Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 4.519

Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

NameEntrezDescription
Elk1 13712 ELK1, member of ETS oncogene family
Elk4 13714 ELK4, member of ETS oncogene family
Gabpa 14390 GA repeat binding protein, alpha
Gabpb1 14391 GA repeat binding protein, beta 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Gabpb1chr2_-_1265011730.661.3e-05Click!
Elk1chrX_-_20527674-0.546.2e-04Click!
Gabpachr16_+_848351310.473.5e-03Click!
Elk4chr1_+_1339041620.298.9e-02Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr16_-_22163035 18.999 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr13_+_98011057 16.296 NM_007930
Enc1
ectodermal-neural cortex 1
chr2_-_34227309 15.457 NM_016768
Pbx3
pre B-cell leukemia transcription factor 3
chr8_+_107821562 14.728 NM_148952
E2f4
E2F transcription factor 4
chr1_-_93309713 14.641 NM_019479
Hes6
hairy and enhancer of split 6 (Drosophila)
chr4_+_124392019 13.866 NM_029157
Sf3a3
splicing factor 3a, subunit 3
chr16_-_22163264 13.813 NM_183029
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr9_-_96789818 12.846 NM_153420
Acpl2
acid phosphatase-like 2
chr15_-_10644312 12.422 NM_001166408
Rai14
retinoic acid induced 14
chr13_-_8995234 12.404 NM_027000
Gtpbp4
GTP binding protein 4
chr4_+_131830270 12.282 NM_025579
Taf12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_+_130493536 12.166 NM_025922
Itpa
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
chr4_-_123427465 12.040 NM_023423
Akirin1
akirin 1
chr6_+_120314442 11.920 Kdm5a
lysine (K)-specific demethylase 5A
chr14_-_32308152 11.838 NM_025907
Mettl6
methyltransferase like 6
chr1_+_63319842 11.834 NM_028673
Zdbf2
zinc finger, DBF-type containing 2
chr11_-_44283916 11.752 NM_024475
Ublcp1
ubiquitin-like domain containing CTD phosphatase 1
chr6_-_29559792 11.604 Tnpo3
transportin 3
chr11_+_101303558 11.567 NM_011289
Rpl27
ribosomal protein L27
chr3_+_87734217 11.285 NM_177663
Isg20l2
interferon stimulated exonuclease gene 20-like 2
chr3_+_137806411 11.263 NM_175389
Rg9mtd2
RNA (guanine-9-) methyltransferase domain containing 2
chr15_-_75911326 11.176 NM_028364
NM_133691
Puf60

poly-U binding splicing factor 60

chr1_-_16647097 11.149 Tceb1
transcription elongation factor B (SIII), polypeptide 1
chr8_+_113580224 11.142 NM_028274
Exosc6
exosome component 6
chr4_-_45333366 10.912 NM_025513
Exosc3
exosome component 3
chr7_-_133935952 10.888 NM_019674
Ppp4c
protein phosphatase 4, catalytic subunit
chr12_+_3960002 10.619 Pomc
pro-opiomelanocortin-alpha
chr19_+_5366812 10.568 NM_027236
Eif1ad
eukaryotic translation initiation factor 1A domain containing
chrX_+_108009728 10.220 NM_008901
Pou3f4
POU domain, class 3, transcription factor 4
chr1_-_123464468 10.203 NM_025860
Ddx18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr16_+_31948631 10.110 NM_026554
Ncbp2
nuclear cap binding protein subunit 2
chr5_-_30399962 10.012 NM_021288
Tyms
thymidylate synthase
chr2_+_14976877 9.820 NM_029466
Arl5b
ADP-ribosylation factor-like 5B
chr3_+_87774988 9.701 NM_016701
Nes
nestin
chr11_+_70461024 9.699 NM_027445
Rnf167
ring finger protein 167
chrX_+_45610055 9.669 NM_028276
Utp14a
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr10_+_94977721 9.554 NM_080560
Ube2n
ubiquitin-conjugating enzyme E2N
chr14_-_70553471 9.519 2610301G19Rik
RIKEN cDNA 2610301G19 gene
chr2_-_5765967 9.501 NM_133837
Cdc123
cell division cycle 123 homolog (S. cerevisiae)
chr16_-_64770740 9.493 NM_026273
4930453N24Rik
RIKEN cDNA 4930453N24 gene
chr2_+_5766274 9.415 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr1_+_53353919 9.384 NM_145517
Ormdl1
ORM1-like 1 (S. cerevisiae)
chr9_-_114690887 9.357 NM_133978
Cmtm7
CKLF-like MARVEL transmembrane domain containing 7
chr8_-_94325138 9.016 NM_008393
Irx3
Iroquois related homeobox 3 (Drosophila)
chr14_-_52924792 8.884 NM_019721
Mettl3
methyltransferase like 3
chr19_+_38129500 8.851 NM_028293
NM_001164362
NM_028760
Cep55


centrosomal protein 55


chr11_+_43342241 8.789 NM_001045530
Ccnjl
cyclin J-like
chr11_-_35647952 8.582 NM_025936
Rars
arginyl-tRNA synthetase
chr13_+_38296760 8.558 NM_026382
Snrnp48
small nuclear ribonucleoprotein 48 (U11/U12)
chr17_-_3557712 8.537 NM_146074
Tfb1m
transcription factor B1, mitochondrial
chr9_+_122832164 8.529 NM_009544
Zfp105
zinc finger protein 105
chr19_-_7280741 8.473 NM_134150
Otub1
OTU domain, ubiquitin aldehyde binding 1
chr5_+_67651890 8.445 NM_028975
NM_030108
Tmem33

transmembrane protein 33

chr11_-_94515034 8.434 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr14_-_52924739 8.398 Mettl3
methyltransferase like 3
chr13_+_12487614 8.394 NM_144835
Heatr1
HEAT repeat containing 1
chr11_-_59653240 8.354 NM_011991
Cops3
COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)
chr19_+_6984613 8.333 Trmt112
tRNA methyltransferase 11-2 homolog (S. cerevisiae)
chr1_+_42752608 8.254


chrX_-_48371127 8.225 NM_172413
Rap2c
RAP2C, member of RAS oncogene family
chr1_-_135506798 8.160 NM_009227
Snrpe
small nuclear ribonucleoprotein E
chr9_-_71333706 8.026 NM_178602
Grinl1a
glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
chrX_-_137077133 8.009 Tsc22d3
TSC22 domain family, member 3
chr13_-_99086890 8.008 NM_145455
NM_001170540
Btf3

basic transcription factor 3

chr7_-_54175214 7.959 NM_021884
Tsg101
tumor susceptibility gene 101
chr18_+_46757333 7.956 NM_010120
Eif1a
eukaryotic translation initiation factor 1A
chr4_+_44313764 7.939 NM_010790
Melk
maternal embryonic leucine zipper kinase
chr9_-_107996781 7.931 NM_146226
Apeh
acylpeptide hydrolase
chr4_+_59639079 7.921 NM_153158
NM_001015681
E130308A19Rik

RIKEN cDNA E130308A19 gene

chr13_+_69948718 7.831 NM_138596
Med10
mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)
chr9_+_37296867 7.780 NM_146222
BC024479
cDNA sequence BC024479
chr16_+_13780778 7.749 NM_001039521
Rrn3
RRN3 RNA polymerase I transcription factor homolog (yeast)
chrX_-_106029678 7.701 NM_001081477
Brwd3
bromodomain and WD repeat domain containing 3
chr19_-_10651550 7.599 NM_028411
Tmem138
transmembrane protein 138
chr17_-_71351465 7.585 2900073G15Rik
RIKEN cDNA 2900073G15 gene
chr2_+_152512797 7.582 NM_025543
Mcts2
malignant T cell amplified sequence 2
chr11_-_70051361 7.576 NM_001177601
NM_001177603
NM_001177606
NM_001177607
NM_026757
NM_145758
0610010K14Rik





RIKEN cDNA 0610010K14 gene





chr8_-_74035629 7.560 Plvap
plasmalemma vesicle associated protein
chr17_-_37088578 7.547 NM_029632
Ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr7_-_28835041 7.526 NM_011874
Psmc4
proteasome (prosome, macropain) 26S subunit, ATPase, 4
chr8_-_97125577 7.493 NM_028221
Fam192a
family with sequence similarity 192, member A
chr2_+_71227270 7.471 NM_026115
Hat1
histone aminotransferase 1
chr13_-_59777105 7.446 NM_001035122
NM_027307
Golm1

golgi membrane protein 1

chrX_-_99352341 7.421 NM_146235
Ercc6l
excision repair cross-complementing rodent repair deficiency complementation group 6 - like
chr1_+_74648028 7.330 NM_175031
Stk36
serine/threonine kinase 36 (fused homolog, Drosophila)
chr19_-_28085534 7.316 NM_011265
Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr11_-_100956699 7.259 NM_008949
Psmc3ip
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
chr3_-_146184337 7.257 NM_027332
NM_027371
Rpf1

ribosome production factor 1 homolog (S. cerevisiae)

chr13_+_17787239 7.255 NM_025479
2810021B07Rik
RIKEN cDNA 2810021B07 gene
chr16_-_38522680 7.208 NM_024273
4930455C21Rik
RIKEN cDNA 4930455C21 gene
chr8_-_72519966 7.174 NM_001113345
NM_145596
Gatad2a

GATA zinc finger domain containing 2A

chr2_+_4480799 7.134 NM_001177844
Frmd4a
FERM domain containing 4A
chr10_+_74980789 7.127 Snrpd3
small nuclear ribonucleoprotein D3
chr11_+_69809250 7.121 NM_030064
Phf23
PHD finger protein 23
chr12_-_70298068 7.120 1110034A24Rik
RIKEN cDNA 1110034A24 gene
chr11_+_116704828 7.076 NM_028865
1110005A03Rik
RIKEN cDNA 1110005A03 gene
chr15_-_77801154 7.071 NM_018749
Eif3d
eukaryotic translation initiation factor 3, subunit D
chr16_+_52031733 7.042 Cblb
Casitas B-lineage lymphoma b
chr8_-_73183546 7.032 Pgpep1
pyroglutamyl-peptidase I
chr8_-_73183574 6.949 NM_023217
Pgpep1
pyroglutamyl-peptidase I
chr16_-_17928207 6.945 Slc25a1
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
chr15_-_97923632 6.945 NM_144851
Senp1
SUMO1/sentrin specific peptidase 1
chr3_+_79395280 6.940 NM_026352
Ppid
peptidylprolyl isomerase D (cyclophilin D)
chr1_+_121422719 6.931 NM_146103
Tmem185b
transmembrane protein 185B
chr17_+_35272395 6.916 Bag6
BCL2-associated athanogene 6
chr5_-_31210054 6.881 NM_001134692
Ost4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr12_+_110691637 6.879 NM_001190703
NM_001190704
NM_001190705
NM_010052
Dlk1



delta-like 1 homolog (Drosophila)



chr4_-_107596123 6.877 NM_009949
Cpt2
carnitine palmitoyltransferase 2
chr10_-_92185071 6.874 NM_008682
Nedd1
neural precursor cell expressed, developmentally down-regulated gene 1
chr10_-_117229719 6.864 NM_134010
Nup107
nucleoporin 107
chr10_-_114821533 6.859 Thap2
THAP domain containing, apoptosis associated protein 2
chr4_-_40704838 6.852 Smu1
smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
chr5_-_9161670 6.833 NM_001110327
NM_011806
Dmtf1

cyclin D binding myb-like transcription factor 1

chr5_+_149996135 6.833 NM_001013378
NM_001115149
NM_001115150
NM_001115151
NM_001115153
Uspl1




ubiquitin specific peptidase like 1




chr5_-_86601756 6.809 NM_172712
Uba6
ubiquitin-like modifier activating enzyme 6
chr15_-_81702298 6.798 NM_026737
Phf5a
PHD finger protein 5A
chr8_+_74763920 6.791 Ap1m1
adaptor-related protein complex AP-1, mu subunit 1
chr12_-_3426640 6.739 1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr8_-_74035667 6.695 NM_032398
Plvap
plasmalemma vesicle associated protein
chr15_-_64214314 6.682 Asap1
ArfGAP with SH# domain, ankyrin repeat and PH domain1
chr7_+_5013744 6.676 NM_133671
U2af2
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
chr10_+_127472624 6.659 Naca
nascent polypeptide-associated complex alpha polypeptide
chr12_+_106923552 6.657 NM_178613
4933433P14Rik
RIKEN cDNA 4933433P14 gene
chr11_+_4795308 6.651 NM_172438
Thoc5
THO complex 5
chr7_+_118172447 6.632 NM_009431
Ctr9
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr16_-_17928270 6.627 NM_153150
Slc25a1
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
chr7_-_31758185 6.582 Lsr
lipolysis stimulated lipoprotein receptor
chr15_-_102181072 6.575 NM_153416
Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr1_-_34496128 6.554 Ccdc115
coiled-coil domain containing 115
chr9_+_72961223 6.544 NM_198609
Rsl24d1
ribosomal L24 domain containing 1
chr3_-_57455612 6.539 Commd2
COMM domain containing 2
chr16_+_52031704 6.533 Cblb
Casitas B-lineage lymphoma b
chr18_-_57134974 6.512 NM_029909
C330018D20Rik
RIKEN cDNA C330018D20 gene
chr9_-_60535699 6.494 Lrrc49
leucine rich repeat containing 49
chr3_-_101728226 6.469 NM_001039371
Slc22a15
solute carrier family 22 (organic anion/cation transporter), member 15
chr4_+_125781197 6.452 NM_001145827
NM_028800
Stk40

serine/threonine kinase 40

chr1_-_157882999 6.436 Tor1aip1
torsin A interacting protein 1
chr10_-_79896330 6.415 Tcf3
transcription factor 3
chr10_-_14425271 6.370 NM_025418
Vta1
Vps20-associated 1 homolog (S. cerevisiae)
chr9_+_72887524 6.368 2310009A05Rik
5031420N21Rik
RIKEN cDNA 2310009A05 gene
RIKEN cDNA 5031420N21 gene
chr16_+_20517042 6.352 NM_007889
Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr12_+_21292157 6.298 NM_018813
Cpsf3
cleavage and polyadenylation specificity factor 3
chr13_-_108680257 6.293 NM_145456
Zswim6
zinc finger, SWIM domain containing 6
chr13_+_41096358 6.290 NM_026550
Pak1ip1
PAK1 interacting protein 1
chrX_-_12339096 6.280 NM_001048208
NM_012005
Med14

mediator complex subunit 14

chr3_-_99966292 6.280 NM_175552
Wdr3
WD repeat domain 3
chr7_+_148068262 6.274 NM_011875
Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr6_+_88415396 6.274 NM_019685
Ruvbl1
RuvB-like protein 1
chr9_+_120401824 6.270 Eif1b
eukaryotic translation initiation factor 1B
chr2_-_26207615 6.258 NM_001139503
NM_001139504
NM_026828
Dnlz


DNL-type zinc finger


chr9_-_45792865 6.249 NM_008775
Pafah1b2
2610005M20Rik
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
RIKEN cDNA 2610005M20 gene
chr1_+_161162285 6.192 NM_011931
Rfwd2
ring finger and WD repeat domain 2
chr17_+_35258394 6.181 NM_001128597
Gpank1
G patch domain and ankyrin repeats 1
chr11_+_101594342 6.179 Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr19_+_18787654 6.177 NM_177640
D030056L22Rik
RIKEN cDNA D030056L22 gene
chr8_-_97125464 6.168 Fam192a
family with sequence similarity 192, member A
chr19_-_8848911 6.160 NM_026325
Tmem179b
transmembrane protein 179B
chr5_+_34678976 6.153 NM_011278
Rnf4
ring finger protein 4
chr2_-_130455670 6.107 NM_080562
Ubox5
Fastkd5
U box domain containing 5
FAST kinase domains 5
chr7_-_133935662 6.093 Ppp4c
protein phosphatase 4, catalytic subunit
chr9_-_15084310 6.074 NM_144933
Med17
mediator complex subunit 17
chr11_-_116704762 6.074 NM_033398
Jmjd6
jumonji domain containing 6
chr13_-_21532756 6.029 NM_001012311
NM_001162920
Pgbd1

piggyBac transposable element derived 1

chr3_+_135101248 6.020 Ube2d3
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
chr9_-_20703010 6.006 NM_016876
Eif3g
eukaryotic translation initiation factor 3, subunit G
chr2_-_38499436 5.992 Psmb7
proteasome (prosome, macropain) subunit, beta type 7
chr18_+_32996878 5.973 NM_001110015
NM_001110016
NM_144863
Wdr36


WD repeat domain 36


chr6_-_115758729 5.934 NM_172086
Rpl32
ribosomal protein L32
chr12_+_86560429 5.929 NM_145445
Eif2b2
eukaryotic translation initiation factor 2B, subunit 2 beta
chr6_+_35202672 5.884 1810058I24Rik
RIKEN cDNA 1810058I24 gene
chr17_+_36053855 5.872 NM_175934
Ppp1r10
protein phosphatase 1, regulatory subunit 10
chr14_-_14953416 5.866 NM_025550
Psmd6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr19_-_7025977 5.855 Bad
BCL2-associated agonist of cell death
chr8_-_109580565 5.852 Cog8
component of oligomeric golgi complex 8
chr10_-_116500780 5.841 NM_007636
Cct2
chaperonin containing Tcp1, subunit 2 (beta)
chr4_+_118081908 5.839 NM_020000
NM_173719
Med8

mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)

chr3_-_129534201 5.833 NM_026578
Gar1
GAR1 ribonucleoprotein homolog (yeast)
chr5_+_3803180 5.811 Krit1
KRIT1, ankyrin repeat containing
chr19_+_36908682 5.800 NM_001163635
Tnks2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr10_+_79317409 5.780 Ptbp1
polypyrimidine tract binding protein 1
chrX_-_149471740 5.774 NM_023788
Mageh1
melanoma antigen, family H, 1
chr17_-_87424652 5.758 NM_008838
Pigf
phosphatidylinositol glycan anchor biosynthesis, class F
chr5_-_137462712 5.753 Znhit1
zinc finger, HIT domain containing 1
chr6_+_124989841 5.741 NM_133345
Ing4
inhibitor of growth family, member 4
chr2_-_11699120 5.740 NM_015792
Fbxo18
F-box protein 18
chr9_-_21921573 5.729 Elof1
elongation factor 1 homolog (ELF1, S. cerevisiae)
chr4_-_116300068 5.705 NM_001081475
Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr14_-_52816830 5.700 NM_033618
Supt16h
suppressor of Ty 16 homolog (S. cerevisiae)
chr17_+_46339730 5.693 NM_028198
Xpo5
exportin 5
chr18_-_36829750 5.692 NM_001164406
NM_025291
Sra1

steroid receptor RNA activator 1

chr16_+_18876817 5.684 NM_010435
Hira
histone cell cycle regulation defective homolog A (S. cerevisiae)
chr2_-_22751051 5.663 A130006I12Rik
RIKEN cDNA A130006I12 gene
chr5_-_137971968 5.660 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr3_-_130433225 5.660 NM_026724
Rpl34-ps1
Rpl34
ribosomal protein L34, pseudogene 1
ribosomal protein L34
chr17_+_34729159 5.654 Pbx2
pre B-cell leukemia transcription factor 2
chr8_-_124353386 5.630 NM_145605
Klhdc4
kelch domain containing 4
chr4_-_86503198 5.625 NM_009096
Rps6
ribosomal protein S6
chr2_+_90519527 5.619 Nup160
nucleoporin 160
chr9_-_20954341 5.565 NM_016742
Cdc37
cell division cycle 37 homolog (S. cerevisiae)
chr4_+_46151361 5.545 NM_001033201
Ncbp1
nuclear cap binding protein subunit 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
1.96 9.82e-95 GO:0044260 cellular macromolecule metabolic process
1.82 8.58e-81 GO:0043170 macromolecule metabolic process
1.65 8.59e-70 GO:0044237 cellular metabolic process
2.19 1.05e-64 GO:0010467 gene expression
1.61 1.52e-62 GO:0044238 primary metabolic process
2.10 2.02e-59 GO:0090304 nucleic acid metabolic process
1.94 3.81e-55 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.49 7.91e-50 GO:0008152 metabolic process
3.55 8.30e-46 GO:0006396 RNA processing
1.80 4.10e-45 GO:0034641 cellular nitrogen compound metabolic process
2.03 2.22e-44 GO:0016070 RNA metabolic process
1.77 1.20e-43 GO:0006807 nitrogen compound metabolic process
2.01 7.65e-40 GO:0044267 cellular protein metabolic process
1.90 1.17e-35 GO:0034645 cellular macromolecule biosynthetic process
3.82 1.23e-35 GO:0016071 mRNA metabolic process
4.17 1.33e-35 GO:0006397 mRNA processing
1.90 1.47e-35 GO:0009059 macromolecule biosynthetic process
4.10 2.89e-32 GO:0008380 RNA splicing
1.76 1.13e-28 GO:0019538 protein metabolic process
2.54 3.15e-28 GO:0007049 cell cycle
3.66 1.53e-25 GO:0006412 translation
1.65 6.31e-25 GO:0044249 cellular biosynthetic process
3.20 6.77e-25 GO:0000278 mitotic cell cycle
2.73 9.89e-25 GO:0022402 cell cycle process
4.27 5.73e-24 GO:0022613 ribonucleoprotein complex biogenesis
1.62 6.96e-24 GO:0009058 biosynthetic process
4.11 3.90e-23 GO:0071843 cellular component biogenesis at cellular level
1.73 1.40e-21 GO:0071841 cellular component organization or biogenesis at cellular level
1.51 1.33e-17 GO:0060255 regulation of macromolecule metabolic process
1.18 8.67e-17 GO:0009987 cellular process
1.84 1.96e-16 GO:0006996 organelle organization
1.54 2.96e-16 GO:0071840 cellular component organization or biogenesis
2.66 3.39e-16 GO:0044265 cellular macromolecule catabolic process
2.52 4.21e-16 GO:0006259 DNA metabolic process
1.56 1.19e-15 GO:0010468 regulation of gene expression
2.57 8.66e-15 GO:0022403 cell cycle phase
1.62 1.58e-14 GO:0071842 cellular component organization at cellular level
2.93 2.62e-14 GO:0006281 DNA repair
2.61 2.76e-14 GO:0006974 response to DNA damage stimulus
2.97 9.14e-14 GO:0006511 ubiquitin-dependent protein catabolic process
2.89 1.57e-13 GO:0051603 proteolysis involved in cellular protein catabolic process
1.44 2.09e-13 GO:0080090 regulation of primary metabolic process
2.90 3.28e-13 GO:0019941 modification-dependent protein catabolic process
3.95 3.72e-13 GO:0042254 ribosome biogenesis
2.84 4.36e-13 GO:0044257 cellular protein catabolic process
2.88 4.98e-13 GO:0043632 modification-dependent macromolecule catabolic process
2.37 6.53e-13 GO:0009057 macromolecule catabolic process
5.14 1.28e-12 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
1.42 1.97e-12 GO:0031323 regulation of cellular metabolic process
1.39 2.03e-12 GO:0019222 regulation of metabolic process
1.52 2.19e-12 GO:2000112 regulation of cellular macromolecule biosynthetic process
5.20 2.40e-12 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.64 3.17e-12 GO:0051301 cell division
4.99 3.52e-12 GO:0071826 ribonucleoprotein complex subunit organization
5.12 4.03e-12 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
5.12 4.03e-12 GO:0000398 nuclear mRNA splicing, via spliceosome
5.12 4.03e-12 GO:0022618 ribonucleoprotein complex assembly
5.05 6.70e-12 GO:0000375 RNA splicing, via transesterification reactions
2.67 8.55e-12 GO:0030163 protein catabolic process
4.01 9.57e-12 GO:0031398 positive regulation of protein ubiquitination
4.91 1.79e-11 GO:0051352 negative regulation of ligase activity
4.91 1.79e-11 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.91 1.79e-11 GO:0051444 negative regulation of ubiquitin-protein ligase activity
4.73 2.33e-11 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.62 2.57e-11 GO:0032774 RNA biosynthetic process
1.62 3.86e-11 GO:0006351 transcription, DNA-dependent
1.49 4.08e-11 GO:0010556 regulation of macromolecule biosynthetic process
2.91 7.37e-11 GO:0048285 organelle fission
4.34 7.40e-11 GO:0031397 negative regulation of protein ubiquitination
1.45 9.20e-11 GO:0016043 cellular component organization
4.29 1.10e-10 GO:0006414 translational elongation
2.91 1.18e-10 GO:0000087 M phase of mitotic cell cycle
4.49 1.33e-10 GO:0051443 positive regulation of ubiquitin-protein ligase activity
1.50 1.58e-10 GO:0051252 regulation of RNA metabolic process
3.43 2.58e-10 GO:0010498 proteasomal protein catabolic process
3.43 2.58e-10 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
4.38 3.02e-10 GO:0051351 positive regulation of ligase activity
2.87 5.67e-10 GO:0000280 nuclear division
2.87 5.67e-10 GO:0007067 mitosis
2.47 6.03e-10 GO:0000279 M phase
2.50 6.84e-10 GO:0016568 chromatin modification
3.34 7.56e-10 GO:0031396 regulation of protein ubiquitination
2.82 7.94e-10 GO:0034660 ncRNA metabolic process
2.18 1.02e-09 GO:0051276 chromosome organization
4.07 1.45e-09 GO:0051438 regulation of ubiquitin-protein ligase activity
3.04 1.78e-09 GO:0034470 ncRNA processing
3.99 2.93e-09 GO:0006364 rRNA processing
3.99 2.93e-09 GO:0051340 regulation of ligase activity
2.94 6.65e-09 GO:0016570 histone modification
1.77 7.00e-09 GO:0044085 cellular component biogenesis
3.86 8.10e-09 GO:0016072 rRNA metabolic process
7.07 1.04e-08 GO:0000387 spliceosomal snRNP assembly
1.47 1.17e-08 GO:0006355 regulation of transcription, DNA-dependent
2.90 1.25e-08 GO:0016569 covalent chromatin modification
1.54 4.32e-08 GO:0043412 macromolecule modification
1.41 5.76e-08 GO:0031326 regulation of cellular biosynthetic process
1.41 6.44e-08 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.24 8.51e-08 GO:0006325 chromatin organization
1.40 1.44e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.39 1.69e-07 GO:0009889 regulation of biosynthetic process
2.34 1.99e-07 GO:0070647 protein modification by small protein conjugation or removal
1.53 2.89e-07 GO:0006464 protein modification process
2.49 3.72e-07 GO:0032269 negative regulation of cellular protein metabolic process
3.46 4.65e-07 GO:0007059 chromosome segregation
1.86 7.25e-07 GO:0033554 cellular response to stress
2.28 1.15e-06 GO:0034621 cellular macromolecular complex subunit organization
2.39 2.05e-06 GO:0051248 negative regulation of protein metabolic process
2.78 2.73e-06 GO:0031400 negative regulation of protein modification process
2.85 3.18e-06 GO:0006260 DNA replication
2.38 6.94e-06 GO:0010608 posttranscriptional regulation of gene expression
2.33 1.06e-05 GO:0032446 protein modification by small protein conjugation
1.93 3.83e-05 GO:0051726 regulation of cell cycle
1.82 5.73e-05 GO:0071844 cellular component assembly at cellular level
1.95 6.24e-05 GO:0051247 positive regulation of protein metabolic process
2.21 7.06e-05 GO:0034622 cellular macromolecular complex assembly
3.46 8.35e-05 GO:0006473 protein acetylation
2.30 8.68e-05 GO:0016567 protein ubiquitination
3.64 1.12e-04 GO:0006352 transcription initiation, DNA-dependent
1.77 1.22e-04 GO:0046907 intracellular transport
3.05 1.27e-04 GO:0051325 interphase
3.03 2.54e-04 GO:0051329 interphase of mitotic cell cycle
3.48 2.67e-04 GO:0006475 internal protein amino acid acetylation
3.48 2.67e-04 GO:0018393 internal peptidyl-lysine acetylation
3.88 2.80e-04 GO:0006367 transcription initiation from RNA polymerase II promoter
2.67 3.04e-04 GO:0006417 regulation of translation
3.43 3.52e-04 GO:0018394 peptidyl-lysine acetylation
1.56 3.57e-04 GO:0008104 protein localization
4.15 4.18e-04 GO:0006368 transcription elongation from RNA polymerase II promoter
2.58 4.60e-04 GO:0006457 protein folding
1.90 5.47e-04 GO:0032270 positive regulation of cellular protein metabolic process
1.54 7.24e-04 GO:0044248 cellular catabolic process
3.42 7.24e-04 GO:0016573 histone acetylation
3.90 1.20e-03 GO:0006354 transcription elongation, DNA-dependent
3.21 1.29e-03 GO:0050657 nucleic acid transport
3.21 1.29e-03 GO:0050658 RNA transport
3.21 1.29e-03 GO:0051236 establishment of RNA localization
1.46 1.69e-03 GO:0010604 positive regulation of macromolecule metabolic process
4.21 1.77e-03 GO:0006413 translational initiation
2.93 2.51e-03 GO:0043543 protein acylation
1.47 2.52e-03 GO:0033036 macromolecule localization
3.09 2.65e-03 GO:0006403 RNA localization
1.56 6.31e-03 GO:0045184 establishment of protein localization
2.73 6.36e-03 GO:0006310 DNA recombination
2.84 7.53e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.48 1.14e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.55 1.15e-02 GO:0015031 protein transport
1.47 1.28e-02 GO:0051641 cellular localization
3.09 1.37e-02 GO:0051028 mRNA transport
2.46 1.46e-02 GO:0006366 transcription from RNA polymerase II promoter
3.16 1.74e-02 GO:0006302 double-strand break repair
1.51 2.21e-02 GO:0051649 establishment of localization in cell
1.81 3.78e-02 GO:0031401 positive regulation of protein modification process
1.46 3.82e-02 GO:0032268 regulation of cellular protein metabolic process
1.49 4.21e-02 GO:0022607 cellular component assembly
2.71 4.26e-02 GO:0040029 regulation of gene expression, epigenetic
1.43 4.53e-02 GO:0051246 regulation of protein metabolic process
2.56 4.82e-02 GO:0018205 peptidyl-lysine modification

Gene overrepresentation in compartment category:

enrichment p-value GO term description
1.47 2.90e-108 GO:0005622 intracellular
1.48 7.30e-105 GO:0044424 intracellular part
1.95 2.52e-102 GO:0005634 nucleus
1.53 7.95e-91 GO:0043229 intracellular organelle
1.53 1.00e-90 GO:0043226 organelle
1.58 3.77e-89 GO:0043227 membrane-bounded organelle
1.58 6.34e-89 GO:0043231 intracellular membrane-bounded organelle
2.66 1.74e-79 GO:0044428 nuclear part
1.84 2.79e-62 GO:0044446 intracellular organelle part
2.49 1.18e-61 GO:0070013 intracellular organelle lumen
2.49 1.96e-61 GO:0043233 organelle lumen
2.46 1.33e-60 GO:0031974 membrane-enclosed lumen
1.81 1.16e-59 GO:0044422 organelle part
2.56 8.89e-57 GO:0031981 nuclear lumen
1.87 2.20e-50 GO:0032991 macromolecular complex
3.70 3.30e-46 GO:0030529 ribonucleoprotein complex
2.56 3.37e-38 GO:0005654 nucleoplasm
1.35 4.15e-31 GO:0005737 cytoplasm
5.28 2.31e-28 GO:0005681 spliceosomal complex
1.76 8.36e-27 GO:0043228 non-membrane-bounded organelle
1.76 8.36e-27 GO:0043232 intracellular non-membrane-bounded organelle
1.64 2.26e-22 GO:0043234 protein complex
5.90 7.13e-21 GO:0071013 catalytic step 2 spliceosome
1.13 2.25e-18 GO:0005623 cell
1.13 2.25e-18 GO:0044464 cell part
2.26 9.78e-17 GO:0044451 nucleoplasm part
2.70 1.11e-15 GO:0005730 nucleolus
2.35 1.49e-12 GO:0005694 chromosome
1.68 4.64e-12 GO:0005829 cytosol
5.33 5.02e-12 GO:0000502 proteasome complex
3.19 8.41e-11 GO:0005840 ribosome
2.22 2.33e-09 GO:0044427 chromosomal part
1.26 6.18e-09 GO:0044444 cytoplasmic part
6.84 3.14e-07 GO:0030532 small nuclear ribonucleoprotein complex
4.04 1.08e-06 GO:0000123 histone acetyltransferase complex
2.91 1.37e-06 GO:0016604 nuclear body
4.41 2.03e-06 GO:0015935 small ribosomal subunit
2.44 2.15e-06 GO:0005815 microtubule organizing center
4.54 2.71e-06 GO:0022626 cytosolic ribosome
3.00 7.55e-06 GO:0044445 cytosolic part
2.39 1.82e-05 GO:0000228 nuclear chromosome
3.64 2.17e-05 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
2.36 5.25e-05 GO:0005813 centrosome
6.61 1.47e-04 GO:0008023 transcription elongation factor complex
5.39 1.84e-04 GO:0070461 SAGA-type complex
4.63 2.09e-04 GO:0022627 cytosolic small ribosomal subunit
2.58 3.07e-04 GO:0000775 chromosome, centromeric region
5.62 3.36e-04 GO:0015030 Cajal body
4.01 7.12e-04 GO:0000313 organellar ribosome
4.01 7.12e-04 GO:0005761 mitochondrial ribosome
6.32 9.83e-04 GO:0005669 transcription factor TFIID complex
5.15 1.00e-03 GO:0005689 U12-type spliceosomal complex
1.67 1.28e-03 GO:0015630 microtubule cytoskeleton
2.66 1.34e-03 GO:0000151 ubiquitin ligase complex
2.24 1.56e-03 GO:0044454 nuclear chromosome part
2.18 2.99e-03 GO:0005635 nuclear envelope
6.42 3.18e-03 GO:0033276 transcription factor TFTC complex
2.09 3.53e-03 GO:0000785 chromatin
1.37 4.02e-03 GO:0005739 mitochondrion
2.66 4.63e-03 GO:0000790 nuclear chromatin
2.28 4.92e-03 GO:0005759 mitochondrial matrix
3.27 6.71e-03 GO:0016607 nuclear speck
2.74 6.86e-03 GO:0000776 kinetochore
2.58 7.89e-03 GO:0000793 condensed chromosome
5.06 1.04e-02 GO:0000152 nuclear ubiquitin ligase complex
6.05 2.07e-02 GO:0030914 STAGA complex
4.16 2.78e-02 GO:0071339 MLL1 complex
1.33 3.16e-02 GO:0005856 cytoskeleton
3.32 3.51e-02 GO:0005643 nuclear pore
8.03 4.47e-02 GO:0000808 origin recognition complex
8.03 4.47e-02 GO:0005664 nuclear origin of replication recognition complex
8.03 4.47e-02 GO:0005832 chaperonin-containing T-complex
8.03 4.47e-02 GO:0046540 U4/U6 x U5 tri-snRNP complex

Gene overrepresentation in function category:

enrichment p-value GO term description
1.96 9.79e-45 GO:0003676 nucleic acid binding
3.04 6.41e-43 GO:0003723 RNA binding
1.22 1.59e-20 GO:0005488 binding
1.59 1.03e-13 GO:0000166 nucleotide binding
1.57 2.28e-10 GO:0003677 DNA binding
3.87 4.18e-09 GO:0008135 translation factor activity, nucleic acid binding
3.36 4.03e-08 GO:0003735 structural constituent of ribosome
1.50 6.63e-08 GO:0017076 purine nucleotide binding
1.50 7.54e-08 GO:0032555 purine ribonucleotide binding
1.50 7.97e-08 GO:0032553 ribonucleotide binding
1.50 9.00e-08 GO:0035639 purine ribonucleoside triphosphate binding
1.55 1.54e-07 GO:0030554 adenyl nucleotide binding
1.55 1.75e-07 GO:0032559 adenyl ribonucleotide binding
1.54 3.47e-07 GO:0005524 ATP binding
4.27 1.18e-05 GO:0043021 ribonucleoprotein binding
1.78 1.18e-05 GO:0017111 nucleoside-triphosphatase activity
2.85 1.35e-05 GO:0004386 helicase activity
1.75 1.74e-05 GO:0016462 pyrophosphatase activity
1.74 2.20e-05 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.74 2.38e-05 GO:0016817 hydrolase activity, acting on acid anhydrides
2.73 2.73e-05 GO:0003713 transcription coactivator activity
1.20 2.75e-05 GO:0005515 protein binding
3.81 4.71e-05 GO:0003743 translation initiation factor activity
1.90 1.25e-04 GO:0016874 ligase activity
2.14 4.46e-04 GO:0003712 transcription cofactor activity
2.13 5.04e-04 GO:0000989 transcription factor binding transcription factor activity
1.43 6.42e-04 GO:0008270 zinc ion binding
2.11 7.23e-04 GO:0000988 protein binding transcription factor activity
2.47 1.07e-03 GO:0004518 nuclease activity
2.91 2.01e-03 GO:0051082 unfolded protein binding
1.18 2.06e-03 GO:0003824 catalytic activity
2.81 3.72e-03 GO:0003729 mRNA binding
1.85 6.90e-03 GO:0008134 transcription factor binding
5.06 1.34e-02 GO:0043022 ribosome binding
3.18 2.28e-02 GO:0004527 exonuclease activity
2.46 2.34e-02 GO:0016779 nucleotidyltransferase activity
1.89 2.58e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
2.00 3.39e-02 GO:0019787 small conjugating protein ligase activity
2.03 4.03e-02 GO:0004842 ubiquitin-protein ligase activity
1.92 4.26e-02 GO:0016881 acid-amino acid ligase activity