, 1
chr10_-_126467848 1.847 NM_025537
Tsfm
Ts translation elongation factor, mitochondrial
chr3_-_157587998 1.823 NM_145953
Cth
cystathionase (cystathionine gamma-lyase)
chr6_+_91828040 1.822 NM_172730
C130022K22Rik
RIKEN cDNA C130022K22 gene
chr2_-_33323966 1.820 NM_001025594
NM_027947
Zbtb43

zinc finger and BTB domain containing 43

chrY_+_234230 1.811 NM_011419
Kdm5d
lysine (K)-specific demethylase 5D
chr7_+_118172447 1.796 NM_009431
Ctr9
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr5_+_89012537 1.748 Rufy3
RUN and FYVE domain containing 3
chr14_-_48037815 1.739 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr7_-_36103433 1.728 NM_026181
Gpatch1
G patch domain containing 1
chr2_+_158450623 1.661 NM_175419
Actr5
ARP5 actin-related protein 5 homolog (yeast)
chr3_+_142428186 1.640 NM_145546
Gtf2b
general transcription factor IIB
chr2_+_172847371 1.607 NM_019547
Rbm38
RNA binding motif protein 38
chr11_-_54601163 1.593 NM_178626
Cdc42se2
CDC42 small effector 2
chr12_-_82695944 1.574 NM_027213
Med6
mediator of RNA polymerase II transcription, subunit 6 homolog (yeast)
chr4_-_148511650 1.567 NM_027263
Apitd1
apoptosis-inducing, TAF9-like domain 1
chr15_+_76709688 1.565 NM_145916
Zfp7
zinc finger protein 7
chr16_+_27388907 1.563 NM_001025615
NM_026202
Ccdc50

coiled-coil domain containing 50

chr6_+_134961629 1.556 NM_026360
Ddx47
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
chr7_+_13063673 1.540 Zfp606
zinc finger protein 606
chr7_+_65913571 1.532 NM_009728
Atp10a
ATPase, class V, type 10A
chr10_-_12912880 1.532 NM_181470
Ltv1
LTV1 homolog (S. cerevisiae)
chr11_+_98667577 1.531 Msl1
male-specific lethal 1 homolog (Drosophila)
chr4_-_124370770 1.530 NM_026031
Utp11l
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr11_-_120459646 1.520 NM_011568
Thoc4
THO complex 4
chr9_-_107673268 1.511 Rbm5
RNA binding motif protein 5
chr3_-_115832327 1.503 Vcam1
vascular cell adhesion molecule 1
chr6_-_88848650 1.503 NM_008564
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr6_-_134847832 1.502 NM_001167695
NM_001167696
NM_001167693
NM_001167694
NM_001167700
Gpr19




G protein-coupled receptor 19




chr9_+_15110657 1.498 NM_027261
NM_029248
Taf1d

TATA box binding protein (Tbp)-associated factor, RNA polymerase I, D

chr9_-_10904725 1.492 NM_001033359
NM_001170787
Cntn5

contactin 5

chr14_-_25306175 1.490 Polr3a
polymerase (RNA) III (DNA directed) polypeptide A
chr14_-_20796411 1.489 NM_001038637
NM_010315
Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr11_+_80196766 1.488 NM_001130169
NM_001130170
NM_001130171
NM_011751
Zfp207



zinc finger protein 207



chr17_-_71202829 1.487 NM_001164074
Tgif1
TGFB-induced factor homeobox 1
chrX_+_162608411 1.478 NM_146238
Gemin8
gem (nuclear organelle) associated protein 8
chr11_-_43239663 1.470 NM_001131054
Pttg1
pituitary tumor-transforming gene 1
chr9_-_114690887 1.459 NM_133978
Cmtm7
CKLF-like MARVEL transmembrane domain containing 7
chr2_-_60719361 1.446 NM_001141931
NM_001141932
Rbms1

RNA binding motif, single stranded interacting protein 1

chr6_-_97010364 1.445 NM_177233
Fam19a4
family with sequence similarity 19, member A4
chr13_+_120251565 1.441 NM_001113550
NM_026127
4833420G17Rik

RIKEN cDNA 4833420G17 gene

chr7_+_86040793 1.416 NM_001162939
NM_026531
Aen

apoptosis enhancing nuclease

chr6_+_113102884 1.415 Setd5
SET domain containing 5
chr1_+_176102903 1.414 NM_011465
Spna1
spectrin alpha 1
chr2_+_119722957 1.414 NM_001164274
NM_013720
Mga

MAX gene associated

chr2_-_118375365 1.400 NM_138313
Bmf
BCL2 modifying factor
chr5_+_31754808 1.393 NM_172993
Zfp512
zinc finger protein 512
chr2_+_109120894 1.391 NM_139303
Kif18a
kinesin family member 18A
chr4_+_135728188 1.381 NM_177733
E2f2
E2F transcription factor 2
chr6_+_114347929 1.381 NM_008285
Hrh1
histamine receptor H1
chr3_-_89856250 1.378 NM_001165983
NM_001165985
NM_001165987
NM_028475
NM_153489
NM_001165984
NM_001165986
NM_001165988
Ubap2l







ubiquitin associated protein 2-like







chr2_-_120796395 1.377 NM_009461
Ubr1
ubiquitin protein ligase E3 component n-recognin 1
chrM_-_13886 1.368


chr17_-_26232411 1.366 NM_019731
Nme4
non-metastatic cells 4, protein expressed in
chr18_+_50287848 1.363 NM_008292
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
chr11_-_99091732 1.357 Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr9_-_107673288 1.356 Rbm5
RNA binding motif protein 5
chr11_+_34214821 1.353 NM_001025382
Fam196b
family with sequence similarity 196, member B
chr2_+_69560861 1.343 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chrX_-_7544940 1.343 NM_008089
Gata1
GATA binding protein 1
chrX_-_6765768 1.338 NM_016691
Clcn5
chloride channel 5
chr11_+_93905443 1.334 Spag9
sperm associated antigen 9
chr3_-_94846454 1.332 NM_008951
Psmd4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
chr3_+_145784635 1.329 NM_134160
Mcoln3
mucolipin 3
chr4_-_91066674 1.323 NM_207685
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_+_53353919 1.319 NM_145517
Ormdl1
ORM1-like 1 (S. cerevisiae)
chr3_-_95161071 1.311 NM_001163641
NM_001163642
NM_018877
Setdb1


SET domain, bifurcated 1


chr13_+_49777464 1.299 NM_172015
Iars
isoleucine-tRNA synthetase
chr1_-_180267841 1.298 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr3_+_63780020 1.296 Gmps
guanine monophosphate synthetase
chr4_+_122731563 1.293 Trit1
tRNA isopentenyltransferase 1
chr7_-_85992096 1.287 NM_029585
Det1
de-etiolated homolog 1 (Arabidopsis)
chr7_+_25055436 1.286 NM_009567
Zfp93
zinc finger protein 93
chr12_+_82049290 1.281 Srsf5
serine/arginine-rich splicing factor 5
chrX_+_45610055 1.277 NM_028276
Utp14a
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr11_+_53138176 1.258 NM_026479
Zcchc10
zinc finger, CCHC domain containing 10
chr2_+_74707394 1.252 Mtx2
metaxin 2
chr4_-_147183894 1.242 NM_001127189
Gm13157
2610036A22Rik
predicted gene 13157
RIKEN cDNA 2610036A22 gene
chr5_-_140797483 1.228 NM_010752
Mad1l1
mitotic arrest deficient 1-like 1
chr19_-_40261753 1.228 NM_145499
Cyp2c70
cytochrome P450, family 2, subfamily c, polypeptide 70
chr16_+_55966387 1.222 NM_024218
Rpl24
ribosomal protein L24
chr12_+_16817741 1.204 E2f6
E2F transcription factor 6
chr2_-_144376513 1.202 NM_015754
Rbbp9
retinoblastoma binding protein 9
chr15_+_102126735 1.201 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr16_-_32079317 1.200 NM_177326
Pak2
p21 protein (Cdc42/Rac)-activated kinase 2
chr10_+_68996455 1.199 NM_146005
NM_170688
NM_170689
NM_170690
NM_170728
NM_170729
NM_170730
Ank3






ankyrin 3, epithelial






chr6_-_49195555 1.186 Tra2a
transformer 2 alpha homolog (Drosophila)
chr13_+_78337168 1.184 A830082K12Rik
RIKEN cDNA A830082K12 gene
chr17_-_23908488 1.179 NM_153791
Flywch1
FLYWCH-type zinc finger 1
chrX_+_50911075 1.173 NM_028375
Cxx1c
CAAX box 1 homolog C (human)
chrX_-_103207106 1.159 NM_001190409
NM_025952
Magt1

magnesium transporter 1

chr2_-_4573118 1.140 NM_026045
Prpf18
PRP18 pre-mRNA processing factor 18 homolog (yeast)
chr4_-_107743887 1.139 Scp2
sterol carrier protein 2, liver
chr1_-_196957694 1.135 NM_013499
Cr1l
complement component (3b/4b) receptor 1-like
chr19_+_46781939 1.128 As3mt
arsenic (+3 oxidation state) methyltransferase
chr1_+_137914635 1.117 NM_001160146
Tmem9
transmembrane protein 9
chr4_-_120597563 1.112 NM_001160043
NM_028457
Dem1

defects in morphology 1 homolog (S. cerevisiae)

chr8_+_73053287 1.110 Fkbp8
FK506 binding protein 8
chr4_+_15211137 1.101 Tmem64
transmembrane protein 64
chr16_+_32914183 1.087 NM_001081255
Lrch3
leucine-rich repeats and calponin homology (CH) domain containing 3
chr15_-_81222718 1.083 St13
suppression of tumorigenicity 13
chr5_+_144309573 1.068 NM_026050
NM_133703
2810453I06Rik

RIKEN cDNA 2810453I06 gene

chr16_-_55934909 1.067 NM_001159364
NM_001159365
NM_001159366
NM_028815
Cep97



centrosomal protein 97



chr11_+_115265054 1.062 NM_026729
Ict1
immature colon carcinoma transcript 1
chr17_-_23330163 1.058 NM_009555
Zfp40
zinc finger protein 40
chr7_-_52560744 1.039 Trpm4
transient receptor potential cation channel, subfamily M, member 4
chr3_-_65940346 1.026 NM_028357
Veph1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr4_+_140257340 1.022 NM_173867
Rcc2
regulator of chromosome condensation 2
chr11_-_58615400 1.018 NM_001162878
NM_029283
Fam183b

family with sequence similarity 183, member B

chr1_+_159436875 1.014 NM_033354
Sec16b
SEC16 homolog B (S. cerevisiae)
chr15_-_98748371 1.008 NM_029098
Lmbr1l
limb region 1 like
chr10_+_97028134 1.006 NM_008524
Lum
lumican
chr9_+_104955563 1.006 NM_053159
Mrpl3
mitochondrial ribosomal protein L3
chr9_-_64188945 0.997 NM_001001295
Dis3l
DIS3 mitotic control homolog (S. cerevisiae)-like
chr6_-_6528581 0.997 NM_009169
Shfm1
split hand/foot malformation (ectrodactyly) type 1
chr17_-_5440223 0.994 NM_027457
5730437N04Rik
RIKEN cDNA 5730437N04 gene
chr15_+_102126686 0.992 NM_001014976
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr2_+_28323580 0.985 NM_001166031
NM_080452
Mrps2

mitochondrial ribosomal protein S2

chr5_+_135058559 0.976 NM_020022
Rfc2
replication factor C (activator 1) 2
chr4_+_126354857 0.974 NM_011970
Psmb2
proteasome (prosome, macropain) subunit, beta type 2
chr14_-_20796199 0.974 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr15_-_102501463 0.973 NM_026468
Atp5g2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)
chr13_-_21875234 0.971 NM_178207
Hist1h3i
histone cluster 1, H3i
chr19_+_32694494 0.969 NM_011864
Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr5_-_145927883 0.966 Ptcd1
pentatricopeptide repeat domain 1
chr4_-_126738303 0.961 NM_026670
Zmym1
zinc finger, MYM domain containing 1
chr3_+_82859422 0.960 NM_016784
Plrg1
pleiotropic regulator 1, PRL1 homolog (Arabidopsis)
chr6_+_120413200 0.958 NM_008359
Il17ra
interleukin 17 receptor A
chr13_-_21532756 0.950 NM_001012311
NM_001162920
Pgbd1

piggyBac transposable element derived 1

chr19_+_18787654 0.948 NM_177640
D030056L22Rik
RIKEN cDNA D030056L22 gene
chr3_-_10331334 0.942 NM_018864
Impa1
inositol (myo)-1(or 4)-monophosphatase 1
chrX_+_146981959 0.942 NM_001102446
NM_009653
Alas2

aminolevulinic acid synthase 2, erythroid

chr10_-_129717244 0.940 NM_007501
Neurod4
neurogenic differentiation 4
chr10_+_128143313 0.936 NM_021882
Pmel
premelanosome protein
chr11_+_105927362 0.929 NM_027346
Taco1
translational activator of mitochondrially encoded cytochrome c oxidase I
chr9_+_72122785 0.926 Zfp280d
zinc finger protein 280D
chrX_+_20235512 0.924 NM_009457
Uba1
ubiquitin-like modifier activating enzyme 1
chr5_+_136592559 0.924 NM_011293
Polr2j
polymerase (RNA) II (DNA directed) polypeptide J
chr12_+_86311859 0.916 NM_028632
Fcf1
FCF1 small subunit (SSU) processome component homolog (S. cerevisiae)
chr7_-_151656610 0.910 NM_007803
Cttn
cortactin
chr16_-_4077714 0.904 NM_026508
Trap1
TNF receptor-associated protein 1
chr1_+_129101570 0.901 Mgat5
mannoside acetylglucosaminyltransferase 5
chr7_-_107731579 0.896 NM_198831
Mrpl48
mitochondrial ribosomal protein L48
chr15_+_6395311 0.895 NM_013485
C9
complement component 9
chr10_+_39332934 0.887 Traf3ip2
TRAF3 interacting protein 2
chr7_+_106415956 0.886 NM_001048167
NM_010837
Mtap6

microtubule-associated protein 6

chr17_-_26206459 0.885 Rab11fip3
RAB11 family interacting protein 3 (class II)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.42 9.11e-06 GO:0010467 gene expression
2.41 6.14e-05 GO:0016070 RNA metabolic process
2.25 1.12e-04 GO:0090304 nucleic acid metabolic process
2.08 2.63e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
5.13 3.31e-04 GO:0000278 mitotic cell cycle
1.79 6.77e-04 GO:0044260 cellular macromolecule metabolic process
1.96 7.25e-04 GO:0034641 cellular nitrogen compound metabolic process
1.91 1.55e-03 GO:0006807 nitrogen compound metabolic process
1.67 4.29e-03 GO:0043170 macromolecule metabolic process
3.68 7.51e-03 GO:0022402 cell cycle process
1.55 1.05e-02 GO:0044237 cellular metabolic process
3.03 2.45e-02 GO:0007049 cell cycle
3.94 2.96e-02 GO:0022403 cell cycle phase
1.49 4.38e-02 GO:0044238 primary metabolic process

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.02 1.71e-08 GO:0005634 nucleus
1.56 5.79e-06 GO:0043231 intracellular membrane-bounded organelle
1.56 6.46e-06 GO:0043227 membrane-bounded organelle
1.41 2.24e-05 GO:0044424 intracellular part
1.48 2.83e-05 GO:0043229 intracellular organelle
1.47 3.32e-05 GO:0043226 organelle
1.38 8.18e-05 GO:0005622 intracellular
3.83 3.96e-03 GO:0030529 ribonucleoprotein complex
2.18 1.00e-02 GO:0044428 nuclear part
29.15 1.46e-02 GO:0030684 preribosome

Gene overrepresentation in function category:

enrichment p-value GO term description
2.32 1.09e-05 GO:0003676 nucleic acid binding
2.17 1.11e-02 GO:0003677 DNA binding