Motif ID: HAND1,2.p2

Z-value: 1.484

Transcription factors associated with HAND1,2.p2:

NameEntrezDescription
Hand1 15110 heart and neural crest derivatives expressed transcript 1
Hand2 15111 heart and neural crest derivatives expressed transcript 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Hand2chr8_+_59799779-0.086.5e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr1_-_137064124 29.087 NM_134438
Gpr37l1
G protein-coupled receptor 37-like 1
chr15_+_91881593 18.059 NM_001159648
Cntn1
contactin 1
chr5_-_75073816 12.963 NM_001159578
NM_001159579
NM_001159580
NM_010727
Lnx1



ligand of numb-protein X 1



chr10_-_10802102 12.024 NM_001114333
NM_016976
Grm1

glutamate receptor, metabotropic 1

chr7_-_149843316 11.006 NM_001122737
Igf2
insulin-like growth factor 2
chr1_+_45368443 9.675 Col3a1
collagen, type III, alpha 1
chr8_-_3625251 8.778 NM_008790
Pcp2
Purkinje cell protein 2 (L7)
chr15_+_81767188 7.958 NM_145473
Csdc2
cold shock domain containing C2, RNA binding
chr11_-_69419419 7.913 NM_013415
Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr10_+_60638341 7.088 Tbata
thymus, brain and testes associated
chr1_+_95132413 5.684 NM_172463
Sned1
sushi, nidogen and EGF-like domains 1
chr6_-_60778740 5.560 NM_001042451
Snca
synuclein, alpha
chrM_+_6139 5.432


chr5_+_27588462 5.184 NM_001136060
Dpp6
dipeptidylpeptidase 6
chr14_-_104242892 5.090 NM_007904
Ednrb
endothelin receptor type B
chr8_+_56040445 4.430 Gpm6a
glycoprotein m6a
chrX_+_133357268 4.359 NM_011123
Plp1
proteolipid protein (myelin) 1
chr6_+_147995935 4.302 NM_178797
Far2
fatty acyl CoA reductase 2
chr15_+_89116972 4.275 Ppp6r2
protein phosphatase 6, regulatory subunit 2
chr14_-_122138082 3.860 NM_001128307
NM_001128308
Dock9

dedicator of cytokinesis 9

chr11_+_62389367 3.842 Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr11_+_56825307 3.808 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr7_+_19469999 3.701 NM_009402
Pglyrp1
peptidoglycan recognition protein 1
chr11_+_94797565 3.655 NM_007742
Col1a1
collagen, type I, alpha 1
chr11_+_56825258 3.573 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr15_+_82086506 3.427 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr7_-_147340532 3.328 NM_183147
Sprn
shadow of prion protein
chr9_+_37175190 3.164 NM_175189
Hepacam
hepatocyte cell adhesion molecule
chrM_+_5398 3.160


chr13_+_37437194 3.146 NM_010745
Ly86
lymphocyte antigen 86
chr15_+_3976598 3.092 Oxct1
3-oxoacid CoA transferase 1
chrM_+_5462 3.066


chr19_-_23522811 3.063 NM_174857
Mamdc2
MAM domain containing 2
chr10_+_96942181 3.062 Dcn
decorin
chr11_+_56825192 2.942 NM_001113325
NM_008165
Gria1

glutamate receptor, ionotropic, AMPA1 (alpha 1)

chr7_+_134094045 2.937 NM_144926
Sez6l2
seizure related 6 homolog like 2
chr4_-_136441982 2.895 NM_009777
C1qb
complement component 1, q subcomponent, beta polypeptide
chr1_-_172040852 2.827 Ddr2
discoidin domain receptor family, member 2
chr7_+_133966816 2.809 NM_029978
Fam57b
family with sequence similarity 57, member B
chr4_+_130469187 2.746 NM_010686
Laptm5
lysosomal-associated protein transmembrane 5
chr2_+_84976516 2.733 NM_011784
Aplnr
apelin receptor
chr6_-_60779848 2.705 NM_009221
Snca
synuclein, alpha
chr18_-_78320126 2.696 NM_001171010
NM_028122
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr15_-_81527706 2.689 NM_001164320
Chadl
chondroadherin-like
chr14_-_104243541 2.670 Ednrb
endothelin receptor type B
chr11_+_100437204 2.651 NM_001146318
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr11_-_102758340 2.610 Gfap
glial fibrillary acidic protein
chr2_-_170232008 2.587 Bcas1
breast carcinoma amplified sequence 1
chr8_+_56040211 2.583 Gpm6a
glycoprotein m6a
chr5_-_138052555 2.524 NM_008788
Pcolce
procollagen C-endopeptidase enhancer protein
chr14_-_73785035 2.511 Itm2b
integral membrane protein 2B
chr1_+_87791084 2.364 NM_022417
Itm2c
integral membrane protein 2C
chr8_+_56040553 2.347 Gpm6a
glycoprotein m6a
chr5_-_121010389 2.273 Tpcn1
two pore channel 1
chr11_-_109856977 2.226 NM_013851
Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr5_+_23870625 2.219 NM_008713
Nos3
nitric oxide synthase 3, endothelial cell
chr7_-_26154721 2.180 NM_001081375
NM_028219
Cnfn

cornifelin

chr18_-_46733959 2.169 NM_173394
Ticam2
toll-like receptor adaptor molecule 2
chr10_+_39089594 2.165 NM_001122892
NM_001122893
NM_008054
Fyn


Fyn proto-oncogene


chr13_-_105653835 2.135 NM_029984
Fam159b
family with sequence similarity 159, member B
chr1_-_156993820 2.093 NM_008209
Mr1
major histocompatibility complex, class I-related
chr2_-_7002344 2.091 NM_001110229
NM_001110230
NM_001160292
Celf2


CUGBP, Elav-like family member 2


chr17_+_70871444 2.064 NM_001128180
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr3_-_95695852 1.935 NM_153513
BC028528
cDNA sequence BC028528
chr11_-_98636538 1.831 NM_145434
Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr11_-_55233366 1.806 Sparc
secreted acidic cysteine rich glycoprotein
chr2_+_61884596 1.769 NM_033552
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr18_+_37581071 1.752 NM_053136
Pcdhb11
protocadherin beta 11
chr12_-_77923303 1.711 NM_134050
Rab15
RAB15, member RAS oncogene family
chr7_-_147268395 1.711 NM_001190385
NM_026769
Caly

calcyon neuron-specific vesicular protein

chr11_-_3404756 1.706 NM_172439
Inpp5j
inositol polyphosphate 5-phosphatase J
chr11_-_119878383 1.701 Aatk
apoptosis-associated tyrosine kinase
chrX_+_98494487 1.701 NM_172932
Nlgn3
neuroligin 3
chr2_+_181501718 1.625 NM_001171616
NM_008665
Myt1

myelin transcription factor 1

chr4_+_130378728 1.612 Sdc3
syndecan 3
chr18_-_78320014 1.610 Slc14a1
solute carrier family 14 (urea transporter), member 1
chr3_+_89866717 1.609 NM_028567
1700094D03Rik
RIKEN cDNA 1700094D03 gene
chr15_-_99358024 1.591 Faim2
Fas apoptotic inhibitory molecule 2
chr6_-_113293879 1.533 NM_133926
Camk1
calcium/calmodulin-dependent protein kinase I
chr2_-_7002287 1.481 Celf2
CUGBP, Elav-like family member 2
chr2_-_131855937 1.477 Rassf2
Ras association (RalGDS/AF-6) domain family member 2
chr11_-_116515602 1.463 NM_030206
Cygb
cytoglobin
chr19_+_4855178 1.454 Ctsf
cathepsin F
chr8_-_34752419 1.451 NM_178648
Ubxn8
UBX domain protein 8
chr19_+_38339167 1.445 NM_020278
Lgi1
leucine-rich repeat LGI family, member 1
chr18_-_31476527 1.425 Rit2
Ras-like without CAAX 2
chr10_+_126951992 1.412 NM_001098789
Ndufa4l2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr14_-_73785067 1.390 Itm2b
integral membrane protein 2B
chr16_-_10395401 1.357 NM_001099275
Tekt5
tektin 5
chr2_+_164311755 1.329 NM_026797
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr4_+_102432773 1.322 Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr11_+_68316520 1.317 NM_001004435
NM_001081566
Pik3r6

phosphoinositide-3-kinase, regulatory subunit 6

chr11_+_78312621 1.307 NM_011707
Vtn
vitronectin
chr5_+_151062363 1.300 NM_172887
Fry
furry homolog (Drosophila)
chr2_+_25251393 1.258 NM_009849
Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr11_-_55233339 1.239 Sparc
secreted acidic cysteine rich glycoprotein
chr1_+_36748379 1.234 Cox5b
cytochrome c oxidase, subunit Vb
chr4_-_124742875 1.222 NM_175223
Dnali1
dynein, axonemal, light intermediate polypeptide 1
chr6_-_8728094 1.205 Ica1
islet cell autoantigen 1
chr11_-_88725877 1.187 NM_001042541
Akap1
A kinase (PRKA) anchor protein 1
chr4_+_62360705 1.165 Rgs3
regulator of G-protein signaling 3
chr18_+_37607310 1.150 NM_053139
Pcdhb14
protocadherin beta 14
chr5_-_124804583 1.142 NM_013812
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr11_+_3388229 1.113 NM_172791
Pla2g3
phospholipase A2, group III
chr5_-_130354822 1.081 NM_011079
Phkg1
phosphorylase kinase gamma 1
chr5_-_135096236 1.074 Eif4h
eukaryotic translation initiation factor 4H
chr18_+_37644674 1.032 NM_053142
Pcdhb17
protocadherin beta 17
chr1_-_74350713 1.012 Tmbim1
transmembrane BAX inhibitor motif containing 1
chr11_-_33893151 1.003 NM_001190886
Kcnip1
Kv channel-interacting protein 1
chr19_-_40439627 1.001


chr6_+_29718515 0.995 Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr14_+_63754443 0.988 Ctsb
cathepsin B
chr11_+_120094240 0.973 NM_198423
Bahcc1
BAH domain and coiled-coil containing 1
chr11_+_59476181 0.972 Mprip
myosin phosphatase Rho interacting protein
chr12_+_4133370 0.958 NM_001159536
NM_001159537
Adcy3

adenylate cyclase 3

chr9_+_56712850 0.955 NM_139001
Cspg4
chondroitin sulfate proteoglycan 4
chr11_+_97547236 0.955 NM_001085500
Cisd3
CDGSH iron sulfur domain 3
chrX_-_18038399 0.946 NM_175228
4930578C19Rik
RIKEN cDNA 4930578C19 gene
chr16_-_18407565 0.933 Comt
catechol-O-methyltransferase
chr8_-_28239121 0.914 Brf2
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
chr3_+_81736518 0.900 NM_177662
Ctso
cathepsin O
chr11_-_58996318 0.900 NM_175452
Gjc2
gap junction protein, gamma 2
chr2_+_130953108 0.868 NM_028306
Hspa12b
heat shock protein 12B
chr9_+_60560923 0.859 NM_026235
Larp6
La ribonucleoprotein domain family, member 6
chr2_+_174170886 0.852 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr14_-_56503058 0.850 Cbln3
cerebellin 3 precursor protein
chr8_+_56040193 0.850 Gpm6a
glycoprotein m6a
chr11_+_96902859 0.835 NM_026154
Mrpl10
mitochondrial ribosomal protein L10
chr5_-_143667004 0.831 Actb
actin, beta
chr5_-_37380147 0.772 NM_011716
Wfs1
Wolfram syndrome 1 homolog (human)
chr7_-_31699888 0.757 Mag
myelin-associated glycoprotein
chr15_+_74785366 0.754 NM_001164037
NM_001164038
NM_001164039
NM_001164036
NM_008529
NM_001164040
Ly6e





lymphocyte antigen 6 complex, locus E





chr1_-_137271539 0.742 NM_175259
Shisa4
shisa homolog 4 (Xenopus laevis)
chr1_+_17135421 0.742 NM_010267
Gdap1
ganglioside-induced differentiation-associated-protein 1
chr11_+_28753190 0.734 NM_146015
Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr1_+_95917069 0.728 NM_173772
Neu4
sialidase 4
chr10_-_74495269 0.726 NM_001163534
NM_001163535
NM_001163533
NM_027730
Rtdr1



rhabdoid tumor deletion region gene 1



chr2_-_17652725 0.725 Nebl
nebulette
chr16_-_85173978 0.717 App
amyloid beta (A4) precursor protein
chr13_-_95055235 0.705 NM_029153
Scamp1
secretory carrier membrane protein 1
chr2_-_6805937 0.696 NM_001110228
NM_001160293
NM_010160
Celf2


CUGBP, Elav-like family member 2


chr18_+_40416615 0.695 2900055J20Rik
RIKEN cDNA 2900055J20 gene
chr1_+_155747072 0.680 NM_008131
Glul
glutamate-ammonia ligase (glutamine synthetase)
chrM_+_13998 0.679


chr12_-_32893074 0.669 NM_001146201
NM_020272
NM_001146200
Pik3cg


phosphoinositide-3-kinase, catalytic, gamma polypeptide


chr14_+_61757271 0.655 NM_172809
Sacs
sacsin
chr6_-_94650118 0.636 NM_008377
Lrig1
leucine-rich repeats and immunoglobulin-like domains 1
chr5_+_44260035 0.634 NM_007646
Cd38
CD38 antigen
chr4_-_117559857 0.615 NM_033617
Atp6v0b
ATPase, H+ transporting, lysosomal V0 subunit B
chr2_+_174171525 0.608 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr11_+_78312784 0.597 Vtn
vitronectin
chr1_-_137063881 0.590 Gpr37l1
G protein-coupled receptor 37-like 1
chr10_+_101974855 0.585 NM_146240
Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr11_-_100632238 0.579 NM_031871
Ghdc
GH3 domain containing
chr11_+_75813413 0.579 NM_198637
1700016K19Rik
RIKEN cDNA 1700016K19 gene
chr4_-_150026205 0.569 NM_173774
Slc45a1
solute carrier family 45, member 1
chrX_-_20508584 0.568 NM_008823
Cfp
complement factor properdin
chr19_-_55177562 0.567 Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
chr18_+_37560490 0.557 NM_053134
Pcdhb9
protocadherin beta 9
chr9_+_56712829 0.552 Cspg4
chondroitin sulfate proteoglycan 4
chr11_-_55233354 0.545 Sparc
secreted acidic cysteine rich glycoprotein
chr3_-_123375305 0.540 NM_031186
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr6_+_125502943 0.539 Vwf
Von Willebrand factor homolog
chr2_+_31951149 0.537 NM_145521
Ppapdc3
phosphatidic acid phosphatase type 2 domain containing 3
chr10_+_59762775 0.537 Psap
prosaposin
chr8_-_83404256 0.531


chr3_+_135488454 0.530 NM_026228
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr4_+_149022266 0.512


chr9_-_64585562 0.512 NM_017382
Rab11a
RAB11a, member RAS oncogene family
chr4_+_41709182 0.505 NM_010549
Il11ra1
interleukin 11 receptor, alpha chain 1
chr8_+_13785611 0.498 NM_025924
Upf3a
UPF3 regulator of nonsense transcripts homolog A (yeast)
chr4_-_96220294 0.495 NM_010008
Cyp2j6
cytochrome P450, family 2, subfamily j, polypeptide 6
chr17_-_37160143 0.492 Mog
myelin oligodendrocyte glycoprotein
chr9_-_37062963 0.488 Slc37a2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr11_+_119961534 0.485


chr4_+_102432879 0.480 Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr14_-_32454060 0.474 Hacl1
2-hydroxyacyl-CoA lyase 1
chr19_-_7877136 0.474 NM_146232
BC014805
cDNA sequence BC014805
chr4_+_151470827 0.472 NM_001004156
Plekhg5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr13_+_113296053 0.470 Il6st
interleukin 6 signal transducer
chr11_-_48684659 0.466 NM_008326
Irgm1
immunity-related GTPase family M member 1
chr9_+_111277323 0.465 Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
chr6_-_126116761 0.459 NM_001164034
NM_008742
Ntf3

neurotrophin 3

chr5_-_31597792 0.455 NM_022424
Fndc4
fibronectin type III domain containing 4
chrX_+_12164878 0.451 NM_027439
Atp6ap2
ATPase, H+ transporting, lysosomal accessory protein 2
chr2_+_177876635 0.449 NM_028806
Phactr3
phosphatase and actin regulator 3
chr19_+_4855128 0.442 NM_019861
Ctsf
cathepsin F
chr19_+_6384413 0.431 NM_011224
Pygm
muscle glycogen phosphorylase
chr11_+_54128404 0.431 NM_001033599
Acsl6
acyl-CoA synthetase long-chain family member 6
chr15_+_76490272 0.427 Kifc2
kinesin family member C2
chr3_+_115711207 0.421 NM_001163514
Extl2
exostoses (multiple)-like 2
chr7_-_52230117 0.413 NM_153679
Cpt1c
carnitine palmitoyltransferase 1c
chr4_+_154929136 0.408 Gnb1
guanine nucleotide binding protein (G protein), beta 1
chr15_-_79192753 0.405 Tmem184b
transmembrane protein 184b
chr14_+_57194455 0.402 NM_001145978
Parp4
poly (ADP-ribose) polymerase family, member 4
chr11_-_55125758 0.398 NM_001029988
Fat2
FAT tumor suppressor homolog 2 (Drosophila)
chr12_+_105644917 0.398 NM_009252
Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
chr1_-_39535525 0.398 NM_018775
Tbc1d8
TBC1 domain family, member 8
chr12_-_101397818 0.395 NM_183155
BC002230
cDNA sequence BC002230
chr18_+_37467108 0.387 NM_053129
Pcdhb4
protocadherin beta 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
7.90 4.08e-03 GO:0031644 regulation of neurological system process
5.68 5.25e-03 GO:0044057 regulation of system process
8.10 1.33e-02 GO:0050804 regulation of synaptic transmission
7.51 2.14e-02 GO:0051969 regulation of transmission of nerve impulse
18.49 3.38e-02 GO:0050806 positive regulation of synaptic transmission
17.07 4.64e-02 GO:0051971 positive regulation of transmission of nerve impulse

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.12 8.83e-04 GO:0005886 plasma membrane
2.08 1.38e-03 GO:0071944 cell periphery
11.38 1.56e-03 GO:0044420 extracellular matrix part
6.26 4.44e-03 GO:0005578 proteinaceous extracellular matrix
4.66 5.84e-03 GO:0045202 synapse
3.37 6.45e-03 GO:0044421 extracellular region part
5.50 1.09e-02 GO:0031012 extracellular matrix
5.34 1.35e-02 GO:0044456 synapse part
1.49 2.04e-02 GO:0016020 membrane
25.60 2.30e-02 GO:0005581 collagen
3.51 3.04e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment p-value GO term description
1.78 1.99e-03 GO:0005515 protein binding