Motif ID: GLI1..3.p2

Z-value: 1.241

Transcription factors associated with GLI1..3.p2:

NameEntrezDescription
Gli1 14632 GLI-Kruppel family member GLI1
Gli2 14633 GLI-Kruppel family member GLI2
Gli3 14634 GLI-Kruppel family member GLI3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Gli2chr1_-_120950111-0.643.1e-05Click!
Gli1chr10_-_126778634-0.316.3e-02Click!
Gli3chr13_+_15555483-0.154.0e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr12_+_75098739 6.596 NM_172804
Syt16
synaptotagmin XVI
chr11_+_120582777 5.872 NM_133223
Rac3
RAS-related C3 botulinum substrate 3
chr1_-_127808723 5.849 Lypd1
Ly6/Plaur domain containing 1
chr2_+_157385835 5.746 NM_010923
NM_180960
Nnat

neuronatin

chr2_-_29108440 5.556 6530402F18Rik
RIKEN cDNA 6530402F18 gene
chr3_+_45182311 5.555 NM_001098170
NM_001098171
NM_001098172
NM_011043
Pcdh10



protocadherin 10



chr13_-_100286446 4.330 Mtap1b
microtubule-associated protein 1B
chr7_+_152082435 3.824 NM_008003
Fgf15
fibroblast growth factor 15
chr9_-_56265833 3.792 NM_172924
C230081A13Rik
RIKEN cDNA C230081A13 gene
chr13_+_55050729 3.647 NM_153131
Unc5a
unc-5 homolog A (C. elegans)
chr11_-_41814008 3.536 NM_008073
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr13_+_54676356 3.390 NM_019968
Arl10
ADP-ribosylation factor-like 10
chr1_+_50984361 3.368 NM_019790
Tmeff2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr6_-_32538191 3.276 NM_175750
Plxna4
plexin A4
chr4_+_144482979 3.068 NM_011303
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_+_68996455 3.008 NM_146005
NM_170688
NM_170689
NM_170690
NM_170728
NM_170729
NM_170730
Ank3






ankyrin 3, epithelial






chrX_-_70905062 2.966 NM_012040
Pnck
pregnancy upregulated non-ubiquitously expressed CaM kinase
chr3_-_127202153 2.845 Ank2
ankyrin 2, brain
chr6_+_124946723 2.835 NM_175696
C530028O21Rik
RIKEN cDNA C530028O21 gene
chr17_+_37182910 2.703 NM_019439
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chrX_+_130939318 2.692 NM_010078
Drp2
dystrophin related protein 2
chr14_+_67852128 2.657 NM_010095
Ebf2
early B-cell factor 2
chr13_-_100286521 2.646 NM_008634
Mtap1b
microtubule-associated protein 1B
chr2_+_106533281 2.626 Mpped2
metallophosphoesterase domain containing 2
chr10_-_61573705 2.443 NM_027251
2010107G23Rik
RIKEN cDNA 2010107G23 gene
chr17_-_24826873 2.436 NM_011522
Syngr3
synaptogyrin 3
chr15_-_64143929 2.333 Asap1
ArfGAP with SH# domain, ankyrin repeat and PH domain1
chr3_-_127201974 2.328 Ank2
ankyrin 2, brain
chr1_+_131170034 2.327 Thsd7b
thrombospondin, type I, domain containing 7B
chrX_+_98494487 2.316 NM_172932
Nlgn3
neuroligin 3
chr8_+_56040211 2.307 Gpm6a
glycoprotein m6a
chr3_-_26230791 2.284 NM_138666
Nlgn1
neuroligin 1
chr10_+_105907394 2.182 NM_177373
Ppfia2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr12_-_71212591 2.172 Nin
ninein
chr7_+_89319681 2.156 Sh3gl3
SH3-domain GRB2-like 3
chr9_+_109834266 2.141 NM_008633
Mtap4
microtubule-associated protein 4
chr2_+_157386313 2.126 Nnat
neuronatin
chr6_+_110595574 2.107 Grm7
glutamate receptor, metabotropic 7
chr10_+_126515962 2.068 NM_001033263
Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr5_+_99283433 2.039 NM_173404
Bmp3
bone morphogenetic protein 3
chr5_-_133017901 1.978 Auts2
autism susceptibility candidate 2
chr8_+_56040193 1.933 Gpm6a
glycoprotein m6a
chr4_+_42930076 1.926 NM_172690
N28178
expressed sequence N28178
chr6_-_88824977 1.867 Podxl2
podocalyxin-like 2
chr4_-_68615382 1.862 NM_019967
Dbc1
deleted in bladder cancer 1 (human)
chr16_-_30550622 1.856 NM_172614
Tmem44
transmembrane protein 44
chr11_-_41813792 1.774 NM_177408
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr12_+_45429857 1.743 NM_001146031
NM_176930
Nrcam

neuron-glia-CAM-related cell adhesion molecule

chr10_+_86241749 1.696 NM_175331
Nt5dc3
5'-nucleotidase domain containing 3
chr2_-_132211105 1.679 NM_144944
Prokr2
prokineticin receptor 2
chr8_-_67171805 1.672 NM_013494
Cpe
carboxypeptidase E
chr5_+_115751128 1.638


chr4_-_147504787 1.611 NM_027426
2610109H07Rik
RIKEN cDNA 2610109H07 gene
chr7_-_25372613 1.604 NM_001033205
Zfp575
zinc finger protein 575
chr4_+_144482722 1.580 NM_001172424
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chrX_-_70905384 1.567 Pnck
pregnancy upregulated non-ubiquitously expressed CaM kinase
chr5_-_3803095 1.567 NM_001003909
Ankib1
ankyrin repeat and IBR domain containing 1
chr2_+_156246644 1.536 NM_001003815
NM_013510
Epb4.1l1

erythrocyte protein band 4.1-like 1

chr2_+_157387284 1.535 Nnat
neuronatin
chr9_+_109834324 1.525 Mtap4
microtubule-associated protein 4
chr17_-_24826812 1.507 Syngr3
synaptogyrin 3
chr11_+_109287259 1.497 NM_025275
Amz2
archaelysin family metallopeptidase 2
chr12_+_45429894 1.492 Nrcam
neuron-glia-CAM-related cell adhesion molecule
chr7_+_89319717 1.487 NM_017400
Sh3gl3
SH3-domain GRB2-like 3
chr4_+_85699818 1.469 NM_029967
Adamtsl1
ADAMTS-like 1
chr14_-_37911383 1.468 NM_130878
Cdhr1
cadherin-related family member 1
chr12_+_45429966 1.449 Nrcam
neuron-glia-CAM-related cell adhesion molecule
chrX_-_69901382 1.428 NM_008067
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr14_+_105657949 1.428 Ndfip2
Nedd4 family interacting protein 2
chr19_+_4711207 1.416 Spnb3
spectrin beta 3
chr17_-_56279684 1.408 NM_001130456
Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr15_+_84493635 1.396 Prr5
proline rich 5 (renal)
chr9_+_122481617 1.386 9530059O14Rik
RIKEN cDNA 9530059O14 gene
chr3_+_7503409 1.359 NM_173181
Fam164a
family with sequence similarity 164, member A
chr11_-_33743416 1.355 NM_001190885
NM_027398
Kcnip1

Kv channel-interacting protein 1

chr2_-_29108499 1.352 6530402F18Rik
RIKEN cDNA 6530402F18 gene
chr6_+_30688050 1.350 NM_008590
Mest
mesoderm specific transcript
chr4_-_68615283 1.347 Dbc1
deleted in bladder cancer 1 (human)
chr2_+_49474775 1.340 NM_008449
Kif5c
kinesin family member 5C
chr1_-_95532278 1.329 NM_021537
Stk25
serine/threonine kinase 25 (yeast)
chr12_+_45429913 1.313 Nrcam
neuron-glia-CAM-related cell adhesion molecule
chr1_+_154802091 1.297 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr2_-_60800904 1.296 Rbms1
RNA binding motif, single stranded interacting protein 1
chr2_-_168567436 1.286 Atp9a
ATPase, class II, type 9A
chr1_-_108610861 1.283 NM_009741
NM_177410
Bcl2

B-cell leukemia/lymphoma 2

chr1_+_154802144 1.271 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chrX_+_117403867 1.260 NM_001081385
Pcdh11x
protocadherin 11 X-linked
chr19_+_18706474 1.259 NM_145497
BC016495
cDNA sequence BC016495
chrX_-_71126088 1.257 NM_008478
L1cam
L1 cell adhesion molecule
chr6_+_41555460 1.248 NM_001146351
NM_007680
Ephb6

Eph receptor B6

chr19_-_18706239 1.247 NM_017375
Ostf1
osteoclast stimulating factor 1
chr11_-_30168153 1.242 Spnb2
spectrin beta 2
chr14_-_21613162 1.240 NM_001039138
NM_001039139
NM_178597
Camk2g


calcium/calmodulin-dependent protein kinase II gamma


chr16_-_67621054 1.210 NM_001145977
NM_178721
Cadm2

cell adhesion molecule 2

chr19_-_5085487 1.188 Tmem151a
transmembrane protein 151A
chr9_+_45238375 1.188 NM_001081270
Dscaml1
Down syndrome cell adhesion molecule-like 1
chr1_-_64167952 1.184 NM_033563
Klf7
Kruppel-like factor 7 (ubiquitous)
chr2_-_151458299 1.182 Snph
syntaphilin
chr1_+_131170053 1.160 Thsd7b
thrombospondin, type I, domain containing 7B
chrX_+_156065141 1.160 NM_001135727
Sh3kbp1
SH3-domain kinase binding protein 1
chr18_+_40416615 1.156 2900055J20Rik
RIKEN cDNA 2900055J20 gene
chr15_-_85412250 1.095 NM_009528
Wnt7b
wingless-related MMTV integration site 7B
chr5_-_3802874 1.089 Ankib1
ankyrin repeat and IBR domain containing 1
chr12_+_62624134 1.087 Lrfn5
leucine rich repeat and fibronectin type III domain containing 5
chr5_-_118694869 1.085 NM_172998
NM_001109902
Rnft2

ring finger protein, transmembrane 2

chr16_-_22439642 1.085 NM_023794
Etv5
ets variant gene 5
chr2_-_77118632 1.078 NM_175465
Sestd1
SEC14 and spectrin domains 1
chr16_+_78301923 1.073 NM_001025192
NM_009988
Cxadr

coxsackie virus and adenovirus receptor

chr8_-_33028674 1.068 NM_178591
Nrg1
neuregulin 1
chrX_+_33735898 1.059 NM_028325
Zcchc12
zinc finger, CCHC domain containing 12
chr15_-_94234549 1.052 Adamts20
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
chr13_+_34967479 1.049 Prpf4b
PRP4 pre-mRNA processing factor 4 homolog B (yeast)
chr4_-_41222121 1.048 NM_026872
Ubap2
ubiquitin-associated protein 2
chr7_-_6649139 1.042 NM_011769
Zim1
zinc finger, imprinted 1
chr9_+_69137694 1.028 Rora
RAR-related orphan receptor alpha
chr13_+_54472705 1.026 NM_009946
Cplx2
complexin 2
chr11_-_120239930 1.020 NM_027980
2310003H01Rik
RIKEN cDNA 2310003H01 gene
chr4_-_150482562 1.013 Camta1
calmodulin binding transcription activator 1
chr17_-_24346280 1.008 NM_010947
Ntn3
netrin 3
chr8_+_87560809 0.995 NM_145390
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr5_-_133018666 0.993 Auts2
autism susceptibility candidate 2
chr13_-_54712629 0.992 NM_028870
Cltb
clathrin, light polypeptide (Lcb)
chr1_-_108610520 0.991 Bcl2
B-cell leukemia/lymphoma 2
chr13_+_81922310 0.961 Cetn3
centrin 3
chr17_+_87362450 0.958 NM_145491
Rhoq
ras homolog gene family, member Q
chr9_+_56842653 0.948 NM_019651
Ptpn9
protein tyrosine phosphatase, non-receptor type 9
chrX_+_97963061 0.944 NM_001177778
NM_016747
Dlg3

discs, large homolog 3 (Drosophila)

chr17_+_24625530 0.943 Caskin1
CASK interacting protein 1
chr11_-_101087738 0.943 NM_007970
Ezh1
enhancer of zeste homolog 1 (Drosophila)
chr7_+_134094045 0.937 NM_144926
Sez6l2
seizure related 6 homolog like 2
chr16_-_17928270 0.924 NM_153150
Slc25a1
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
chr2_+_174155592 0.918 NM_001077510
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr10_-_67741461 0.917 NM_023598
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr14_+_105657968 0.907 Ndfip2
Nedd4 family interacting protein 2
chr11_+_78059452 0.906 Sdf2
stromal cell derived factor 2
chr2_+_126378563 0.904 NM_011978
Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
chr4_-_129118034 0.893 NM_153541
Zbtb8b
zinc finger and BTB domain containing 8b
chr2_+_169459145 0.892 NM_080455
Tshz2
teashirt zinc finger family member 2
chr1_-_72921438 0.891 NM_010518
Igfbp5
insulin-like growth factor binding protein 5
chr11_+_68505612 0.889 Myh10
myosin, heavy polypeptide 10, non-muscle
chr10_-_126497197 0.888 NM_001033262
March9
membrane-associated ring finger (C3HC4) 9
chr18_-_70301202 0.882 NM_001082553
Rab27b
RAB27b, member RAS oncogene family
chrX_-_133403050 0.876 NM_176971
Rab9b
RAB9B, member RAS oncogene family
chr14_-_47809063 0.868 NM_008102
Gch1
GTP cyclohydrolase 1
chr1_+_155747072 0.868 NM_008131
Glul
glutamate-ammonia ligase (glutamine synthetase)
chr16_+_49855691 0.862 NM_010581
Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chrX_+_151696991 0.858 NM_019736
Acot9
acyl-CoA thioesterase 9
chr4_+_108551674 0.856 NM_023537
Rab3b
RAB3B, member RAS oncogene family
chr5_-_139801315 0.854 NM_172723
Adap1
ArfGAP with dual PH domains 1
chrX_-_91787353 0.853 Maged1
melanoma antigen, family D, 1
chr2_+_31101302 0.852 NM_019681
Ncs1
neuronal calcium sensor 1
chr9_+_56843159 0.852 Ptpn9
protein tyrosine phosphatase, non-receptor type 9
chr2_+_28048511 0.843 Olfm1
olfactomedin 1
chrX_-_93152262 0.841 NM_152822
Las1l
LAS1-like (S. cerevisiae)
chr13_-_34169854 0.829 NM_009450
Tubb2a
tubulin, beta 2A
chr9_+_68501551 0.829 NM_013646
Rora
RAR-related orphan receptor alpha
chr14_+_105657889 0.829 NM_001190989
NM_029561
Ndfip2

Nedd4 family interacting protein 2

chr7_-_36103433 0.823 NM_026181
Gpatch1
G patch domain containing 1
chr4_+_73897782 0.820 NM_144787
Kdm4c
lysine (K)-specific demethylase 4C
chr1_-_95532242 0.817 Stk25
serine/threonine kinase 25 (yeast)
chr9_-_45714409 0.816 Rnf214
ring finger protein 214
chr14_-_52898915 0.806 Rab2b
RAB2B, member RAS oncogene family
chr7_-_81158546 0.805 NM_009181
St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr8_-_13890244 0.805 NM_025556
2410022L05Rik
RIKEN cDNA 2410022L05 gene
chr18_+_37637421 0.804 NM_053141
Pcdhb16
protocadherin beta 16
chr2_+_32143868 0.802 Golga2
golgi autoantigen, golgin subfamily a, 2
chr12_+_25183430 0.802 NM_020614
Taf1b
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B
chr13_+_54472833 0.800 Cplx2
complexin 2
chr11_+_29592946 0.799 Rtn4
reticulon 4
chr6_-_72389491 0.798 NM_145569
Mat2a
methionine adenosyltransferase II, alpha
chr4_-_147222474 0.793 NM_198619
Zfp933
zinc finger protein 933
chr7_+_133966816 0.793 NM_029978
Fam57b
family with sequence similarity 57, member B
chr4_+_144483110 0.786 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr8_-_125777949 0.786 NM_028200
1300018I17Rik
RIKEN cDNA 1300018I17 gene
chr11_+_79404713 0.782 NM_175543
Rab11fip4
RAB11 family interacting protein 4 (class II)
chr5_-_124545776 0.778 NM_019875
Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr2_-_103637795 0.778 NM_001111291
NM_016739
Caprin1

cell cycle associated protein 1

chr10_-_49508472 0.777 NM_001111268
NM_010349
Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr3_-_97672147 0.776 NM_177145
Pde4dip
phosphodiesterase 4D interacting protein (myomegalin)
chr11_-_8368505 0.766 Tns3
tensin 3
chr8_-_67171481 0.765 Cpe
carboxypeptidase E
chr19_+_55390770 0.764 NM_016862
Vti1a
vesicle transport through interaction with t-SNAREs homolog 1A (yeast)
chr3_+_96400524 0.763 NM_001024851
Ankrd34a
ankyrin repeat domain 34A
chr11_-_30168142 0.761 Spnb2
spectrin beta 2
chr6_+_29383152 0.759 NM_001081185
Flnc
filamin C, gamma
chr13_-_53472719 0.759 NM_009269
Sptlc1
serine palmitoyltransferase, long chain base subunit 1
chr1_-_127808790 0.758 NM_145100
Lypd1
Ly6/Plaur domain containing 1
chr3_+_55586431 0.755 NM_010750
Mab21l1
mab-21-like 1 (C. elegans)
chr1_-_97564139 0.746 NM_001159745
NM_009183
St8sia4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr16_+_91547266 0.746 NM_008338
Ifngr2
interferon gamma receptor 2
chr17_-_80689434 0.745 Dhx57
DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
chr9_-_108092712 0.737 NM_007567
Bsn
bassoon
chr7_+_138009310 0.732 NM_133942
Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_-_92886300 0.732 NM_001177536
Prdm11
PR domain containing 11
chr15_-_75397243 0.724 NM_001135688
Ly6h
lymphocyte antigen 6 complex, locus H
chr9_-_88333710 0.724 NM_172926
Snx14
sorting nexin 14
chr1_+_75542840 0.722 NM_009208
Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr7_-_26082941 0.719 NM_008776
Pafah1b3
platelet-activating factor acetylhydrolase, isoform 1b, subunit 3
chr12_+_3365147 0.717 Kif3c
kinesin family member 3C
chr12_+_33063653 0.716 NM_001162903
2010109K11Rik
RIKEN cDNA 2010109K11 gene

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
11.29 3.51e-07 GO:0007409 axonogenesis
10.30 1.01e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
5.33 1.01e-06 GO:0048699 generation of neurons
8.82 1.33e-06 GO:0048858 cell projection morphogenesis
6.42 1.66e-06 GO:0030182 neuron differentiation
9.84 1.68e-06 GO:0048812 neuron projection morphogenesis
8.65 1.69e-06 GO:0032990 cell part morphogenesis
8.32 2.68e-06 GO:0031175 neuron projection development
5.00 2.94e-06 GO:0022008 neurogenesis
7.08 5.20e-06 GO:0048666 neuron development
6.83 8.24e-06 GO:0000902 cell morphogenesis
8.12 1.44e-05 GO:0000904 cell morphogenesis involved in differentiation
6.27 2.37e-05 GO:0032989 cellular component morphogenesis
6.11 3.27e-05 GO:0030030 cell projection organization
13.17 8.84e-05 GO:0007411 axon guidance
4.34 1.58e-04 GO:0048468 cell development
21.87 1.65e-04 GO:0050808 synapse organization
3.69 1.65e-04 GO:0007399 nervous system development
8.84 4.34e-04 GO:0016337 cell-cell adhesion
2.69 1.62e-03 GO:0048869 cellular developmental process
2.66 3.25e-03 GO:0030154 cell differentiation
2.56 4.03e-03 GO:0071842 cellular component organization at cellular level
2.43 9.93e-03 GO:0071841 cellular component organization or biogenesis at cellular level
2.22 1.03e-02 GO:0016043 cellular component organization
8.22 1.24e-02 GO:0043062 extracellular structure organization
4.17 1.56e-02 GO:0007155 cell adhesion
5.64 1.65e-02 GO:0019226 transmission of nerve impulse
5.64 1.65e-02 GO:0035637 multicellular organismal signaling
4.13 1.69e-02 GO:0022610 biological adhesion
6.41 1.90e-02 GO:0006935 chemotaxis
6.41 1.90e-02 GO:0042330 taxis
6.34 2.06e-02 GO:0007268 synaptic transmission
2.12 2.37e-02 GO:0071840 cellular component organization or biogenesis
2.26 3.36e-02 GO:0048731 system development
2.03 3.96e-02 GO:0032502 developmental process
6.75 4.34e-02 GO:0051051 negative regulation of transport

Gene overrepresentation in compartment category:

enrichment p-value GO term description
6.43 1.03e-06 GO:0045202 synapse
4.79 2.98e-04 GO:0043005 neuron projection
1.91 9.18e-03 GO:0071944 cell periphery
1.89 1.51e-02 GO:0005886 plasma membrane
5.08 1.83e-02 GO:0043025 neuronal cell body
4.91 2.30e-02 GO:0044456 synapse part
81.62 2.43e-02 GO:0008091 spectrin
4.84 2.54e-02 GO:0044297 cell body
5.50 2.91e-02 GO:0030424 axon

Gene overrepresentation in function category:

enrichment p-value GO term description
1.47 8.36e-05 GO:0005488 binding
1.82 2.30e-04 GO:0005515 protein binding
29.16 1.48e-02 GO:0016917 GABA receptor activity