Motif ID: GUAGUGU

Z-value: 0.831

Mature miRNA associated with seed GUAGUGU:

NamemiRBase Accession
mmu-miR-142-3p MIMAT0000155



Activity profile for motif GUAGUGU.

activity profile for motif GUAGUGU


Sorted Z-values histogram for motif GUAGUGU

Sorted Z-values for motif GUAGUGU



Network of associatons between targets according to the STRING database.



First level regulatory network of GUAGUGU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr12_-_56087322 3.612 NM_013815
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr8_+_74659107 3.333 NM_001001491
Tpm4
tropomyosin 4
chr6_+_128312987 2.583 NM_008021
Foxm1
forkhead box M1
chr7_-_71083734 2.578 NM_021366
Klf13
Kruppel-like factor 13
chr4_+_47366162 2.471 NM_009370
Tgfbr1
transforming growth factor, beta receptor I
chr1_+_133807034 2.334 NM_001145804
NM_175294
Nucks1

nuclear casein kinase and cyclin-dependent kinase substrate 1

chr3_+_65332306 2.004 NM_178892
Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
chr2_-_23011403 1.981 NM_025979
Mastl
microtubule associated serine/threonine kinase-like
chr18_+_5591869 1.955 NM_011546
Zeb1
zinc finger E-box binding homeobox 1
chr10_-_126725826 1.909 NM_033072
Mbd6
methyl-CpG binding domain protein 6
chr15_-_99650502 1.873 NM_023063
Lima1
LIM domain and actin binding 1
chr11_+_94491055 1.840 NM_133807
Lrrc59
leucine rich repeat containing 59
chr2_+_155207581 1.748 NM_178111
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr15_-_77672472 1.712 NM_022410
Myh9
myosin, heavy polypeptide 9, non-muscle
chr13_-_3610328 1.704 NM_134063
BC016423
cDNA sequence BC016423
chr9_-_22193627 1.701 NM_028390
Anln
anillin, actin binding protein
chr12_-_28027541 1.696 NM_009234
Sox11
SRY-box containing gene 11
chr2_-_44968728 1.683 NM_015753
Zeb2
zinc finger E-box binding homeobox 2
chrX_-_138825032 1.666 NM_001033600
NM_019477
NM_207625
Acsl4


acyl-CoA synthetase long-chain family member 4


chr7_+_52273317 1.661 NM_009101
Rras
Harvey rat sarcoma oncogene, subgroup R
chr9_-_35007458 1.611 NM_001177847
NM_001177846
NM_054096
Tirap


toll-interleukin 1 receptor (TIR) domain-containing adaptor protein


chr8_-_112261607 1.551 NM_001080930
Atxn1l
ataxin 1-like
chr11_-_23397927 1.549 NM_172391
Ahsa2
AHA1, activator of heat shock protein ATPase homolog 2 (yeast)
chr6_-_83391623 1.513 NM_183138
Tet3
tet oncogene family member 3
chr15_-_73015345 1.495 NM_153178
Eif2c2
eukaryotic translation initiation factor 2C, 2
chr10_-_80813067 1.476 NM_001163165
NM_010440
Hmg20b

high mobility group 20 B

chr15_-_94420206 1.448 NM_008971
Twf1
twinfilin, actin-binding protein, homolog 1 (Drosophila)
chr15_-_83002624 1.444 NM_029787
Cyb5r3
cytochrome b5 reductase 3
chr11_-_77421308 1.417 NM_144825
Taok1
TAO kinase 1
chr4_+_148178500 1.413 NM_001159344
NM_027195
Casz1

castor homolog 1, zinc finger (Drosophila)

chr5_+_73882264 1.397 NM_001190733
NM_178896
Dcun1d4

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)

chr2_+_83564553 1.345 NM_008402
Itgav
integrin alpha V
chr11_+_75492764 1.340 NM_133656
Crk
v-crk sarcoma virus CT10 oncogene homolog (avian)
chr15_-_3945704 1.332 NM_145930
AW549877
expressed sequence AW549877
chr10_-_7675872 1.324 NM_138667
Tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr12_-_52792851 1.324 NM_001172098
NM_052973
Strn3

striatin, calmodulin binding protein 3

chr16_+_87699143 1.264 NM_007520
Bach1
BTB and CNC homology 1
chr14_-_73109722 1.227 NM_207636
Fndc3a
fibronectin type III domain containing 3A
chr2_+_6243767 1.195 NM_001080548
Usp6nl
USP6 N-terminal like
chr13_+_113254277 1.148 NM_010560
Il6st
interleukin 6 signal transducer
chr8_-_123191878 1.145 NM_010926
Cox4nb
COX4 neighbor
chr18_-_6241497 1.133 NM_008448
Kif5b
kinesin family member 5B
chr5_-_149864518 1.108 NM_010439
Hmgb1
high mobility group box 1
chr12_-_52930506 1.089 NM_144788
Hectd1
HECT domain containing 1
chr1_+_182260606 1.067 NM_001081175
Itpkb
inositol 1,4,5-trisphosphate 3-kinase B
chr11_+_115685365 1.064 NM_145438
Llgl2
lethal giant larvae homolog 2 (Drosophila)
chr4_-_150432002 1.027 NM_009498
Vamp3
vesicle-associated membrane protein 3
chr5_+_65361309 0.987 NM_026667
Fam114a1
family with sequence similarity 114, member A1
chr17_+_36053855 0.976 NM_175934
Ppp1r10
protein phosphatase 1, regulatory subunit 10
chr3_-_135086338 0.967 NM_025902
Cisd2
CDGSH iron sulfur domain 2
chr4_-_135577545 0.945 NM_013736
Tceb3
transcription elongation factor B (SIII), polypeptide 3
chr2_-_12223518 0.924 NM_001001309
Itga8
integrin alpha 8
chr3_+_21975544 0.904 NM_030732
Tbl1xr1
transducin (beta)-like 1X-linked receptor 1
chr17_-_31992708 0.874 NM_010831
Sik1
salt inducible kinase 1
chr15_-_102087673 0.873 NM_011244
Rarg
retinoic acid receptor, gamma
chr9_-_90165508 0.863 NM_194334
Tbc1d2b
TBC1 domain family, member 2B
chr11_-_31571811 0.822 NM_001024919
Bod1
biorientation of chromosomes in cell division 1
chr7_-_151739579 0.812 NM_001033319
NM_001195086
Ppfia1

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

chr5_+_43624701 0.771 NM_001177379
NM_175937
Cpeb2

cytoplasmic polyadenylation element binding protein 2

chr9_-_42913797 0.754 NM_027144
Arhgef12
Rho guanine nucleotide exchange factor (GEF) 12
chr5_+_108890247 0.752 NM_172716
Pcgf3
polycomb group ring finger 3
chr1_-_134439500 0.746 NM_177129
Cntn2
contactin 2
chr5_+_104183148 0.746 NM_133919
Aff1
AF4/FMR2 family, member 1
chr14_-_21871647 0.733 NM_018829
Ap3m1
adaptor-related protein complex 3, mu 1 subunit
chr10_-_88906629 0.724 NM_001033331
NM_001079876
Gas2l3

growth arrest-specific 2 like 3

chr7_-_133618335 0.702 NM_001081459
NM_011363
Sh2b1

SH2B adaptor protein 1

chr16_-_56717337 0.697 NM_019678
Tfg
Trk-fused gene
chr11_-_90499370 0.695 NM_011505
Stxbp4
syntaxin binding protein 4
chrX_-_139401258 0.693 NM_019496
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 homolog (human)
chr8_-_124175827 0.690 NM_080855
Zcchc14
zinc finger, CCHC domain containing 14
chr4_-_35173039 0.668 NM_001081343
3110043O21Rik
RIKEN cDNA 3110043O21 gene
chr15_-_99705812 0.667 NM_001113545
Lima1
LIM domain and actin binding 1
chr17_-_84587278 0.665 NM_001001806
Zfp36l2
zinc finger protein 36, C3H type-like 2
chrX_+_98449866 0.655 NM_018789
Foxo4
forkhead box O4
chr18_+_42435006 0.649 NM_172626
Rbm27
RNA binding motif protein 27
chr11_+_68505416 0.638 NM_175260
Myh10
myosin, heavy polypeptide 10, non-muscle
chr10_-_36858671 0.617 NM_008538
Marcks
myristoylated alanine rich protein kinase C substrate
chr10_+_69559860 0.610 NM_001111121
Ccdc6
coiled-coil domain containing 6
chr17_+_34066835 0.603 NM_009059
Rgl2
ral guanine nucleotide dissociation stimulator-like 2
chr1_-_163806710 0.596 NM_172645
AI848100
expressed sequence AI848100
chr11_+_80242103 0.585 NM_178616
Psmd11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr5_+_151325197 0.578 NM_009765
NM_001081001
Brca2

breast cancer 2

chr13_+_51503986 0.573 NM_010101
S1pr3
sphingosine-1-phosphate receptor 3
chr5_-_37187944 0.549 NM_026242
Mrfap1
Morf4 family associated protein 1
chr12_+_16901671 0.530 NM_009072
Rock2
Rho-associated coiled-coil containing protein kinase 2
chr4_+_130219255 0.529 NM_001159603
NM_001159604
NM_001159605
NM_001159606
NM_030722
Pum1




pumilio 1 (Drosophila)




chr9_-_14419410 0.505 NM_001081395
Amotl1
angiomotin-like 1
chr17_+_28046196 0.492 NM_181413
Anks1
ankyrin repeat and SAM domain containing 1
chr1_+_141318927 0.451 NM_172643
Zbtb41
zinc finger and BTB domain containing 41 homolog
chr1_+_129670740 0.441 NM_028399
Ccnt2
cyclin T2
chr5_-_63157309 0.438 NM_178407
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_53851046 0.437 NM_146234
Mmgt1
membrane magnesium transporter 1
chr7_+_3646102 0.432 NM_024168
Tsen34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr2_+_22923653 0.431 NM_001102436
NM_028793
Acbd5

acyl-Coenzyme A binding domain containing 5

chrX_-_106029678 0.431 NM_001081477
Brwd3
bromodomain and WD repeat domain containing 3
chr1_+_59538966 0.428 NM_008057
Fzd7
frizzled homolog 7 (Drosophila)
chr11_+_20991321 0.395 NM_023324
Peli1
pellino 1
chr3_-_115710131 0.394 NM_023214
Slc30a7
solute carrier family 30 (zinc transporter), member 7
chr12_-_92828018 0.394 NM_031391
Gtf2a1
general transcription factor II A, 1
chrX_-_6765768 0.381 NM_016691
Clcn5
chloride channel 5
chr1_-_46910333 0.376 NM_172653
Slc39a10
solute carrier family 39 (zinc transporter), member 10
chr8_-_36028698 0.357 NM_175091
Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr7_-_72516109 0.353 NM_001163574
NM_009386
Tjp1

tight junction protein 1

chr7_+_19679892 0.348 NM_011383
Six5
sine oculis-related homeobox 5 homolog (Drosophila)
chr10_+_69388242 0.345 NM_009670
NM_170687
Ank3

ankyrin 3, epithelial

chr10_+_20032269 0.321 NM_001025392
NM_001025393
NM_153787
Bclaf1


BCL2-associated transcription factor 1


chr14_+_14845004 0.320 NM_139227
Atxn7
ataxin 7
chr9_-_45792865 0.318 NM_008775
Pafah1b2
2610005M20Rik
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
RIKEN cDNA 2610005M20 gene
chr4_+_32504409 0.316 NM_001109661
Bach2
BTB and CNC homology 2
chr4_+_116393559 0.315 NM_146151
Tesk2
testis-specific kinase 2
chr11_-_88579517 0.314 NM_054043
Msi2
Musashi homolog 2 (Drosophila)
chr15_+_12047555 0.306 NM_011767
Zfr
zinc finger RNA binding protein
chr11_+_77796215 0.283 NM_174852
Phf12
PHD finger protein 12
chr17_-_10512217 0.282 NM_001159516
NM_001159517
NM_021881
Qk


quaking


chrX_+_126284271 0.280 NM_172493
Diap2
diaphanous homolog 2 (Drosophila)
chr17_+_83750246 0.279 NM_001114361
NM_001114362
NM_199466
Eml4


echinoderm microtubule associated protein like 4


chr6_-_115944822 0.275 NM_026376
Plxnd1
plexin D1
chr5_-_66543123 0.250 NM_001127382
Rbm47
RNA binding motif protein 47
chr6_-_24614975 0.248 NM_001167745
NM_028459
Wasl

Wiskott-Aldrich syndrome-like (human)

chr12_-_55963776 0.231 NM_007688
Cfl2
cofilin 2, muscle
chr7_-_73834420 0.225 NM_080443
Asb7
ankyrin repeat and SOCS box-containing 7
chr5_-_136020946 0.222 NM_146001
Hip1
huntingtin interacting protein 1
chr17_-_32525894 0.217 NM_011717
Wiz
widely-interspaced zinc finger motifs
chr10_+_70810540 0.208 NM_027184
Ipmk
inositol polyphosphate multikinase
chr4_+_34497840 0.205 NM_001007589
Akirin2
akirin 2
chr2_+_52716901 0.201 NM_172409
Fmnl2
formin-like 2
chr19_-_12870612 0.193 NM_053009
Zfp91
zinc finger protein 91
chr7_+_3645211 0.191 NM_001164204
NM_001164205
Tsen34

tRNA splicing endonuclease 34 homolog (S. cerevisiae)

chr2_-_7317824 0.181 NM_001110231
Celf2
CUGBP, Elav-like family member 2
chr15_-_50721552 0.178 NM_032000
Trps1
trichorhinophalangeal syndrome I (human)
chr9_-_53475610 0.168 NM_001161618
NM_027807
Cul5

cullin 5

chr2_+_22924561 0.167 NM_001102437
NM_001102438
Acbd5

acyl-Coenzyme A binding domain containing 5

chr8_+_109674517 0.164 NM_025558
Cyb5b
cytochrome b5 type B
chr5_+_123844794 0.162 NM_133917
NM_177582
Mlxip

MLX interacting protein

chr16_+_45224449 0.156 NM_001037719
NM_177584
Btla

B and T lymphocyte associated

chr16_-_32246968 0.130 NM_173439
Fbxo45
F-box protein 45
chr5_-_143579060 0.112 NM_001122730
NM_178242
Tnrc18

trinucleotide repeat containing 18

chr9_-_44689356 0.110 NM_001081049
Mll1
myeloid/lymphoid or mixed-lineage leukemia 1
chr11_+_23156022 0.106 NM_001035226
NM_134014
Xpo1

exportin 1, CRM1 homolog (yeast)

chr18_-_39646734 0.103 NM_008173
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr8_-_83404377 0.102 NM_021356
Gab1
growth factor receptor bound protein 2-associated protein 1
chr8_+_113370907 0.101 NM_133973
Cog4
component of oligomeric golgi complex 4
chr7_-_123182257 0.082 NM_001025559
Sox6
SRY-box containing gene 6
chr5_-_107125783 0.081 NM_026856
Zfp644
zinc finger protein 644
chr2_-_169956719 0.076 NM_001033299
Zfp217
zinc finger protein 217
chr3_-_144382959 0.072 NM_019464
Sh3glb1
SH3-domain GRB2-like B1 (endophilin)
chr17_+_27194207 0.066 NM_080553
Itpr3
inositol 1,4,5-triphosphate receptor 3
chr10_+_21698470 0.065 NM_001161847
Sgk1
serum/glucocorticoid regulated kinase 1
chr3_-_100489393 0.057 NM_010763
Man1a2
mannosidase, alpha, class 1A, member 2
chr7_+_97278722 0.053 NM_146194
Picalm
phosphatidylinositol binding clathrin assembly protein
chr12_+_112812710 0.048 NM_021516
NM_022801
Mark3

MAP/microtubule affinity-regulating kinase 3

chr15_-_79518160 0.047 NM_028792
Josd1
Josephin domain containing 1
chr11_-_95171521 0.045 NM_001195003
NM_001195004
NM_177619
Myst2


MYST histone acetyltransferase 2


chr1_-_167124442 0.043 NM_145512
Sft2d2
SFT2 domain containing 2
chr4_-_129317873 0.038 NM_001005506
Txlna
taxilin alpha
chr6_+_136467315 0.037 NM_019426
Atf7ip
activating transcription factor 7 interacting protein
chr18_-_14841294 0.032 NM_001161369
NM_001161370
NM_001161371
NM_009280
Ss18



synovial sarcoma translocation, Chromosome 18



chr4_-_59562054 0.031 NM_144904
NM_178164
Rod1

ROD1 regulator of differentiation 1 (S. pombe)

chr17_+_53706283 0.028 NM_020005
Kat2b
K(lysine) acetyltransferase 2B
chr15_-_102076706 0.020 NM_001042727
Rarg
retinoic acid receptor, gamma
chr10_-_80813198 0.013 NM_001163166
Hmg20b
high mobility group 20 B
chr1_-_162964371 0.010 NM_173424
Zbtb37
zinc finger and BTB domain containing 37
chr3_-_51129908 0.010 NM_023502
Elf2
E74-like factor 2
chr13_+_81022644 0.003 NM_001042591
Arrdc3
arrestin domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.80 5.45e-04 GO:0031323 regulation of cellular metabolic process
3.48 4.40e-03 GO:0030154 cell differentiation
2.48 4.52e-03 GO:0019222 regulation of metabolic process
3.37 6.32e-03 GO:0048869 cellular developmental process
2.57 8.76e-03 GO:0080090 regulation of primary metabolic process
3.69 1.10e-02 GO:0048583 regulation of response to stimulus
2.88 1.16e-02 GO:0048856 anatomical structure development
3.02 1.21e-02 GO:0048731 system development
4.19 1.68e-02 GO:0009966 regulation of signal transduction
3.79 1.86e-02 GO:0023051 regulation of signaling
2.53 2.03e-02 GO:0060255 regulation of macromolecule metabolic process
2.54 3.32e-02 GO:0032502 developmental process
3.85 3.62e-02 GO:0010604 positive regulation of macromolecule metabolic process
5.47 3.67e-02 GO:0019220 regulation of phosphate metabolic process
5.47 3.67e-02 GO:0051174 regulation of phosphorus metabolic process
2.61 4.10e-02 GO:0007275 multicellular organismal development
3.78 4.28e-02 GO:0031325 positive regulation of cellular metabolic process

Gene overrepresentation in compartment category:

enrichment p-value GO term description
79.72 6.16e-04 GO:0032153 cell division site
79.72 6.16e-04 GO:0032155 cell division site part
141.71 7.59e-03 GO:0005826 actomyosin contractile ring
1.52 1.06e-02 GO:0005622 intracellular
121.47 1.06e-02 GO:0070938 contractile ring
31.12 1.13e-02 GO:0001725 stress fiber
29.00 1.39e-02 GO:0032432 actin filament bundle
27.74 1.59e-02 GO:0042641 actomyosin
2.17 2.27e-02 GO:0044422 organelle part
77.30 2.76e-02 GO:0032154 cleavage furrow
1.57 4.45e-02 GO:0043229 intracellular organelle
7.58 4.49e-02 GO:0015629 actin cytoskeleton
2.61 4.68e-02 GO:0043228 non-membrane-bounded organelle
2.61 4.68e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.57 4.74e-02 GO:0043226 organelle

Gene overrepresentation in function category:

enrichment p-value GO term description
1.54 5.67e-03 GO:0005488 binding
141.71 6.28e-03 GO:0000400 four-way junction DNA binding
4.67 1.95e-02 GO:0001071 nucleic acid binding transcription factor activity
4.67 1.95e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
56.70 4.34e-02 GO:0000217 DNA secondary structure binding
7.11 4.99e-02 GO:0003779 actin binding