Motif ID: GATA6.p2

Z-value: 1.485

Transcription factors associated with GATA6.p2:

NameEntrezDescription
Gata6 14465 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Gata6chr18_+_110524640.581.8e-04Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr11_+_32176599 44.406 NM_010405
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr7_-_111001598 21.381 NM_008221
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr18_+_20823908 12.210 Ttr
transthyretin
chr9_-_44150387 9.815 NM_001110251
Hmbs
hydroxymethylbilane synthase
chr9_+_46036788 8.111 Apoa1
apolipoprotein A-I
chr6_+_55967487 6.847 Gsbs
G substrate
chr4_-_46416895 6.775 Hemgn
hemogen
chr1_+_6720153 6.058 St18
suppression of tumorigenicity 18
chr19_-_40261753 6.005 NM_145499
Cyp2c70
cytochrome P450, family 2, subfamily c, polypeptide 70
chr5_+_91201521 4.957 Pf4
platelet factor 4
chr3_-_82853711 4.874 NM_181849
Fgb
fibrinogen beta chain
chr6_+_71149869 4.294 NM_017399
Fabp1
fatty acid binding protein 1, liver
chr3_+_101814059 4.286 NM_178777
Nhlh2
nescient helix loop helix 2
chr6_-_41654290 4.256 NM_032540
Kel
Kell blood group
chrX_+_146981989 4.043 Alas2
aminolevulinic acid synthase 2, erythroid
chr9_-_71743854 3.922 Tcf12
transcription factor 12
chr4_-_109960078 3.904 NM_001038698
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_+_127336055 3.654 NM_009718
Neurog2
neurogenin 2
chr1_+_12682572 3.338 Sulf1
sulfatase 1
chr9_+_46036799 3.146 Apoa1
apolipoprotein A-I
chr2_+_34631438 3.092 Hspa5
heat shock protein 5
chr2_+_34631124 3.032 Hspa5
heat shock protein 5
chr4_+_134420419 2.931 NM_011270
Rhd
Rh blood group, D antigen
chr7_-_146768633 2.919 NM_183248
Nkx6-2
NK6 homeobox 2
chr1_+_6720087 2.844 NM_173868
St18
suppression of tumorigenicity 18
chr7_-_106387077 2.700 NM_177448
Mogat2
monoacylglycerol O-acyltransferase 2
chrX_+_146981959 2.654 NM_001102446
NM_009653
Alas2

aminolevulinic acid synthase 2, erythroid

chrX_+_9829439 2.332 NM_008769
Otc
ornithine transcarbamylase
chr15_-_24957039 2.309 Gm2824
predicted gene 2824
chr1_+_45368443 2.242 Col3a1
collagen, type III, alpha 1
chr4_-_118862555 2.221 NM_013848
Ermap
erythroblast membrane-associated protein
chr18_-_78320014 2.077 Slc14a1
solute carrier family 14 (urea transporter), member 1
chr2_-_140497183 2.051 Flrt3
fibronectin leucine rich transmembrane protein 3
chr1_+_176102903 1.956 NM_011465
Spna1
spectrin alpha 1
chr1_-_158404299 1.924 NM_009230
Soat1
sterol O-acyltransferase 1
chr6_+_86028044 1.831 NM_013458
Add2
adducin 2 (beta)
chr1_+_12682510 1.797 NM_001198565
NM_001198566
Sulf1

sulfatase 1

chr4_-_46417054 1.653 NM_053149
Hemgn
hemogen
chr10_+_96942181 1.592 Dcn
decorin
chr3_+_88940063 1.581 NM_013631
Pklr
pyruvate kinase liver and red blood cell
chr15_+_80453912 1.572 NM_010815
Grap2
GRB2-related adaptor protein 2
chr9_-_21767872 1.569 NM_010149
Epor
erythropoietin receptor
chr14_-_71107810 1.568 Xpo7
exportin 7
chr1_-_134264461 1.536 Tmcc2
transmembrane and coiled-coil domains 2
chr3_+_94641626 1.529 Pogz
pogo transposable element with ZNF domain
chr1_-_173987681 1.501 NM_010916
Nhlh1
nescient helix loop helix 1
chr17_-_45707285 1.484 Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr4_-_33010429 1.407 NM_001012450
NM_080471
Ankrd6

ankyrin repeat domain 6

chr10_+_96942263 1.403 Dcn
decorin
chr17_+_40948047 1.392 NM_011269
Rhag
Rhesus blood group-associated A glycoprotein
chr15_+_76734729 1.368 Rpl8
ribosomal protein L8
chr9_-_65675327 1.349 NM_172536
Zfp609
zinc finger protein 609
chrX_+_104115963 1.324 NM_175271
Lpar4
lysophosphatidic acid receptor 4
chr2_-_140497204 1.307 NM_001172160
NM_178382
Flrt3

fibronectin leucine rich transmembrane protein 3

chr6_+_55967502 1.256 NM_011153
Gsbs
G substrate
chr17_-_45730551 1.238 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr11_+_87861165 1.231 NM_001078167
NM_173374
Srsf1

serine/arginine-rich splicing factor 1

chr2_-_172195998 1.190 NM_011497
Aurka
aurora kinase A
chr17_+_37006518 1.161 NM_011280
Trim10
tripartite motif-containing 10
chr5_+_104864136 1.150 NM_009263
Spp1
secreted phosphoprotein 1
chr2_+_34631709 1.125 Hspa5
heat shock protein 5
chr10_-_114622068 1.121 NM_173391
Tph2
tryptophan hydroxylase 2
chr6_-_71582871 1.061 NM_001038695
Kdm3a
lysine (K)-specific demethylase 3A
chr17_+_17539908 1.058 Lix1
limb expression 1 homolog (chicken)
chr1_+_12708582 1.027 NM_172294
Sulf1
sulfatase 1
chr8_+_87425826 1.025 NM_010635
Klf1
Kruppel-like factor 1 (erythroid)
chr6_-_51416921 0.985 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chrX_+_93435278 0.983 F630028O10Rik
RIKEN cDNA F630028O10 gene
chr14_-_118450875 0.966 NM_010024
Dct
dopachrome tautomerase
chr17_+_28960526 0.942 Brpf3
bromodomain and PHD finger containing, 3
chr9_+_20833816 0.932 NM_023892
Icam4
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
chr18_+_7869704 0.914 Wac
WW domain containing adaptor with coiled-coil
chr14_+_31699648 0.894 NM_001159299
NM_018746
Itih4

inter alpha-trypsin inhibitor, heavy chain 4

chr2_-_153067043 0.890 NM_018807
Plagl2
pleiomorphic adenoma gene-like 2
chr12_-_28027541 0.876 NM_009234
Sox11
SRY-box containing gene 11
chr13_-_117099629 0.864 NM_021459
Isl1
ISL1 transcription factor, LIM/homeodomain
chr8_+_13037791 0.852 F10
coagulation factor X
chr11_-_3831963 0.802 NM_001130459
NM_015749
NM_001130458
Tcn2


transcobalamin 2


chr10_-_86164623 0.800 Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr2_+_58607580 0.799 NM_029692
Upp2
uridine phosphorylase 2
chr6_-_127059521 0.798 NM_177003
9630033F20Rik
RIKEN cDNA 9630033F20 gene
chr11_-_83100174 0.776 NM_001166028
Slfn14-ps
schlafen family member 14, pseudogene
chr8_-_125222837 0.766 NM_009824
Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr9_+_107948285 0.764 Ip6k1
inositol hexaphosphate kinase 1
chr6_+_108015037 0.761 NM_178391
Setmar
SET domain and mariner transposase fusion gene
chrX_-_137491205 0.757 NM_001164177
NM_016883
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr19_-_42276620 0.756 NM_018780
Sfrp5
secreted frizzled-related sequence protein 5
chr10_-_7357774 0.747 Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr3_-_137794277 0.732 NM_008642
Mttp
microsomal triglyceride transfer protein
chr8_-_108467275 0.731 Lcat
lecithin cholesterol acyltransferase
chr11_+_70452623 0.731 NM_010326
Gp1ba
glycoprotein 1b, alpha polypeptide
chr6_+_5340417 0.730 Asb4
ankyrin repeat and SOCS box-containing 4
chr5_-_122286761 0.712 NM_008507
Sh2b3
SH2B adaptor protein 3
chr10_+_126437764 0.711 NM_009635
Avil
advillin
chr12_-_82068951 0.695 Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr19_+_20676453 0.692 NM_013467
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chrX_+_155897056 0.678 Mtap7d2
MAP7 domain containing 2
chr19_-_7093834 0.659 Fermt3
fermitin family homolog 3 (Drosophila)
chr11_+_100437204 0.652 NM_001146318
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr17_-_45707358 0.622 Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr4_-_87452140 0.618 NM_029931
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr10_-_112363848 0.615 Atxn7l3b
ataxin 7-like 3B
chr8_+_107257897 0.598 NM_001190330
NM_133960
Ces2a

carboxylesterase 2A

chr10_+_98486068 0.595 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr15_-_82237600 0.583 NM_010005
Cyp2d10
cytochrome P450, family 2, subfamily d, polypeptide 10
chr2_+_152695336 0.581 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr1_-_146622545 0.558 NM_022881
Rgs18
regulator of G-protein signaling 18
chr16_+_45093784 0.550 Ccdc80
coiled-coil domain containing 80
chr4_+_134483092 0.543


chr11_+_61890494 0.541 NM_001029936
Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr11_-_102331042 0.533 NM_010575
Itga2b
integrin alpha 2b
chr5_+_91201538 0.518 Pf4
platelet factor 4
chr17_-_35973192 0.504 Tubb5
tubulin, beta 5
chr11_+_72812583 0.498 NM_008771
P2rx1
purinergic receptor P2X, ligand-gated ion channel, 1
chr18_-_77285981 0.493 Katnal2
katanin p60 subunit A-like 2
chr5_-_122286849 0.485 Sh2b3
SH2B adaptor protein 3
chr2_-_140497116 0.467 Flrt3
fibronectin leucine rich transmembrane protein 3
chr9_+_74899844 0.462 Arpp19
cAMP-regulated phosphoprotein 19
chr9_+_72584532 0.460 Nedd4
neural precursor cell expressed, developmentally down-regulated 4
chr8_-_25686797 0.458 NM_145949
Ido2
indoleamine 2,3-dioxygenase 2
chr4_-_140609574 0.445 NM_172122
Crocc
ciliary rootlet coiled-coil, rootletin
chr10_+_61111426 0.444 Ppa1
pyrophosphatase (inorganic) 1
chr3_+_94282235 0.442 Celf3
VCUGBP, Elav-like family member 3
chr1_+_153191613 0.442 NM_001039511
NM_001039512
NM_054102
Ivns1abp


influenza virus NS1A binding protein


chrX_+_155897136 0.433 Mtap7d2
MAP7 domain containing 2
chr10_-_8665041 0.422


chr19_-_7025977 0.417 Bad
BCL2-associated agonist of cell death
chr1_-_88253690 0.406 Ncl
nucleolin
chr9_-_112090150 0.404 NM_033264
NM_001177615
NM_001177620
NM_028755
Arpp21



cyclic AMP-regulated phosphoprotein, 21



chr16_-_16560240 0.400 NM_139232
NM_139234
Fgd4

FYVE, RhoGEF and PH domain containing 4

chr5_-_93611701 0.396


chr4_+_98697606 0.387 NM_013913
Angptl3
angiopoietin-like 3
chr19_-_60842585 0.377 Eif3a
eukaryotic translation initiation factor 3, subunit A
chr2_-_6642489 0.372 Celf2
CUGBP, Elav-like family member 2
chr5_-_87521574 0.372 NM_001029867
Ugt2b36
UDP glucuronosyltransferase 2 family, polypeptide B36
chrM_+_9458 0.363 ND3
NADH dehydrogenase subunit 3
chrX_-_92853721 0.362 NM_001003916
Zc4h2
zinc finger, C4H2 domain containing
chr3_+_94926272 0.353


chr10_+_79620689 0.351 Midn
midnolin
chr13_-_30632975 0.330 Uqcrfs1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr1_-_140071818 0.328 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr14_+_52899216 0.328 Tox4
TOX high mobility group box family member 4
chr11_+_20125239 0.328 Rab1
RAB1, member RAS oncogene family
chr6_-_122806042 0.321 C3ar1
complement component 3a receptor 1
chr13_-_4608352 0.320 NM_018859
Akr1e1
aldo-keto reductase family 1, member E1
chr14_-_55272452 0.316 NM_019567
NM_001085472
Acin1

apoptotic chromatin condensation inducer 1

chr13_+_56805028 0.313 NM_001164042
Smad5
MAD homolog 5 (Drosophila)
chr14_-_57719048 0.306 Gjb2
gap junction protein, beta 2
chr3_+_146260100 0.306 NM_009474
Uox
urate oxidase
chr3_-_59066744 0.302 NM_027571
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr10_-_4752710 0.300 NM_026793
Myct1
myc target 1
chr7_-_149838254 0.299 Igf2
insulin-like growth factor 2
chr3_+_87924435 0.298 Iqgap3
IQ motif containing GTPase activating protein 3
chr15_+_76734500 0.298 NM_012053
Rpl8
ribosomal protein L8
chrX_-_103798800 0.289 NM_021476
Cysltr1
cysteinyl leukotriene receptor 1
chr19_-_41289045 0.281 Tm9sf3
transmembrane 9 superfamily member 3
chr3_+_60305108 0.279 NM_020007
Mbnl1
muscleblind-like 1 (Drosophila)
chr7_-_52147751 0.276 Med25
mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)
chr17_+_48499240 0.274 NM_027763
Treml1
triggering receptor expressed on myeloid cells-like 1
chr9_+_66198234 0.271 NM_145617
Herc1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr5_-_23835349 0.267 Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr19_+_10271150 0.265 Fads1
fatty acid desaturase 1
chr3_-_37024751 0.265 NM_008366
Il2
interleukin 2
chr11_-_75114563 0.262 Rpa1
replication protein A1
chr5_-_114292851 0.259 Coro1c
coronin, actin binding protein 1C
chr18_+_35966147 0.259 Ube2d2
ubiquitin-conjugating enzyme E2D 2
chr16_-_19983049 0.257 NM_183390
Klhl6
kelch-like 6 (Drosophila)
chr9_-_44550762 0.255 Arcn1
archain 1
chr19_-_4009363 0.255 Ndufv1
NADH dehydrogenase (ubiquinone) flavoprotein 1
chrX_+_136014905 0.254 NM_175326
D330045A20Rik
RIKEN cDNA D330045A20 gene
chr9_+_72596925 0.248 Nedd4
neural precursor cell expressed, developmentally down-regulated 4
chr11_+_79845841 0.245 Suz12
suppressor of zeste 12 homolog (Drosophila)
chr1_-_184271729 0.244 NM_175127
Fbxo28
F-box protein 28
chr2_-_10052196 0.242 NM_010582
Itih2
inter-alpha trypsin inhibitor, heavy chain 2
chr8_+_88364729 0.241 NM_199446
Phkb
phosphorylase kinase beta
chrX_-_71470766 0.237 Flna
filamin, alpha
chr13_+_67274117 0.230 NM_001013769
Rsl1
regulator of sex limited protein 1
chr1_-_172989475 0.230 NM_010188
Fcgr3
Fc receptor, IgG, low affinity III
chr17_-_35309483 0.229 Aif1
allograft inflammatory factor 1
chr19_+_55700193 0.228


chr2_+_162759398 0.223 Srsf6
serine/arginine-rich splicing factor 6
chr1_+_45368568 0.220 Col3a1
collagen, type III, alpha 1
chr11_-_121085356 0.219 BC017643
cDNA sequence BC017643
chr3_+_68272097 0.219 Schip1
schwannomin interacting protein 1
chr5_+_23870625 0.217 NM_008713
Nos3
nitric oxide synthase 3, endothelial cell
chr1_-_164796660 0.216 NM_010231
Fmo1
flavin containing monooxygenase 1
chr14_+_29831283 0.213 NM_176920
Lrtm1
leucine-rich repeats and transmembrane domains 1
chr13_+_49639847 0.212 Aspn
asporin
chr2_-_72931338 0.212


chr14_+_65885454 0.211 NM_015795
Fbxo16
F-box protein 16
chr9_+_35024031 0.211 Srpr
signal recognition particle receptor ('docking protein')
chr16_+_45094163 0.208 NM_026439
Ccdc80
coiled-coil domain containing 80
chr13_-_55629845 0.206 NM_013739
Dok3
docking protein 3
chr2_-_155299483 0.204 Ncoa6
nuclear receptor coactivator 6
chr5_+_136259172 0.202 Mdh2
malate dehydrogenase 2, NAD (mitochondrial)
chr9_-_103190558 0.201 NM_027918
1300017J02Rik
RIKEN cDNA 1300017J02 gene
chr7_+_104991475 0.195 Pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr3_+_94641479 0.195 NM_001165948
NM_172683
Pogz

pogo transposable element with ZNF domain

chr4_+_154929136 0.186 Gnb1
guanine nucleotide binding protein (G protein), beta 1
chr1_-_4350323 0.186 NM_011283
Rp1
retinitis pigmentosa 1 (human)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
68.33 3.60e-03 GO:0015669 gas transport
2.54 7.00e-03 GO:0032502 developmental process
3.27 9.29e-03 GO:0065008 regulation of biological quality
45.56 1.28e-02 GO:0006779 porphyrin biosynthetic process
45.56 1.28e-02 GO:0033014 tetrapyrrole biosynthetic process
182.19 1.52e-02 GO:0072488 ammonium transmembrane transport
4.38 2.46e-02 GO:0042592 homeostatic process
2.50 2.59e-02 GO:0007275 multicellular organismal development
2.02 2.65e-02 GO:0032501 multicellular organismal process
3.09 3.46e-02 GO:0048513 organ development
29.56 4.80e-02 GO:0006778 porphyrin metabolic process
29.56 4.80e-02 GO:0033013 tetrapyrrole metabolic process

Gene overrepresentation in compartment category:

enrichment p-value GO term description
145.75 5.82e-03 GO:0005833 hemoglobin complex
4.19 4.35e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment p-value GO term description
13.19 4.70e-04 GO:0031406 carboxylic acid binding
182.19 3.63e-03 GO:0008519 ammonium transmembrane transporter activity
18.23 4.84e-02 GO:0005496 steroid binding