Motif ID: EVI1.p2

Z-value: 1.671

Transcription factors associated with EVI1.p2:

NameEntrezDescription
Mecom 14013 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Mecomchr3_-_29911982-0.298.6e-02Click!


Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr6_+_30756073 18.532 Copg2as2
coatomer protein complex, subunit gamma 2, antisense 2
chr10_+_99478457 11.570 NM_013598
Kitl
kit ligand
chr14_+_66963139 7.669 NM_019675
Stmn4
stathmin-like 4
chr8_-_3624988 7.457 NM_001129804
Pcp2
Purkinje cell protein 2 (L7)
chrX_-_132738383 7.442 NM_177919
Tceal5
transcription elongation factor A (SII)-like 5
chr3_+_95985065 7.424 NM_022030
Sv2a
synaptic vesicle glycoprotein 2 a
chr2_-_170232008 7.355 Bcas1
breast carcinoma amplified sequence 1
chr9_-_117161564 7.012 NM_001172122
NM_001172123
NM_001172124
NM_001172126
NM_178660
Rbms3




RNA binding motif, single stranded interacting protein




chr17_+_80706746 6.794 NM_001145452
Arhgef33
Rho guanine nucleotide exchange factor (GEF) 33
chr15_-_48623520 6.623 NM_001081391
Csmd3
CUB and Sushi multiple domains 3
chr9_-_30978164 6.601 Aplp2
amyloid beta (A4) precursor-like protein 2
chrX_-_161765324 6.497 Glra2
glycine receptor, alpha 2 subunit
chr5_+_72091188 6.368 NM_008069
Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr2_+_164328123 6.240 Pigt
phosphatidylinositol glycan anchor biosynthesis, class T
chrM_+_1091 5.623


chrM_+_1550 5.609


chr13_+_105077914 5.444 NM_001081020
Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr2_+_71624985 5.347 NM_008397
Itga6
integrin alpha 6
chr8_-_3625251 4.941 NM_008790
Pcp2
Purkinje cell protein 2 (L7)
chr11_+_42234760 4.685 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr6_+_141472906 4.244 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chr6_+_105627738 4.206 NM_001109749
NM_173004
Cntn4

contactin 4

chr2_+_4897167 3.957 NM_001113558
NM_001165932
NM_026754
Ucma


upper zone of growth plate and cartilage matrix associated


chr6_+_79968948 3.819 Lrrtm4
leucine rich repeat transmembrane neuronal 4
chr1_+_171585621 3.751 NM_009063
Rgs5
regulator of G-protein signaling 5
chr15_-_81222718 3.679 St13
suppression of tumorigenicity 13
chr13_-_25361773 3.584 NM_009513
Nrsn1
neurensin 1
chr4_-_82151657 3.547 Nfib
nuclear factor I/B
chr12_+_110783593 3.406 Meg3
maternally expressed 3
chr11_-_115228986 3.364 NM_175454
C630004H02Rik
RIKEN cDNA C630004H02 gene
chr10_-_42722514 3.321 Sobp
sine oculis-binding protein homolog (Drosophila)
chr9_-_10904725 3.062 NM_001033359
NM_001170787
Cntn5

contactin 5

chr10_-_6606128 3.055 NM_001159942
Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr3_+_136598485 3.003 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr1_+_148342795 2.986 NM_153539
Fam5c
family with sequence similarity 5, member C
chr12_-_42212538 2.905 Lrrn3
leucine rich repeat protein 3, neuronal
chr10_+_57504720 2.903 NM_021272
Fabp7
fatty acid binding protein 7, brain
chrX_+_111587911 2.766 NM_172781
Klhl4
kelch-like 4 (Drosophila)
chr6_+_103461323 2.721 Chl1
cell adhesion molecule with homology to L1CAM
chr2_+_107130745 2.708 NM_021275
Kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr19_+_22522646 2.668 NM_177341
Trpm3
transient receptor potential cation channel, subfamily M, member 3
chr16_-_45408997 2.634 NM_010818
Cd200
2300009N04Rik
CD200 antigen
RIKEN cDNA 2300009N04 gene
chr5_+_19413335 2.617 NM_001170745
NM_015823
Magi2

membrane associated guanylate kinase, WW and PDZ domain containing 2

chr9_-_117161234 2.604 Rbms3
RNA binding motif, single stranded interacting protein
chr6_+_96063137 2.596 NM_182808
Fam19a1
family with sequence similarity 19, member A1
chr8_-_3154851 2.570 Insr
insulin receptor
chr17_-_45707358 2.525 Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr19_-_8797529 2.489 Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr8_+_68141935 2.484 NM_001166372
March1
membrane-associated ring finger (C3HC4) 1
chrM_+_13998 2.482


chr11_+_78137699 2.423 NM_009657
Aldoc
aldolase C, fructose-bisphosphate
chr2_-_25325248 2.369 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr5_-_139801315 2.264 NM_172723
Adap1
ArfGAP with dual PH domains 1
chr1_+_187278726 2.254 NM_001033286
Slc30a10
solute carrier family 30, member 10
chr5_+_130221363 2.238 NM_025450
Mrps17
mitochondrial ribosomal protein S17
chr9_+_120058842 2.230 NM_001039364
NM_001039365
NM_008614
Mobp


myelin-associated oligodendrocytic basic protein


chr15_-_79359998 2.171 Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr13_-_16115192 2.164 B230303A05Rik
RIKEN cDNA B230303A05 gene
chrM_+_13543 2.156


chrM_+_13320 2.142


chr18_-_31476721 2.141 NM_009065
Rit2
Ras-like without CAAX 2
chr2_+_4897196 2.129 Ucma
upper zone of growth plate and cartilage matrix associated
chr17_-_91492065 2.049 NM_020252
NM_177284
Nrxn1

neurexin I

chr11_+_75570317 2.046 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr3_+_136598184 2.000 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr5_-_113739711 1.983 NM_001162965
NM_172718
Sgsm1

small G protein signaling modulator 1

chr9_-_21820860 1.973 Elavl3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chrX_+_45976982 1.953 NM_001166450
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr1_-_20608010 1.933 NM_153179
Pkhd1
polycystic kidney and hepatic disease 1
chr2_+_65458814 1.916


chr9_-_49311823 1.894 Ncam1
neural cell adhesion molecule 1
chr18_+_37663917 1.859 NM_053145
Pcdhb20
protocadherin beta 20
chr13_-_100199745 1.858 Mtap1b
microtubule-associated protein 1B
chr11_-_41995688 1.841 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr1_-_184397778 1.836 Capn2
calpain 2
chr18_+_37633193 1.812 NM_053140
Pcdhb15
protocadherin beta 15
chr16_-_85056592 1.807 App
amyloid beta (A4) precursor protein
chr10_-_92773778 1.782 NM_013508
Elk3
ELK3, member of ETS oncogene family
chr10_+_59764990 1.761 Psap
prosaposin
chr16_+_49913305 1.728 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr10_-_10802102 1.728 NM_001114333
NM_016976
Grm1

glutamate receptor, metabotropic 1

chr6_+_7505070 1.725 NM_009311
Tac1
tachykinin 1
chr11_+_56825307 1.722 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr6_+_103460955 1.712 Chl1
cell adhesion molecule with homology to L1CAM
chr11_+_102291759 1.705 Grn
granulin
chr2_-_6805937 1.695 NM_001110228
NM_001160293
NM_010160
Celf2


CUGBP, Elav-like family member 2


chr7_+_134072351 1.676 NM_172747
Kctd13
potassium channel tetramerisation domain containing 13
chr1_+_23768764 1.633 NM_172124
B3gat2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr3_-_108830522 1.623 NM_001163567
Fam102b
family with sequence similarity 102, member B
chrX_-_163645313 1.617 Tmsb4x
thymosin, beta 4, X chromosome
chr1_-_108610520 1.615 Bcl2
B-cell leukemia/lymphoma 2
chr16_-_85120798 1.611 App
amyloid beta (A4) precursor protein
chr9_+_37175190 1.575 NM_175189
Hepacam
hepatocyte cell adhesion molecule
chr5_-_151992724 1.559 NM_001163493
NM_146258
Stard13

StAR-related lipid transfer (START) domain containing 13

chr8_+_13167807 1.521 Lamp1
lysosomal-associated membrane protein 1
chr3_-_107888282 1.483 Ampd2
adenosine monophosphate deaminase 2
chr7_-_148620437 1.477 NM_001177576
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr9_-_52484889 1.457 AI593442
expressed sequence AI593442
chr19_-_11410534 1.457 NM_027836
NM_001025610
Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr10_+_3366075 1.444 NM_001170800
NM_001170801
NM_001170802
Ipcef1


interaction protein for cytohesin exchange factors 1


chr10_+_122701051 1.433 NM_182807
Fam19a2
family with sequence similarity 19, member A2
chr6_-_23789419 1.431 Cadps2
Ca2+-dependent activator protein for secretion 2
chr9_-_117160916 1.430 Rbms3
RNA binding motif, single stranded interacting protein
chr12_-_31058094 1.416 NM_172951
Sntg2
syntrophin, gamma 2
chr1_-_156993820 1.409 NM_008209
Mr1
major histocompatibility complex, class I-related
chr9_-_21822333 1.404 Elavl3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr19_-_5797068 1.401


chr17_+_37210011 1.401 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr2_+_174167321 1.364


chr7_-_134968017 1.353 NM_024414
Stx1b
syntaxin 1B
chr2_+_136539202 1.352 Snap25
synaptosomal-associated protein 25
chr4_+_21801372 1.342 Sfrs18
serine/arginine-rich splicing factor 18
chr12_+_8944952 1.341


chr4_-_82151590 1.325 Nfib
nuclear factor I/B
chr9_+_117161650 1.296


chr18_-_31476626 1.281 Rit2
Ras-like without CAAX 2
chrX_-_92361778 1.272 NM_001033329
Arhgef9
CDC42 guanine nucleotide exchange factor (GEF) 9
chr17_+_70318387 1.245 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr2_+_174167172 1.244 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr2_-_76820599 1.242 NM_011652
NM_028004
Ttn

titin

chr5_-_121459496 1.241 NM_011286
Rph3a
rabphilin 3A
chr16_-_84831712 1.211 Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr14_-_104215770 1.209 Ednrb
endothelin receptor type B
chr15_-_79158683 1.209 NM_001199023
NM_001199024
NM_001199025
NM_016915
Pla2g6



phospholipase A2, group VI



chr2_+_158201373 1.196 NM_175692
Snhg11
small nucleolar RNA host gene 11
chr7_+_98239427 1.190 Dlg2
discs, large homolog 2 (Drosophila)
chr2_+_131735663 1.187 NM_011170
Prnp
prion protein
chr17_-_45707285 1.161 Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chrM_-_13886 1.159


chr10_-_63552994 1.141 NM_178678
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr5_+_104864136 1.127 NM_009263
Spp1
secreted phosphoprotein 1
chr9_+_64026089 1.121


chr7_-_26460133 1.118 Tmem91
transmembrane protein 91
chr2_+_143371807 1.100 NM_008792
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr3_+_156224757 1.098 NM_001039094
NM_177274
Negr1

neuronal growth regulator 1

chr2_+_136539143 1.097 NM_011428
Snap25
synaptosomal-associated protein 25
chrX_+_133242520 1.093 NM_146236
Tceal1
transcription elongation factor A (SII)-like 1
chr10_-_89083993 1.093 NM_182959
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr17_+_56125891 1.084 NM_183178
Fsd1
fibronectin type 3 and SPRY domain-containing protein
chr11_-_41813792 1.083 NM_177408
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr8_+_65430028 1.072 NM_023689
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr11_+_117623703 1.067 Tnrc6c
trinucleotide repeat containing 6C
chr18_+_37637421 1.065 NM_053141
Pcdhb16
protocadherin beta 16
chr14_+_63752151 1.041 Ctsb
cathepsin B
chr11_+_44431601 1.039 NM_007897
Ebf1
early B-cell factor 1
chrX_+_133371611 1.036 Plp1
proteolipid protein (myelin) 1
chr7_-_107663293 1.033 NM_153527
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr16_-_38713367 1.026 Arhgap31
Rho GTPase activating protein 31
chr14_+_62218348 1.013 NM_023233
Trim13
tripartite motif-containing 13
chr2_+_70400179 1.011 NM_008077
Gad1
glutamic acid decarboxylase 1
chr12_+_89961317 1.007 NM_001198587
Nrxn3
neurexin III
chr17_-_43803963 1.006 NM_028711
Slc25a27
solute carrier family 25, member 27
chr10_+_40349816 1.005 NM_027442
Ddo
D-aspartate oxidase
chr14_+_56180060 1.003 Dcaf11
DDB1 and CUL4 associated factor 11
chr3_-_50247306 1.000 NM_011990
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr5_+_75548337 0.987 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr7_-_117009158 0.984 NM_020052
Scube2
signal peptide, CUB domain, EGF-like 2
chr8_-_33028674 0.977 NM_178591
Nrg1
neuregulin 1
chr9_-_39411199 0.973 AW551984
expressed sequence AW551984
chr11_-_90252228 0.968 NM_172563
Hlf
hepatic leukemia factor
chrX_-_161764912 0.968 NM_183427
Glra2
glycine receptor, alpha 2 subunit
chr8_-_86095743 0.963


chr1_+_163072784 0.961 NM_028664
Ankrd45
ankyrin repeat domain 45
chr12_+_77425836 0.960 NM_001101471
Akap5
A kinase (PRKA) anchor protein 5
chr11_-_79317471 0.948 Omg
oligodendrocyte myelin glycoprotein
chrX_-_67618136 0.924 Ids
iduronate 2-sulfatase
chr11_-_53083217 0.920 Hspa4
heat shock protein 4
chr11_+_75570397 0.918 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr7_-_27966073 0.906 Mia1
melanoma inhibitory activity 1
chr6_+_103460834 0.904 NM_007697
Chl1
cell adhesion molecule with homology to L1CAM
chr6_-_72297660 0.888


chr4_+_12067263 0.887 NM_028226
Rbm12b
RNA binding motif protein 12B
chr2_-_79296732 0.884 NM_010894
Neurod1
neurogenic differentiation 1
chr10_-_27336648 0.872 NM_008481
Lama2
laminin, alpha 2
chr19_+_10278684 0.867 NM_026919
1810006K21Rik
RIKEN cDNA 1810006K21 gene
chr14_-_78936606 0.863 NM_001164503
Akap11
A kinase (PRKA) anchor protein 11
chr11_+_29642059 0.855 Rtn4
reticulon 4
chr11_+_29607599 0.848 Rtn4
reticulon 4
chr16_+_11066390 0.846 NM_009223
Snn
stannin
chr11_+_98667577 0.843 Msl1
male-specific lethal 1 homolog (Drosophila)
chr2_+_157385835 0.842 NM_010923
NM_180960
Nnat

neuronatin

chr10_+_69487700 0.832 Ank3
ankyrin 3, epithelial
chr14_-_26588341 0.832 NM_001101433
Zcchc24
zinc finger, CCHC domain containing 24
chr3_-_123375305 0.830 NM_031186
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr8_+_26211563 0.826 2700026D01Rik
RIKEN cDNA 2700026D01 gene
chr9_+_103014279 0.817 Rab6b
RAB6B, member RAS oncogene family
chrX_-_35793335 0.812 Lamp2
lysosomal-associated membrane protein 2
chr11_+_97702093 0.801 NM_001080935
B230217C12Rik
RIKEN cDNA B230217C12 gene
chr1_+_91351435 0.801 Agap1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr1_+_9591347 0.796 NM_178399
3110035E14Rik
RIKEN cDNA 3110035E14 gene
chrX_+_6154374 0.795 Shroom4
shroom family member 4
chr14_-_65035722 0.791 Msra
methionine sulfoxide reductase A
chr13_+_83663817 0.790 Mef2c
myocyte enhancer factor 2C
chr1_-_175263540 0.787 NM_010045
Darc
Duffy blood group, chemokine receptor
chr17_-_33897428 0.783 NM_008997
Rab11b
RAB11B, member RAS oncogene family
chr10_+_80217947 0.777 NM_199322
Dot1l
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr4_-_116313684 0.772 Akr1a4
aldo-keto reductase family 1, member A4 (aldehyde reductase)
chr17_-_27717411 0.769 Nudt3
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr9_-_66883879 0.769 Tpm1
tropomyosin 1, alpha
chr10_-_90582332 0.767 Slc25a3
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
8.59 6.94e-07 GO:0007268 synaptic transmission
7.29 1.63e-06 GO:0019226 transmission of nerve impulse
7.29 1.63e-06 GO:0035637 multicellular organismal signaling
5.95 2.44e-05 GO:0007267 cell-cell signaling
6.04 6.05e-05 GO:0007610 behavior
13.91 8.09e-05 GO:0006836 neurotransmitter transport
4.35 2.60e-04 GO:0007154 cell communication
2.11 1.27e-03 GO:0051179 localization
2.22 2.27e-03 GO:0006810 transport
2.19 3.32e-03 GO:0051234 establishment of localization
4.04 3.38e-03 GO:0007155 cell adhesion
4.00 3.74e-03 GO:0022610 biological adhesion
17.98 6.13e-03 GO:0007269 neurotransmitter secretion
12.49 6.32e-03 GO:0001505 regulation of neurotransmitter levels
59.32 1.01e-02 GO:0051290 protein heterotetramerization
52.73 1.51e-02 GO:0006878 cellular copper ion homeostasis
43.14 2.93e-02 GO:0055070 copper ion homeostasis
3.11 4.09e-02 GO:0022607 cellular component assembly
2.10 4.15e-02 GO:0048731 system development
8.71 4.95e-02 GO:0003001 generation of a signal involved in cell-cell signaling
8.71 4.95e-02 GO:0023061 signal release

Gene overrepresentation in compartment category:

enrichment p-value GO term description
7.30 3.56e-11 GO:0045202 synapse
2.55 1.08e-10 GO:0071944 cell periphery
8.56 4.65e-10 GO:0044456 synapse part
2.51 6.75e-10 GO:0005886 plasma membrane
1.61 8.06e-06 GO:0016020 membrane
9.83 1.05e-05 GO:0045211 postsynaptic membrane
3.34 2.18e-05 GO:0000267 cell fraction
4.16 2.05e-04 GO:0030054 cell junction
3.16 3.45e-04 GO:0042995 cell projection
1.62 3.73e-04 GO:0044425 membrane part
3.38 4.36e-04 GO:0005626 insoluble fraction
6.09 8.38e-04 GO:0030424 axon
3.35 9.13e-04 GO:0005624 membrane fraction
1.23 9.23e-04 GO:0005623 cell
1.23 9.23e-04 GO:0044464 cell part
2.48 1.11e-03 GO:0044459 plasma membrane part
4.00 1.52e-03 GO:0043005 neuron projection
7.24 2.16e-03 GO:0034702 ion channel complex
15.82 2.20e-03 GO:0034707 chloride channel complex
3.44 2.24e-03 GO:0031982 vesicle
8.15 3.52e-03 GO:0019717 synaptosome
3.89 4.28e-03 GO:0031988 membrane-bounded vesicle
1.60 4.95e-03 GO:0031224 intrinsic to membrane
4.92 5.31e-03 GO:0043025 neuronal cell body
4.69 7.98e-03 GO:0044297 cell body
4.25 8.14e-03 GO:0044463 cell projection part
1.61 1.06e-02 GO:0044444 cytoplasmic part
4.51 1.09e-02 GO:0005625 soluble fraction
15.82 1.65e-02 GO:0042734 presynaptic membrane
3.20 1.70e-02 GO:0031410 cytoplasmic vesicle
1.42 2.29e-02 GO:0005737 cytoplasm
3.47 4.76e-02 GO:0016023 cytoplasmic membrane-bounded vesicle

Gene overrepresentation in function category:

enrichment p-value GO term description
37.67 2.92e-05 GO:0016917 GABA receptor activity
3.27 2.45e-04 GO:0005215 transporter activity
5.37 4.19e-04 GO:0032403 protein complex binding
14.84 5.23e-04 GO:0005230 extracellular ligand-gated ion channel activity
35.16 7.32e-04 GO:0004890 GABA-A receptor activity
3.45 7.35e-04 GO:0022857 transmembrane transporter activity
4.32 7.59e-04 GO:0019904 protein domain specific binding
3.60 7.76e-04 GO:0022891 substrate-specific transmembrane transporter activity
3.14 4.59e-03 GO:0022892 substrate-specific transporter activity
8.88 1.01e-02 GO:0015276 ligand-gated ion channel activity
8.88 1.01e-02 GO:0022834 ligand-gated channel activity
11.99 1.02e-02 GO:0005254 chloride channel activity
5.13 1.14e-02 GO:0022836 gated channel activity
10.84 1.66e-02 GO:0005253 anion channel activity
4.34 1.80e-02 GO:0005216 ion channel activity
105.45 2.02e-02 GO:0019911 structural constituent of myelin sheath
4.25 2.15e-02 GO:0022838 substrate-specific channel activity
4.12 2.78e-02 GO:0015267 channel activity
4.11 2.84e-02 GO:0022803 passive transmembrane transporter activity
4.07 3.02e-02 GO:0030695 GTPase regulator activity
3.95 3.86e-02 GO:0060589 nucleoside-triphosphatase regulator activity
79.09 4.02e-02 GO:0032564 dATP binding
79.09 4.02e-02 GO:0051425 PTB domain binding