Motif ID: EOMES.p2

Z-value: 0.676

Transcription factors associated with EOMES.p2:

NameEntrezDescription
Eomes 13813 eomesodermin homolog (Xenopus laevis)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Eomeschr9_+_1183877480.231.7e-01Click!


Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr12_+_110783593 2.027 Meg3
maternally expressed 3
chr4_-_118966829 1.721 Ybx1
Y box protein 1
chr2_+_70312979 1.696 NM_022435
Sp5
trans-acting transcription factor 5
chr4_-_49858561 1.450 Grin3a
glutamate receptor ionotropic, NMDA3A
chr10_-_24919916 1.197 Akap7
A kinase (PRKA) anchor protein 7
chr12_+_110783786 1.065 Meg3
maternally expressed 3
chr17_-_90436488 1.040 Nrxn1
neurexin I
chr3_+_145421870 1.013 Ddah1
dimethylarginine dimethylaminohydrolase 1
chr17_+_21093929 0.931 Ppp2r1a
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
chr17_+_23957239 0.912 Srrm2
serine/arginine repetitive matrix 2
chr5_+_19413335 0.907 NM_001170745
NM_015823
Magi2

membrane associated guanylate kinase, WW and PDZ domain containing 2

chr6_-_127075853 0.900 Ccnd2
cyclin D2
chr7_+_26052714 0.887 Cic
capicua homolog (Drosophila)
chr2_-_12933305 0.876 C1ql3
C1q-like 3
chr6_-_94650118 0.863 NM_008377
Lrig1
leucine-rich repeats and immunoglobulin-like domains 1
chr11_-_100621034 0.842 NM_001081194
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr6_+_114081227 0.780 NM_172890
Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr10_+_122701051 0.746 NM_182807
Fam19a2
family with sequence similarity 19, member A2
chr8_+_86671936 0.708 NM_001163752
NM_029045
4930432K21Rik

RIKEN cDNA 4930432K21 gene

chr2_+_181287207 0.704 Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr2_-_57034164 0.695 BB557941
expressed sequence BB557941
chr8_-_86671651 0.675 NM_145970
Cc2d1a
coiled-coil and C2 domain containing 1A
chr5_-_143667004 0.599 Actb
actin, beta
chr1_-_166368439 0.596 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr19_-_6982094 0.558 Prdx5
peroxiredoxin 5
chr12_-_76697148 0.553 Ppp2r5e
protein phosphatase 2, regulatory subunit B (B56), epsilon isoform
chr2_+_155213904 0.552 Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr1_+_6792987 0.536 St18
suppression of tumorigenicity 18
chr5_-_31505192 0.534


chr14_+_84843366 0.512 NM_001013753
Pcdh17
protocadherin 17
chr15_-_75397601 0.491 NM_011837
Ly6h
lymphocyte antigen 6 complex, locus H
chr18_+_45719101 0.489 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr7_+_19469999 0.483 NM_009402
Pglyrp1
peptidoglycan recognition protein 1
chr9_-_49351134 0.481 Ncam1
neural cell adhesion molecule 1
chr1_-_186696546 0.478 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr18_-_43552694 0.469 NM_009468
Dpysl3
dihydropyrimidinase-like 3
chr11_+_69154265 0.464 A030009H04Rik
RIKEN cDNA A030009H04 gene
chr2_+_164773719 0.463 NM_013599
Mmp9
matrix metallopeptidase 9
chr2_+_34631124 0.435 Hspa5
heat shock protein 5
chr5_-_143666064 0.433 Actb
actin, beta
chr7_+_116084192 0.425


chr4_+_48058102 0.425 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr9_-_49311823 0.413 Ncam1
neural cell adhesion molecule 1
chrM_+_3320 0.409


chr16_-_50732795 0.408 5330426P16Rik
RIKEN cDNA 5330426P16 gene
chr5_-_3802874 0.402 Ankib1
ankyrin repeat and IBR domain containing 1
chr12_-_76697214 0.401 Ppp2r5e
protein phosphatase 2, regulatory subunit B (B56), epsilon isoform
chr6_+_125502943 0.391 Vwf
Von Willebrand factor homolog
chr7_-_25772525 0.391 Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chrM_+_7714 0.389 Gm10925
ATP6
predicted gene 10925
ATP synthase F0 subunit 6
chr18_+_37968450 0.388 Pcdhgc3
protocadherin gamma subfamily C, 3
chr10_+_127832280 0.380


chrX_+_45976982 0.373 NM_001166450
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr4_-_118954780 0.370 Ybx1
Y box protein 1
chr18_+_45719464 0.369 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_-_115750649 0.355 Dynll1
dynein light chain LC8-type 1
chr6_+_114081375 0.347 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr5_-_143665474 0.346


chrX_-_147091911 0.341 NM_001002272
NM_019548
Tro

trophinin

chr18_+_10325174 0.340 NM_001083628
Greb1l
growth regulation by estrogen in breast cancer-like
chr17_-_65944300 0.337 Vapa
vesicle-associated membrane protein, associated protein A
chr11_-_49488485 0.321 Cnot6
CCR4-NOT transcription complex, subunit 6
chr11_+_78139476 0.320 Aldoc
aldolase C, fructose-bisphosphate
chrX_+_133200913 0.320 NM_001029978
Tceal3
transcription elongation factor A (SII)-like 3
chr2_-_32136262 0.319


chr10_-_42893894 0.319 Sobp
sine oculis-binding protein homolog (Drosophila)
chr8_+_97530174 0.319 Gpr56
G protein-coupled receptor 56
chr13_+_54605152 0.318 NM_176987
4732471D19Rik
RIKEN cDNA 4732471D19 gene
chr2_+_162760505 0.309


chr12_+_101447480 0.303 Calm1
calmodulin 1
chr12_+_37040755 0.301 NM_025312
Sostdc1
sclerostin domain containing 1
chr6_-_24905939 0.300 NM_177013
Tmem229a
transmembrane protein 229A
chr18_+_61123204 0.299 NM_009792
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr6_-_115625875 0.299 Raf1
v-raf-leukemia viral oncogene 1
chr7_+_86956134 0.296 Mesp2
mesoderm posterior 2
chr4_-_153532466 0.296 Tprgl
transformation related protein 63 regulated like
chr13_-_97312427 0.295 NM_012048
Polk
polymerase (DNA directed), kappa
chr13_-_43399540 0.295 NM_001033399
Gfod1
glucose-fructose oxidoreductase domain containing 1
chr14_-_68742863 0.294 Nefm
neurofilament, medium polypeptide
chrX_+_135751704 0.293 NM_001164631
NM_001164632
NM_001164633
Mum1l1


melanoma associated antigen (mutated) 1-like 1


chr4_-_57929087 0.293 NM_178727
D630039A03Rik
RIKEN cDNA D630039A03 gene
chr3_-_158224306 0.293 Lrrc7
leucine rich repeat containing 7
chr2_+_121135107 0.291 Mtap1a
microtubule-associated protein 1 A
chr1_-_134287712 0.288 NM_178874
Tmcc2
transmembrane and coiled-coil domains 2
chr11_+_75546480 0.286 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr8_+_49195311 0.286 NM_178788
NM_001161515
Dctd

dCMP deaminase

chr1_-_36864987 0.286 Tmem131
transmembrane protein 131
chr16_-_67621054 0.286 NM_001145977
NM_178721
Cadm2

cell adhesion molecule 2

chr17_+_29230715 0.283 NM_007669
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr5_+_13125413 0.279 LOC100503462
hypothetical LOC100503462
chr9_-_26816373 0.279 Vps26b
vacuolar protein sorting 26 homolog B (yeast)
chr18_+_38456280 0.278 NM_001164622
NM_020012
Rnf14

ring finger protein 14

chr3_+_75361454 0.278 NM_009250
Serpini1
serine (or cysteine) peptidase inhibitor, clade I, member 1
chr17_-_45705198 0.277 Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr4_+_115894199 0.276 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr19_-_7557678 0.275 Rtn3
reticulon 3
chr8_-_87542451 0.275 Asna1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr4_-_132066370 0.272 NM_144907
Sesn2
sestrin 2
chr11_-_74710462 0.272 Sgsm2
small G protein signaling modulator 2
chr1_-_31006599 0.271 NM_011200
Ptp4a1
protein tyrosine phosphatase 4a1
chr6_-_60778740 0.264 NM_001042451
Snca
synuclein, alpha
chr12_-_76697166 0.264 NM_012024
Ppp2r5e
protein phosphatase 2, regulatory subunit B (B56), epsilon isoform
chr11_-_120422109 0.263 P4hb
prolyl 4-hydroxylase, beta polypeptide
chr9_+_15043488 0.259 NM_026955
2200002K05Rik
RIKEN cDNA 2200002K05 gene
chr5_+_138187390 0.257 Tsc22d4
TSC22 domain family, member 4
chr18_+_37644674 0.254 NM_053142
Pcdhb17
protocadherin beta 17
chr9_-_58050340 0.254 NM_001161538
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chrX_-_131285919 0.253 NM_001007578
Armcx6
armadillo repeat containing, X-linked 6
chr2_+_121134843 0.253 Mtap1a
microtubule-associated protein 1 A
chr6_+_42236683 0.250 NM_013491
Clcn1
chloride channel 1
chr9_-_107516538 0.249


chr3_+_66789859 0.248 Rsrc1
arginine/serine-rich coiled-coil 1
chr5_-_122907269 0.247 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr2_-_168427037 0.247 NM_001037178
Nfatc2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr11_-_116711807 0.247 Srsf2
serine/arginine-rich splicing factor 2
chr4_-_100854453 0.247 Jak1
Janus kinase 1
chr11_+_23978110 0.246 Bcl11a
B-cell CLL/lymphoma 11A (zinc finger protein)
chr8_-_25549415 0.244 NM_026931
1810011O10Rik
RIKEN cDNA 1810011O10 gene
chr2_+_143371807 0.243 NM_008792
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr4_-_63681749 0.242 NM_011607
Tnc
tenascin C
chr18_-_46372017 0.240 NM_178872
Trim36
tripartite motif-containing 36
chr12_-_76697229 0.239 Ppp2r5e
protein phosphatase 2, regulatory subunit B (B56), epsilon isoform
chr1_-_133141708 0.238 NM_018750
Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chr11_+_95198329 0.236 NM_172543
Fam117a
family with sequence similarity 117, memberA
chr3_+_108163704 0.235 Sort1
sortilin 1
chr1_+_169528706 0.235 Rxrg
retinoid X receptor gamma
chr9_-_58049765 0.233 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr8_-_11199802 0.232 Col4a1
collagen, type IV, alpha 1
chr4_-_63156984 0.230 NM_001008791
NM_001008792
NM_001008793
NM_001008794
NM_001008795
NM_001008796
NM_028640
Whrn






whirlin






chr16_-_94509462 0.228 NM_139145
Hlcs
holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
chr15_+_79177959 0.227 Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chrX_-_133267605 0.226


chr3_-_115955629 0.226 Gpr88
G-protein coupled receptor 88
chr2_+_163051189 0.225 NM_001098799
Tox2
TOX high mobility group box family member 2
chr11_-_59025422 0.225 Arf1
ADP-ribosylation factor 1
chr16_-_11220854 0.224 Gspt1
G1 to S phase transition 1
chr9_+_15043658 0.223 2200002K05Rik
RIKEN cDNA 2200002K05 gene
chr1_+_174012641 0.222 NM_009938
Copa
coatomer protein complex subunit alpha
chr9_-_108476927 0.221 Wdr6
WD repeat domain 6
chr6_-_87793459 0.221 Cnbp
cellular nucleic acid binding protein
chr7_-_34977928 0.221 Pdcd2l
programmed cell death 2-like
chr5_+_115751128 0.221


chr1_-_193007202 0.220 NM_007498
Atf3
activating transcription factor 3
chr7_-_116073666 0.220 NM_175532
Nlrp10
NLR family, pyrin domain containing 10
chr18_+_23468585 0.219 Dtna
dystrobrevin alpha
chr8_+_116167112 0.219 NM_001048145
NM_029139
Syce1l

synaptonemal complex central element protein 1 like

chr11_-_6328316 0.217


chr15_-_48623520 0.215 NM_001081391
Csmd3
CUB and Sushi multiple domains 3
chr3_+_105255444 0.214 Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr2_-_77541328 0.213 NM_001113399
Zfp385b
zinc finger protein 385B
chr6_+_148303173 0.212 Rps4y2
ribosomal protein S4, Y-linked 2
chr1_+_38054854 0.212 NM_198303
Eif5b
eukaryotic translation initiation factor 5B
chr2_+_162759135 0.210 Srsf6
serine/arginine-rich splicing factor 6
chr11_+_120459734 0.209 NM_025389
Anapc11
anaphase promoting complex subunit 11
chr10_+_28749890 0.205


chr12_-_70260137 0.204 NM_009093
Rps29
ribosomal protein S29
chr16_-_32868355 0.204 NM_172615
1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr10_+_25949512 0.203 NM_001013766
NM_001115154
Samd3

sterile alpha motif domain containing 3

chr3_-_86352170 0.203 NM_011839
Mab21l2
mab-21-like 2 (C. elegans)
chr3_-_75360749 0.201 Pdcd10
programmed cell death 10
chr19_-_8787313 0.200 Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr3_+_96433850 0.198 NM_001102407
NM_025875
Rbm8a

RNA binding motif protein 8a

chr2_+_84903869 0.197 Tnks1bp1
tankyrase 1 binding protein 1
chr10_+_98725871 0.196 Dusp6
dual specificity phosphatase 6
chr4_+_28740314 0.192 Epha7
Eph receptor A7
chr11_+_28753190 0.192 NM_146015
Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr3_+_96023838 0.191 NM_178213
Hist2h2ab
histone cluster 2, H2ab
chr6_+_135312948 0.191 NM_010128
Emp1
epithelial membrane protein 1
chr9_-_35018552 0.188 Foxred1
FAD-dependent oxidoreductase domain containing 1
chr1_+_173053280 0.188 1700009P17Rik
RIKEN cDNA 1700009P17 gene
chrX_+_133200982 0.185 Tceal3
transcription elongation factor A (SII)-like 3
chr6_-_93863547 0.183 NM_001083321
NM_001083320
Magi1

membrane associated guanylate kinase, WW and PDZ domain containing 1

chr16_-_5222390 0.182 NM_001033220
AU021092
expressed sequence AU021092
chr3_-_127202153 0.181 Ank2
ankyrin 2, brain
chr13_-_89881804 0.179 Vcan
versican
chr1_-_137335507 0.178 Nav1
neuron navigator 1
chr19_+_5493612 0.178 Cfl1
cofilin 1, non-muscle
chr10_-_76172218 0.176 Col6a1
collagen, type VI, alpha 1
chr2_-_152142120 0.175


chr4_-_126427788 0.175 Ncdn
neurochondrin
chr12_-_103807640 0.175 Itpk1
inositol 1,3,4-triphosphate 5/6 kinase
chr15_+_12082671 0.175 Zfr
zinc finger RNA binding protein
chr4_-_137869546 0.174 Pink1
PTEN induced putative kinase 1
chr1_+_60466568 0.174 Abi2
abl-interactor 2
chr1_+_173319048 0.174 NM_001005508
Arhgap30
Rho GTPase activating protein 30
chr7_-_148629218 0.173 NM_022654
Lrdd
leucine-rich and death domain containing
chr16_+_20674298 0.173 Eif4g1
eukaryotic translation initiation factor 4, gamma 1
chr10_+_80642896 0.172 Eef2
eukaryotic translation elongation factor 2
chr18_-_65553541 0.172 NM_001037294
Alpk2
alpha-kinase 2
chr11_-_3245718 0.171 Limk2
LIM motif-containing protein kinase 2
chr12_+_110806715 0.171 Meg3
maternally expressed 3
chr5_-_138227400 0.171 Mepce
methylphosphate capping enzyme
chr18_-_12394814 0.171 Npc1
Niemann Pick type C1
chr10_-_61802814 0.171 Hk1
hexokinase 1
chr1_-_95311418 0.171 Hdlbp
high density lipoprotein (HDL) binding protein
chr4_-_49857952 0.170 NM_001033351
Grin3a
glutamate receptor ionotropic, NMDA3A
chr9_-_58049842 0.170 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr4_+_144482979 0.169 NM_011303
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr5_-_114292851 0.168 Coro1c
coronin, actin binding protein 1C
chr19_-_8787823 0.168 Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment p-value GO term description
72.11 2.31e-03 GO:0016597 amino acid binding
43.65 6.32e-03 GO:0043176 amine binding
35.26 9.67e-03 GO:0031406 carboxylic acid binding