Motif ID: FOX{C1,C2}.p2

Z-value: 0.461

Transcription factors associated with FOX{C1,C2}.p2:

NameEntrezDescription
Foxc1 17300 forkhead box C1
Foxc2 14234 forkhead box C2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Foxc2chr8_+_1236400690.363.2e-02Click!
Foxc1chr13_+_318985010.353.5e-02Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr1_+_45368443 2.317 Col3a1
collagen, type III, alpha 1
chr11_+_108256590 2.079 NM_013475
Apoh
apolipoprotein H
chr19_+_39361574 1.920 NM_007815
Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
chr4_-_49562319 1.302 NM_144903
Aldob
aldolase B, fructose-bisphosphate
chr1_-_42749940 1.062 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr6_+_71149869 1.011 NM_017399
Fabp1
fatty acid binding protein 1, liver
chr2_-_10052196 0.681 NM_010582
Itih2
inter-alpha trypsin inhibitor, heavy chain 2
chr7_-_112748624 0.614 NM_017371
Hpx
hemopexin
chr15_-_98764960 0.578 Tuba1b
tubulin, alpha 1B
chr1_+_21230683 0.555 Gsta3
glutathione S-transferase, alpha 3
chr10_+_127528632 0.517 Baz2a
bromodomain adjacent to zinc finger domain, 2A
chr1_+_196765124 0.517 Cd34
CD34 antigen
chr10_+_87323855 0.512 NM_001111274
NM_001111276
NM_184052
Igf1


insulin-like growth factor 1


chr6_+_86321479 0.496 NM_026506
Snrpg
small nuclear ribonucleoprotein polypeptide G
chr1_+_196765014 0.458 NM_001111059
NM_133654
Cd34

CD34 antigen

chr2_+_44966657 0.433 NM_001177394
Gm13476
predicted gene 13476
chr6_-_55124983 0.418 NM_009349
Inmt
indolethylamine N-methyltransferase
chr1_+_173155184 0.412 NM_013474
Apoa2
apolipoprotein A-II
chr17_-_33822327 0.383 NM_001109913
NM_029804
Hnrnpm

heterogeneous nuclear ribonucleoprotein M

chr6_+_47194393 0.382 NM_025771
Cntnap2
contactin associated protein-like 2
chr1_-_89291303 0.377 NM_001110227
Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr4_+_98590642 0.360 Usp1
ubiquitin specific peptidase 1
chr9_-_71440061 0.359 NM_001033208
Gcom1
GRINL1A complex locus
chr12_-_105195097 0.350 NM_009247
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr14_+_33413112 0.346 NM_001001796
Prrxl1
paired related homeobox protein-like 1
chr14_+_70008874 0.339 Loxl2
lysyl oxidase-like 2
chr4_-_59796621 0.331 NM_001013577
1110054O05Rik
RIKEN cDNA 1110054O05 gene
chr2_+_172847371 0.326 NM_019547
Rbm38
RNA binding motif protein 38
chr17_+_12571455 0.288 NM_008877
Plg
plasminogen
chr14_-_41780085 0.285 NM_145928
Tspan14
tetraspanin 14
chr3_-_57098670 0.277 Tm4sf1
transmembrane 4 superfamily member 1
chr1_+_196765079 0.276 Cd34
CD34 antigen
chr2_-_140497183 0.275 Flrt3
fibronectin leucine rich transmembrane protein 3
chr7_+_36182085 0.273 NM_028120
Ccdc123
coiled-coil domain containing 123
chr11_+_100943878 0.270 NM_027896
Coasy
Coenzyme A synthase
chr19_+_40734282 0.266 NM_009848
Entpd1
ectonucleoside triphosphate diphosphohydrolase 1
chr11_+_48615164 0.259 Gnb2l1
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
chr6_-_127075853 0.254 Ccnd2
cyclin D2
chr17_+_12571494 0.247 Plg
plasminogen
chr1_-_170362244 0.245 Pbx1
pre B-cell leukemia transcription factor 1
chr6_-_49214015 0.241 NM_198102
Tra2a
transformer 2 alpha homolog (Drosophila)
chr11_-_86400309 0.239 Tmem49
transmembrane protein 49
chr13_-_74908036 0.239 Cast
calpastatin
chr1_+_45368568 0.237 Col3a1
collagen, type III, alpha 1
chr9_-_121825422 0.235 NM_010012
Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
chr2_+_162760505 0.233


chr11_+_66725482 0.231 NM_178656
Pirt
phosphoinositide-interacting regulator of transient receptor potential channels
chr4_+_154335029 0.231 NM_010419
Hes5
hairy and enhancer of split 5 (Drosophila)
chr2_+_72817468 0.230 1700011J10Rik
RIKEN cDNA 1700011J10 gene
chr14_-_80061976 0.229 NM_010701
Lect1
leukocyte cell derived chemotaxin 1
chr16_-_17680714 0.227 Med15
mediator complex subunit 15
chr19_-_24355054 0.224 NM_008044
Fxn
frataxin
chr16_-_17125198 0.222 NM_183287
2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr4_+_98590565 0.211 Usp1
ubiquitin specific peptidase 1
chr14_-_52780511 0.209 Supt16h
suppressor of Ty 16 homolog (S. cerevisiae)
chr18_+_42713035 0.207 Tcerg1
transcription elongation regulator 1 (CA150)
chr16_+_20674298 0.204 Eif4g1
eukaryotic translation initiation factor 4, gamma 1
chr11_-_120441643 0.196 Arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr11_-_101828286 0.195 NM_024449
Sost
sclerostin
chr3_+_102824458 0.195 NM_001161854
NM_144901
Csde1

cold shock domain containing E1, RNA binding

chr1_+_182571464 0.192 NM_001103182
NM_175186
Lin9

lin-9 homolog (C. elegans)

chr15_+_6336747 0.186 NM_001037905
NM_001102400
NM_023118
Dab2


disabled homolog 2 (Drosophila)


chr11_+_34934956 0.185 NM_011412
Slit3
slit homolog 3 (Drosophila)
chr11_-_96688959 0.181 Nfe2l1
nuclear factor, erythroid derived 2,-like 1
chr1_-_193399352 0.177 Dtl
denticleless homolog (Drosophila)
chr19_-_39537540 0.176 NM_010002
Cyp2c38
cytochrome P450, family 2, subfamily c, polypeptide 38
chr4_-_82698070 0.173 NM_001198811
Frem1
Fras1 related extracellular matrix protein 1
chrX_+_68916841 0.171 NM_010340
Gpr50
G-protein-coupled receptor 50
chr14_+_58691522 0.167 NM_013518
Fgf9
fibroblast growth factor 9
chr13_+_42776161 0.166 Phactr1
phosphatase and actin regulator 1
chrM_+_9458 0.162 ND3
NADH dehydrogenase subunit 3
chr7_-_112748585 0.161 Hpx
hemopexin
chr3_-_87067445 0.160 NM_030707
Fcrls
Fc receptor-like S, scavenger receptor
chr1_-_140071818 0.158 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr2_+_163519756 0.156 NM_011106
Pkig
protein kinase inhibitor, gamma
chr5_-_137592066 0.156 NM_201373
Trim56
tripartite motif-containing 56
chr2_+_30663433 0.147 NM_170592
Mettl11a
methyltransferase like 11A
chr7_-_134158053 0.143 NM_080638
Mvp
major vault protein
chr17_+_30272123 0.142 Zfand3
zinc finger, AN1-type domain 3
chr10_-_88996314 0.142 NM_001163504
Nr1h4
nuclear receptor subfamily 1, group H, member 4
chr12_-_105011767 0.142 Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr19_-_60937266 0.142 NM_053198
Sfxn4
sideroflexin 4
chr15_+_78860623 0.141


chr19_-_45817227 0.141 NM_001166361
NM_001166362
NM_001166363
NM_010205
Fgf8



fibroblast growth factor 8



chr10_-_106560683 0.140 NM_001142804
NM_198636
Acss3

acyl-CoA synthetase short-chain family member 3

chr19_-_24299389 0.135 Tjp2
tight junction protein 2
chr2_-_140497116 0.135 Flrt3
fibronectin leucine rich transmembrane protein 3
chr14_-_32454146 0.135 NM_019975
Hacl1
2-hydroxyacyl-CoA lyase 1
chr2_-_66622823 0.131 NM_009135
Scn7a
sodium channel, voltage-gated, type VII, alpha
chr12_+_77471506 0.131 Zbtb1
zinc finger and BTB domain containing 1
chr14_-_80061875 0.129 Lect1
leukocyte cell derived chemotaxin 1
chr18_-_78320014 0.128 Slc14a1
solute carrier family 14 (urea transporter), member 1
chrX_+_42444080 0.128 NM_026841
1110059M19Rik
RIKEN cDNA 1110059M19 gene
chr7_+_128084130 0.125 Polr3e
polymerase (RNA) III (DNA directed) polypeptide E
chr8_+_48072271 0.124 NM_177304
Enpp6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chrX_+_57252630 0.124 NM_007979
F9
coagulation factor IX
chr11_-_101413104 0.121 NM_009764
Brca1
breast cancer 1
chr13_-_108516475 0.118 Zswim6
zinc finger, SWIM domain containing 6
chr1_-_71686889 0.117 Fn1
fibronectin 1
chr12_-_105228099 0.117 NM_199314
NM_001166350
Serpina11

serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11

chr18_-_66162268 0.115 NM_001172062
NM_027400
Lman1

lectin, mannose-binding, 1

chr2_-_140497204 0.114 NM_001172160
NM_178382
Flrt3

fibronectin leucine rich transmembrane protein 3

chr10_-_60561635 0.114


chr3_+_102824539 0.112 Csde1
cold shock domain containing E1, RNA binding
chr1_+_135142673 0.111 NM_001160268
NM_182930
Plekha6

pleckstrin homology domain containing, family A member 6

chr4_-_58999931 0.110 NM_025968
Ptgr1
prostaglandin reductase 1
chr1_+_174051459 0.109 Copa
coatomer protein complex subunit alpha
chr17_-_45823086 0.105 Tmem63b
transmembrane protein 63b
chr8_-_47060486 0.103 NM_001033148
1700029J07Rik
RIKEN cDNA 1700029J07 gene
chr17_-_45706642 0.103 Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr7_+_138712015 0.102 Bub3
budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae)
chr10_+_128227964 0.102 NM_001164197
NM_021412
Mmp19

matrix metallopeptidase 19

chr3_-_90318178 0.102 NM_011309
S100a1
S100 calcium binding protein A1
chrX_-_12250659 0.101 NM_175141
1810030O07Rik
RIKEN cDNA 1810030O07 gene
chr8_+_120225803 0.101 NM_008290
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_-_70465629 0.099 Pfn1
profilin 1
chr2_+_58607580 0.099 NM_029692
Upp2
uridine phosphorylase 2
chr4_+_98590457 0.099 NM_146144
Usp1
ubiquitin specific peptidase 1
chr9_-_101101334 0.098 NM_172144
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr18_+_37979199 0.098 NM_033583
Pcdhgb4
Pcdhgc5
protocadherin gamma subfamily B, 4
protocadherin gamma subfamily C, 5
chr6_+_51494591 0.097 Snx10
sorting nexin 10
chr16_+_62854129 0.097 NM_011173
Pros1
protein S (alpha)
chr18_-_33623527 0.096 D0H4S114
DNA segment, human D4S114
chr11_-_110112926 0.094 NM_001166556
NM_001166557
NM_147218
Abca6


ATP-binding cassette, sub-family A (ABC1), member 6


chr19_-_54018933 0.093 Bbip1
BBSome interacting protein 1
chr11_-_11790403 0.092 NM_016672
Ddc
dopa decarboxylase
chr2_+_155212610 0.091 Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr11_-_90499370 0.090 NM_011505
Stxbp4
syntaxin binding protein 4
chr2_+_118993521 0.087 NM_177157
Gchfr
GTP cyclohydrolase I feedback regulator
chr6_-_87793898 0.086 Cnbp
cellular nucleic acid binding protein
chr11_+_48615302 0.085 Gnb2l1
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
chr6_-_87931475 0.084 NM_198622
H1fx
H1 histone family, member X
chr16_-_94591826 0.084 NM_001159619
NM_001159620
Pigp

phosphatidylinositol glycan anchor biosynthesis, class P

chr4_+_55093796 0.084 Zfp462
zinc finger protein 462
chr13_-_113385269 0.084


chr3_+_102824510 0.083 Csde1
cold shock domain containing E1, RNA binding
chr16_-_44016471 0.082 NM_153528
Gramd1c
GRAM domain containing 1C
chr7_+_13610378 0.081 Trim28
tripartite motif-containing 28
chr5_+_125048757 0.079 NM_026486
Tctn2
tectonic family member 2
chrX_-_70163744 0.079 Cetn2
centrin 2
chr7_+_109044853 0.079 NM_027532
3200002M19Rik
RIKEN cDNA 3200002M19 gene
chr4_-_99495806 0.078 NM_026348
Itgb3bp
integrin beta 3 binding protein (beta3-endonexin)
chr19_-_24299471 0.078 NM_011597
Tjp2
tight junction protein 2
chr2_+_75670296 0.077 Agps
alkylglycerone phosphate synthase
chr10_+_18189773 0.075 NM_001163592
Nhsl1
NHS-like 1
chrX_+_139997806 0.074 NM_008778
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr11_+_115626733 0.074 NM_028014
2310067B10Rik
RIKEN cDNA 2310067B10 gene
chr8_-_75005707 0.073 Slc35e1
solute carrier family 35, member E1
chr8_+_107607652 0.072 NM_001159415
NM_144511
Ces3b

carboxylesterase 3B

chr18_+_57628139 0.070 NM_001134697
Ctxn3
cortexin 3
chr3_+_102824561 0.069 Csde1
cold shock domain containing E1, RNA binding
chr14_+_27473359 0.067 Arf4
ADP-ribosylation factor 4
chr14_-_32454060 0.067 Hacl1
2-hydroxyacyl-CoA lyase 1
chr15_-_82996562 0.067 Cyb5r3
cytochrome b5 reductase 3
chr2_+_25359044 0.066 Fbxw5
F-box and WD-40 domain protein 5
chr12_+_109873955 0.065 NM_001163396
Evl
Ena-vasodilator stimulated phosphoprotein
chr7_-_149571459 0.064 Ctsd
cathepsin D
chr2_-_120389527 0.064 Zfp106
zinc finger protein 106
chr17_-_35309483 0.064 Aif1
allograft inflammatory factor 1
chr10_+_126727846 0.063 NM_007837
Ddit3
DNA-damage inducible transcript 3
chr4_-_142718290 0.062 Prdm2
PR domain containing 2, with ZNF domain
chr7_-_35005925 0.062 Gpi1
glucose phosphate isomerase 1
chr10_+_98478207 0.061 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr2_-_155479292 0.061 Trpc4ap
transient receptor potential cation channel, subfamily C, member 4 associated protein
chr16_+_7069927 0.060 NM_183188
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr7_+_87169699 0.060 NM_001145999
NM_001146000
Zfp710

zinc finger protein 710

chr8_-_25686797 0.060 NM_145949
Ido2
indoleamine 2,3-dioxygenase 2
chr17_-_35286889 0.060 Prrc2a
proline-rich coiled-coil 2A
chr5_-_100392845 0.059 Hnrnpd
heterogeneous nuclear ribonucleoprotein D
chr11_+_29642059 0.058 Rtn4
reticulon 4
chr10_-_126719287 0.058 Mbd6
methyl-CpG binding domain protein 6
chr3_-_157694667 0.057 NM_001093753
Srsf11
serine/arginine-rich splicing factor 11
chr9_+_69855789 0.057 Bnip2
BCL2/adenovirus E1B interacting protein 2
chr5_-_124875507 0.056 Sbno1
sno, strawberry notch homolog 1 (Drosophila)
chr6_-_118089060 0.056 NM_030165
Csgalnact2
chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr8_+_97530174 0.056 Gpr56
G protein-coupled receptor 56
chr6_-_127059521 0.056 NM_177003
9630033F20Rik
RIKEN cDNA 9630033F20 gene
chr8_-_93837120 0.055 NM_173431
Rpgrip1l
Rpgrip1-like
chr14_+_56097682 0.055 Dhrs4
dehydrogenase/reductase (SDR family) member 4
chr1_-_193399412 0.054 NM_029766
Dtl
denticleless homolog (Drosophila)
chr16_-_16560240 0.052 NM_139232
NM_139234
Fgd4

FYVE, RhoGEF and PH domain containing 4

chr1_+_157887985 0.052 NM_001160181
NM_022329
Tor1aip2

torsin A interacting protein 2

chr1_-_170362388 0.052 NM_008783
NM_183355
Pbx1

pre B-cell leukemia transcription factor 1

chr9_+_21397165 0.051 NM_178619
1810026J23Rik
RIKEN cDNA 1810026J23 gene
chr10_+_5057034 0.051


chr7_+_121889279 0.051 NM_173767
Insc
inscuteable homolog (Drosophila)
chr9_-_20896404 0.051 NM_027911
Raver1
ribonucleoprotein, PTB-binding 1
chr2_-_27331122 0.049 NM_001113573
NM_001113574
Brd3

bromodomain containing 3

chrX_+_97925185 0.047 NM_023608
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr10_-_80170648 0.047


chr14_-_122364309 0.046 NM_183031
Gpr183
G protein-coupled receptor 183
chr14_-_62058627 0.046 NM_008466
Kpna3
karyopherin (importin) alpha 3
chr13_-_41923709 0.046 9530008L14Rik
RIKEN cDNA 9530008L14 gene
chr10_-_79538107 0.046 Sbno2
strawberry notch homolog 2 (Drosophila)
chr7_-_91558407 0.045 Arnt2
aryl hydrocarbon receptor nuclear translocator 2
chr7_+_148656076 0.044 Cd151
CD151 antigen
chr15_+_78427476 0.043 NM_028195
Cyth4
cytohesin 4
chr8_+_131256428 0.042 Itgb1
integrin beta 1 (fibronectin receptor beta)
chr4_-_58999972 0.042 Ptgr1
prostaglandin reductase 1
chr11_+_52202137 0.042 Vdac1
voltage-dependent anion channel 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
38.83 1.26e-03 GO:0051345 positive regulation of hydrolase activity

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment p-value GO term description
48.19 1.10e-04 GO:0005543 phospholipid binding
22.17 1.12e-03 GO:0008289 lipid binding