Motif ID: ATF6.p2

Z-value: 0.882

Transcription factors associated with ATF6.p2:

NameEntrezDescription
Atf6 226641 activating transcription factor 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Atf6chr1_-_172797866-0.326.0e-02Click!


Activity profile for motif ATF6.p2.

activity profile for motif ATF6.p2


Sorted Z-values histogram for motif ATF6.p2

Sorted Z-values for motif ATF6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr6_+_7505070 2.489 NM_009311
Tac1
tachykinin 1
chr1_+_162965292 1.803 Gas5
growth arrest specific 5
chr12_+_80231774 1.763 NM_009705
Arg2
arginase type II
chr5_+_28492235 1.736 NM_010134
En2
engrailed 2
chr16_-_23890909 1.671 NM_009215
Sst
somatostatin
chr14_+_76245136 1.656 Tpt1
tumor protein, translationally-controlled 1
chr1_+_50984361 1.579 NM_019790
Tmeff2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr12_+_3891743 1.544 NM_153743
Dnmt3a
DNA methyltransferase 3A
chr4_+_71862277 1.496 C630043F03Rik
RIKEN cDNA C630043F03 gene
chr12_-_88225714 1.492 NM_145836
6430527G18Rik
RIKEN cDNA 6430527G18 gene
chr1_+_63319842 1.449 NM_028673
Zdbf2
zinc finger, DBF-type containing 2
chr5_+_120881778 1.441 NM_008499
Lhx5
LIM homeobox protein 5
chr1_-_127808723 1.347 Lypd1
Ly6/Plaur domain containing 1
chr13_+_13876570 1.318 Gng4
guanine nucleotide binding protein (G protein), gamma 4
chr7_-_147234897 1.317 NM_010836
Msx3
homeobox, msh-like 3
chr2_+_155207542 1.277 Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr16_+_94592373 1.274 Ttc3
tetratricopeptide repeat domain 3
chr16_+_94592307 1.260 NM_009441
Ttc3
tetratricopeptide repeat domain 3
chr7_+_90015842 1.193 NM_175366
Mex3b
mex3 homolog B (C. elegans)
chr2_+_155207581 1.180 NM_178111
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr3_+_134491969 1.159 NM_021382
Tacr3
tachykinin receptor 3
chr2_-_32143495 1.157 NM_175190
2900010J23Rik
RIKEN cDNA 2900010J23 gene
chr19_+_59335367 1.134 NM_172523
Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr14_+_76245144 1.133 Tpt1
tumor protein, translationally-controlled 1
chr12_-_36769054 1.107 NM_025359
Tspan13
tetraspanin 13
chr7_-_144506091 1.074 Ebf3
early B-cell factor 3
chrX_-_58146562 1.028 NM_009237
Sox3
SRY-box containing gene 3
chr7_+_140122848 1.018 Zranb1
zinc finger, RAN-binding domain containing 1
chr11_-_84338922 1.012 NM_008498
Lhx1
LIM homeobox protein 1
chr1_-_91827726 1.003 NM_010262
Gbx2
gastrulation brain homeobox 2
chr6_+_29383152 0.998 NM_001081185
Flnc
filamin C, gamma
chr4_+_13670582 0.994 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr13_-_112280018 0.991 NM_001122963
NM_028487
Gpbp1

GC-rich promoter binding protein 1

chr13_-_19487596 0.986 NM_024270
Stard3nl
STARD3 N-terminal like
chr11_-_120852554 0.981 Csnk1d
casein kinase 1, delta
chr16_+_94592359 0.971 Ttc3
tetratricopeptide repeat domain 3
chr7_-_52722144 0.956 NM_007527
Bax
BCL2-associated X protein
chr8_-_94325138 0.948 NM_008393
Irx3
Iroquois related homeobox 3 (Drosophila)
chr11_-_120852609 0.942 NM_027874
NM_139059
Csnk1d

casein kinase 1, delta

chr4_-_108874820 0.935 Osbpl9
oxysterol binding protein-like 9
chr2_+_75497282 0.928 NM_053263
NM_146130
NM_198090
Hnrnpa3


Gm6793
heterogeneous nuclear ribonucleoprotein A3


heterogeneous nuclear ribonucleoprotein A3 pseudogene
chr5_+_143722032 0.915 NM_007984
Fscn1
fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
chr5_+_139230946 0.914 NM_030565
Fam20c
family with sequence similarity 20, member C
chr4_+_43419445 0.909 NM_199057
Rusc2
RUN and SH3 domain containing 2
chr5_-_92566671 0.908


chr1_+_168309297 0.906 NM_030245
Tada1
transcriptional adaptor 1
chr2_+_156546758 0.892 Dlgap4
discs, large homolog-associated protein 4 (Drosophila)
chr7_-_52384104 0.851 NM_009438
Rpl13a
ribosomal protein L13A
chr19_+_4756524 0.839 NM_025717
Rbm4b
RNA binding motif protein 4B
chr4_+_8462805 0.831 Rab2a
RAB2A, member RAS oncogene family
chr9_+_108241599 0.830 NM_008160
Gpx1
glutathione peroxidase 1
chr6_-_128312829 0.829 5930416I19Rik
RIKEN cDNA 5930416I19 gene
chr6_-_149137169 0.817 NM_001113424
Amn1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr16_-_17928270 0.787 NM_153150
Slc25a1
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
chr5_+_110973321 0.780 NM_198306
Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr17_-_36046961 0.775 NM_001142744
NM_001142745
NM_028476
Atat1


alpha tubulin acetyltransferase 1


chr1_+_154802144 0.767 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr8_+_35870347 0.760 Dusp4
dual specificity phosphatase 4
chr11_+_83777922 0.756 NM_001115009
NM_194341
Synrg

synergin, gamma

chr12_-_60112987 0.755 NM_009147
Sec23a
SEC23A (S. cerevisiae)
chr2_+_121275069 0.749 Serf2
small EDRK-rich factor 2
chr14_+_76245115 0.739 Tpt1
tumor protein, translationally-controlled 1
chr8_-_118231677 0.738 Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr7_+_6683288 0.733 NM_021323
Usp29
ubiquitin specific peptidase 29
chrX_+_131252542 0.726 Armcx1
armadillo repeat containing, X-linked 1
chr6_+_83065466 0.722 NM_020619
Mogs
mannosyl-oligosaccharide glucosidase
chr2_+_35992148 0.692 Mrrf
mitochondrial ribosome recycling factor
chr1_+_154802091 0.691 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr1_+_75476106 0.689 NM_177056
Tmem198
transmembrane protein 198
chr2_+_160471695 0.689 Top1
topoisomerase (DNA) I
chr6_-_118429262 0.681 Zfp9
zinc finger protein 9
chr11_+_16157685 0.676 NM_145967
Vstm2a
V-set and transmembrane domain containing 2A
chr7_-_97624504 0.671 NM_026734
Tmem126b
transmembrane protein 126B
chr10_-_128360523 0.665 NM_015740
Bloc1s1
biogenesis of lysosome-related organelles complex-1, subunit 1
chr14_-_34260323 0.656 NM_016700
Mapk8
mitogen-activated protein kinase 8
chr4_+_46502141 0.653 NM_053179
Nans
N-acetylneuraminic acid synthase (sialic acid synthase)
chr4_-_47487166 0.650 Alg2
asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase)
chr3_-_126928844 0.638 Ank2
ankyrin 2, brain
chr17_-_29484429 0.628 Mtch1
mitochondrial carrier homolog 1 (C. elegans)
chr5_+_45911467 0.625 NM_025895
Med28
mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)
chrY_-_582062 0.610 NM_009484
Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr11_+_22890575 0.608 NM_009837
Cct4
chaperonin containing Tcp1, subunit 4 (delta)
chr3_-_37623250 0.606 NM_198657
Gm5148
predicted gene 5148
chr11_+_22890632 0.591 Cct4
chaperonin containing Tcp1, subunit 4 (delta)
chr11_+_84339151 0.589 1500016L03Rik
RIKEN cDNA 1500016L03 gene
chr9_-_35075338 0.584 NM_194257
NM_175411
Fam118b

family with sequence similarity 118, member B

chr12_+_73543228 0.570 NM_001142729
Lrrc9
leucine rich repeat containing 9
chrX_-_45245608 0.561 NM_053123
Smarca1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr4_+_48598013 0.552 NM_021436
Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr6_-_25759187 0.546 Pot1a
protection of telomeres 1A
chr8_-_24318788 0.545 NM_018743
Agpat6
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
chr5_+_145016060 0.542 NM_018772
Bri3
brain protein I3
chr1_-_172105009 0.534 NM_133806
Uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr18_+_52928026 0.533 Gm5078
Sncaip
predicted gene 5078
synuclein, alpha interacting protein (synphilin)
chr12_+_103707313 0.532 NM_001199004
Golga5
golgi autoantigen, golgin subfamily a, 5
chr18_-_43059156 0.529 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr9_+_120401723 0.529 NM_026892
Eif1b
eukaryotic translation initiation factor 1B
chr11_+_102254699 0.527 NM_016759
Rundc3a
RUN domain containing 3A
chr12_-_17183330 0.526 Kcnf1
potassium voltage-gated channel, subfamily F, member 1
chr16_-_17928207 0.523 Slc25a1
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
chr5_+_30431701 0.521 NM_001167879
Fam59b
family with sequence similarity 59, member B
chr5_-_23953594 0.519 NM_022418
Tmub1
transmembrane and ubiquitin-like domain containing 1
chr1_-_75476031 0.517 NM_001001565
NM_001001566
Chpf

chondroitin polymerizing factor

chr2_+_37307786 0.506 Rabgap1
RAB GTPase activating protein 1
chr16_+_23989051 0.503


chr12_-_32746061 0.498 NM_011158
Prkar2b
protein kinase, cAMP dependent regulatory, type II beta
chr2_-_44968508 0.497 Zeb2
zinc finger E-box binding homeobox 2
chr12_-_70284991 0.497 Rpl36al
ribosomal protein L36A-like
chrX_-_131343508 0.497 Armcx2
armadillo repeat containing, X-linked 2
chr3_-_143868114 0.491 Lmo4
LIM domain only 4
chr6_-_51419726 0.491 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr18_-_35374663 0.490 NM_178005
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr2_+_152495244 0.489 H13
histocompatibility 13
chr1_+_154613763 0.488 Arpc5
actin related protein 2/3 complex, subunit 5
chr8_-_73223897 0.482 Gm11175
predicted gene 11175
chr4_-_129317873 0.481 NM_001005506
Txlna
taxilin alpha
chr9_-_35365985 0.477 NM_013932
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr10_+_20672352 0.473 NM_026203
Ahi1
Abelson helper integration site 1
chr2_-_35992076 0.473 NM_001159635
NM_026434
Rbm18

RNA binding motif protein 18

chr11_-_79068138 0.470 NM_019653
Wsb1
WD repeat and SOCS box-containing 1
chr11_-_76057153 0.468 Glod4
glyoxalase domain containing 4
chrX_-_34529689 0.466 NM_001177324
NM_019942
Sept6

septin 6

chrX_-_131285919 0.463 NM_001007578
Armcx6
armadillo repeat containing, X-linked 6
chr8_-_67171692 0.456 Cpe
carboxypeptidase E
chr12_+_83717883 0.455 NM_015812
Rgs6
regulator of G-protein signaling 6
chr17_-_33822327 0.455 NM_001109913
NM_029804
Hnrnpm

heterogeneous nuclear ribonucleoprotein M

chrX_-_45561726 0.455 NM_172465
Zdhhc9
zinc finger, DHHC domain containing 9
chr18_+_31919477 0.453 Ammecr1l
AMME chromosomal region gene 1-like
chr8_-_107813357 0.452 NM_001166394
NM_028888
4931428F04Rik

RIKEN cDNA 4931428F04 gene

chr7_-_52347489 0.449 NM_026555
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr2_-_132403964 0.448 NM_001042671
NM_001042672
NM_028802
Gpcpd1


glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)


chr5_-_65884169 0.443 1110003E01Rik
RIKEN cDNA 1110003E01 gene
chr14_-_60705571 0.442 NM_015803
Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr6_-_39327637 0.440 NM_028123
Slc37a3
solute carrier family 37 (glycerol-3-phosphate transporter), member 3
chr4_+_3866023 0.439 NM_001190323
NM_001190324
NM_001190322
NM_181391
Chchd7



coiled-coil-helix-coiled-coil-helix domain containing 7



chr7_-_150085870 0.438 NM_009377
Th
tyrosine hydroxylase
chr4_+_11083585 0.436 NM_021897
Trp53inp1
transformation related protein 53 inducible nuclear protein 1
chr12_-_66066481 0.436 NM_025707
Klhl28
kelch-like 28 (Drosophila)
chr9_-_76171352 0.435 NM_198962
Hcrtr2
hypocretin (orexin) receptor 2
chr4_+_47487510 0.434 NM_024171
Sec61b
Sec61 beta subunit
chr16_-_94592095 0.433 NM_001159618
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr5_-_138721164 0.430 NM_172412
Gpc2
glypican 2 (cerebroglycan)
chr12_+_8214912 0.429 NM_172401
NM_001167768
NM_001167767
1110057K04Rik


RIKEN cDNA 1110057K04 gene


chr1_+_153191613 0.428 NM_001039511
NM_001039512
NM_054102
Ivns1abp


influenza virus NS1A binding protein


chr2_+_119722957 0.427 NM_001164274
NM_013720
Mga

MAX gene associated

chr19_+_10278684 0.425 NM_026919
1810006K21Rik
RIKEN cDNA 1810006K21 gene
chr3_+_109143558 0.425 NM_020505
Vav3
vav 3 oncogene
chr14_-_67627598 0.424 NM_009761
Bnip3l
BCL2/adenovirus E1B interacting protein 3-like
chr8_-_88079180 0.424 Dnaja2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr8_-_67171805 0.424 NM_013494
Cpe
carboxypeptidase E
chr6_-_118429289 0.422 NM_011763
Zfp9
zinc finger protein 9
chr1_-_127808790 0.419 NM_145100
Lypd1
Ly6/Plaur domain containing 1
chr4_-_133801438 0.418 NM_024215
Zfp593
zinc finger protein 593
chr6_+_124881437 0.416 Mlf2
myeloid leukemia factor 2
chr5_+_92566909 0.415 NM_019490
Uso1
USO1 homolog, vesicle docking protein (yeast)
chr14_+_68701838 0.411 NM_010910
Nefl
neurofilament, light polypeptide
chr7_+_116077911 0.410 NM_025344
Eif3f
eukaryotic translation initiation factor 3, subunit F
chr1_+_64579358 0.409 NM_001037726
NM_009952
NM_133828
Creb1


cAMP responsive element binding protein 1


chr1_-_66864088 0.409 NM_001122738
NM_177645
1110028C15Rik

RIKEN cDNA 1110028C15 gene

chr8_+_93432505 0.406 Chd9
chromodomain helicase DNA binding protein 9
chr4_+_8462756 0.405 Rab2a
RAB2A, member RAS oncogene family
chr13_-_58228398 0.402 Hnrnpa0
heterogeneous nuclear ribonucleoprotein A0
chr8_-_35209773 0.399 NM_026609
Leprotl1
leptin receptor overlapping transcript-like 1
chr5_+_73684087 0.398 Ociad1
OCIA domain containing 1
chr2_-_74416925 0.397 NM_001110209
NM_027133
Lnp

limb and neural patterns

chr4_+_132091462 0.395 NM_172400
Dnajc8
DnaJ (Hsp40) homolog, subfamily C, member 8
chr10_-_127930880 0.395 NM_010860
Myl6
myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
chr4_-_115747606 0.394 Uqcrh
ubiquinol-cytochrome c reductase hinge protein
chr4_-_129317895 0.392 Txlna
taxilin alpha
chr10_-_127103595 0.392 NM_001122895
NM_008668
Nab2

Ngfi-A binding protein 2

chrX_+_20938001 0.390 Gm5124
predicted pseudogene 5124
chr8_+_116729508 0.390 NM_173016
Vat1l
vesicle amine transport protein 1 homolog-like (T. californica)
chr14_-_34260308 0.389 Mapk8
mitogen-activated protein kinase 8
chr7_-_20093663 0.387 NM_177692
Bloc1s3
biogenesis of lysosome-related organelles complex-1, subunit 3
chr6_-_72908018 0.386 NM_001039392
Tmsb10
thymosin, beta 10
chr11_+_86940545 0.385 NM_197987
Trim37
tripartite motif-containing 37
chr7_+_25315666 0.385 NM_153134
Irgq
immunity-related GTPase family, Q
chr5_-_72559220 0.384 NM_178599
Commd8
COMM domain containing 8
chr13_-_108680257 0.384 NM_145456
Zswim6
zinc finger, SWIM domain containing 6
chr17_-_80689434 0.382 Dhx57
DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
chr4_-_71861756 0.381 Tle1
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
chr5_-_136646451 0.381 NM_178751
Orai2
ORAI calcium release-activated calcium modulator 2
chr11_-_93746982 0.380 Utp18
UTP18, small subunit (SSU) processome component, homolog (yeast)
chr1_+_59969845 0.377 NM_001037725
Fam117b
family with sequence similarity 117, member B
chr4_-_108874844 0.376 NM_133885
Osbpl9
oxysterol binding protein-like 9
chr2_-_11423673 0.376 NM_001177752
NM_001177753
NM_001177754
NM_001177755
NM_001177756
NM_001177757
NM_133232
Pfkfb3






6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3






chr8_-_73011217 0.374 NM_182991
Tmem59l
transmembrane protein 59-like
chr10_+_84380305 0.369 NM_183172
Ric8b
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr11_+_101286405 0.368 Rundc1
RUN domain containing 1
chr15_+_103103286 0.367 Copz1
coatomer protein complex, subunit zeta 1
chr3_-_154756325 0.367 NM_029330
Fpgt
fucose-1-phosphate guanylyltransferase
chr19_+_46227039 0.365 NM_178930
Gbf1
golgi-specific brefeldin A-resistance factor 1
chr4_+_8462766 0.365 NM_021518
Rab2a
RAB2A, member RAS oncogene family
chr3_+_89856713 0.363 NM_025762
NM_027500
4933434E20Rik

RIKEN cDNA 4933434E20 gene

chr1_-_95375372 0.361 NM_133808
Hdlbp
high density lipoprotein (HDL) binding protein
chr3_+_102975621 0.356 NM_026602
Bcas2
breast carcinoma amplified sequence 2
chr9_+_106073265 0.356 Wdr82
WD repeat domain containing 82
chr16_+_55973916 0.355 NM_173026
Zbtb11
zinc finger and BTB domain containing 11
chr11_+_83116262 0.355 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr12_-_70260041 0.355 Rps29
ribosomal protein S29

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
37.82 6.17e-04 GO:0030902 hindbrain development
54.01 4.10e-03 GO:0021549 cerebellum development
251.93 4.70e-03 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
46.30 6.55e-03 GO:0022037 metencephalon development
215.94 6.57e-03 GO:0007217 tachykinin receptor signaling pathway
188.95 8.75e-03 GO:0021692 cerebellar Purkinje cell layer morphogenesis
188.95 8.75e-03 GO:0021694 cerebellar Purkinje cell layer formation
188.95 8.75e-03 GO:0021702 cerebellar Purkinje cell differentiation
11.49 1.08e-02 GO:0007420 brain development
167.96 1.12e-02 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
151.17 1.40e-02 GO:0021936 regulation of cerebellar granule cell precursor proliferation
125.98 2.06e-02 GO:0021697 cerebellar cortex formation
107.99 2.83e-02 GO:0021533 cell differentiation in hindbrain
107.99 2.83e-02 GO:0021680 cerebellar Purkinje cell layer development
8.93 3.53e-02 GO:0007417 central nervous system development

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.43 6.88e-03 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment p-value GO term description
7.20 2.48e-03 GO:0043565 sequence-specific DNA binding