Motif ID: FOXL1.p2

Z-value: 1.200

Transcription factors associated with FOXL1.p2:

NameEntrezDescription
Foxl1 14241 forkhead box L1



Activity profile for motif FOXL1.p2.

activity profile for motif FOXL1.p2


Sorted Z-values histogram for motif FOXL1.p2

Sorted Z-values for motif FOXL1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXL1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chrM_+_3320 11.181


chrM_+_2750 9.084


chr7_-_29678773 8.937 Actn4
actinin alpha 4
chrM_+_11741 7.316 ND5
NADH dehydrogenase subunit 5
chrM_+_11812 7.291


chr9_-_91255831 5.484 Zic1
zinc finger protein of the cerebellum 1
chrM_+_15355 4.914


chrM_+_11027 4.604


chr18_+_69843730 4.344 Tcf4
transcription factor 4
chr9_+_120058842 4.337 NM_001039364
NM_001039365
NM_008614
Mobp


myelin-associated oligodendrocytic basic protein


chrM_+_3913 4.034


chrM_+_14143 3.764


chr17_+_80706746 3.662 NM_001145452
Arhgef33
Rho guanine nucleotide exchange factor (GEF) 33
chr12_+_101447480 3.239 Calm1
calmodulin 1
chr11_+_117623703 3.181 Tnrc6c
trinucleotide repeat containing 6C
chr2_+_138104219 3.063 NM_145534
Btbd3
BTB (POZ) domain containing 3
chrM_+_12383 2.774


chr14_+_122879276 2.753 Zic2
zinc finger protein of the cerebellum 2
chr11_+_29642253 2.749 Rtn4
reticulon 4
chr1_+_155756310 2.717 Glul
glutamate-ammonia ligase (glutamine synthetase)
chr6_-_87793459 2.552 Cnbp
cellular nucleic acid binding protein
chr7_+_107789414 2.511 Rab6
RAB6, member RAS oncogene family
chr11_+_29642059 2.497 Rtn4
reticulon 4
chr8_-_108467294 2.246 NM_008490
Lcat
lecithin cholesterol acyltransferase
chrM_-_16187 2.171


chr15_+_78860623 2.109


chr10_-_24919916 2.057 Akap7
A kinase (PRKA) anchor protein 7
chrM_+_12178 2.005


chr5_+_90889913 1.987 NM_009654
Alb
albumin
chr2_+_136539202 1.986 Snap25
synaptosomal-associated protein 25
chrM_+_7714 1.907 Gm10925
ATP6
predicted gene 10925
ATP synthase F0 subunit 6
chr8_-_127093601 1.844 NM_007428
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr10_-_36855292 1.809 Marcks
myristoylated alanine rich protein kinase C substrate
chr19_-_5801011 1.759 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr1_+_179374783 1.758 NM_001012330
Zfp238
zinc finger protein 238
chr11_+_29618696 1.688 Rtn4
reticulon 4
chr4_+_138012860 1.649 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr3_+_136598485 1.598 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr2_+_136539143 1.593 NM_011428
Snap25
synaptosomal-associated protein 25
chrM_+_3844 1.548


chr3_-_82853711 1.494 NM_181849
Fgb
fibrinogen beta chain
chr9_-_21822333 1.468 Elavl3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chrM_+_13998 1.441


chr19_-_60842585 1.409 Eif3a
eukaryotic translation initiation factor 3, subunit A
chr11_-_97023157 1.394 Kpnb1
karyopherin (importin) beta 1
chr16_-_85120798 1.380 App
amyloid beta (A4) precursor protein
chrM_+_1550 1.361


chr9_-_49311823 1.352 Ncam1
neural cell adhesion molecule 1
chr6_-_51416921 1.334 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chrM_+_13543 1.310


chr5_+_104864136 1.211 NM_009263
Spp1
secreted phosphoprotein 1
chr19_+_5493612 1.210 Cfl1
cofilin 1, non-muscle
chr1_-_180264067 1.191 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr1_+_173155184 1.145 NM_013474
Apoa2
apolipoprotein A-II
chrM_+_13320 1.130


chr11_-_106642684 1.083 Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr6_+_4455686 1.054 NM_007743
Col1a2
collagen, type I, alpha 2
chr17_+_34766489 1.029 NM_030890
Prrt1
proline-rich transmembrane protein 1
chr11_-_79317583 1.028 NM_019409
Omg
oligodendrocyte myelin glycoprotein
chr1_+_59543450 1.026


chr8_+_59934719 1.008 NM_009136
Scrg1
scrapie responsive gene 1
chr13_+_59234737 0.975 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr6_+_134874663 0.974 Cdkn1b
cyclin-dependent kinase inhibitor 1B
chr3_+_95465860 0.971 Mcl1
myeloid cell leukemia sequence 1
chr2_-_84490666 0.971 NM_001085453
Ctnnd1
catenin (cadherin associated protein), delta 1
chr16_+_49911557 0.952 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chrM_+_1091 0.952


chr10_+_69169221 0.945 Ank3
ankyrin 3, epithelial
chr9_-_55983967 0.922 Tspan3
tetraspanin 3
chr3_+_95985065 0.916 NM_022030
Sv2a
synaptic vesicle glycoprotein 2 a
chr14_+_51490036 0.907


chrM_+_9875 0.899 ND4L
NADH dehydrogenase subunit 4L
chr11_-_100576628 0.866


chr19_-_40261753 0.848 NM_145499
Cyp2c70
cytochrome P450, family 2, subfamily c, polypeptide 70
chr17_-_35971913 0.848 Tubb5
tubulin, beta 5
chr6_-_136824323 0.838 NM_008597
Mgp
matrix Gla protein
chr2_+_69588414 0.824 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chrX_+_133371611 0.822 Plp1
proteolipid protein (myelin) 1
chr11_-_116711807 0.795 Srsf2
serine/arginine-rich splicing factor 2
chr10_-_10802102 0.787 NM_001114333
NM_016976
Grm1

glutamate receptor, metabotropic 1

chrM_-_13886 0.781


chr10_+_60638341 0.772 Tbata
thymus, brain and testes associated
chr1_-_72920776 0.772 Igfbp5
insulin-like growth factor binding protein 5
chr6_-_49195555 0.762 Tra2a
transformer 2 alpha homolog (Drosophila)
chr19_-_5800268 0.759


chr13_+_23830671 0.751 NM_015786
Hist1h1c
histone cluster 1, H1c
chr11_-_42134509 0.743 Gabra6
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
chr1_-_174259356 0.742 NM_008429
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr4_+_21801372 0.736 Sfrs18
serine/arginine-rich splicing factor 18
chrM_+_409 0.730


chr11_-_79317471 0.718 Omg
oligodendrocyte myelin glycoprotein
chr17_+_70871444 0.715 NM_001128180
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr1_-_42724504 0.681 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr5_+_22988226 0.680


chr7_-_133943848 0.670 NM_001177308
Aldoa
aldolase A, fructose-bisphosphate
chr19_+_4711220 0.633 NM_021287
Spnb3
spectrin beta 3
chr10_+_127795461 0.630 Cs
citrate synthase
chr5_+_32780438 0.626 Ppp1cb
protein phosphatase 1, catalytic subunit, beta isoform
chr9_-_52484889 0.624 AI593442
expressed sequence AI593442
chr2_+_90936845 0.614 NM_011355
Sfpi1
SFFV proviral integration 1
chr4_+_11118855 0.611 NM_009830
Ccne2
cyclin E2
chr1_-_180260325 0.610


chr9_+_92502908 0.601 Plod2
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
chr2_+_109739389 0.595 Lin7c
lin-7 homolog C (C. elegans)
chr1_-_134603848 0.594 NM_001160318
Nfasc
neurofascin
chr11_-_54533036 0.591


chr18_+_78016353 0.584 Atp5a1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1
chr5_-_115722862 0.580 NM_016698
Rnf10
ring finger protein 10
chr11_-_30000031 0.572 Spnb2
spectrin beta 2
chr10_+_97028409 0.569 Lum
lumican
chr8_+_97197870 0.562 Arl2bp
ADP-ribosylation factor-like 2 binding protein
chr18_+_35776026 0.561 Paip2
polyadenylate-binding protein-interacting protein 2
chr4_+_8534378 0.561 Rab2a
RAB2A, member RAS oncogene family
chr2_+_152106052 0.554 Csnk2a1
casein kinase 2, alpha 1 polypeptide
chr17_-_27717411 0.540 Nudt3
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr10_-_101953046 0.539 NM_024435
Nts
neurotensin
chr8_+_13167807 0.531 Lamp1
lysosomal-associated membrane protein 1
chr1_-_142079842 0.529 NM_009888
Cfh
complement component factor h
chr18_+_63112372 0.527 Apcdd1
adenomatosis polyposis coli down-regulated 1
chr7_-_34926107 0.516 Uba2
ubiquitin-like modifier activating enzyme 2
chr1_+_67169588 0.512 NM_001080809
Cps1
carbamoyl-phosphate synthetase 1
chr2_-_57905140 0.512 NM_029972
Ermn
ermin, ERM-like protein
chr16_-_84831712 0.508 Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr19_+_53214934 0.507 NM_001164099
NM_001164101
Add3

adducin 3 (gamma)

chr11_+_29607599 0.499 Rtn4
reticulon 4
chr2_+_125860377 0.495 NM_008008
Fgf7
fibroblast growth factor 7
chr5_+_119214935 0.491 Med13l
mediator complex subunit 13-like
chr7_-_112748624 0.489 NM_017371
Hpx
hemopexin
chr6_-_136824277 0.488 Mgp
matrix Gla protein
chr3_-_83967952 0.483 Trim2
tripartite motif-containing 2
chr3_+_136598184 0.470 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr11_-_115941908 0.470 Wbp2
WW domain binding protein 2
chr7_-_87857062 0.462


chr2_-_84265422 0.462 NM_018782
Calcrl
calcitonin receptor-like
chr7_+_94735020 0.459 C030032F19Rik
RIKEN cDNA C030032F19 gene
chr9_-_96233411 0.458 Atp1b3
ATPase, Na+/K+ transporting, beta 3 polypeptide
chr1_-_180259336 0.441 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr2_+_181287207 0.441 Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr14_+_120724380 0.438 Mbnl2
muscleblind-like 2
chr16_+_87731736 0.437 Bach1
BTB and CNC homology 1
chr1_+_111880313 0.425 NM_172853
Cdh7
cadherin 7, type 2
chr11_+_100488379 0.417


chr8_-_3154851 0.416 Insr
insulin receptor
chr11_+_75578548 0.413 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chrX_+_71549202 0.412


chr8_-_88077181 0.408 Dnaja2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr13_+_55802874 0.408 B230219D22Rik
RIKEN cDNA B230219D22 gene
chr1_+_145487825 0.406 NM_020025
B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr10_+_69388242 0.398 NM_009670
NM_170687
Ank3

ankyrin 3, epithelial

chr2_-_10052196 0.396 NM_010582
Itih2
inter-alpha trypsin inhibitor, heavy chain 2
chr16_+_57152994 0.396 Tomm70a
translocase of outer mitochondrial membrane 70 homolog A (yeast)
chr17_-_90487479 0.390 Nrxn1
neurexin I
chr2_-_56976530 0.389 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr11_+_94812919 0.388 Col1a1
collagen, type I, alpha 1
chr1_+_164569280 0.388 NM_010865
Myoc
myocilin
chr11_+_54683866 0.385


chr1_-_167523348 0.384 Mpzl1
myelin protein zero-like 1
chr1_+_45368443 0.380 Col3a1
collagen, type III, alpha 1
chr10_+_20059547 0.376 Bclaf1
BCL2-associated transcription factor 1
chrM_-_14069 0.376 ND6
NADH dehydrogenase subunit 6
chr4_-_134081867 0.375 Fam54b
family with sequence similarity 54, member B
chr15_-_54109855 0.375 NM_008764
Tnfrsf11b
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
chr12_+_87702066 0.374 NM_001159500
Esrrb
estrogen related receptor, beta
chr13_-_108516475 0.372 Zswim6
zinc finger, SWIM domain containing 6
chr11_+_97699719 0.368


chr15_-_79359998 0.368 Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr10_+_101974855 0.368 NM_146240
Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr3_+_84756090 0.368 NM_080428
Fbxw7
F-box and WD-40 domain protein 7
chr16_+_56477956 0.367 NM_001014399
NM_001014422
NM_001014423
NM_001014424
NM_178790
Abi3bp




ABI gene family, member 3 (NESH) binding protein




chr19_+_8665743 0.366 NM_001164634
NM_031194
Slc22a8

solute carrier family 22 (organic anion transporter), member 8

chr7_+_13511152 0.366


chr5_-_75073816 0.365 NM_001159578
NM_001159579
NM_001159580
NM_010727
Lnx1



ligand of numb-protein X 1



chr8_-_37631772 0.362 Dlc1
deleted in liver cancer 1
chr17_+_88382830 0.357 Msh6
mutS homolog 6 (E. coli)
chr3_-_123375305 0.353 NM_031186
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr11_-_118163704 0.352 Timp2
tissue inhibitor of metalloproteinase 2
chr11_-_70458027 0.351 Slc25a11
solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
chr16_+_49913305 0.350 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr5_-_100391613 0.348 Hnrnpd
heterogeneous nuclear ribonucleoprotein D
chr11_-_49488485 0.346 Cnot6
CCR4-NOT transcription complex, subunit 6
chr3_-_107474108 0.345 Ahcyl1
S-adenosylhomocysteine hydrolase-like 1
chr3_-_142456600 0.343 Pkn2
protein kinase N2
chr2_+_17976897 0.338 NM_010804
Mllt10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr10_-_116652417 0.333 Yeats4
YEATS domain containing 4
chr12_+_110800212 0.331 Meg3
maternally expressed 3
chr5_-_115119973 0.330 Gltp
glycolipid transfer protein
chr1_-_72905107 0.326 Igfbp5
insulin-like growth factor binding protein 5
chr14_-_62250728 0.326 Dleu2
deleted in lymphocytic leukemia, 2
chr1_-_184397778 0.322 Capn2
calpain 2
chr4_+_57906588 0.321 Akap2
A kinase (PRKA) anchor protein 2
chr10_+_87321789 0.320 NM_001111275
NM_010512
Igf1

insulin-like growth factor 1

chr2_-_126719808 0.319 2010106G01Rik
RIKEN cDNA 2010106G01 gene
chr11_-_83406475 0.318 NM_009139
Ccl6
chemokine (C-C motif) ligand 6
chr1_-_80272987 0.318


chr11_-_120441272 0.315 Arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr5_-_51945054 0.314 NM_008904
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr17_-_34256254 0.314 Brd2
bromodomain containing 2
chr8_-_96496001 0.313 Amfr
autocrine motility factor receptor
chr2_+_67955769 0.312 NM_020283
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr19_+_4711207 0.311 Spnb3
spectrin beta 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
29.17 4.48e-03 GO:0006606 protein import into nucleus
28.36 5.01e-03 GO:0051170 nuclear import
8.55 6.00e-03 GO:0060341 regulation of cellular localization
8.43 6.58e-03 GO:0007417 central nervous system development
15.21 7.69e-03 GO:0006605 protein targeting
1.86 9.75e-03 GO:0050789 regulation of biological process
5.52 1.02e-02 GO:0009888 tissue development
1.89 1.25e-02 GO:0050794 regulation of cellular process
21.73 1.44e-02 GO:0034504 protein localization to nucleus
9.50 1.48e-02 GO:0051046 regulation of secretion
13.24 1.50e-02 GO:0033365 protein localization to organelle
4.56 1.72e-02 GO:0033036 macromolecule localization
3.17 2.01e-02 GO:0048731 system development
19.83 2.06e-02 GO:0017038 protein import
3.66 2.12e-02 GO:0065008 regulation of biological quality
5.78 2.27e-02 GO:0051049 regulation of transport
2.95 2.30e-02 GO:0048518 positive regulation of biological process
8.62 2.55e-02 GO:0051050 positive regulation of transport
1.78 2.59e-02 GO:0065007 biological regulation
8.36 3.02e-02 GO:0007610 behavior
3.06 3.06e-02 GO:0048522 positive regulation of cellular process
11.36 3.11e-02 GO:0031644 regulation of neurological system process
145.76 3.49e-02 GO:0010873 positive regulation of cholesterol esterification
145.76 3.49e-02 GO:0034370 triglyceride-rich lipoprotein particle remodeling
17.03 3.75e-02 GO:0010038 response to metal ion
34.80 3.80e-02 GO:0009749 response to glucose stimulus
34.03 4.07e-02 GO:0009746 response to hexose stimulus
7.85 4.28e-02 GO:0044057 regulation of system process
33.29 4.35e-02 GO:0034284 response to monosaccharide stimulus
6.20 4.64e-02 GO:0046907 intracellular transport

Gene overrepresentation in compartment category:

enrichment p-value GO term description
8.74 4.52e-03 GO:0005625 soluble fraction
15.03 1.17e-02 GO:0019717 synaptosome
4.39 1.17e-02 GO:0042995 cell projection
13.81 1.62e-02 GO:0005938 cell cortex
3.29 2.39e-02 GO:0005576 extracellular region
5.14 2.84e-02 GO:0005615 extracellular space
7.95 3.17e-02 GO:0043025 neuronal cell body
2.46 3.56e-02 GO:0032991 macromolecular complex
7.57 3.96e-02 GO:0044297 cell body
19.15 4.32e-02 GO:0071013 catalytic step 2 spliceosome
1.97 4.91e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment p-value GO term description
2.67 3.22e-07 GO:0005515 protein binding
6.97 3.55e-03 GO:0019904 protein domain specific binding
1.60 3.65e-03 GO:0005488 binding
4.98 1.03e-02 GO:0019899 enzyme binding
5.22 2.15e-02 GO:0003723 RNA binding