Motif ID: ETS1,2.p2

Z-value: 1.184

Transcription factors associated with ETS1,2.p2:

NameEntrezDescription
Ets1 23871 E26 avian leukemia oncogene 1, 5' domain
Ets2 23872 E26 avian leukemia oncogene 2, 3' domain

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Ets1chr9_+_32503600-0.316.6e-02Click!
Ets2chr16_+_959239880.298.3e-02Click!


Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr7_-_135561641 5.010 NM_026418
Rgs10
regulator of G-protein signalling 10
chr2_+_91490266 4.895 NM_001145902
Arhgap1
Rho GTPase activating protein 1
chr11_-_48630854 4.035 NM_145377
Trim41
tripartite motif-containing 41
chr9_+_118387306 3.962 NM_001164789
NM_010136
Eomes

eomesodermin homolog (Xenopus laevis)

chr1_-_164408008 3.919 Dnm3
dynamin 3
chr2_-_91489909 3.801 NM_001033451
Zfp408
zinc finger protein 408
chr2_+_91490332 3.750 Arhgap1
Rho GTPase activating protein 1
chr9_+_58430210 3.515 Nptn
neuroplastin
chr14_+_35124004 3.495 Glud1
glutamate dehydrogenase 1
chr8_+_74092790 2.947 NM_011977
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr14_-_20796411 2.892 NM_001038637
NM_010315
Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr3_-_80606500 2.872 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr1_+_154802144 2.774 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr3_+_89222458 2.686 NM_011368
Shc1
src homology 2 domain-containing transforming protein C1
chr8_-_26895633 2.636 NM_026121
Bag4
BCL2-associated athanogene 4
chr6_+_30756073 2.600 Copg2as2
coatomer protein complex, subunit gamma 2, antisense 2
chr5_+_122841885 2.594 NM_019824
Arpc3
actin related protein 2/3 complex, subunit 3
chr10_-_83111346 2.561 NM_145220
Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr1_+_17135421 2.531 NM_010267
Gdap1
ganglioside-induced differentiation-associated-protein 1
chr5_-_9725274 2.486 NM_181850
Grm3
glutamate receptor, metabotropic 3
chr19_-_61302538 2.481 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr2_+_134611879 2.479 NM_001145830
NM_019677
Plcb1

phospholipase C, beta 1

chr3_+_89222501 2.412 Shc1
src homology 2 domain-containing transforming protein C1
chr12_+_3235767 2.411 1700012B15Rik
RIKEN cDNA 1700012B15 gene
chr17_+_79451501 2.410 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr2_-_155340538 2.396 NM_144786
Ggt7
gamma-glutamyltransferase 7
chr9_-_110379093 2.357 NM_177771
Klhl18
kelch-like 18 (Drosophila)
chr2_-_90420626 2.350 NM_008982
Ptprj
protein tyrosine phosphatase, receptor type, J
chr6_-_136123091 2.305 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr2_+_28061156 2.272 NM_001038612
NM_019498
Olfm1

olfactomedin 1

chr5_-_9725158 2.259 Grm3
glutamate receptor, metabotropic 3
chr9_-_31019234 2.239 Aplp2
amyloid beta (A4) precursor-like protein 2
chr1_+_154802091 2.188 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr9_+_34296315 2.179 NM_001190911
NM_001190912
NM_001190913
NM_001190914
NM_026324
Kirrel3




kin of IRRE like 3 (Drosophila)




chr11_+_94871643 2.164 Samd14
sterile alpha motif domain containing 14
chr11_+_70460758 2.135 Rnf167
ring finger protein 167
chr10_+_126602182 2.133 NM_008080
B4galnt1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr8_-_88364846 2.116 NM_028007
Itfg1
integrin alpha FG-GAP repeat containing 1
chr14_-_16271386 2.113 NM_146052
Lrrc3b
leucine rich repeat containing 3B
chr2_+_163428073 2.074 Ttpal
tocopherol (alpha) transfer protein-like
chr2_+_163245523 2.023 2900093K20Rik
RIKEN cDNA 2900093K20 gene
chr3_+_82162091 2.001 Mtap9
microtubule-associated protein 9
chr12_-_60162456 1.996 Trappc6b
trafficking protein particle complex 6B
chr12_+_81745188 1.992 NM_026244
Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr1_-_157883515 1.970 NM_001160018
NM_144791
Tor1aip1

torsin A interacting protein 1

chr8_+_74743673 1.959 Fam32a
family with sequence similarity 32, member A
chr12_+_81745254 1.935 Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr8_-_107850154 1.916 NM_177449
Lrrc29
leucine rich repeat containing 29
chr1_+_187278726 1.905 NM_001033286
Slc30a10
solute carrier family 30, member 10
chr15_-_63891810 1.891 NM_144846
Fam49b
family with sequence similarity 49, member B
chr9_+_110379461 1.869 NM_010628
Kif9
kinesin family member 9
chr11_-_6100014 1.821 Nudcd3
NudC domain containing 3
chr11_+_16652205 1.819 NM_007912
NM_207655
Egfr

epidermal growth factor receptor

chrX_+_35954355 1.809 Mcts1
malignant T cell amplified sequence 1
chr8_+_26895748 1.803 Lsm1
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr3_-_80606598 1.792 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr19_+_18706474 1.788 NM_145497
BC016495
cDNA sequence BC016495
chr9_+_58430031 1.776 NM_009145
Nptn
neuroplastin
chr17_+_8503966 1.775 NM_134114
Sft2d1
SFT2 domain containing 1
chr9_+_110379481 1.739 NM_001163569
Kif9
kinesin family member 9
chr12_-_60162382 1.739 NM_030057
Trappc6b
trafficking protein particle complex 6B
chr19_-_61303137 1.732 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr7_+_19469999 1.706 NM_009402
Pglyrp1
peptidoglycan recognition protein 1
chr19_-_18706239 1.696 NM_017375
Ostf1
osteoclast stimulating factor 1
chr1_-_137584672 1.694 Nav1
neuron navigator 1
chr1_-_164408123 1.659 Dnm3
dynamin 3
chr3_+_82162037 1.651 Mtap9
microtubule-associated protein 9
chr3_+_99966382 1.648 Gdap2
ganglioside-induced differentiation-associated-protein 2
chrX_+_165758315 1.641 Gm15246
predicted gene 15246
chr7_-_117129643 1.629 Tmem41b
transmembrane protein 41B
chr14_-_76956445 1.623 NM_001160326
Serp2
stress-associated endoplasmic reticulum protein family member 2
chr10_-_61573705 1.614 NM_027251
2010107G23Rik
RIKEN cDNA 2010107G23 gene
chr19_+_34266716 1.612 NM_029682
Stambpl1
STAM binding protein like 1
chr8_-_88364760 1.589 Itfg1
integrin alpha FG-GAP repeat containing 1
chr2_+_132607013 1.586 NM_007694
Chgb
chromogranin B
chr3_+_28162135 1.560 NM_001163007
NM_001163008
NM_001163009
NM_026910
Tnik



TRAF2 and NCK interacting kinase



chr7_+_69493148 1.555 NM_010882
Ndn
necdin
chr3_-_80606641 1.550 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr10_+_84849558 1.543 NM_028709
Btbd11
BTB (POZ) domain containing 11
chr9_-_31019412 1.534 Aplp2
amyloid beta (A4) precursor-like protein 2
chr4_+_137860641 1.502 NM_007838
Ddost
dolichyl-di-phosphooligosaccharide-protein glycotransferase
chr3_+_138868817 1.500 NM_198659
B930007M17Rik
RIKEN cDNA B930007M17 gene
chr7_+_25688004 1.500 NM_001130150
NM_001130151
NM_001130153
NM_008488
Arhgef1



Rho guanine nucleotide exchange factor (GEF) 1



chr10_-_57252184 1.480 Serinc1
serine incorporator 1
chr10_-_121484248 1.474 NM_001081037
Srgap1
SLIT-ROBO Rho GTPase activating protein 1
chr2_-_31701432 1.469 NM_178887
Fibcd1
fibrinogen C domain containing 1
chr16_+_84835361 1.459 NM_008065
Gabpa
GA repeat binding protein, alpha
chr12_+_81744869 1.457 Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr9_-_75531734 1.455 NM_001164790
NM_009130
Scg3

secretogranin III

chr2_+_179992080 1.448 NM_025587
Rps21
ribosomal protein S21
chr12_+_3235481 1.446 1700012B15Rik
RIKEN cDNA 1700012B15 gene
chr9_-_31019392 1.444 NM_001102455
NM_001102456
NM_009691
Aplp2


amyloid beta (A4) precursor-like protein 2


chr8_+_107850249 1.417 NM_025486
Tmem208
transmembrane protein 208
chr10_-_57252252 1.415 NM_019760
Serinc1
serine incorporator 1
chr3_-_10440061 1.410 NM_001127191
NM_029068
Snx16

sorting nexin 16

chr18_-_24761954 1.401 Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr2_+_180701920 1.401 NM_001177707
NM_001177708
NM_001177709
NM_001177710
NM_145760
Arfgap1




ADP-ribosylation factor GTPase activating protein 1




chr17_+_29405732 1.397 NM_030561
BC004004
cDNA sequence BC004004
chr6_+_5675638 1.395 NM_001191023
NM_001191025
NM_001191026
NM_001191027
NM_010063
Dync1i1




dynein cytoplasmic 1 intermediate chain 1




chr1_-_16646922 1.389 NM_026456
Tceb1
transcription elongation factor B (SIII), polypeptide 1
chr2_-_73150559 1.387 NM_025854
Cir1
corepressor interacting with RBPJ, 1
chr7_+_5031809 1.382 NM_010147
Epn1
epsin 1
chr9_+_65756816 1.379 NM_173185
Csnk1g1
casein kinase 1, gamma 1
chr11_-_75609557 1.375 NM_007873
Doc2b
double C2, beta
chr4_+_120527397 1.375 Rims3
regulating synaptic membrane exocytosis 3
chr11_-_93816916 1.362 NM_001077529
Nme2
non-metastatic cells 2, protein (NM23B) expressed in
chr8_+_74092759 1.357 Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr2_+_172825609 1.356 NM_175112
Rae1
RAE1 RNA export 1 homolog (S. pombe)
chr10_-_6980199 1.350 NM_133485
Ppp1r14c
protein phosphatase 1, regulatory (inhibitor) subunit 14c
chr6_+_83129579 1.332 NM_007835
Dctn1
dynactin 1
chr5_-_124329899 1.320 NM_175520
Gpr81
G protein-coupled receptor 81
chr6_-_13789847 1.317 NM_145066
Gpr85
G protein-coupled receptor 85
chr5_+_58109278 1.298 Pcdh7
protocadherin 7
chr8_+_74743620 1.278 NM_026455
Fam32a
family with sequence similarity 32, member A
chr4_+_44025519 1.262 Clta
clathrin, light polypeptide (Lca)
chr19_+_45063750 1.257 NM_011976
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr9_+_57437238 1.243 NM_027895
Ulk3
unc-51-like kinase 3 (C. elegans)
chr11_+_94871181 1.241 NM_146025
Samd14
sterile alpha motif domain containing 14
chr3_-_80606704 1.240 NM_001039195
NM_001083806
NM_013540
Gria2


glutamate receptor, ionotropic, AMPA2 (alpha 2)


chr10_-_127935725 1.236 NM_172259
Myl6b
myosin, light polypeptide 6B
chr10_-_6979959 1.225 Ppp1r14c
protein phosphatase 1, regulatory (inhibitor) subunit 14c
chr3_+_137530638 1.215 NM_001033155
Dnajb14
DnaJ (Hsp40) homolog, subfamily B, member 14
chr17_+_86567003 1.202 NM_011104
Prkce
protein kinase C, epsilon
chr10_+_23869117 1.202 NM_016797
Stx7
syntaxin 7
chr13_-_54850954 1.202 NM_012014
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr11_+_109301411 1.195 Amz2
archaelysin family metallopeptidase 2
chr7_+_51846254 1.194 NM_008422
Kcnc3
potassium voltage gated channel, Shaw-related subfamily, member 3
chr17_+_35960291 1.193 NM_008027
Flot1
flotillin 1
chr11_-_75268137 1.183 NM_138950
Wdr81
WD repeat domain 81
chr8_-_72425538 1.167 Ndufa13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr17_+_32822572 1.156 NM_134127
Cyp4f15
cytochrome P450, family 4, subfamily f, polypeptide 15
chr7_+_87414580 1.151 Vps33b
vacuolar protein sorting 33B (yeast)
chr6_+_125502979 1.147 NM_011708
Vwf
Von Willebrand factor homolog
chr8_+_125748717 1.136 NM_194444
NM_194446
Cdk10

cyclin-dependent kinase 10

chr2_+_136539143 1.135 NM_011428
Snap25
synaptosomal-associated protein 25
chr9_-_58050091 1.131 NM_001161536
NM_177193
NM_001161539
Islr2


immunoglobulin superfamily containing leucine-rich repeat 2


chr10_+_21714471 1.127 NM_011361
Sgk1
serum/glucocorticoid regulated kinase 1
chr11_+_32433265 1.127 NM_009288
Stk10
serine/threonine kinase 10
chr8_+_40068850 1.119 NM_030254
Tusc3
tumor suppressor candidate 3
chr14_-_20796255 1.116 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr1_-_108610520 1.109 Bcl2
B-cell leukemia/lymphoma 2
chr5_+_9266137 1.109 NM_172706
9330182L06Rik
RIKEN cDNA 9330182L06 gene
chr6_+_124959207 1.101 Zfp384
zinc finger protein 384
chr19_+_18706439 1.101 BC016495
cDNA sequence BC016495
chr8_+_72332573 1.097 NM_198101
Gmip
Gem-interacting protein
chr1_-_164408133 1.093 NM_001038619
NM_172646
Dnm3

dynamin 3

chr11_+_29592946 1.087 Rtn4
reticulon 4
chr15_+_35301320 1.085 Vps13b
vacuolar protein sorting 13B (yeast)
chr9_+_45714587 1.076 NM_008794
Pcsk7
Rnf214
proprotein convertase subtilisin/kexin type 7
ring finger protein 214
chr3_+_99966396 1.070 Gdap2
ganglioside-induced differentiation-associated-protein 2
chr9_-_60535841 1.068 NM_001146046
NM_145616
Lrrc49

leucine rich repeat containing 49

chr11_+_113510808 1.067 NM_013581
Cog1
component of oligomeric golgi complex 1
chr11_-_93817311 1.059 NM_008705
Nme2
non-metastatic cells 2, protein (NM23B) expressed in
chr11_+_31770872 1.054 Cpeb4
cytoplasmic polyadenylation element binding protein 4
chr2_-_92886300 1.053 NM_001177536
Prdm11
PR domain containing 11
chr11_+_79404517 1.051 Rab11fip4
RAB11 family interacting protein 4 (class II)
chr19_-_60019520 1.050 NM_001164367
Rab11fip2
RAB11 family interacting protein 2 (class I)
chr12_-_81744771 1.045 NM_007951
Erh
enhancer of rudimentary homolog (Drosophila)
chr2_+_136539202 1.038 Snap25
synaptosomal-associated protein 25
chr4_-_49858561 1.038 Grin3a
glutamate receptor ionotropic, NMDA3A
chr1_+_16678536 1.037 NM_001159711
NM_016923
Ly96

lymphocyte antigen 96

chr14_-_70842930 1.036 Polr3d
polymerase (RNA) III (DNA directed) polypeptide D
chrX_-_147091911 1.035 NM_001002272
NM_019548
Tro

trophinin

chr9_+_21807437 1.029 NM_008925
Prkcsh
protein kinase C substrate 80K-H
chr19_-_7292086 1.026 NM_007750
Cox8a
cytochrome c oxidase, subunit VIIIa
chr2_-_91803660 1.025 NM_138306
Dgkz
diacylglycerol kinase zeta
chr2_+_134611931 1.024 Plcb1
phospholipase C, beta 1
chr8_+_24780132 1.020 NM_177086
Zmat4
zinc finger, matrin type 4
chr13_-_100286521 1.019 NM_008634
Mtap1b
microtubule-associated protein 1B
chr1_+_95132413 1.015 NM_172463
Sned1
sushi, nidogen and EGF-like domains 1
chr14_+_12386094 1.013 Ptprg
protein tyrosine phosphatase, receptor type, G
chr9_-_79641213 1.012 NM_133718
Tmem30a
transmembrane protein 30A
chr9_+_34296412 1.010 Kirrel3
kin of IRRE like 3 (Drosophila)
chr6_+_122824491 1.008 NM_026267
Necap1
NECAP endocytosis associated 1
chr3_+_98186414 1.003 Zfp697
zinc finger protein 697
chr4_+_155108890 1.000 NM_001101506
Gm5151
predicted gene 5151
chr3_-_127111968 0.998 Ank2
ankyrin 2, brain
chr11_-_6100164 0.997 Nudcd3
NudC domain containing 3
chr2_-_5635547 0.995 NM_177343
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr2_+_179992126 0.995 Rps21
ribosomal protein S21
chr9_-_29219382 0.988 Ntm
neurotrimin
chr18_+_62708564 0.988 NM_177829
Spink10
serine peptidase inhibitor, Kazal type 10
chr1_-_67085155 0.981 Lancl1
LanC (bacterial lantibiotic synthetase component C)-like 1
chr11_+_95896221 0.981 NM_033568
Snf8
SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
chr4_-_155043283 0.976 NM_145124
Mib2
mindbomb homolog 2 (Drosophila)
chr6_+_83745142 0.975 NM_001164187
Nagk
N-acetylglucosamine kinase
chr3_+_101180976 0.974 NM_207205
Igsf3
immunoglobulin superfamily, member 3
chr4_-_126430511 0.971 NM_011986
Ncdn
neurochondrin
chr11_+_29593131 0.971


chr8_+_11758322 0.968 NM_001113518
NM_017402
Arhgef7

Rho guanine nucleotide exchange factor (GEF7)

chr1_-_79436564 0.967 NM_009129
Scg2
secretogranin II
chr7_+_24919177 0.966 NM_019941
Zfp235
zinc finger protein 235
chr11_-_106650166 0.966 Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr11_+_62389367 0.965 Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr17_-_34987137 0.956 NM_021337
Skiv2l
superkiller viralicidic activity 2-like (S. cerevisiae)
chr9_-_60535274 0.953 NM_001146047
Lrrc49
leucine rich repeat containing 49
chrX_-_101176600 0.949 NM_011276
Rlim
ring finger protein, LIM domain interacting
chr4_+_143002828 0.949 Pramef8
PRAME family member 8
chrX_+_58962671 0.948 NM_001018087
Ldoc1
leucine zipper, down-regulated in cancer 1
chrX_-_6998125 0.945 2010204K13Rik
RIKEN cDNA 2010204K13 gene

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
14.66 1.67e-02 GO:0050806 positive regulation of synaptic transmission
22.52 2.04e-02 GO:0007215 glutamate signaling pathway
5.76 2.06e-02 GO:0001558 regulation of cell growth
6.63 2.16e-02 GO:0010975 regulation of neuron projection development
13.54 2.47e-02 GO:0051971 positive regulation of transmission of nerve impulse
4.16 2.49e-02 GO:0040008 regulation of growth
12.57 3.55e-02 GO:0031646 positive regulation of neurological system process
7.20 4.10e-02 GO:0010720 positive regulation of cell development
3.10 4.38e-02 GO:0048699 generation of neurons
5.15 4.90e-02 GO:0008361 regulation of cell size

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.67 3.47e-03 GO:0031090 organelle membrane
1.75 5.03e-03 GO:0044446 intracellular organelle part
6.48 5.37e-03 GO:0031252 cell leading edge
2.68 8.17e-03 GO:0042995 cell projection
1.71 8.39e-03 GO:0044422 organelle part
2.95 1.62e-02 GO:0012505 endomembrane system
9.64 2.67e-02 GO:0043197 dendritic spine
14.08 2.86e-02 GO:0042734 presynaptic membrane
9.39 3.04e-02 GO:0044309 neuron spine
1.71 3.22e-02 GO:0005886 plasma membrane
3.61 3.83e-02 GO:0005768 endosome
1.38 4.03e-02 GO:0016020 membrane
8.48 4.88e-02 GO:0014069 postsynaptic density
22.22 4.92e-02 GO:0008328 ionotropic glutamate receptor complex

Gene overrepresentation in function category:

enrichment p-value GO term description
1.70 1.54e-04 GO:0005515 protein binding
19.42 7.70e-03 GO:0008066 glutamate receptor activity
1.29 4.21e-02 GO:0005488 binding