Motif ID: GUAACAG

Z-value: 0.694

Mature miRNA associated with seed GUAACAG:

NamemiRBase Accession
mmu-miR-194 MIMAT0000224



Activity profile for motif GUAACAG.

activity profile for motif GUAACAG


Sorted Z-values histogram for motif GUAACAG

Sorted Z-values for motif GUAACAG



Network of associatons between targets according to the STRING database.



First level regulatory network of GUAACAG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr12_+_3891743 5.232 NM_153743
Dnmt3a
DNA methyltransferase 3A
chr3_+_5218545 2.798 NM_030708
Zfhx4
zinc finger homeodomain 4
chr7_+_119822831 2.210 NM_001166584
NM_009346
Tead1

TEA domain family member 1

chr17_+_15841889 2.170 NM_007690
Chd1
chromodomain helicase DNA binding protein 1
chr2_+_29917543 2.012 NM_023871
Set
SET nuclear oncogene
chr1_-_153937364 1.910 NM_197990
LOC545371
1700025G04Rik
hypothetical protein LOC545371
RIKEN cDNA 1700025G04 gene
chr2_+_4802609 1.871 NM_175400
Sephs1
selenophosphate synthetase 1
chr5_+_34064372 1.861 NM_008010
NM_001163215
Fgfr3

fibroblast growth factor receptor 3

chr2_+_92024338 1.811 NM_138755
Phf21a
PHD finger protein 21A
chr9_+_72655019 1.791 NM_175485
Prtg
protogenin homolog (Gallus gallus)
chr6_-_39156706 1.730 NM_001033430
Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr5_+_124889925 1.692 NM_030241
Setd8
SET domain containing (lysine methyltransferase) 8
chr6_+_125045998 1.562 NM_145979
Chd4
chromodomain helicase DNA binding protein 4
chr17_-_79420125 1.559 NM_001171004
NM_029239
Prkd3

protein kinase D3

chr12_-_85559793 1.417 NM_001163501
C130039O16Rik
RIKEN cDNA C130039O16 gene
chr16_+_44139908 1.371 NM_028108
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr8_-_27229485 1.307 NM_207659
Hook3
hook homolog 3 (Drosophila)
chr13_+_109106530 1.279 NM_178683
Depdc1b
DEP domain containing 1B
chr2_+_155207581 1.232 NM_178111
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr3_+_61168428 1.149 NM_028712
Rap2b
RAP2B, member of RAS oncogene family
chr1_+_133807034 1.077 NM_001145804
NM_175294
Nucks1

nuclear casein kinase and cyclin-dependent kinase substrate 1

chr7_+_75097142 1.002 NM_010513
Igf1r
insulin-like growth factor I receptor
chr18_+_83080270 0.985 NM_183033
Zfp516
zinc finger protein 516
chr15_-_64214427 0.973 NM_010026
Asap1
ArfGAP with SH# domain, ankyrin repeat and PH domain1
chr2_+_92025639 0.943 NM_001109691
Phf21a
PHD finger protein 21A
chr2_-_179711350 0.932 NM_001081092
Taf4a
TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr17_-_46419939 0.929 NM_028751
Tjap1
tight junction associated protein 1
chr15_+_96117952 0.866 NM_175251
Arid2
AT rich interactive domain 2 (ARID, RFX-like)
chr17_-_71202829 0.843 NM_001164074
Tgif1
TGFB-induced factor homeobox 1
chr17_-_51971946 0.825 NM_009122
Satb1
special AT-rich sequence binding protein 1
chr16_-_32079317 0.814 NM_177326
Pak2
p21 protein (Cdc42/Rac)-activated kinase 2
chr9_-_114753191 0.808 NM_027294
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr7_-_107007359 0.802 NM_025668
Spcs2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr1_-_84835871 0.801 NM_133975
Trip12
thyroid hormone receptor interactor 12
chr11_-_82684653 0.776 NM_001007465
NM_001164569
NM_001164571
Rffl


ring finger and FYVE like domain containing protein


chr2_+_112106470 0.768 NM_133649
Slc12a6
solute carrier family 12, member 6
chr6_+_113027481 0.758 NM_028385
Setd5
SET domain containing 5
chr11_-_77421308 0.709 NM_144825
Taok1
TAO kinase 1
chr18_+_5591869 0.687 NM_011546
Zeb1
zinc finger E-box binding homeobox 1
chr8_-_36558514 0.680 NM_026067
Eri1
exoribonuclease 1
chr1_+_168931547 0.676 NM_001160261
NM_001160262
NM_175461
Fam78b


family with sequence similarity 78, member B


chr12_-_28027541 0.665 NM_009234
Sox11
SRY-box containing gene 11
chrX_-_6765768 0.660 NM_016691
Clcn5
chloride channel 5
chr8_+_130882920 0.660 NM_008737
Nrp1
neuropilin 1
chr19_+_55816299 0.642 NM_001142918
NM_001142919
NM_001142920
NM_001142921
NM_001142922
NM_001142923
NM_009333
Tcf7l2






transcription factor 7-like 2, T-cell specific, HMG-box






chr4_-_129012546 0.635 NM_009030
Rbbp4
retinoblastoma binding protein 4
chr14_+_47502637 0.633 NM_001037221
NM_028966
Samd4

sterile alpha motif domain containing 4

chr5_-_25004598 0.631 NM_001081383
Mll3
myeloid/lymphoid or mixed-lineage leukemia 3
chr14_-_98568744 0.624 NM_001038610
NM_007826
Dach1

dachshund 1 (Drosophila)

chr17_-_71199129 0.617 NM_001164076
Tgif1
TGFB-induced factor homeobox 1
chr5_-_20561610 0.616 NM_011203
Ptpn12
protein tyrosine phosphatase, non-receptor type 12
chr18_+_35758269 0.613 NM_026420
Paip2
polyadenylate-binding protein-interacting protein 2
chr7_-_107128967 0.609 NM_175388
Rnf169
ring finger protein 169
chr6_-_72849854 0.602 NM_019715
Kcmf1
potassium channel modulatory factor 1
chrX_-_50723622 0.595 NM_027409
Mospd1
motile sperm domain containing 1
chr1_+_191552133 0.594 NM_008976
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr10_+_127176590 0.593 NM_198035
Zbtb39
zinc finger and BTB domain containing 39
chr2_-_115890747 0.580 NM_001136072
NM_001159567
NM_001159568
NM_010825
Meis2



Meis homeobox 2



chr15_-_50721552 0.577 NM_032000
Trps1
trichorhinophalangeal syndrome I (human)
chr6_-_13627853 0.573 NM_175312
B630005N14Rik
RIKEN cDNA B630005N14 gene
chr6_+_83276009 0.547 NM_145571
Mobkl1b
MOB1, Mps One Binder kinase activator-like 1B (yeast)
chr17_-_51951378 0.537 NM_001163630
Satb1
special AT-rich sequence binding protein 1
chr5_+_137960107 0.529 NM_031408
Gigyf1
GRB10 interacting GYF protein 1
chr1_-_163181251 0.528 NM_007453
Prdx6
peroxiredoxin 6
chr3_-_66100663 0.528 NM_145820
Veph1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr17_-_71200462 0.527 NM_009372
Tgif1
TGFB-induced factor homeobox 1
chrX_+_10294490 0.518 NM_001166635
NM_026524
Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

chr17_-_51972514 0.517 NM_001163632
Satb1
special AT-rich sequence binding protein 1
chr7_+_134628622 0.505 NM_010183
Fbrs
fibrosin
chr15_+_38837839 0.475 NM_008056
Fzd6
frizzled homolog 6 (Drosophila)
chr9_-_86465373 0.472 NM_001163746
NM_028352
Pgm3

phosphoglucomutase 3

chr12_+_72116953 0.459 NM_001081195
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr8_-_8660610 0.458 NM_010111
Efnb2
ephrin B2
chr6_+_146837012 0.454 NM_001170433
NM_026221
Ppfibp1

PTPRF interacting protein, binding protein 1 (liprin beta 1)

chr11_+_59953583 0.447 NM_001037764
Rai1
retinoic acid induced 1
chr2_+_49307005 0.446 NM_172663
Epc2
enhancer of polycomb homolog 2 (Drosophila)
chr7_-_72516109 0.444 NM_001163574
NM_009386
Tjp1

tight junction protein 1

chr8_-_91568060 0.442 NM_021390
Sall1
sal-like 1 (Drosophila)
chr8_+_81033220 0.442 NM_029736
Slc10a7
solute carrier family 10 (sodium/bile acid cotransporter family), member 7
chrX_+_162782484 0.437 NM_001177955
NM_001177956
NM_001177957
NM_001177958
NM_001177959
NM_001177960
Gpm6b





glycoprotein m6b





chr3_+_88336316 0.436 NM_001029890
Mex3a
mex3 homolog A (C. elegans)
chr1_-_64784316 0.424 NM_001042659
NM_022721
Fzd5

frizzled homolog 5 (Drosophila)

chr4_-_135129534 0.424 NM_001013756
Grhl3
grainyhead-like 3 (Drosophila)
chr1_+_140860285 0.424 NM_001166501
Dennd1b
DENN/MADD domain containing 1B
chr9_-_65972570 0.419 NM_019727
Snx1
sorting nexin 1
chr15_-_38008565 0.416 NM_001081359
NM_001112721
Ubr5

ubiquitin protein ligase E3 component n-recognin 5

chr13_+_48356795 0.412 NM_031166
Id4
inhibitor of DNA binding 4
chr10_-_117283020 0.407 NM_024457
Rap1b
RAS related protein 1b
chr5_-_64360058 0.406 NM_145923
Rell1
RELT-like 1
chr18_+_83084023 0.395 NM_001177464
Zfp516
zinc finger protein 516
chr2_-_164268672 0.395 NM_011521
Sdc4
syndecan 4
chr5_-_108561512 0.391 NM_028876
Tmed5
transmembrane emp24 protein transport domain containing 5
chr12_+_4924157 0.385 NM_001099628
Atad2b
ATPase family, AAA domain containing 2B
chr5_-_52581705 0.381 NM_001042620
NM_007839
Dhx15

DEAH (Asp-Glu-Ala-His) box polypeptide 15

chr11_+_75492764 0.370 NM_133656
Crk
v-crk sarcoma virus CT10 oncogene homolog (avian)
chr2_-_37278415 0.355 NM_001100591
Rc3h2
ring finger and CCCH-type zinc finger domains 2
chr2_-_115890247 0.352 NM_001159569
NM_001159570
Meis2

Meis homeobox 2

chr7_-_54263783 0.349 NM_175318
Spty2d1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr12_-_40763924 0.348 NM_007487
Arl4a
ADP-ribosylation factor-like 4A
chr2_-_173102033 0.337 NM_022995
Pmepa1
prostate transmembrane protein, androgen induced 1
chr19_-_28085534 0.327 NM_011265
Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chrX_+_70884742 0.326 NM_029352
Dusp9
dual specificity phosphatase 9
chr6_+_38383918 0.324 NM_177185
Ubn2
ubinuclein 2
chr17_-_26206121 0.322 NM_001162868
NM_001162869
Rab11fip3

RAB11 family interacting protein 3 (class II)

chr14_-_70919994 0.321 NM_009755
Bmp1
bone morphogenetic protein 1
chr5_-_20457608 0.320 NM_001080977
Rsbn1l
round spermatid basic protein 1-like
chr1_-_183950050 0.313 NM_001083120
NM_001083121
NM_008680
NM_010135
Enah



enabled homolog (Drosophila)



chr7_-_123182257 0.312 NM_001025559
Sox6
SRY-box containing gene 6
chr3_-_116126932 0.310 NM_001080818
NM_001173553
Cdc14a

CDC14 cell division cycle 14 homolog A (S. cerevisiae)

chr3_-_65940346 0.309 NM_028357
Veph1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chrX_-_138825032 0.309 NM_001033600
NM_019477
NM_207625
Acsl4


acyl-CoA synthetase long-chain family member 4


chr8_+_13869640 0.297 NM_181854
Zfp828
zinc finger protein 828
chr2_-_156005873 0.291 NM_133242
Rbm39
RNA binding motif protein 39
chr2_-_180655611 0.291 NM_173761
Ythdf1
YTH domain family 1
chr7_-_141416778 0.289 NM_007400
Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr13_+_55694491 0.288 NM_026211
Tmed9
transmembrane emp24 protein transport domain containing 9
chr11_+_87881747 0.287 NM_016686
Vezf1
vascular endothelial zinc finger 1
chr9_+_118515769 0.281 NM_133721
Itga9
integrin alpha 9
chr17_-_10512217 0.281 NM_001159516
NM_001159517
NM_021881
Qk


quaking


chr19_+_47654508 0.279 NM_001164639
NM_009289
Slk

STE20-like kinase (yeast)

chr5_-_123439064 0.277 NM_001003953
Kdm2b
lysine (K)-specific demethylase 2B
chr9_-_71440061 0.275 NM_001033208
Gcom1
GRINL1A complex locus
chr10_-_120748244 0.274 NM_029057
Tbc1d30
TBC1 domain family, member 30
chr7_-_34953455 0.269 NM_016682
Uba2
ubiquitin-like modifier activating enzyme 2
chr4_-_41045132 0.263 NM_016689
Aqp3
aquaporin 3
chr9_+_103014374 0.263 NM_173781
Rab6b
RAB6B, member RAS oncogene family
chr2_-_72817311 0.253 NM_001098425
Sp3
trans-acting transcription factor 3
chr13_-_47025086 0.251 NM_010617
Kif13a
kinesin family member 13A
chr1_+_52176281 0.249 NM_009283
Stat1
signal transducer and activator of transcription 1
chr19_-_28754566 0.243 NM_175459
Glis3
GLIS family zinc finger 3
chr12_-_53072250 0.242 NM_177171
Heatr5a
HEAT repeat containing 5A
chr5_-_51945054 0.232 NM_008904
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr10_-_121063321 0.232 NM_001081056
Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr11_-_120852609 0.216 NM_027874
NM_139059
Csnk1d

casein kinase 1, delta

chr1_+_193730645 0.216 NM_009579
Slc30a1
solute carrier family 30 (zinc transporter), member 1
chr5_+_135625533 0.214 NM_013763
Tbl2
transducin (beta)-like 2
chr5_-_123350242 0.210 NM_013910
Kdm2b
lysine (K)-specific demethylase 2B
chr6_-_71773747 0.209 NM_025430
Mrpl35
mitochondrial ribosomal protein L35
chr16_+_32608981 0.208 NM_011638
Tfrc
transferrin receptor
chr1_+_92949986 0.207 NM_001111311
NM_008515
Lrrfip1

leucine rich repeat (in FLII) interacting protein 1

chr3_-_148617598 0.198 NM_001081298
Lphn2
latrophilin 2
chr1_-_140071818 0.192 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr19_+_57435498 0.191 NM_145505
Fam160b1
family with sequence similarity 160, member B1
chr5_-_123438517 0.189 NM_001005866
Kdm2b
lysine (K)-specific demethylase 2B
chr3_+_84668066 0.189 NM_001177774
Fbxw7
F-box and WD-40 domain protein 7
chr7_+_19679892 0.188 NM_011383
Six5
sine oculis-related homeobox 5 homolog (Drosophila)
chr15_+_80629020 0.188 NM_177124
Tnrc6b
trinucleotide repeat containing 6b
chr14_-_100548982 0.187 NM_010636
Klf12
Kruppel-like factor 12
chr16_+_33185137 0.180 NM_176840
Osbpl11
oxysterol binding protein-like 11
chrX_+_82819294 0.177 NM_025729
Tab3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr9_+_7184513 0.176 NM_029775
Dcun1d5
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chrX_+_98572571 0.175 NM_008124
Gjb1
gap junction protein, beta 1
chr11_-_82704059 0.173 NM_011235
Rad51l3
RAD51-like 3 (S. cerevisiae)
chr15_+_38837818 0.171 NM_001162494
Fzd6
frizzled homolog 6 (Drosophila)
chr13_+_49436905 0.164 NM_001039179
NM_001039180
NM_029791
Bicd2


bicaudal D homolog 2 (Drosophila)


chr9_+_35018704 0.150 NM_026130
Srpr
signal recognition particle receptor ('docking protein')
chr10_+_7400978 0.148 NM_010690
Lats1
large tumor suppressor
chr14_+_65977510 0.146 NM_199029
Zfp395
zinc finger protein 395
chr4_-_45421590 0.145 NM_001009949
Mcart1
mitochondrial carrier triple repeat 1
chr9_+_70390659 0.142 NM_025690
Sltm
SAFB-like, transcription modulator
chr18_+_10325174 0.141 NM_001083628
Greb1l
growth regulation by estrogen in breast cancer-like
chr7_-_117129702 0.132 NM_153525
Tmem41b
transmembrane protein 41B
chr2_+_173902521 0.122 NM_001102423
NM_001102424
NM_001102425
NM_172675
Stx16



syntaxin 16



chr11_+_59761707 0.120 NM_138675
Med9
mediator of RNA polymerase II transcription, subunit 9 homolog (yeast)
chr4_+_41296028 0.115 NM_023305
Ubap1
ubiquitin-associated protein 1
chr15_+_87455659 0.112 NM_134096
Fam19a5
family with sequence similarity 19, member A5
chr11_+_101177524 0.111 NM_011192
Psme3
proteaseome (prosome, macropain) 28 subunit, 3
chr7_+_119902897 0.111 NM_001166585
Tead1
TEA domain family member 1
chrX_-_71330931 0.110 NM_010788
NM_001081979
Mecp2

methyl CpG binding protein 2

chr4_+_63205780 0.105 NM_024173
Atp6v1g1
ATPase, H+ transporting, lysosomal V1 subunit G1
chr2_-_20889276 0.104 NM_001081364
NM_001128084
Arhgap21

Rho GTPase activating protein 21

chr3_-_141645214 0.103 NM_007560
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr1_-_163061538 0.102 NM_001039482
Klhl20
kelch-like 20 (Drosophila)
chr3_-_108365340 0.100 NM_026198
Tmem167b
transmembrane protein 167B
chr11_-_3309227 0.100 NM_010718
Limk2
LIM motif-containing protein kinase 2
chr5_+_3803163 0.097 NM_001170552
NM_030675
Krit1

KRIT1, ankyrin repeat containing

chr8_-_98412220 0.095 NM_010325
Got2
glutamate oxaloacetate transaminase 2, mitochondrial
chr5_+_108697913 0.095 NM_026106
Dr1
down-regulator of transcription 1
chr6_+_120314116 0.094 NM_145997
Kdm5a
lysine (K)-specific demethylase 5A
chr11_-_100711785 0.084 NM_001113563
Stat5b
signal transducer and activator of transcription 5B
chr15_-_86016336 0.078 NM_145475
Cerk
ceramide kinase
chr6_+_115803545 0.078 NM_001167763
NM_031177
Ift122

intraflagellar transport 122 homolog (Chlamydomonas)

chr1_+_78654399 0.075 NM_001001981
NM_001033606
NM_001136222
NM_028817
Utp14b
Acsl3


UTP14, U3 small nucleolar ribonucleoprotein, homolog B (yeast)
acyl-CoA synthetase long-chain family member 3


chr10_-_94878845 0.067 NM_001168655
Socs2
suppressor of cytokine signaling 2
chr18_-_77952721 0.067 NM_178670
8030462N17Rik
RIKEN cDNA 8030462N17 gene
chr3_-_51129908 0.066 NM_023502
Elf2
E74-like factor 2
chr5_+_102910409 0.062 NM_029270
NM_146161
Arhgap24

Rho GTPase activating protein 24

chr13_-_58229884 0.059 NM_029872
Hnrnpa0
heterogeneous nuclear ribonucleoprotein A0
chr4_+_138748812 0.050 NM_009798
NM_001037761
Capzb

capping protein (actin filament) muscle Z-line, beta

chr6_+_8459595 0.045 NM_133236
Glcci1
glucocorticoid induced transcript 1
chr10_+_20032269 0.044 NM_001025392
NM_001025393
NM_153787
Bclaf1


BCL2-associated transcription factor 1


chr17_+_4995073 0.033 NM_001085355
Arid1b
AT rich interactive domain 1B (SWI-like)
chr1_-_16609325 0.032 NM_025773
Ube2w
ubiquitin-conjugating enzyme E2W (putative)
chr7_-_53355395 0.026 NM_010602
Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
chr12_+_60232417 0.025 NM_001165253
Ctage5
CTAGE family, member 5
chr6_+_91423694 0.021 NM_028766
Tmem43
transmembrane protein 43
chr14_-_49686341 0.020 NM_207214
Exoc5
exocyst complex component 5
chr9_-_67407509 0.018 NM_001081242
Tln2
talin 2
chr9_+_56266618 0.010 NM_025812
Hmg20a
high mobility group 20A
chr1_+_185858324 0.009 NM_022019
Dusp10
dual specificity phosphatase 10

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
16.73 1.61e-04 GO:0016568 chromatin modification
14.59 3.58e-04 GO:0006325 chromatin organization
11.13 1.70e-03 GO:0051276 chromosome organization
3.47 3.10e-02 GO:0051171 regulation of nitrogen compound metabolic process
3.44 3.34e-02 GO:0009889 regulation of biosynthetic process
3.83 3.58e-02 GO:0071841 cellular component organization or biogenesis at cellular level
3.07 3.72e-02 GO:0060255 regulation of macromolecule metabolic process
4.35 3.88e-02 GO:0006351 transcription, DNA-dependent
4.34 3.92e-02 GO:0032774 RNA biosynthetic process
3.70 4.72e-02 GO:0006355 regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.67 2.09e-03 GO:0005634 nucleus
1.84 4.35e-02 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

enrichment p-value GO term description
73.97 1.51e-02 GO:0035064 methylated histone residue binding