Motif ID: FOXA2.p3

Z-value: 1.824

Transcription factors associated with FOXA2.p3:

NameEntrezDescription
Foxa2 15376 forkhead box A2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Foxa2chr2_-_1478716300.661.1e-05Click!


Activity profile for motif FOXA2.p3.

activity profile for motif FOXA2.p3


Sorted Z-values histogram for motif FOXA2.p3

Sorted Z-values for motif FOXA2.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA2.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr7_-_111001598 34.065 NM_008221
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr1_-_42749940 19.654 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr18_+_20823908 17.597 Ttr
transthyretin
chr16_+_22892112 9.612 NM_013465
Ahsg
alpha-2-HS-glycoprotein
chr14_+_73637697 8.577 NM_175116
Lpar6
lysophosphatidic acid receptor 6
chr12_+_7984451 7.750 NM_009693
Apob
apolipoprotein B
chr7_-_112748624 7.539 NM_017371
Hpx
hemopexin
chr3_-_95708543 7.497 NM_011797
Car14
carbonic anhydrase 14
chr15_-_96861590 7.489 Slc38a4
solute carrier family 38, member 4
chr7_+_147949708 6.658 NM_021282
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr1_+_67169588 6.100 NM_001080809
Cps1
carbamoyl-phosphate synthetase 1
chr11_+_108256590 6.044 NM_013475
Apoh
apolipoprotein H
chr11_+_32176599 5.947 NM_010405
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr2_+_44966657 5.902 NM_001177394
Gm13476
predicted gene 13476
chrX_+_109424956 5.887 NM_026565
Apool
apolipoprotein O-like
chr5_-_146691425 5.778 NM_007818
Cyp3a11
cytochrome P450, family 3, subfamily a, polypeptide 11
chr4_+_104438905 5.754 NM_133882
C8b
complement component 8, beta polypeptide
chr19_-_58529766 5.680 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr17_+_12571494 5.344 Plg
plasminogen
chr1_+_72353980 5.059 NM_009533
Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr19_-_34329804 4.818 NM_007392
Acta2
actin, alpha 2, smooth muscle, aorta
chr17_+_12571455 4.791 NM_008877
Plg
plasminogen
chr3_+_5218545 4.705 NM_030708
Zfhx4
zinc finger homeodomain 4
chr18_-_60661144 4.458 2010002N04Rik
RIKEN cDNA 2010002N04 gene
chr3_-_27052733 4.458 NM_001177625
NM_007900
Ect2

ect2 oncogene

chr10_-_86956393 4.399 NM_008553
Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr2_+_167363696 4.336 NM_011427
Snai1
snail homolog 1 (Drosophila)
chr5_-_103640272 4.292 NM_001081567
NM_009158
Mapk10

mitogen-activated protein kinase 10

chr19_+_5041341 4.151 NM_134155
Brms1
breast cancer metastasis-suppressor 1
chrX_+_93651684 3.994 NM_001159627
NM_181273
Heph

hephaestin

chr4_-_49562319 3.936 NM_144903
Aldob
aldolase B, fructose-bisphosphate
chr6_+_5340417 3.801 Asb4
ankyrin repeat and SOCS box-containing 4
chr6_-_87793459 3.757 Cnbp
cellular nucleic acid binding protein
chr2_-_70663453 3.738 NM_172664
Tlk1
tousled-like kinase 1
chr7_-_77511242 3.724 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr15_-_99481964 3.661 NM_012025
Racgap1
Rac GTPase-activating protein 1
chr3_-_81779636 3.486 NM_019911
Tdo2
tryptophan 2,3-dioxygenase
chr4_+_11118855 3.447 NM_009830
Ccne2
cyclin E2
chr6_-_51416921 3.401 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr3_-_95708606 3.390 Car14
carbonic anhydrase 14
chr7_-_139508857 3.374 Chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr2_-_126959605 3.288 NM_144818
Ncaph
non-SMC condensin I complex, subunit H
chr12_-_101121613 3.204 NM_030172
2610021K21Rik
RIKEN cDNA 2610021K21 gene
chr9_+_109735261 3.159 NM_018757
Nme6
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
chr3_-_145312928 3.090 NM_010516
Cyr61
cysteine rich protein 61
chr6_-_65094691 3.068 NM_019455
Hpgds
hematopoietic prostaglandin D synthase
chr6_-_127089169 3.047 Ccnd2
cyclin D2
chr4_-_6202747 2.970 NM_007824
Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
chr10_-_24647243 2.860 NM_007482
Arg1
arginase, liver
chr6_+_34659440 2.837 NM_145575
Cald1
caldesmon 1
chr8_+_3567980 2.722 NM_001024728
C330021F23Rik
RIKEN cDNA C330021F23 gene
chr2_-_66622823 2.693 NM_009135
Scn7a
sodium channel, voltage-gated, type VII, alpha
chr12_-_105195097 2.687 NM_009247
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr3_-_82853711 2.611 NM_181849
Fgb
fibrinogen beta chain
chr10_-_117252126 2.581


chr12_-_82068951 2.562 Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chrX_+_104115963 2.466 NM_175271
Lpar4
lysophosphatidic acid receptor 4
chr10_+_127705664 2.421 Apof
apolipoprotein F
chr16_+_17331507 2.350 Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr4_-_55545337 2.290 NM_010637
Klf4
Kruppel-like factor 4 (gut)
chrX_-_91368427 2.266 Zfx
zinc finger protein X-linked
chr15_-_84686558 2.260 NM_001081166
Phf21b
PHD finger protein 21B
chr4_+_140257340 2.243 NM_173867
Rcc2
regulator of chromosome condensation 2
chr1_-_180259336 2.234 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr2_-_92232506 2.232 Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr7_-_112748585 2.192 Hpx
hemopexin
chr8_-_112102961 2.185 Hp
haptoglobin
chr9_-_107612238 2.184 Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr1_-_163181251 2.181 NM_007453
Prdx6
peroxiredoxin 6
chr7_+_120909625 2.144 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr13_-_22127419 2.126 NM_175659
Hist1h2ah
histone cluster 1, H2ah
chr10_-_60915251 2.105 NM_010124
Eif4ebp2
eukaryotic translation initiation factor 4E binding protein 2
chr4_-_87452140 2.100 NM_029931
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr19_-_10630215 2.070 Tmem216
transmembrane protein 216
chr8_+_120225803 2.003 NM_008290
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_-_82698070 2.003 NM_001198811
Frem1
Fras1 related extracellular matrix protein 1
chr16_+_17331463 1.973 NM_008223
Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr10_+_66648458 1.945 Jmjd1c
jumonji domain containing 1C
chr12_+_53198729 1.931 NM_029760
Nubpl
nucleotide binding protein-like
chr6_-_3444484 1.922 NM_178899
Hepacam2
HEPACAM family member 2
chr12_+_77471506 1.858 Zbtb1
zinc finger and BTB domain containing 1
chr3_-_115832327 1.844 Vcam1
vascular cell adhesion molecule 1
chr4_-_129317873 1.821 NM_001005506
Txlna
taxilin alpha
chrX_+_146981959 1.810 NM_001102446
NM_009653
Alas2

aminolevulinic acid synthase 2, erythroid

chr15_-_97835044 1.810 NM_001113515
NM_031163
Col2a1

collagen, type II, alpha 1

chr19_+_30105077 1.801 Uhrf2
ubiquitin-like, containing PHD and RING finger domains 2
chr15_+_80453912 1.794 NM_010815
Grap2
GRB2-related adaptor protein 2
chr17_+_47641999 1.789 NM_001081635
NM_001081636
Ccnd3

cyclin D3

chr5_-_87335956 1.784 NM_153598
Ugt2b34
UDP glucuronosyltransferase 2 family, polypeptide B34
chrX_-_46641408 1.775 NM_145951
Enox2
ecto-NOX disulfide-thiol exchanger 2
chr7_+_148645664 1.759 Pnpla2
patatin-like phospholipase domain containing 2
chr10_+_127691166 1.757 NM_133996
Apon
apolipoprotein N
chr16_-_84735425 1.745 NM_017404
Mrpl39
mitochondrial ribosomal protein L39
chr4_+_154929136 1.730 Gnb1
guanine nucleotide binding protein (G protein), beta 1
chr15_+_25682945 1.722 Myo10
myosin X
chr12_-_58646914 1.722 Foxa1
forkhead box A1
chr3_+_146260100 1.701 NM_009474
Uox
urate oxidase
chr9_+_78463569 1.679 Cd109
CD109 antigen
chr6_+_142246944 1.665 NM_010491
Iapp
islet amyloid polypeptide
chr18_+_77365613 1.661 Pias2
protein inhibitor of activated STAT 2
chr19_+_55816320 1.645 Tcf7l2
transcription factor 7-like 2, T-cell specific, HMG-box
chr8_-_125222837 1.627 NM_009824
Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr13_+_49678115 1.619 NM_012050
Omd
osteomodulin
chr14_-_118450875 1.601 NM_010024
Dct
dopachrome tautomerase
chr1_-_157882999 1.596 Tor1aip1
torsin A interacting protein 1
chr1_-_134264461 1.589 Tmcc2
transmembrane and coiled-coil domains 2
chr12_+_60114357 1.582 NM_025656
Sip1
survival of motor neuron protein interacting protein 1
chr9_-_14588941 1.582 Ankrd49
ankyrin repeat domain 49
chr16_+_22951183 1.542 Hrg
histidine-rich glycoprotein
chr1_-_174128558 1.528 Pea15a
phosphoprotein enriched in astrocytes 15A
chr18_+_37880036 1.523 NM_033576
Pcdhgb4
protocadherin gamma subfamily B, 4
chr6_-_119338677 1.516 Adipor2
adiponectin receptor 2
chr10_-_20880559 1.506 NM_001198914
NM_010848
Myb

myeloblastosis oncogene

chr6_-_5143755 1.497 NM_011134
Pon1
paraoxonase 1
chr13_-_47201478 1.495 NM_025900
Dek
DEK oncogene (DNA binding)
chr19_+_30104914 1.492 NM_144873
Uhrf2
ubiquitin-like, containing PHD and RING finger domains 2
chr11_-_77707282 1.486 NM_008952
Pipox
pipecolic acid oxidase
chr11_-_97023157 1.486 Kpnb1
karyopherin (importin) beta 1
chr11_-_40508405 1.484 Mat2b
methionine adenosyltransferase II, beta
chr1_-_163181313 1.480 Prdx6
peroxiredoxin 6
chr19_+_45225176 1.459 NM_021901
Tlx1
T-cell leukemia, homeobox 1
chr4_-_21694265 1.452 2610029I01Rik
RIKEN cDNA 2610029I01 gene
chr8_-_48799252 1.440 NM_172407
Cdkn2aip
CDKN2A interacting protein
chr7_+_148662315 1.429 Tspan4
tetraspanin 4
chr10_+_110943412 1.425 Phlda1
pleckstrin homology-like domain, family A, member 1
chr2_+_69560861 1.424 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr1_+_194681115 1.417


chr16_+_20611637 1.401 NM_025462
NM_177940
NM_177941
Ece2


endothelin converting enzyme 2


chr10_+_97110043 1.389 Epyc
epiphycan
chr7_-_29678773 1.364 Actn4
actinin alpha 4
chr11_+_69812965 1.331 Phf23
PHD finger protein 23
chr7_-_148629877 1.319 Lrdd
leucine-rich and death domain containing
chr4_-_62815137 1.313 NM_007443
Ambp
alpha 1 microglobulin/bikunin
chr7_+_107685608 1.292 NM_183270
Chchd8
coiled-coil-helix-coiled-coil-helix domain containing 8
chr8_-_112102946 1.283 Hp
haptoglobin
chr11_+_20125239 1.282 Rab1
RAB1, member RAS oncogene family
chr2_+_69560922 1.269 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr16_-_94591826 1.266 NM_001159619
NM_001159620
Pigp

phosphatidylinositol glycan anchor biosynthesis, class P

chr19_+_12708001 1.257 Glyat
glycine-N-acyltransferase
chr5_-_87355527 1.250 NM_152811
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
chr13_-_108516475 1.236 Zswim6
zinc finger, SWIM domain containing 6
chr15_-_78299035 1.220 NM_027902
Tmprss6
transmembrane serine protease 6
chr14_-_71166340 1.220 NM_023045
Xpo7
exportin 7
chr12_+_78339071 1.219 Fut8
fucosyltransferase 8
chr2_-_140497183 1.197 Flrt3
fibronectin leucine rich transmembrane protein 3
chr6_+_135313010 1.197 Emp1
epithelial membrane protein 1
chr3_+_108163704 1.160 Sort1
sortilin 1
chr7_-_129164546 1.157 NM_028758
Gga2
golgi associated, gamma adaptin ear containing, ARF binding protein 2
chr5_+_16059312 1.155 NM_010427
Hgf
hepatocyte growth factor
chr13_+_23622912 1.153 NM_153173
Hist1h4h
histone cluster 1, H4h
chr1_-_128634766 1.142 Nckap5
NCK-associated protein 5
chr1_-_141273617 1.136 NM_133239
Crb1
crumbs homolog 1 (Drosophila)
chr7_+_27814096 1.128 NM_133657
Cyp2a12
cytochrome P450, family 2, subfamily a, polypeptide 12
chr11_+_87895626 1.126 Vezf1
vascular endothelial zinc finger 1
chr4_+_108520389 1.123 NM_029571
Kti12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr8_-_87366624 1.099 Calr
calreticulin
chr1_+_158769044 1.086 NM_028333
Angptl1
angiopoietin-like 1
chr5_-_38215607 1.069 NM_010835
Msx1
homeobox, msh-like 1
chr17_-_36157472 1.061 NM_008207
H2-T24
histocompatibility 2, T region locus 24
chr3_-_27052794 1.060 NM_001177626
Ect2
ect2 oncogene
chr9_+_72584532 1.050 Nedd4
neural precursor cell expressed, developmentally down-regulated 4
chr3_+_116564564 1.042 NM_009146
Frrs1
ferric-chelate reductase 1
chr6_-_65094862 1.041 Hpgds
hematopoietic prostaglandin D synthase
chr19_-_4906607 1.035 NM_001033128
Bbs1
Bardet-Biedl syndrome 1 (human)
chr16_+_5086296 1.031


chr9_+_108851568 1.020


chr8_+_68910191 1.018 NM_001166375
March1
membrane-associated ring finger (C3HC4) 1
chr6_-_51413182 1.016 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr4_-_43512476 1.006 NM_001013377
E130306D19Rik
RIKEN cDNA E130306D19 gene
chr1_-_46910333 1.003 NM_172653
Slc39a10
solute carrier family 39 (zinc transporter), member 10
chr1_+_6720153 1.002 St18
suppression of tumorigenicity 18
chr14_-_31756446 1.002 NM_008406
Itih1
inter-alpha trypsin inhibitor, heavy chain 1
chr15_-_96886327 1.002 NM_027052
Slc38a4
solute carrier family 38, member 4
chr4_+_59016013 0.985 NM_001033165
Dnajc25
DnaJ (Hsp40) homolog, subfamily C, member 25
chr3_+_17695743 0.978 6430547I21Rik
RIKEN cDNA 6430547I21 gene
chr2_+_25036524 0.978 Nrarp
Notch-regulated ankyrin repeat protein
chr12_-_103196366 0.974 NM_001167914
NM_029705
Atxn3

ataxin 3

chr17_-_46290450 0.973 Mad2l1bp
MAD2L1 binding protein
chr4_+_118081908 0.973 NM_020000
NM_173719
Med8

mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)

chr14_+_73637961 0.970 Lpar6
lysophosphatidic acid receptor 6
chr16_+_37868511 0.962 Lrrc58
leucine rich repeat containing 58
chr1_-_13364092 0.958 NM_001077695
NM_008678
Ncoa2

nuclear receptor coactivator 2

chr7_-_15023845 0.957 2810007J24Rik
RIKEN cDNA 2810007J24 gene
chr3_+_19857053 0.954 NM_001042611
NM_007752
Cp

ceruloplasmin

chr19_+_7131270 0.952 Macrod1
MACRO domain containing 1
chr10_-_127325725 0.932 NM_017473
NM_001150749
Rdh7

retinol dehydrogenase 7

chr2_+_118872854 0.929 NM_029617
Casc5
cancer susceptibility candidate 5
chr2_-_134380065 0.926 NM_010403
Hao1
hydroxyacid oxidase 1, liver
chr2_+_91297678 0.922 NM_001145857
NM_172668
Lrp4

low density lipoprotein receptor-related protein 4

chr2_-_94104877 0.910 E530001K10Rik
RIKEN cDNA E530001K10 gene
chr6_+_29325052 0.908 Calu
calumenin
chr10_+_18189773 0.907 NM_001163592
Nhsl1
NHS-like 1
chr11_-_101413104 0.904 NM_009764
Brca1
breast cancer 1
chr5_+_30969259 0.896 NM_007681
Cenpa
centromere protein A
chr12_-_105011767 0.891 Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr9_+_85739048 0.890 Tpbg
trophoblast glycoprotein
chr9_-_101101334 0.881 NM_172144
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr16_+_15637951 0.879 NM_011159
Prkdc
protein kinase, DNA activated, catalytic polypeptide
chrX_-_71598873 0.878 NM_025410
Lage3
L antigen family, member 3
chr14_+_120830603 0.877 Mbnl2
muscleblind-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.07 2.50e-03 GO:0048518 positive regulation of biological process
2.14 5.71e-03 GO:0048519 negative regulation of biological process
1.43 9.08e-03 GO:0065007 biological regulation
56.42 1.17e-02 GO:0051918 negative regulation of fibrinolysis
43.88 2.77e-02 GO:0019433 triglyceride catabolic process
2.08 3.45e-02 GO:0048523 negative regulation of cellular process
39.50 3.93e-02 GO:0051917 regulation of fibrinolysis

Gene overrepresentation in compartment category:

enrichment p-value GO term description
6.03 1.12e-05 GO:0005792 microsome
5.88 1.54e-05 GO:0042598 vesicular fraction
3.59 1.79e-04 GO:0005615 extracellular space
3.14 2.33e-04 GO:0044421 extracellular region part
3.11 4.80e-04 GO:0005626 insoluble fraction
3.10 8.72e-04 GO:0005624 membrane fraction
2.31 1.48e-03 GO:0005576 extracellular region
2.55 6.02e-03 GO:0000267 cell fraction
16.46 1.23e-02 GO:0032994 protein-lipid complex
16.46 1.23e-02 GO:0034358 plasma lipoprotein particle

Gene overrepresentation in function category:

enrichment p-value GO term description
9.16 4.50e-04 GO:0020037 heme binding
8.64 7.00e-04 GO:0046906 tetrapyrrole binding
6.05 3.17e-03 GO:0005506 iron ion binding
1.57 5.46e-03 GO:0005515 protein binding
18.16 1.10e-02 GO:0019825 oxygen binding
1.31 1.10e-02 GO:0005488 binding
7.53 2.50e-02 GO:0004867 serine-type endopeptidase inhibitor activity
5.80 3.57e-02 GO:0004866 endopeptidase inhibitor activity
5.59 4.48e-02 GO:0061135 endopeptidase regulator activity
5.49 5.00e-02 GO:0030414 peptidase inhibitor activity