Motif ID: EWSR1-FLI1.p2

Z-value: 1.744

Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

NameEntrezDescription
Ewsr1 14030 Ewing sarcoma breakpoint region 1
Fli1 14247 Friend leukemia integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Fli1chr9_-_32348863-0.684.2e-06Click!
Ewsr1chr11_-_4999069-0.202.4e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr11_+_31900378 24.948 NM_008741
Nsg2
neuron specific gene family member 2
chr4_+_43419445 23.230 NM_199057
Rusc2
RUN and SH3 domain containing 2
chr6_-_77929543 17.321 Ctnna2
catenin (cadherin associated protein), alpha 2
chr6_-_77929575 14.593 Ctnna2
catenin (cadherin associated protein), alpha 2
chr1_-_128389495 14.412 NM_172484
Nckap5
NCK-associated protein 5
chr17_+_79451501 14.233 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr5_-_36740713 12.653 NM_030889
Sorcs2
sortilin-related VPS10 domain containing receptor 2
chrX_-_133403050 12.622 NM_176971
Rab9b
RAB9B, member RAS oncogene family
chr16_-_42340613 12.307 NM_008083
Gap43
growth associated protein 43
chr7_-_147268395 10.508 NM_001190385
NM_026769
Caly

calcyon neuron-specific vesicular protein

chr6_-_77929685 9.879 Ctnna2
catenin (cadherin associated protein), alpha 2
chr2_+_65683823 8.684 NM_153409
NM_178634
Csrnp3

cysteine-serine-rich nuclear protein 3

chr11_-_100621034 8.545 NM_001081194
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr10_+_68996455 7.497 NM_146005
NM_170688
NM_170689
NM_170690
NM_170728
NM_170729
NM_170730
Ank3






ankyrin 3, epithelial






chrX_-_69901382 7.430 NM_008067
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr4_+_140566594 7.359 Mfap2
microfibrillar-associated protein 2
chr1_-_193141946 7.022 NM_025424
Nenf
neuron derived neurotrophic factor
chr6_-_77929660 6.458 NM_001109764
NM_009819
NM_145732
Ctnna2


catenin (cadherin associated protein), alpha 2


chr7_-_4397194 4.885 NM_175372
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr10_-_70747929 4.078 NM_145420
Ube2d1
ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog (yeast)
chr4_+_140566551 3.876 NM_008546
Mfap2
microfibrillar-associated protein 2
chr18_+_52927362 3.616 NM_026408
Sncaip
synuclein, alpha interacting protein (synphilin)
chr13_+_55565627 3.588 NM_001030296
Prr7
proline rich 7 (synaptic)
chr13_+_91600662 3.533 NM_024186
NM_024272
Ssbp2

single-stranded DNA binding protein 2

chr9_+_104472090 3.240 NM_028719
Cpne4
copine IV
chr11_-_86900220 3.237 1200011M11Rik
RIKEN cDNA 1200011M11 gene
chrX_+_106290703 3.161 NM_019989
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr3_-_122322556 3.068 NM_001114665
NM_153118
Fnbp1l

formin binding protein 1-like

chr1_+_17135421 2.634 NM_010267
Gdap1
ganglioside-induced differentiation-associated-protein 1
chr2_+_13495931 2.548 NM_011701
Vim
vimentin
chr8_-_74009902 2.478 NM_001164679
Ano8
anoctamin 8
chr6_+_138089041 2.435 NM_019946
Mgst1
microsomal glutathione S-transferase 1
chr3_+_156224757 2.381 NM_001039094
NM_177274
Negr1

neuronal growth regulator 1

chr15_-_75956971 2.175 NM_001142968
BC024139
cDNA sequence BC024139
chrX_-_49033575 2.166 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr2_-_44968508 2.126 Zeb2
zinc finger E-box binding homeobox 2
chr12_+_89961317 2.121 NM_001198587
Nrxn3
neurexin III
chr8_-_74009856 2.024 Ano8
anoctamin 8
chr10_+_84380371 1.971 NM_001013441
Ric8b
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr16_+_11066390 1.962 NM_009223
Snn
stannin
chr19_-_40261753 1.941 NM_145499
Cyp2c70
cytochrome P450, family 2, subfamily c, polypeptide 70
chr9_-_57531452 1.922 NM_009993
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
chr5_-_121161656 1.874 NM_008052
Dtx1
deltex 1 homolog (Drosophila)
chr14_-_52924792 1.848 NM_019721
Mettl3
methyltransferase like 3
chr2_+_32480924 1.805 NM_001198791
Ak1
adenylate kinase 1
chr11_-_97560852 1.622 Pcgf2
polycomb group ring finger 2
chr11_-_86900256 1.581 NM_024262
1200011M11Rik
RIKEN cDNA 1200011M11 gene
chrX_-_7753020 1.553 Tbc1d25
TBC1 domain family, member 25
chr2_-_84490827 1.519 NM_001085448
NM_001085449
NM_001085450
NM_007615
Ctnnd1



catenin (cadherin associated protein), delta 1



chr5_+_126012784 1.502 NM_001190352
Tmem132b
transmembrane protein 132B
chr7_-_85722668 1.481 NM_008746
NM_182809
Ntrk3

neurotrophic tyrosine kinase, receptor, type 3

chrX_-_163647088 1.471 NM_021278
Tmsb4x
thymosin, beta 4, X chromosome
chr2_-_69424085 1.387 NM_001081088
Lrp2
low density lipoprotein receptor-related protein 2
chr7_-_4947629 1.354 NM_026741
Zfp579
zinc finger protein 579
chr4_+_40669908 1.325 NM_001164671
NM_001164672
Dnaja1

DnaJ (Hsp40) homolog, subfamily A, member 1

chr15_+_98462650 1.319 NM_001044741
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr9_-_62659736 1.314 Fem1b
feminization 1 homolog b (C. elegans)
chr6_+_142705178 1.226 NM_009908
Cmas
cytidine monophospho-N-acetylneuraminic acid synthetase
chr11_+_23978029 1.208 NM_001159289
NM_016707
Bcl11a

B-cell CLL/lymphoma 11A (zinc finger protein)

chr6_-_32538191 1.187 NM_175750
Plxna4
plexin A4
chr9_+_54711492 1.140 NM_022655
Ireb2
iron responsive element binding protein 2
chr17_-_24346280 1.138 NM_010947
Ntn3
netrin 3
chr17_+_70318387 1.127 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr10_-_85420487 1.117 NM_145422
D10Wsu52e
DNA segment, Chr 10, Wayne State University 52, expressed
chr3_+_159502646 1.104 NM_026582
Wls
wntless homolog (Drosophila)
chr18_-_57134974 1.104 NM_029909
C330018D20Rik
RIKEN cDNA C330018D20 gene
chr10_+_84218792 1.094 NM_001024918
Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr2_+_181255209 1.083 NM_016775
Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr6_+_124999940 1.083 NM_001127340
NM_016845
Acrbp

proacrosin binding protein

chrX_+_8469507 1.035 B630019K06Rik
RIKEN cDNA B630019K06 gene
chr17_+_6106858 0.996 Tulp4
tubby like protein 4
chr14_-_52924739 0.961 Mettl3
methyltransferase like 3
chr1_+_171859069 0.934 NM_001033185
1700084C01Rik
RIKEN cDNA 1700084C01 gene
chr6_+_71657791 0.886 NM_178608
Reep1
receptor accessory protein 1
chr9_+_118387306 0.864 NM_001164789
NM_010136
Eomes

eomesodermin homolog (Xenopus laevis)

chr6_-_124813720 0.833 Gpr162
G protein-coupled receptor 162
chr2_+_119373442 0.818 NM_019769
1500003O03Rik
RIKEN cDNA 1500003O03 gene
chr13_+_42804911 0.812 NM_001005740
Phactr1
phosphatase and actin regulator 1
chr8_+_86521498 0.809 NM_001081415
Samd1
sterile alpha motif domain containing 1
chr9_-_46043339 0.772 NM_023114
Apoc3
apolipoprotein C-III
chr9_-_62659364 0.742 NM_010193
Fem1b
feminization 1 homolog b (C. elegans)
chr9_-_106691395 0.723 NM_030730
Rad54l2
RAD54 like 2 (S. cerevisiae)
chr6_+_124999976 0.721 Ing4
Acrbp
inhibitor of growth family, member 4
proacrosin binding protein
chr18_-_75857207 0.710 NM_201354
Ctif
CBP80/20-dependent translation initiation factor
chr2_+_154959216 0.708 NM_008395
Itch
itchy, E3 ubiquitin protein ligase
chr6_-_60778740 0.708 NM_001042451
Snca
synuclein, alpha
chr2_-_181048957 0.707 Stmn3
stathmin-like 3
chr11_-_5815126 0.685 Gck
glucokinase
chr14_+_56211303 0.681


chr17_-_33495772 0.670 NM_207541
Zfp81
zinc finger protein 81
chr6_+_88852244 0.648 NM_011906
Tpra1
transmembrane protein, adipocyte asscociated 1
chr5_-_45190857 0.639 NM_001077398
NM_010698
Ldb2

LIM domain binding 2

chr9_+_108197453 0.638


chrX_+_8469478 0.620 NM_175327
B630019K06Rik
RIKEN cDNA B630019K06 gene
chr12_+_110784600 0.599 Meg3
maternally expressed 3
chr16_+_17759703 0.581 NM_145479
Klhl22
kelch-like 22 (Drosophila)
chr6_-_128476708 0.561 NM_007376
Pzp
pregnancy zone protein
chr11_+_17157549 0.560 NM_020558
C1d
C1D nuclear receptor co-repressor
chr10_+_81816989 0.556 Gm4924
predicted gene 4924
chr3_-_144233091 0.547 Hs2st1
heparan sulfate 2-O-sulfotransferase 1
chr3_+_30692217 0.543 Sec62
SEC62 homolog (S. cerevisiae)
chr16_+_37580303 0.543 Hgd
homogentisate 1, 2-dioxygenase
chr11_-_84338922 0.535 NM_008498
Lhx1
LIM homeobox protein 1
chr11_-_110112926 0.533 NM_001166556
NM_001166557
NM_147218
Abca6


ATP-binding cassette, sub-family A (ABC1), member 6


chr7_+_135754831 0.533 NM_178641
Inpp5f
inositol polyphosphate-5-phosphatase F
chr3_-_144233110 0.525 NM_011828
Hs2st1
heparan sulfate 2-O-sulfotransferase 1
chr10_-_127057998 0.524 Lrp1
low density lipoprotein receptor-related protein 1
chr1_-_158649117 0.522 Fam20b
family with sequence similarity 20, member B
chr14_-_55735399 0.512 Jph4
junctophilin 4
chr10_+_21601968 0.508 NM_001161845
Sgk1
serum/glucocorticoid regulated kinase 1
chr4_+_126290825 0.504


chr5_-_136674768 0.502 NM_025774
Prkrip1
Prkr interacting protein 1 (IL11 inducible)
chr7_+_123236814 0.498 NM_019772
1110004F10Rik
RIKEN cDNA 1110004F10 gene
chr2_-_44968728 0.493 NM_015753
Zeb2
zinc finger E-box binding homeobox 2
chr7_-_20262106 0.493 Apoc2
apolipoprotein C-II
chr4_+_108551674 0.486 NM_023537
Rab3b
RAB3B, member RAS oncogene family
chr7_-_116759904 0.484 St5
suppression of tumorigenicity 5
chr5_-_90795190 0.482 NM_030886
NM_198010
Ankrd17

ankyrin repeat domain 17

chr3_+_102799658 0.479 NM_025679
Sike1
suppressor of IKBKE 1
chr7_-_91032070 0.478


chr5_-_45190731 0.473 Ldb2
LIM domain binding 2
chr2_+_135883963 0.472 6330527O06Rik
RIKEN cDNA 6330527O06 gene
chr16_+_23224804 0.470 NM_145933
St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr5_-_38550627 0.464 NM_010942
Nsg1
neuron specific gene family member 1
chr3_+_102799653 0.462 Sike1
suppressor of IKBKE 1
chr19_-_46119403 0.452 Ldb1
LIM domain binding 1
chr10_-_127058199 0.451 NM_008512
Lrp1
low density lipoprotein receptor-related protein 1
chr2_+_49307207 0.448 Epc2
enhancer of polycomb homolog 2 (Drosophila)
chr1_-_140743779 0.443 Lhx9
LIM homeobox protein 9
chr5_-_121161653 0.443 Dtx1
deltex 1 homolog (Drosophila)
chr9_-_57531425 0.440 Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
chr15_+_25870456 0.436 NM_025459
Fam134b
family with sequence similarity 134, member B
chr9_+_111341538 0.434 NM_172928
Dclk3
doublecortin-like kinase 3
chr1_-_127332217 0.426 Actr3
ARP3 actin-related protein 3 homolog (yeast)
chr3_-_89126782 0.411 NM_010108
Efna3
ephrin A3
chr10_-_14425271 0.410 NM_025418
Vta1
Vps20-associated 1 homolog (S. cerevisiae)
chr6_+_124999988 0.407 Acrbp
proacrosin binding protein
chr8_-_109417431 0.407 NM_145412
Chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr11_-_74537524 0.400 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr8_+_85913750 0.399 NM_009904
Clgn
calmegin
chr18_+_38115192 0.399 NM_153793
Rell2
RELT-like 2
chr8_-_122364444 0.394 NM_028071
Cotl1
coactosin-like 1 (Dictyostelium)
chr2_+_28048511 0.394 Olfm1
olfactomedin 1
chr4_+_147314951 0.388 NM_029841
2510039O18Rik
RIKEN cDNA 2510039O18 gene
chr6_+_30459848 0.385 NM_027073
1700025E21Rik
RIKEN cDNA 1700025E21 gene
chr4_+_132567420 0.385 NM_146155
Ahdc1
AT hook, DNA binding motif, containing 1
chr16_-_28753276 0.384 NM_010199
Fgf12
fibroblast growth factor 12
chr19_-_5093049 0.382 Cnih2
cornichon homolog 2 (Drosophila)
chr10_-_42722514 0.382 Sobp
sine oculis-binding protein homolog (Drosophila)
chr11_-_94382743 0.381 NM_170671
Mycbpap
MYCBP associated protein
chr8_+_131028275 0.381 Nrp1
neuropilin 1
chr6_-_120772683 0.378 NM_007510
Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr2_-_181049204 0.371 NM_009133
Stmn3
stathmin-like 3
chr7_-_133848235 0.370 NM_009898
Coro1a
coronin, actin binding protein 1A
chr7_-_117758395 0.369 Sbf2
SET binding factor 2
chr7_-_30290470 0.364 NM_001081028
Sipa1l3
signal-induced proliferation-associated 1 like 3
chr5_-_100812885 0.359 Sec31a
Sec31 homolog A (S. cerevisiae)
chr4_+_147976641 0.355 NM_001003893
NM_010767
Masp2

mannan-binding lectin serine peptidase 2

chr16_+_56075506 0.344 NM_001003971
NM_001003972
NM_001003973
NM_025483
Senp7



SUMO1/sentrin specific peptidase 7



chr11_-_6420904 0.334 Myo1g
myosin IG
chr17_-_24346171 0.328 Ntn3
netrin 3
chr2_-_165113250 0.325 NM_144893
Slc35c2
solute carrier family 35, member C2
chr4_+_40669478 0.321 NM_008298
Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr12_-_119539840 0.318 Sp4
trans-acting transcription factor 4
chr4_-_133309484 0.318 NM_001080819
Arid1a
AT rich interactive domain 1A (SWI-like)
chr11_+_97660946 0.312 NM_010688
Lasp1
LIM and SH3 protein 1
chr7_+_51565563 0.311 NM_001034115
Shank1
SH3/ankyrin domain gene 1
chr9_-_64869349 0.310 NM_021345
Ptplad1
protein tyrosine phosphatase-like A domain containing 1
chr3_-_86803173 0.304 NM_007639
Cd1d1
CD1d1 antigen
chr11_-_94938114 0.301 Itga3
integrin alpha 3
chr15_-_101947088 0.300


chr7_+_52955153 0.289 NM_009800
Car11
carbonic anhydrase 11
chr2_+_10294062 0.287 NM_001198809
NM_177386
Sfmbt2

Scm-like with four mbt domains 2

chr10_-_127058163 0.285 Lrp1
low density lipoprotein receptor-related protein 1
chr9_+_111341608 0.282 Dclk3
doublecortin-like kinase 3
chr13_-_4522566 0.280 NM_054080
Akr1c20
aldo-keto reductase family 1, member C20
chr9_+_58100961 0.271 NM_026942
Stoml1
stomatin-like 1
chr7_-_4484000 0.269 NM_001033548
6030429G01Rik
RIKEN cDNA 6030429G01 gene
chr8_-_25686797 0.267 NM_145949
Ido2
indoleamine 2,3-dioxygenase 2
chr1_-_157626552 0.264 Qsox1
quiescin Q6 sulfhydryl oxidase 1
chr9_-_57493393 0.260 Csk
c-src tyrosine kinase
chr8_-_60131768 0.250 NM_001167981
NM_144731
Galnt7

UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7

chr11_-_61680770 0.249 A530017D24Rik
RIKEN cDNA A530017D24 gene
chr6_-_145198693 0.247 NM_021284
Kras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
chr7_+_53040723 0.245 Lmtk3
lemur tyrosine kinase 3
chrX_-_57657081 0.245 NM_001001798
NM_001037863
Atp11c

ATPase, class VI, type 11C

chr2_+_24132788 0.240 NM_019451
Il1f5
interleukin 1 family, member 5 (delta)
chr6_+_8899165 0.238 Nxph1
neurexophilin 1
chr12_-_81537261 0.235 Dcaf5
DDB1 and CUL4 associated factor 5
chr14_+_55502200 0.233 Bcl2l2
BCL2-like 2
chr16_+_56075576 0.232 Senp7
SUMO1/sentrin specific peptidase 7
chr18_+_74375999 0.229 Cxxc1
CXXC finger 1 (PHD domain)
chr19_-_46114019 0.229 NM_010697
Ldb1
LIM domain binding 1
chr2_+_28048592 0.229 NM_001038613
NM_001038614
Olfm1

olfactomedin 1

chr6_-_66846511 0.227 4930597O21Rik
RIKEN cDNA 4930597O21 gene
chr6_-_88396477 0.226 NM_023060
Eefsec
eukaryotic elongation factor, selenocysteine-tRNA-specific
chr11_-_74537877 0.225 NM_013625
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr12_-_119539909 0.224 NM_001166385
NM_009239
Sp4

trans-acting transcription factor 4

chr2_+_152788220 0.223 NM_001083618
NM_029064
Ttll9

tubulin tyrosine ligase-like family, member 9

chr2_-_127410404 0.222 NM_001111029
NM_028141
Zfp661

zinc finger protein 661


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment p-value GO term description
5.28 9.95e-03 GO:0045202 synapse

Nothing significant found in function category.