Motif ID: ESR1.p2

Z-value: 1.347

Transcription factors associated with ESR1.p2:

NameEntrezDescription
Esr1 13982 estrogen receptor 1 (alpha)



Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr11_+_100436283 10.787 Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr10_+_78243239 9.335 NM_009200
Slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr10_+_78243274 8.103 Slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr14_+_122874598 7.003 NM_009574
Zic2
zinc finger protein of the cerebellum 2
chr2_+_25118144 6.139 Tprn
taperin
chr6_+_29867012 5.829 NM_001037740
NM_177204
Fam40b

family with sequence similarity 40, member B

chr3_+_126299858 5.204 NM_001025438
NM_001025439
NM_023813
Camk2d


calcium/calmodulin-dependent protein kinase II, delta


chr9_+_69137694 5.149 Rora
RAR-related orphan receptor alpha
chr11_+_16652205 5.149 NM_007912
NM_207655
Egfr

epidermal growth factor receptor

chr14_+_122874625 4.977 Zic2
zinc finger protein of the cerebellum 2
chr9_-_31019392 4.922 NM_001102455
NM_001102456
NM_009691
Aplp2


amyloid beta (A4) precursor-like protein 2


chr3_+_117278144 4.692 NM_029425
4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr9_-_31019234 4.565 Aplp2
amyloid beta (A4) precursor-like protein 2
chr3_-_107320881 4.052 NM_172271
Slc6a17
solute carrier family 6 (neurotransmitter transporter), member 17
chr10_-_49508472 3.683 NM_001111268
NM_010349
Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr3_+_104442568 3.660 NM_009196
Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr7_+_29236897 3.651 NM_030562
Lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr18_+_33098694 3.550 NM_009793
Camk4
calcium/calmodulin-dependent protein kinase IV
chr5_-_77837037 3.487 NM_001159518
NM_008048
Igfbp7

insulin-like growth factor binding protein 7

chr15_-_101966611 3.484 NM_001033277
Spryd3
SPRY domain containing 3
chr15_-_78994753 3.453 NM_011437
Sox10
SRY-box containing gene 10
chr11_+_68902025 3.343 NM_009497
Vamp2
vesicle-associated membrane protein 2
chr5_-_77524256 3.335 NM_001159900
NM_001159901
Hopx

HOP homeobox

chr5_+_27588462 3.242 NM_001136060
Dpp6
dipeptidylpeptidase 6
chr11_+_98603186 3.192 NM_178060
Thra
thyroid hormone receptor alpha
chr1_+_167693876 3.128 NM_011804
Creg1
cellular repressor of E1A-stimulated genes 1
chr7_+_51565563 3.087 NM_001034115
Shank1
SH3/ankyrin domain gene 1
chr3_+_126300163 3.078 Camk2d
calcium/calmodulin-dependent protein kinase II, delta
chr9_-_107569654 2.989 NM_023805
Slc38a3
solute carrier family 38, member 3
chr2_+_158492854 2.975 NM_001159662
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr9_-_31019412 2.972 Aplp2
amyloid beta (A4) precursor-like protein 2
chr11_-_83881811 2.942 NM_019819
Dusp14
dual specificity phosphatase 14
chr7_-_25790888 2.919 NM_144921
Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr16_+_17276434 2.915 Tmem191c
transmembrane protein 191C
chr4_+_8617613 2.848 Chd7
chromodomain helicase DNA binding protein 7
chr11_+_68901989 2.809 Vamp2
vesicle-associated membrane protein 2
chrX_+_7215705 2.786 NM_009305
Syp
synaptophysin
chr14_-_76956445 2.747 NM_001160326
Serp2
stress-associated endoplasmic reticulum protein family member 2
chr7_-_87547589 2.740 NM_011046
Furin
furin (paired basic amino acid cleaving enzyme)
chr6_-_90760116 2.694 NM_001134384
Iqsec1
IQ motif and Sec7 domain 1
chr8_-_112692071 2.599 NM_007586
Calb2
calbindin 2
chrX_-_100678555 2.573 Xist
inactive X specific transcripts
chr7_+_71646515 2.571 NM_007461
Apba2
amyloid beta (A4) precursor protein-binding, family A, member 2
chr5_+_89315839 2.538 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr17_+_56904233 2.524 Dus3l
dihydrouridine synthase 3-like (S. cerevisiae)
chr9_-_86589782 2.505 NM_008615
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr14_-_102007883 2.460 Tbc1d4
TBC1 domain family, member 4
chr19_+_7631935 2.426 NM_139269
Pla2g16
phospholipase A2, group XVI
chr4_+_126846429 2.413 NM_198618
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr9_-_61970402 2.408 Glce
glucuronyl C5-epimerase
chr5_-_107003702 2.364 Gm8350
predicted gene 8350
chr7_+_129432585 2.363 NM_008855
Prkcb
protein kinase C, beta
chr1_+_91351435 2.342 Agap1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr1_+_59970358 2.304 Fam117b
family with sequence similarity 117, member B
chr2_-_130468507 2.297 NM_197945
Prosapip1
ProSAPiP1 protein
chr2_+_156439426 2.282 NM_146128
Dlgap4
discs, large homolog-associated protein 4 (Drosophila)
chr11_-_53882433 2.281 NM_019417
Pdlim4
PDZ and LIM domain 4
chr5_-_74038829 2.235 NM_011890
Sgcb
sarcoglycan, beta (dystrophin-associated glycoprotein)
chr6_-_113991945 2.230 NM_009723
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr3_-_107320831 2.135 Slc6a17
solute carrier family 6 (neurotransmitter transporter), member 17
chr11_+_77992224 2.118 NM_026708
Tlcd1
TLC domain containing 1
chr6_-_58857000 2.113 NM_021432
Nap1l5
nucleosome assembly protein 1-like 5
chr5_-_138042267 2.112 NM_030037
Mospd3
motile sperm domain containing 3
chr14_+_21895346 2.058 Adk
adenosine kinase
chr1_+_137625754 2.043 NM_007791
Csrp1
cysteine and glycine-rich protein 1
chr18_+_64425037 2.026 St8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr5_+_65498838 2.013


chr4_+_137237557 1.998 NM_001081155
Rap1gap
Rap1 GTPase-activating protein
chr11_+_78002249 1.995 NM_033475
Rab34
RAB34, member of RAS oncogene family
chr14_-_76956664 1.988 Serp2
stress-associated endoplasmic reticulum protein family member 2
chr7_+_51640108 1.970 Syt3
synaptotagmin III
chr5_+_124423712 1.969 Hip1r
huntingtin interacting protein 1 related
chr5_-_143084677 1.967 NM_175217
Mmd2
monocyte to macrophage differentiation-associated 2
chr11_+_98603041 1.938 Thra
thyroid hormone receptor alpha
chr3_+_88168495 1.928 NM_198410
Paqr6
progestin and adipoQ receptor family member VI
chr7_-_142907978 1.927 Mki67
antigen identified by monoclonal antibody Ki 67
chr5_-_115223373 1.918 NM_001077360
NM_019834
NM_001077359
Git2


G protein-coupled receptor kinase-interactor 2


chr2_-_25325248 1.909 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr15_+_54402914 1.898 NM_178920
Mal2
mal, T-cell differentiation protein 2
chr10_+_122115755 1.897 NM_001110218
NM_176919
Ppm1h

protein phosphatase 1H (PP2C domain containing)

chr4_+_97444312 1.862 NM_001122953
NM_010905
Nfia

nuclear factor I/A

chr6_-_124867732 1.812


chr10_-_76086045 1.812 Col6a2
collagen, type VI, alpha 2
chr15_+_40486577 1.802 NM_011766
Zfpm2
zinc finger protein, multitype 2
chr2_-_127346987 1.796 Kcnip3
Kv channel interacting protein 3, calsenilin
chr8_+_11312828 1.795 NM_009932
Col4a2
collagen, type IV, alpha 2
chr1_-_137271539 1.791 NM_175259
Shisa4
shisa homolog 4 (Xenopus laevis)
chr2_+_25251393 1.778 NM_009849
Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr9_+_69137659 1.767 Rora
RAR-related orphan receptor alpha
chr12_-_73171976 1.763 NM_181752
Gpr135
G protein-coupled receptor 135
chr2_+_25733302 1.763 NM_175462
Kcnt1
potassium channel, subfamily T, member 1
chr17_+_37187550 1.729 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr2_-_32837527 1.721 NM_019488
Slc2a8
solute carrier family 2, (facilitated glucose transporter), member 8
chr10_+_93977597 1.696 NM_172051
Tmcc3
transmembrane and coiled coil domains 3
chr14_+_17081782 1.685 NM_021504
Ngly1
N-glycanase 1
chr14_+_66587319 1.657 NM_013492
Clu
clusterin
chr10_+_3134318 1.644 Cnksr3
Cnksr family member 3
chr19_-_9016880 1.641 Gm10353
predicted gene 10353
chr3_+_102538849 1.637 Tspan2
tetraspanin 2
chr10_+_59740430 1.602 Psap
prosaposin
chr5_-_138041861 1.597 Mospd3
motile sperm domain containing 3
chr4_+_84851330 1.594 NM_019535
Sh3gl2
SH3-domain GRB2-like 2
chr10_-_79602040 1.586 Dos
downstream of Stk11
chr11_-_120442681 1.584 Arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr13_-_49311308 1.583 NM_026738
1110007C09Rik
RIKEN cDNA 1110007C09 gene
chrX_+_158154967 1.578 NM_001103367
Rai2
retinoic acid induced 2
chr11_+_75345598 1.571 Slc43a2
solute carrier family 43, member 2
chr7_-_30066910 1.569 NM_001082548
NM_011464
Spint2

serine protease inhibitor, Kunitz type 2

chr8_+_73017009 1.552 NM_018827
Crlf1
cytokine receptor-like factor 1
chrX_+_7496899 1.549 NM_013892
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr11_+_100436316 1.544 Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr17_+_45700882 1.541 Slc35b2
solute carrier family 35, member B2
chr7_+_29237141 1.539 NM_001141921
Lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr1_+_36748379 1.532 Cox5b
cytochrome c oxidase, subunit Vb
chr17_-_36034316 1.525 NM_001033630
2310061I04Rik
RIKEN cDNA 2310061I04 gene
chr19_-_5845462 1.519 Neat1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr5_+_37633317 1.511 NM_001136058
Crmp1
collapsin response mediator protein 1
chr10_-_75226917 1.510 Cabin1
calcineurin binding protein 1
chr11_+_69659873 1.508 NM_001168497
Plscr3
phospholipid scramblase 3
chr7_-_135561641 1.508 NM_026418
Rgs10
regulator of G-protein signalling 10
chr10_+_61245998 1.488


chr1_-_53841997 1.481 NM_133810
Stk17b
serine/threonine kinase 17b (apoptosis-inducing)
chr4_-_141219989 1.480 NM_001033150
Plekhm2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr10_+_81038028 1.461 NM_019725
Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr7_-_20281956 1.459


chr11_-_4749311 1.453 NM_010898
Nf2
neurofibromatosis 2
chr11_-_72080066 1.445 NM_001004148
Slc13a5
solute carrier family 13 (sodium-dependent citrate transporter), member 5
chr3_+_27081918 1.441 NM_178772
Nceh1
arylacetamide deacetylase-like 1
chr4_+_129662110 1.431 Bai2
brain-specific angiogenesis inhibitor 2
chr2_+_22629846 1.414 NM_019456
Apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr9_-_40965718 1.414 Ubash3b
ubiquitin associated and SH3 domain containing, B
chr7_-_6107491 1.413 NM_001013012
Zfp787
zinc finger protein 787
chr9_+_80012873 1.410 Myo6
myosin VI
chr5_-_124171015 1.405 NM_027494
Zcchc8
zinc finger, CCHC domain containing 8
chr5_+_124423632 1.399 NM_145070
Hip1r
huntingtin interacting protein 1 related
chr11_-_83276417 1.359 NM_080453
NM_172797
Mmp28

matrix metallopeptidase 28 (epilysin)

chrX_+_50341236 1.358 NM_013556
Hprt
hypoxanthine guanine phosphoribosyl transferase
chr11_+_109511803 1.353 Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
chr2_+_152987262 1.352 Tm9sf4
transmembrane 9 superfamily protein member 4
chr9_-_55359898 1.350 Etfa
electron transferring flavoprotein, alpha polypeptide
chr5_-_113006173 1.346 NM_019982
Sez6l
seizure related 6 homolog like
chr7_+_107855215 1.317 NM_178764
Fam168a
family with sequence similarity 168, member A
chr18_+_36441115 1.313 Pura
purine rich element binding protein A
chr12_-_112909656 1.283 Ckb
creatine kinase, brain
chr4_+_130348406 1.283 NM_011520
Sdc3
syndecan 3
chr3_+_51028796 1.277 Ccrn4l
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
chr16_+_17276384 1.255 NM_177473
Tmem191c
transmembrane protein 191C
chr5_-_124482223 1.254 NM_177876
Vps37b
vacuolar protein sorting 37B (yeast)
chr17_+_56904162 1.251 NM_144858
Dus3l
dihydrouridine synthase 3-like (S. cerevisiae)
chr8_-_87323958 1.237 Nfix
nuclear factor I/X
chr19_+_10463540 1.235 NM_018801
NM_173067
NM_173068
Syt7


synaptotagmin VII


chr11_+_83223154 1.235 Rasl10b
RAS-like, family 10, member B
chr1_-_33964439 1.235 NM_177235
Bend6
BEN domain containing 6
chr9_+_80012837 1.228 NM_001039546
Myo6
myosin VI
chr10_-_115910911 1.205 Kcnmb4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr10_+_3134299 1.203 NM_172546
Cnksr3
Cnksr family member 3
chr1_+_89160921 1.186 NM_028889
Efhd1
EF hand domain containing 1
chr4_-_140204609 1.182 NM_001112723
NM_172415
Arhgef10l

Rho guanine nucleotide exchange factor (GEF) 10-like

chr14_+_48740583 1.181 Peli2
pellino 2
chr7_+_142729505 1.173 NM_011212
Ptpre
protein tyrosine phosphatase, receptor type, E
chr13_+_93195850 1.171 NM_175455
Ankrd34b
ankyrin repeat domain 34B
chr1_-_95532278 1.168 NM_021537
Stk25
serine/threonine kinase 25 (yeast)
chr2_+_119568028 1.165 NM_146125
Itpka
inositol 1,4,5-trisphosphate 3-kinase A
chr11_+_75300278 1.162 NM_138659
Prpf8
pre-mRNA processing factor 8
chr9_-_86775282 1.161 Snap91
synaptosomal-associated protein 91
chrX_+_158155484 1.154 NM_198409
Rai2
retinoic acid induced 2
chr3_+_81736518 1.152 NM_177662
Ctso
cathepsin O
chr19_-_6915038 1.144 NM_019924
Rps6ka4
ribosomal protein S6 kinase, polypeptide 4
chr11_-_106650166 1.140 Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr12_-_4914313 1.139 NM_145441
Ubxn2a
UBX domain protein 2A
chrX_+_148578716 1.134 NM_001114664
Iqsec2
IQ motif and Sec7 domain 2
chr7_-_88851798 1.132 NM_001164086
NM_011983
Homer2

homer homolog 2 (Drosophila)

chr13_-_69878721 1.118 NM_001145162
Ube2ql1
ubiquitin-conjugating enzyme E2Q family-like 1
chr10_-_120913138 1.118 NM_138956
Rassf3
Ras association (RalGDS/AF-6) domain family member 3
chr15_+_78939343 1.110 NM_177461
Micall1
microtubule associated monoxygenase, calponin and LIM domain containing -like 1
chr1_-_133141708 1.106 NM_018750
Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chr10_+_79605038 1.093 NM_025313
Atp5d
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr2_+_25118098 1.086 NM_175286
Tprn
taperin
chr10_+_81037993 1.084 Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr8_+_125966855 1.071 NM_054046
Def8
differentially expressed in FDCP 8
chr13_-_56397521 1.068 Cxcl14
chemokine (C-X-C motif) ligand 14
chr1_-_177422630 1.067 NM_001199003
NM_011880
Rgs7

regulator of G protein signaling 7

chr10_+_59740373 1.058 NM_001146120
NM_001146121
NM_001146122
NM_001146123
NM_011179
Psap




prosaposin




chr19_-_29722826 1.058 NM_001081213
Ermp1
endoplasmic reticulum metallopeptidase 1
chr4_-_45097427 1.056 NM_001024142
Fbxo10
F-box protein 10
chr15_+_61869529 1.050 Pvt1
plasmacytoma variant translocation 1
chr1_-_182413583 1.049 NM_001081227
6330403A02Rik
RIKEN cDNA 6330403A02 gene
chr11_+_94871620 1.047 Samd14
sterile alpha motif domain containing 14
chr9_+_20807180 1.039 NM_023167
Mrpl4
mitochondrial ribosomal protein L4
chr10_+_74429876 1.029 NM_010311
Gnaz
guanine nucleotide binding protein, alpha z subunit
chr5_-_144984420 1.026 NM_027410
Tecpr1
tectonin beta-propeller repeat containing 1
chr17_+_29230715 1.022 NM_007669
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr11_+_94072732 1.020 NM_009427
Tob1
transducer of ErbB-2.1
chr10_+_85484631 1.019 NM_153195
Fbxo7
F-box protein 7
chr11_+_100436228 1.012 NM_009923
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr11_-_115474200 1.010 Mif4gd
MIF4G domain containing
chr8_+_97056910 1.007 NM_153507
Cpne2
copine II
chr2_+_128891655 1.005 NM_027192
Ttl
tubulin tyrosine ligase
chr16_+_18836666 0.989 NM_001033164
2510002D24Rik
RIKEN cDNA 2510002D24 gene
chrX_-_148776674 0.989 Tspyl2
TSPY-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.43 1.03e-02 GO:0023051 regulation of signaling
2.50 3.17e-02 GO:0009966 regulation of signal transduction

Gene overrepresentation in compartment category:

enrichment p-value GO term description
4.33 5.94e-05 GO:0045202 synapse
1.20 1.11e-03 GO:0005623 cell
1.20 1.11e-03 GO:0044464 cell part
4.38 2.88e-03 GO:0044456 synapse part
2.18 3.67e-03 GO:0044459 plasma membrane part
6.66 3.95e-03 GO:0030136 clathrin-coated vesicle
6.04 7.93e-03 GO:0045211 postsynaptic membrane
5.86 9.83e-03 GO:0030135 coated vesicle
1.29 1.04e-02 GO:0044424 intracellular part
1.69 1.56e-02 GO:0005886 plasma membrane
1.37 1.74e-02 GO:0005737 cytoplasm
4.27 1.78e-02 GO:0030425 dendrite
2.59 1.91e-02 GO:0005626 insoluble fraction
2.35 2.26e-02 GO:0000267 cell fraction
7.37 2.35e-02 GO:0008021 synaptic vesicle
1.65 2.59e-02 GO:0071944 cell periphery
3.07 2.82e-02 GO:0043005 neuron projection
1.27 2.97e-02 GO:0005622 intracellular
3.78 4.76e-02 GO:0043025 neuronal cell body

Gene overrepresentation in function category:

enrichment p-value GO term description
1.56 3.77e-03 GO:0005515 protein binding
4.37 8.59e-03 GO:0022804 active transmembrane transporter activity
6.92 1.30e-02 GO:0005516 calmodulin binding