Motif ID: EN1,2.p2

Z-value: 1.357

Transcription factors associated with EN1,2.p2:

NameEntrezDescription
En1 13798 engrailed 1
En2 13799 engrailed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
En1chr1_+_122498985-0.625.0e-05Click!
En2chr5_+_28492235-0.591.6e-04Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chrM_+_11027 11.197


chrM_+_13543 10.264


chr2_-_25325248 10.108 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chrM_+_13998 9.683


chrM_+_14143 8.183


chr15_-_88808967 6.010 NM_133241
Mlc1
megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
chr11_-_79317471 5.976 Omg
oligodendrocyte myelin glycoprotein
chr7_+_129776837 5.409 Prkcb
protein kinase C, beta
chrM_+_409 5.174


chr7_-_27966073 4.375 Mia1
melanoma inhibitory activity 1
chrX_+_133357268 4.315 NM_011123
Plp1
proteolipid protein (myelin) 1
chrM_+_3320 4.292


chrM_-_13886 3.965


chr11_-_118355393 3.955


chr8_-_3625251 3.607 NM_008790
Pcp2
Purkinje cell protein 2 (L7)
chr19_-_47089605 3.598 NM_001164363
Nt5c2
5'-nucleotidase, cytosolic II
chr2_+_14151018 3.586 NM_008625
Mrc1
mannose receptor, C type 1
chr19_+_47089736 3.360 Ina
internexin neuronal intermediate filament protein, alpha
chr2_-_7002344 3.275 NM_001110229
NM_001110230
NM_001160292
Celf2


CUGBP, Elav-like family member 2


chr2_-_37502738 3.184 NM_009261
Strbp
spermatid perinuclear RNA binding protein
chr10_+_60638341 2.881 Tbata
thymus, brain and testes associated
chr10_-_42722514 2.692 Sobp
sine oculis-binding protein homolog (Drosophila)
chrM_+_2750 2.562


chrM_-_14069 2.536 ND6
NADH dehydrogenase subunit 6
chrM_+_15355 2.303


chr11_+_28753190 2.193 NM_146015
Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr3_+_14863507 2.152 NM_007606
Car3
carbonic anhydrase 3
chr2_-_7002287 2.029 Celf2
CUGBP, Elav-like family member 2
chr2_+_4897167 2.005 NM_001113558
NM_001165932
NM_026754
Ucma


upper zone of growth plate and cartilage matrix associated


chr10_+_69169221 1.948 Ank3
ankyrin 3, epithelial
chr7_-_148615247 1.882 NM_021316
Cend1
cell cycle exit and neuronal differentiation 1
chrM_-_622 1.821


chr19_+_8692485 1.811 NM_008766
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr2_+_174171525 1.771 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr11_-_79317583 1.599 NM_019409
Omg
oligodendrocyte myelin glycoprotein
chr8_+_122190264 1.587 NM_023395
Wfdc1
WAP four-disulfide core domain 1
chr14_-_65035722 1.567 Msra
methionine sulfoxide reductase A
chr15_-_8584897 1.530 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_-_46401618 1.522 NM_028627
Psd
pleckstrin and Sec7 domain containing
chr18_-_77870871 1.495 2310007O11Rik
RIKEN cDNA 2310007O11 gene
chr11_-_114657186 1.487 NM_028055
Btbd17
BTB (POZ) domain containing 17
chr5_-_52576002 1.483


chr12_+_110783593 1.475 Meg3
maternally expressed 3
chr1_-_166371638 1.418 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr16_+_57121995 1.398 Tomm70a
translocase of outer mitochondrial membrane 70 homolog A (yeast)
chr11_+_3388229 1.334 NM_172791
Pla2g3
phospholipase A2, group III
chrM_+_1091 1.287


chr2_-_79294977 1.265 Neurod1
neurogenic differentiation 1
chr4_-_153532466 1.225 Tprgl
transformation related protein 63 regulated like
chr10_+_59757371 1.221


chr5_-_142985612 1.219 Radil
Ras association and DIL domains
chr11_-_86539846 1.213 Cltc
clathrin, heavy polypeptide (Hc)
chr12_+_110783786 1.210 Meg3
maternally expressed 3
chr9_-_99287199 1.201 Mras
muscle and microspikes RAS
chr5_-_115119973 1.196 Gltp
glycolipid transfer protein
chr2_+_4897196 1.192 Ucma
upper zone of growth plate and cartilage matrix associated
chr7_-_27966167 1.187 NM_019394
Mia1
melanoma inhibitory activity 1
chr7_-_148196526 1.176 Ifitm3
interferon induced transmembrane protein 3
chr7_-_148196606 1.153 Ifitm3
interferon induced transmembrane protein 3
chrX_+_10062237 1.106 NM_019634
Tspan7
tetraspanin 7
chr2_+_136539202 1.102 Snap25
synaptosomal-associated protein 25
chr10_+_127522528 1.102 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr5_+_34967936 1.101 Add1
adducin 1 (alpha)
chrX_+_70748418 1.083 NM_177236
Atp2b3
ATPase, Ca++ transporting, plasma membrane 3
chr2_+_119851954 1.082 Mapkbp1
mitogen-activated protein kinase binding protein 1
chr11_-_50108981 1.063 Canx
calnexin
chrM_+_67 1.063


chr12_+_77505356 1.060 NM_008301
Hspa2
heat shock protein 2
chr14_-_64162562 1.049 Mtmr9
myotubularin related protein 9
chr2_-_42508486 1.033 Lrp1b
low density lipoprotein-related protein 1B (deleted in tumors)
chr4_-_100854453 0.970 Jak1
Janus kinase 1
chr5_-_9725274 0.966 NM_181850
Grm3
glutamate receptor, metabotropic 3
chr3_-_81779636 0.964 NM_019911
Tdo2
tryptophan 2,3-dioxygenase
chr3_-_87804277 0.962 NM_001109758
NM_007529
Bcan

brevican

chr3_-_123375305 0.959 NM_031186
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chrX_-_7709907 0.959 NM_026137
Wdr13
WD repeat domain 13
chr10_-_80131318 0.957 Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr11_-_101032604 0.948 NM_146030
Plekhh3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr8_+_94190341 0.944


chr9_-_54509453 0.932 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr1_+_193399604 0.908 NM_178632
Ints7
integrator complex subunit 7
chr6_-_35258102 0.905 NM_172892
Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr9_-_42776275 0.844 Arhgef12
Rho guanine nucleotide exchange factor (GEF) 12
chr16_+_90220986 0.830 NM_011434
Sod1
superoxide dismutase 1, soluble
chr2_+_121184334 0.830 NM_009897
Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
chr10_+_40349816 0.829 NM_027442
Ddo
D-aspartate oxidase
chr11_+_67399999 0.828 NM_001109657
Gas7
growth arrest specific 7
chr11_-_99105293 0.823 NM_172946
Krt222
keratin 222
chr14_-_64162509 0.821 Mtmr9
myotubularin related protein 9
chr1_-_55283189 0.821 Rftn2
raftlin family member 2
chr15_+_81767188 0.820 NM_145473
Csdc2
cold shock domain containing C2, RNA binding
chr1_-_193399412 0.818 NM_029766
Dtl
denticleless homolog (Drosophila)
chr16_-_46010510 0.817 NM_001134480
Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr3_+_89866717 0.808 NM_028567
1700094D03Rik
RIKEN cDNA 1700094D03 gene
chr11_-_83462722 0.799 NM_011337
Ccl3
chemokine (C-C motif) ligand 3
chr18_+_37849488 0.780 NM_033575
Pcdhgb2
protocadherin gamma subfamily B, 2
chr6_-_51416921 0.774 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr2_+_136539143 0.765 NM_011428
Snap25
synaptosomal-associated protein 25
chr17_+_44215851 0.760 Enpp5
ectonucleotide pyrophosphatase/phosphodiesterase 5
chr11_-_62206116 0.750 Ncor1
nuclear receptor co-repressor 1
chr8_-_114239631 0.740 Bcar1
breast cancer anti-estrogen resistance 1
chr11_-_72609306 0.734 NM_001024926
Cyb5d2
cytochrome b5 domain containing 2
chr8_-_13200534 0.728 NM_025768
Grtp1
GH regulated TBC protein 1
chr14_+_56372605 0.722 2610027L16Rik
RIKEN cDNA 2610027L16 gene
chr2_-_156817751 0.717 NM_013865
NM_180956
Ndrg3

N-myc downstream regulated gene 3

chr19_-_8783535 0.709 Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr9_+_44925922 0.703 NM_001014761
Scn2b
sodium channel, voltage-gated, type II, beta
chr19_-_5797068 0.699


chr17_-_45707358 0.678 Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr12_+_114214947 0.668 Btbd6
BTB (POZ) domain containing 6
chr13_+_103483611 0.661 NM_008533
Cd180
CD180 antigen
chr10_-_60736018 0.658 NM_001081127
Adamts14
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
chr10_+_127523153 0.658 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr14_-_55735399 0.641 Jph4
junctophilin 4
chr1_-_42724504 0.618 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr11_-_115948258 0.609 NM_016852
Wbp2
WW domain binding protein 2
chr16_-_52268571 0.601 Alcam
activated leukocyte cell adhesion molecule
chr7_-_135020290 0.600 NM_146259
Zfp668
zinc finger protein 668
chr18_+_69753035 0.590 Tcf4
transcription factor 4
chr5_-_134718500 0.590 Gtf2i
general transcription factor II I
chr7_+_19661811 0.589 Dmwd
dystrophia myotonica-containing WD repeat motif
chr3_-_146433544 0.559 NM_001164199
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr10_+_80644982 0.559


chr11_-_96679999 0.554 Nfe2l1
nuclear factor, erythroid derived 2,-like 1
chr11_-_53083217 0.553 Hspa4
heat shock protein 4
chr11_+_102994627 0.548 NM_001130516
NM_001130515
NM_027658
Hexim2


hexamthylene bis-acetamide inducible 2


chr18_+_37968450 0.545 Pcdhgc3
protocadherin gamma subfamily C, 3
chr7_-_4636141 0.542 Hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chrX_-_98615096 0.541 NM_001177985
NM_001177986
Zmym3

zinc finger, MYM-type 3

chr14_+_66963139 0.536 NM_019675
Stmn4
stathmin-like 4
chr7_+_128219633 0.527 Mettl9
methyltransferase like 9
chr14_-_73764361 0.522 Itm2b
integral membrane protein 2B
chr10_+_127527153 0.518


chr18_+_20832323 0.517 Ttr
transthyretin
chr7_-_112717810 0.515 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr10_+_90039435 0.508 NM_001177396
NM_001177398
NM_181398
Ipw
Anks1b


imprinted gene in the Prader-Willi syndrome region
ankyrin repeat and sterile alpha motif domain containing 1B


chr10_+_127525425 0.501 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr17_+_34335139 0.500 NM_010724
Psmb8
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
chr14_-_56503058 0.499 Cbln3
cerebellin 3 precursor protein
chr11_+_75578120 0.498 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr14_+_35147355 0.487 Glud1
glutamate dehydrogenase 1
chr9_+_108197453 0.484


chr1_-_180260325 0.477


chr10_+_115455342 0.476 NM_011217
Ptprr
protein tyrosine phosphatase, receptor type, R
chr5_+_150214363 0.467 NM_027519
6330406I15Rik
RIKEN cDNA 6330406I15 gene
chr7_-_82453166 0.464 Sv2b
synaptic vesicle glycoprotein 2 b
chr6_+_124989830 0.459


chr7_-_140913846 0.446 Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr5_-_135103569 0.446


chr8_+_119983664 0.445


chr5_-_136849232 0.444 Cux1
cut-like homeobox 1
chr7_-_106628533 0.441


chr1_+_51346108 0.437 Sdpr
serum deprivation response
chr2_+_102390226 0.435 Pamr1
peptidase domain containing associated with muscle regeneration 1
chr10_-_63552994 0.435 NM_178678
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr11_+_81915343 0.433 NM_011331
Ccl12
chemokine (C-C motif) ligand 12
chrX_+_42444080 0.433 NM_026841
1110059M19Rik
RIKEN cDNA 1110059M19 gene
chrX_-_150130711 0.432 NM_175429
Kctd12b
potassium channel tetramerisation domain containing 12b
chr2_-_25325196 0.431 Ptgds
prostaglandin D2 synthase (brain)
chr3_+_89006938 0.429 Gba
glucosidase, beta, acid
chrX_-_98463514 0.429 NM_013563
Il2rg
interleukin 2 receptor, gamma chain
chr19_+_47938880 0.428 Gsto1
glutathione S-transferase omega 1
chr11_+_42234760 0.423 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr10_+_34018323 0.422 Tspyl4
TSPY-like 4
chr8_+_107572489 0.420 NM_001164681
NM_198672
Ces3a

carboxylesterase 3A

chr10_-_59465725 0.417 Anapc16
anaphase promoting complex subunit 16
chr12_+_17285392 0.410 Pdia6
protein disulfide isomerase associated 6
chr2_-_66278870 0.410 NM_018733
Scn1a
sodium channel, voltage-gated, type I, alpha
chr10_-_75261240 0.405 NM_008185
Gstt1
glutathione S-transferase, theta 1
chr1_-_156993820 0.403 NM_008209
Mr1
major histocompatibility complex, class I-related
chr7_-_135078992 0.398 Prss36
protease, serine, 36
chr1_-_80272987 0.390


chr15_+_76175485 0.389


chr15_+_3224767 0.388 Sepp1
selenoprotein P, plasma, 1
chr5_-_9725158 0.387 Grm3
glutamate receptor, metabotropic 3
chr3_-_120965803 0.386 Tmem56
transmembrane protein 56
chr1_-_88567078 0.384 NM_010933
Nppc
natriuretic peptide type C
chr9_-_106794158 0.382 Manf
mesencephalic astrocyte-derived neurotrophic factor
chr17_+_13208071 0.379 Sod2
superoxide dismutase 2, mitochondrial
chr5_+_143105467 0.370 NM_178398
Wipi2
WD repeat domain, phosphoinositide interacting 2
chr7_-_82453216 0.370 NM_001109753
Sv2b
synaptic vesicle glycoprotein 2 b
chr9_+_53149188 0.369 Exph5
exophilin 5
chr18_+_37999857 0.364


chr2_+_125860377 0.359 NM_008008
Fgf7
fibroblast growth factor 7
chr10_+_80642620 0.358 Eef2
eukaryotic translation elongation factor 2
chr11_+_48615792 0.353 Gnb2l1
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
chr19_-_34952377 0.348 NM_023792
Pank1
pantothenate kinase 1
chr1_-_195068455 0.345 NM_001044751
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
chr11_-_69575192 0.342 NM_019871
Amac1
acyl-malonyl condensing enzyme 1
chr10_-_75243786 0.338 Gstt3
glutathione S-transferase, theta 3
chr4_-_123395382 0.337 NM_001030274
BC002163
Ndufs5
NADH dehydrogenase Fe-S protein 5 pseudogene
NADH dehydrogenase (ubiquinone) Fe-S protein 5
chr15_+_20378816 0.337


chr11_+_5662121 0.334 2210015D19Rik
RIKEN cDNA 2210015D19 gene
chr19_-_41068625 0.332 Blnk
B-cell linker
chr9_+_26541302 0.326 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr2_+_34631124 0.321 Hspa5
heat shock protein 5
chr5_-_123979739 0.318 Vps33a
vacuolar protein sorting 33A (yeast)
chr2_+_69588414 0.316 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr15_+_96199877 0.313 Arid2
AT rich interactive domain 2 (ARID, RFX-like)
chr1_+_89991575 0.310 NM_201642
Ugt1a7c
UDP glucuronosyltransferase 1 family, polypeptide A7C

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment p-value GO term description
9.44 1.49e-02 GO:0016323 basolateral plasma membrane

Nothing significant found in function category.