Motif ID: GFI1.p2

Z-value: 2.985

Transcription factors associated with GFI1.p2:

NameEntrezDescription
Gfi1 14581 growth factor independent 1



Activity profile for motif GFI1.p2.

activity profile for motif GFI1.p2


Sorted Z-values histogram for motif GFI1.p2

Sorted Z-values for motif GFI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GFI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr7_-_56892061 34.142 NM_001005232
Dbx1
developing brain homeobox 1
chr6_-_47763309 25.028 Pdia4
protein disulfide isomerase associated 4
chr7_-_150646883 19.694 NM_001161624
NM_009876
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr8_+_86479405 16.630 NM_024184
Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr3_+_127336055 16.575 NM_009718
Neurog2
neurogenin 2
chr3_-_27052733 16.457 NM_001177625
NM_007900
Ect2

ect2 oncogene

chr3_-_49561168 15.179 NM_130448
Pcdh18
protocadherin 18
chr16_+_38089086 15.100 NM_019827
Gsk3b
glycogen synthase kinase 3 beta
chr2_+_164595415 14.218 NM_026785
Ube2c
ubiquitin-conjugating enzyme E2C
chr11_-_97049143 13.884 Kpnb1
karyopherin (importin) beta 1
chr1_-_78193381 13.802 NM_001159520
NM_008781
Pax3

paired box gene 3

chr9_-_107537602 13.488 NM_008138
Gnai2
guanine nucleotide binding protein (G protein), alpha inhibiting 2
chr4_+_124334876 11.204 NM_011141
Pou3f1
POU domain, class 3, transcription factor 1
chr1_+_42752608 11.020


chr5_-_44492908 10.924 NM_001163577
NM_008935
Prom1

prominin 1

chr1_-_170362244 10.793 Pbx1
pre B-cell leukemia transcription factor 1
chr1_+_122499031 10.636 NM_010133
En1
engrailed 1
chr1_-_176851949 10.635 NM_011825
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr11_+_112643501 10.605 NM_011448
Sox9
SRY-box containing gene 9
chr5_+_125048757 10.563 NM_026486
Tctn2
tectonic family member 2
chr11_-_86922163 10.317 NM_175563
Prr11
proline rich 11
chr1_-_170362278 10.299 Pbx1
pre B-cell leukemia transcription factor 1
chr4_-_22415444 10.260 Pou3f2
POU domain, class 3, transcription factor 2
chr6_+_4697305 9.934 NM_001040611
NM_130877
Peg10

paternally expressed 10

chr18_+_76401531 9.920 NM_010754
Smad2
MAD homolog 2 (Drosophila)
chr5_-_38215607 9.770 NM_010835
Msx1
homeobox, msh-like 1
chr5_+_111846284 9.491 Mn1
meningioma 1
chr11_+_86922732 9.456 NM_025377
Fam33a
family with sequence similarity 33, member A
chr11_-_97048933 9.212 Kpnb1
karyopherin (importin) beta 1
chr4_-_22415277 9.145 NM_008899
Pou3f2
POU domain, class 3, transcription factor 2
chr4_-_124614072 9.100 NM_026560
Cdca8
cell division cycle associated 8
chr16_-_18811669 9.062 NM_001161623
Cdc45
cell division cycle 45 homolog (S. cerevisiae)
chr2_-_172195998 8.892 NM_011497
Aurka
aurora kinase A
chr4_-_41411865 8.853 NM_024241
Kif24
kinesin family member 24
chr13_+_49777464 8.617 NM_172015
Iars
isoleucine-tRNA synthetase
chr11_-_98885428 8.614 NM_011623
Top2a
topoisomerase (DNA) II alpha
chr15_-_98507886 8.580 NM_172612
Rnd1
Rho family GTPase 1
chr8_-_94325138 8.532 NM_008393
Irx3
Iroquois related homeobox 3 (Drosophila)
chr18_-_75120759 8.514 NM_010720
Lipg
lipase, endothelial
chr13_-_72101161 8.183 NM_010573
Irx1
Iroquois related homeobox 1 (Drosophila)
chr17_+_17539832 8.112 Lix1
limb expression 1 homolog (chicken)
chr17_-_15963372 8.091 NM_178615
Rgmb
RGM domain family, member B
chrX_+_166317553 8.006 NM_183151
Mid1
midline 1
chr13_-_3917356 7.977 NM_019671
Net1
neuroepithelial cell transforming gene 1
chr12_+_120085663 7.915 Sp8
trans-acting transcription factor 8
chr15_+_102236709 7.905 NM_013672
Sp1
trans-acting transcription factor 1
chr11_+_70833066 7.741 NM_025993
Mis12
MIS12 homolog (yeast)
chr18_-_77286034 7.734 NM_027721
Katnal2
katanin p60 subunit A-like 2
chr11_-_97049185 7.718 NM_008379
Kpnb1
karyopherin (importin) beta 1
chr7_-_137409721 7.636 Fgfr2
fibroblast growth factor receptor 2
chr10_-_93052348 7.616 NM_027246
Snrpf
small nuclear ribonucleoprotein polypeptide F
chr3_+_90097269 7.583 Gatad2b
GATA zinc finger domain containing 2B
chrX_-_58146562 7.542 NM_009237
Sox3
SRY-box containing gene 3
chr10_-_86168115 7.450 NM_011631
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr18_+_73732352 7.399 NM_001039214
Mex3c
mex3 homolog C (C. elegans)
chr11_-_106860750 7.225 Kpna2
karyopherin (importin) alpha 2
chr10_+_75495391 7.225 Zfp280b
zinc finger protein 280B
chr2_+_73110010 7.110 Sp9
trans-acting transcription factor 9
chr2_-_56967331 7.101 NM_013613
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr14_-_68333666 6.967 NM_001110162
Cdca2
cell division cycle associated 2
chr3_+_133899454 6.955 Cxxc4
CXXC finger 4
chr19_-_8893759 6.941 NM_027412
Ttc9c
tetratricopeptide repeat domain 9C
chr13_+_51740600 6.870 NM_025415
Cks2
CDC28 protein kinase regulatory subunit 2
chr18_-_77285981 6.801 Katnal2
katanin p60 subunit A-like 2
chr4_-_115612507 6.708 NM_001025567
NM_130865
Dmbx1

diencephalon/mesencephalon homeobox 1

chr5_+_124199713 6.619 NM_001042421
Kntc1
kinetochore associated 1
chr2_+_164595389 6.609 Ube2c
ubiquitin-conjugating enzyme E2C
chr11_-_100389160 6.580 Acly
ATP citrate lyase
chr6_+_116214268 6.564 Anubl1
AN1, ubiquitin-like, homolog (Xenopus laevis)
chrX_-_137491205 6.543 NM_001164177
NM_016883
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr3_+_121129396 6.528 NM_028044
Cnn3
calponin 3, acidic
chr16_-_15637390 6.507 NM_008565
Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr2_+_166731527 6.501 NM_023565
Cse1l
chromosome segregation 1-like (S. cerevisiae)
chr19_+_21852816 6.467 NM_001033759
NM_031997
Tmem2

transmembrane protein 2

chr2_+_19367264 6.466 NM_018809
Ptf1a
pancreas specific transcription factor, 1a
chr18_+_34784589 6.449 NM_009004
NM_001166406
Kif20a

kinesin family member 20A

chr8_-_97125577 6.313 NM_028221
Fam192a
family with sequence similarity 192, member A
chr17_+_7374435 6.188 NM_011299
Rps6ka2
ribosomal protein S6 kinase, polypeptide 2
chr17_+_88071837 6.169 NM_008628
Msh2
mutS homolog 2 (E. coli)
chr13_-_23654226 6.105 NM_178205
Hist1h3e
histone cluster 1, H3e
chrX_+_55283804 6.096 NM_009575
Zic3
zinc finger protein of the cerebellum 3
chr3_+_135101248 5.966 Ube2d3
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
chr3_+_19088109 5.940 NM_026182
Mtfr1
mitochondrial fission regulator 1
chr4_+_41082861 5.940 Ube2r2
ubiquitin-conjugating enzyme E2R 2
chr5_-_22939130 5.932 5031425E22Rik
RIKEN cDNA 5031425E22 gene
chr19_-_14672540 5.791 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr8_-_67212325 5.763 NM_025436
Sc4mol
sterol-C4-methyl oxidase-like
chr6_-_125141525 5.745 NM_146171
Ncapd2
non-SMC condensin I complex, subunit D2
chr17_-_48548973 5.733 NM_001110832
NM_010913
Nfya

nuclear transcription factor-Y alpha

chr6_+_64679118 5.726 NM_007500
Atoh1
atonal homolog 1 (Drosophila)
chr11_+_103828032 5.692 Arf2
ADP-ribosylation factor 2
chr15_-_36723254 5.604 Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr6_+_34426352 5.599 NM_007563
Bpgm
2,3-bisphosphoglycerate mutase
chr11_+_103635438 5.536 NM_009521
Wnt3
wingless-related MMTV integration site 3
chr4_-_109960078 5.474 NM_001038698
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_122498985 5.462 En1
engrailed 1
chr9_+_55388955 5.462 NM_027397
Isl2
insulin related protein 2 (islet 2)
chr4_+_100449274 5.462 NM_198037
Cachd1
cache domain containing 1
chrX_-_49967112 5.460 NM_016697
Gpc3
glypican 3
chr1_-_93309713 5.410 NM_019479
Hes6
hairy and enhancer of split 6 (Drosophila)
chr11_+_116295502 5.331 Fam100b
family with sequence similarity 100, member B
chr7_-_106501642 5.309 NM_001111043
NM_001111044
NM_009825
Serpinh1


serine (or cysteine) peptidase inhibitor, clade H, member 1


chr9_-_61794540 5.276 NM_024245
Kif23
kinesin family member 23
chr8_-_97125464 5.252 Fam192a
family with sequence similarity 192, member A
chr11_+_108781661 5.251 NM_015732
Axin2
axin2
chr5_+_137791332 5.240 NM_001159571
NM_010144
Ephb4

Eph receptor B4

chr5_+_34163324 5.213 Whsc1
Wolf-Hirschhorn syndrome candidate 1 (human)
chr19_-_14672472 5.198 NM_011600
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_+_55816320 5.189 Tcf7l2
transcription factor 7-like 2, T-cell specific, HMG-box
chr18_+_67959756 5.172 NM_027556
Cep192
centrosomal protein 192
chr14_-_69902984 5.165 Slc25a37
solute carrier family 25, member 37
chr14_-_104243379 5.113 NM_001136061
Ednrb
endothelin receptor type B
chr1_+_182834384 5.067 NM_133705
Pycr2
pyrroline-5-carboxylate reductase family, member 2
chr7_+_36182085 5.062 NM_028120
Ccdc123
coiled-coil domain containing 123
chr17_-_13153538 4.966 NM_009338
Acat2
acetyl-Coenzyme A acetyltransferase 2
chrX_+_97972559 4.933 NM_001177780
Dlg3
discs, large homolog 3 (Drosophila)
chr6_-_145024487 4.896 Bcat1
branched chain aminotransferase 1, cytosolic
chr6_-_98978185 4.894 NM_001197322
Foxp1
forkhead box P1
chr7_+_30088984 4.881 NM_013874
Dpf1
D4, zinc and double PHD fingers family 1
chr3_+_89019126 4.875 Thbs3
thrombospondin 3
chr6_-_83071206 4.867 Wbp1
WW domain binding protein 1
chr11_+_116295406 4.831 NM_176902
Fam100b
family with sequence similarity 100, member B
chr15_-_99481964 4.830 NM_012025
Racgap1
Rac GTPase-activating protein 1
chr2_-_30329737 4.815 Ier5l
immediate early response 5-like
chr3_+_95392855 4.805 NM_001177669
NM_001177670
NM_146133
Golph3l


golgi phosphoprotein 3-like


chr14_-_48037815 4.794 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr15_-_13103346 4.793 NM_007666
Cdh6
cadherin 6
chr8_+_109127245 4.749 NM_009864
Cdh1
cadherin 1
chr3_+_34548916 4.718 NM_011443
Sox2
SRY-box containing gene 2
chr17_+_17539908 4.718 Lix1
limb expression 1 homolog (chicken)
chr9_-_71743854 4.704 Tcf12
transcription factor 12
chr6_+_34426324 4.698 Bpgm
2,3-bisphosphoglycerate mutase
chr2_-_127657532 4.683 NM_001113179
NM_009772
Bub1

budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)

chr7_-_91827857 4.647 NM_022985
Zfand6
zinc finger, AN1-type domain 6
chr5_+_67999118 4.644 NM_001033415
Shisa3
shisa homolog 3 (Xenopus laevis)
chr8_-_64238879 4.637 Palld
palladin, cytoskeletal associated protein
chr16_+_14163414 4.630 Nde1
nuclear distribution gene E homolog 1 (A nidulans)
chr17_+_27693518 4.629 NM_001166476
NM_001166477
NM_001025427
NM_001039356
NM_001166535
NM_001166536
NM_001166539
NM_001166540
NM_001166541
NM_001166542
NM_001166543
NM_001166544
NM_001166545
NM_001166546
NM_001166537
NM_016660
Hmga1-rs1

Hmga1













high mobility group AT-hook I, related sequence 1

high mobility group AT-hook 1













chr6_-_47763510 4.608 NM_009787
Pdia4
protein disulfide isomerase associated 4
chr12_+_78339071 4.602 Fut8
fucosyltransferase 8
chr14_-_22806999 4.598 Zfp503
zinc finger protein 503
chr15_-_26825266 4.571 NM_176959
Fbxl7
F-box and leucine-rich repeat protein 7
chr4_+_100449375 4.558 Cachd1
cache domain containing 1
chr2_+_53051140 4.557 Arl6ip6
ADP-ribosylation factor-like 6 interacting protein 6
chr14_-_50403002 4.538 NM_026142
3632451O06Rik
RIKEN cDNA 3632451O06 gene
chr17_-_34137221 4.486 NM_001001892
H2-K1
histocompatibility 2, K1, K region
chr6_-_87800966 4.477 NM_001109745
NM_001109746
NM_013493
Cnbp


cellular nucleic acid binding protein


chr5_-_92512683 4.475 NM_001080795
NM_011816
G3bp2

GTPase activating protein (SH3 domain) binding protein 2

chr15_-_78603874 4.472 NM_008595
Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr3_-_100293092 4.470 NM_001142952
Fam46c
family with sequence similarity 46, member C
chr13_-_23714425 4.469 NM_015787
Hist1h1e
histone cluster 1, H1e
chrX_-_49967090 4.466 Gpc3
glypican 3
chr2_+_164595447 4.438 Ube2c
ubiquitin-conjugating enzyme E2C
chr13_-_23666058 4.432 NM_178195
Hist1h2bf
histone cluster 1, H2bf
chr7_-_146768633 4.429 NM_183248
Nkx6-2
NK6 homeobox 2
chr11_+_71855939 4.408 NM_144526
Fam64a
family with sequence similarity 64, member A
chr7_-_106501620 4.401 Serpinh1
serine (or cysteine) peptidase inhibitor, clade H, member 1
chr4_-_11181335 4.400 Ints8
integrator complex subunit 8
chr7_-_29383178 4.391 Pak4
p21 protein (Cdc42/Rac)-activated kinase 4
chr10_-_87609629 4.371 NM_029249
4930547N16Rik
RIKEN cDNA 4930547N16 gene
chr3_+_95392919 4.345 Golph3l
golgi phosphoprotein 3-like
chr11_+_69393851 4.339 NM_001127233
NM_011640
Trp53

transformation related protein 53

chr1_+_9591550 4.330 3110035E14Rik
RIKEN cDNA 3110035E14 gene
chr11_-_100956699 4.324 NM_008949
Psmc3ip
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
chr13_+_23855536 4.321 NM_030609
Hist1h1a
histone cluster 1, H1a
chr3_+_108186721 4.316 NM_001190161
NM_019976
Psrc1

proline/serine-rich coiled-coil 1

chr19_-_7114388 4.314 NM_016737
Stip1
stress-induced phosphoprotein 1
chr4_-_81088575 4.289 NM_010820
Mpdz
multiple PDZ domain protein
chr5_-_138613028 4.282 NM_008568
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr6_+_83276009 4.281 NM_145571
Mobkl1b
MOB1, Mps One Binder kinase activator-like 1B (yeast)
chr3_+_134875526 4.279 NM_173762
Cenpe
centromere protein E
chr6_-_71582871 4.277 NM_001038695
Kdm3a
lysine (K)-specific demethylase 3A
chr16_+_15637951 4.269 NM_011159
Prkdc
protein kinase, DNA activated, catalytic polypeptide
chr6_-_128312829 4.267 5930416I19Rik
RIKEN cDNA 5930416I19 gene
chr4_-_11181373 4.265 Ints8
integrator complex subunit 8
chr10_+_4541075 4.263 NM_025995
Fbxo5
F-box protein 5
chr6_-_47544925 4.253 NM_001146689
NM_007971
Ezh2

enhancer of zeste homolog 2 (Drosophila)

chr10_+_7387285 4.218 NM_145706
Nup43
nucleoporin 43
chr7_+_73834774 4.184 NM_001191001
NM_152815
Lins

lines homolog (Drosophila)

chr11_-_69714395 4.168 NM_027419
2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr1_-_42749940 4.167 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chrX_+_50265390 4.151 NM_027642
Phf6
PHD finger protein 6
chr19_-_47389240 4.136 Sh3pxd2a
SH3 and PX domains 2A
chr5_-_4104331 4.130 Cyp51
cytochrome P450, family 51
chr2_+_72314235 4.094 NM_025866
Cdca7
cell division cycle associated 7
chr11_+_86014819 4.080 4632419I22Rik
RIKEN cDNA 4632419I22 gene
chr13_-_108680257 4.062 NM_145456
Zswim6
zinc finger, SWIM domain containing 6
chr13_-_104968472 4.044 NM_001093759
NM_001093760
NM_025879
2410002O22Rik


RIKEN cDNA 2410002O22 gene


chr11_-_100389196 4.043 NM_134037
Acly
ATP citrate lyase
chr6_+_37820779 4.027 NM_145076
Trim24
tripartite motif-containing 24
chr11_-_86014640 4.025 NM_178309
Brip1
BRCA1 interacting protein C-terminal helicase 1
chr4_-_91042997 4.019 NM_001177883
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_-_29383163 4.008 Pak4
p21 protein (Cdc42/Rac)-activated kinase 4
chr4_-_45839668 3.993 NM_018741
Igfbpl1
insulin-like growth factor binding protein-like 1
chr7_-_56136965 3.983 E2f8
E2F transcription factor 8
chr11_-_78510874 3.969 NM_008702
Nlk
nemo like kinase
chrX_+_104115963 3.951 NM_175271
Lpar4
lysophosphatidic acid receptor 4
chr5_-_4104696 3.919 NM_020010
Cyp51
cytochrome P450, family 51
chr1_+_171899520 3.904 3110045C21Rik
RIKEN cDNA 3110045C21 gene
chr1_-_191511950 3.902 NM_001081363
Cenpf
centromere protein F

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.21 5.31e-27 GO:0090304 nucleic acid metabolic process
2.04 4.95e-25 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.94 1.40e-23 GO:0034641 cellular nitrogen compound metabolic process
3.41 1.59e-23 GO:0007049 cell cycle
1.90 2.71e-22 GO:0006807 nitrogen compound metabolic process
1.75 5.56e-22 GO:0044260 cellular macromolecule metabolic process
3.69 6.40e-20 GO:0022402 cell cycle process
1.85 4.12e-18 GO:0060255 regulation of macromolecule metabolic process
1.98 1.62e-17 GO:0010468 regulation of gene expression
1.96 2.02e-17 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.96 4.47e-17 GO:0022403 cell cycle phase
1.94 6.46e-17 GO:0051171 regulation of nitrogen compound metabolic process
4.38 6.66e-17 GO:0000279 M phase
1.52 1.16e-16 GO:0044237 cellular metabolic process
2.03 1.31e-16 GO:0051252 regulation of RNA metabolic process
1.60 1.84e-16 GO:0043170 macromolecule metabolic process
1.98 2.33e-16 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.02 3.15e-16 GO:0016070 RNA metabolic process
2.02 6.29e-16 GO:0006355 regulation of transcription, DNA-dependent
4.27 1.08e-15 GO:0051301 cell division
1.77 1.48e-15 GO:0080090 regulation of primary metabolic process
1.70 2.09e-15 GO:0019222 regulation of metabolic process
1.93 3.04e-15 GO:0010556 regulation of macromolecule biosynthetic process
1.94 3.33e-15 GO:0010467 gene expression
1.49 4.14e-15 GO:0044238 primary metabolic process
3.48 2.84e-14 GO:0006259 DNA metabolic process
4.93 3.29e-14 GO:0000087 M phase of mitotic cell cycle
1.73 3.38e-14 GO:0031323 regulation of cellular metabolic process
1.93 4.82e-14 GO:0009059 macromolecule biosynthetic process
1.98 5.29e-14 GO:0071841 cellular component organization or biogenesis at cellular level
1.85 5.52e-14 GO:0009889 regulation of biosynthetic process
3.84 6.02e-14 GO:0000278 mitotic cell cycle
1.86 7.59e-14 GO:0031326 regulation of cellular biosynthetic process
1.93 1.16e-13 GO:0034645 cellular macromolecule biosynthetic process
1.99 2.02e-13 GO:0071842 cellular component organization at cellular level
4.79 5.35e-13 GO:0000280 nuclear division
4.79 5.35e-13 GO:0007067 mitosis
1.75 1.11e-12 GO:0009058 biosynthetic process
3.61 1.65e-12 GO:0006974 response to DNA damage stimulus
2.22 1.89e-12 GO:0006996 organelle organization
4.61 2.18e-12 GO:0048285 organelle fission
3.25 3.97e-12 GO:0051276 chromosome organization
1.74 9.42e-12 GO:0044249 cellular biosynthetic process
2.04 1.41e-11 GO:0032774 RNA biosynthetic process
1.39 1.75e-11 GO:0008152 metabolic process
3.29 2.41e-11 GO:0051726 regulation of cell cycle
2.03 2.91e-11 GO:0006351 transcription, DNA-dependent
1.73 5.16e-11 GO:0071840 cellular component organization or biogenesis
4.49 6.34e-11 GO:0010564 regulation of cell cycle process
1.73 2.69e-10 GO:0016043 cellular component organization
2.66 3.97e-09 GO:0033554 cellular response to stress
3.60 1.41e-08 GO:0006281 DNA repair
6.21 2.47e-08 GO:0000075 cell cycle checkpoint
4.72 3.07e-08 GO:0006260 DNA replication
5.81 3.39e-08 GO:0071156 regulation of cell cycle arrest
2.91 1.57e-07 GO:0007417 central nervous system development
1.19 3.02e-07 GO:0009987 cellular process
2.17 5.41e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
3.02 5.98e-07 GO:0006325 chromatin organization
5.19 9.08e-07 GO:0071103 DNA conformation change
4.02 1.36e-06 GO:0007346 regulation of mitotic cell cycle
5.57 4.74e-06 GO:0006323 DNA packaging
6.73 2.13e-05 GO:0031497 chromatin assembly
1.65 2.55e-05 GO:0048523 negative regulation of cellular process
7.14 3.26e-05 GO:0007093 mitotic cell cycle checkpoint
3.08 3.31e-05 GO:0006397 mRNA processing
1.92 3.36e-05 GO:0007399 nervous system development
6.50 3.47e-05 GO:0065004 protein-DNA complex assembly
3.14 3.49e-05 GO:0008380 RNA splicing
7.00 4.26e-05 GO:0006334 nucleosome assembly
2.86 4.88e-05 GO:0007420 brain development
6.18 6.94e-05 GO:0071824 protein-DNA complex subunit organization
5.98 1.08e-04 GO:0006333 chromatin assembly or disassembly
1.50 1.83e-04 GO:0007275 multicellular organismal development
2.05 2.01e-04 GO:0010628 positive regulation of gene expression
1.81 2.30e-04 GO:0010604 positive regulation of macromolecule metabolic process
6.14 2.31e-04 GO:0034728 nucleosome organization
3.24 2.56e-04 GO:0030900 forebrain development
2.69 3.44e-04 GO:0016071 mRNA metabolic process
2.15 3.49e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.26 4.22e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
4.44 4.35e-04 GO:0006310 DNA recombination
6.33 4.90e-04 GO:0031570 DNA integrity checkpoint
4.40 5.02e-04 GO:0007059 chromosome segregation
2.12 5.61e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
2.05 7.14e-04 GO:0045893 positive regulation of transcription, DNA-dependent
3.46 7.36e-04 GO:0045165 cell fate commitment
1.45 7.40e-04 GO:0032502 developmental process
2.02 1.15e-03 GO:0051254 positive regulation of RNA metabolic process
1.51 1.29e-03 GO:0048522 positive regulation of cellular process
6.30 1.64e-03 GO:0000077 DNA damage checkpoint
1.48 1.89e-03 GO:0048856 anatomical structure development
2.79 1.89e-03 GO:0034622 cellular macromolecular complex assembly
2.38 1.93e-03 GO:0048598 embryonic morphogenesis
2.63 1.94e-03 GO:0008283 cell proliferation
2.22 2.33e-03 GO:0006396 RNA processing
2.65 2.40e-03 GO:0034621 cellular macromolecular complex subunit organization
1.86 2.49e-03 GO:0031324 negative regulation of cellular metabolic process
1.95 2.73e-03 GO:0009790 embryo development
8.97 2.81e-03 GO:0031576 G2/M transition checkpoint
1.69 3.34e-03 GO:0009893 positive regulation of metabolic process
1.50 3.87e-03 GO:0048519 negative regulation of biological process
7.34 4.11e-03 GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis
1.89 5.09e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.59 5.58e-03 GO:0048513 organ development
1.82 5.84e-03 GO:0010605 negative regulation of macromolecule metabolic process
2.08 5.89e-03 GO:0045892 negative regulation of transcription, DNA-dependent
2.53 6.02e-03 GO:0016568 chromatin modification
1.44 7.48e-03 GO:0048518 positive regulation of biological process
1.86 7.92e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
2.05 8.79e-03 GO:0051253 negative regulation of RNA metabolic process
1.20 8.97e-03 GO:0050789 regulation of biological process
1.21 9.06e-03 GO:0050794 regulation of cellular process
1.47 1.02e-02 GO:0048731 system development
1.50 1.04e-02 GO:0044267 cellular protein metabolic process
5.85 1.06e-02 GO:0006261 DNA-dependent DNA replication
1.84 1.09e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
3.26 1.13e-02 GO:0045786 negative regulation of cell cycle
1.66 1.14e-02 GO:0009653 anatomical structure morphogenesis
1.67 1.25e-02 GO:0031325 positive regulation of cellular metabolic process
3.88 1.25e-02 GO:0007126 meiosis
3.88 1.25e-02 GO:0051327 M phase of meiotic cell cycle
1.96 1.35e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
3.85 1.41e-02 GO:0051321 meiotic cell cycle
4.68 1.47e-02 GO:0021543 pallium development
21.53 1.70e-02 GO:0043570 maintenance of DNA repeat elements
4.01 1.73e-02 GO:0034504 protein localization to nucleus
10.77 1.80e-02 GO:0010389 regulation of G2/M transition of mitotic cell cycle
1.92 1.83e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
3.25 2.01e-02 GO:0051052 regulation of DNA metabolic process
2.00 2.14e-02 GO:0009887 organ morphogenesis
13.46 2.80e-02 GO:0006270 DNA-dependent DNA replication initiation
1.96 3.23e-02 GO:0043933 macromolecular complex subunit organization
1.18 3.26e-02 GO:0065007 biological regulation
1.71 3.69e-02 GO:0009892 negative regulation of metabolic process
4.63 3.94e-02 GO:0006302 double-strand break repair
1.86 4.34e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.99 4.71e-02 GO:0065003 macromolecular complex assembly

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.16 3.97e-58 GO:0005634 nucleus
1.64 9.76e-43 GO:0043227 membrane-bounded organelle
1.64 4.22e-42 GO:0043231 intracellular membrane-bounded organelle
1.48 2.41e-41 GO:0044424 intracellular part
1.47 2.99e-41 GO:0005622 intracellular
1.56 1.11e-40 GO:0043226 organelle
1.57 1.21e-40 GO:0043229 intracellular organelle
2.56 2.73e-27 GO:0044428 nuclear part
1.86 6.30e-25 GO:0044446 intracellular organelle part
1.84 1.02e-24 GO:0044422 organelle part
2.57 7.37e-22 GO:0031981 nuclear lumen
2.38 2.50e-20 GO:0070013 intracellular organelle lumen
2.36 2.55e-20 GO:0031974 membrane-enclosed lumen
2.38 2.99e-20 GO:0043233 organelle lumen
2.84 1.62e-19 GO:0005654 nucleoplasm
3.88 2.18e-18 GO:0005694 chromosome
4.01 3.66e-18 GO:0044427 chromosomal part
1.78 1.95e-15 GO:0032991 macromolecular complex
1.72 8.24e-11 GO:0043234 protein complex
1.76 6.44e-10 GO:0043228 non-membrane-bounded organelle
1.76 6.44e-10 GO:0043232 intracellular non-membrane-bounded organelle
2.56 3.04e-09 GO:0044451 nucleoplasm part
1.13 1.46e-07 GO:0005623 cell
1.13 1.46e-07 GO:0044464 cell part
3.72 3.15e-07 GO:0000785 chromatin
1.28 3.99e-07 GO:0005737 cytoplasm
5.87 8.66e-07 GO:0032993 protein-DNA complex
4.77 1.69e-06 GO:0005819 spindle
3.51 4.11e-06 GO:0000228 nuclear chromosome
5.32 4.16e-06 GO:0000776 kinetochore
7.00 6.52e-06 GO:0030496 midbody
4.85 7.37e-06 GO:0000793 condensed chromosome
4.19 7.62e-06 GO:0000775 chromosome, centromeric region
3.57 1.89e-05 GO:0044454 nuclear chromosome part
2.29 3.49e-05 GO:0015630 microtubule cytoskeleton
3.82 1.54e-04 GO:0005681 spliceosomal complex
6.04 3.93e-04 GO:0000786 nucleosome
6.57 5.27e-04 GO:0000922 spindle pole
2.96 1.59e-03 GO:0005813 centrosome
1.60 3.13e-03 GO:0005829 cytosol
4.86 3.76e-03 GO:0000794 condensed nuclear chromosome
6.53 6.04e-03 GO:0005793 ER-Golgi intermediate compartment
17.95 7.61e-03 GO:0031616 spindle pole centrosome
2.68 7.76e-03 GO:0005815 microtubule organizing center
8.50 1.31e-02 GO:0045120 pronucleus
1.72 1.32e-02 GO:0044430 cytoskeletal part
4.95 1.97e-02 GO:0016363 nuclear matrix
2.30 2.20e-02 GO:0005667 transcription factor complex
3.70 4.97e-02 GO:0071013 catalytic step 2 spliceosome

Gene overrepresentation in function category:

enrichment p-value GO term description
2.07 3.63e-21 GO:0003676 nucleic acid binding
2.30 1.80e-19 GO:0003677 DNA binding
1.31 6.02e-17 GO:0005488 binding
4.11 8.70e-09 GO:0003682 chromatin binding
1.75 3.01e-08 GO:0000166 nucleotide binding
2.24 3.66e-08 GO:0030528 transcription regulator activity
1.34 8.16e-06 GO:0005515 protein binding
2.26 1.24e-05 GO:0043565 sequence-specific DNA binding
2.10 4.51e-05 GO:0001071 nucleic acid binding transcription factor activity
2.10 4.51e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.74 7.84e-05 GO:0005524 ATP binding
1.73 8.98e-05 GO:0032559 adenyl ribonucleotide binding
1.72 1.12e-04 GO:0030554 adenyl nucleotide binding
3.25 1.60e-04 GO:0043566 structure-specific DNA binding
1.61 5.41e-04 GO:0035639 purine ribonucleoside triphosphate binding
2.61 6.74e-04 GO:0008134 transcription factor binding
1.59 7.49e-04 GO:0032555 purine ribonucleotide binding
1.59 7.68e-04 GO:0032553 ribonucleotide binding
1.58 8.97e-04 GO:0017076 purine nucleotide binding
2.41 6.94e-03 GO:0016564 transcription repressor activity
4.31 7.66e-03 GO:0042393 histone binding
1.61 8.05e-03 GO:0008270 zinc ion binding
26.92 2.04e-02 GO:0032137 guanine/thymine mispair binding
2.51 2.94e-02 GO:0003712 transcription cofactor activity
2.50 3.13e-02 GO:0000989 transcription factor binding transcription factor activity
1.50 3.61e-02 GO:0046914 transition metal ion binding
2.47 3.77e-02 GO:0000988 protein binding transcription factor activity
1.84 3.89e-02 GO:0016462 pyrophosphatase activity
1.83 4.32e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.83 4.47e-02 GO:0016817 hydrolase activity, acting on acid anhydrides
5.25 4.48e-02 GO:0003684 damaged DNA binding