Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 2.035

Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

NameEntrezDescription
Hbp1 73389 high mobility group box transcription factor 1
Hmgb2 97165 high mobility group box 2
Hmgb3 15354 high mobility group box 3
Ssrp1 20833 structure specific recognition protein 1
Ubtf 21429 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Ubtfchr11_-_102180374-0.726.4e-07Click!
Ssrp1chr2_+_848774280.625.7e-05Click!
Hmgb3chrX_+_688091630.582.1e-04Click!
Hbp1chr12_-_326350610.163.5e-01Click!
Hmgb2chr8_+_599906390.057.5e-01Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr1_-_140739020 52.269 NM_001025565
NM_001042577
Lhx9

LIM homeobox protein 9

chr7_-_56892061 46.218 NM_001005232
Dbx1
developing brain homeobox 1
chr3_+_133899454 25.676 Cxxc4
CXXC finger 4
chr1_-_42749940 24.058 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr13_+_95645581 21.064 NM_011021
Otp
orthopedia homolog (Drosophila)
chr6_-_12699189 19.769 NM_001164805
Thsd7a
thrombospondin, type I, domain containing 7A
chr6_+_15135505 17.567 NM_212435
Foxp2
forkhead box P2
chr4_-_6917628 12.757 NM_145711
Tox
thymocyte selection-associated high mobility group box
chr1_+_9591550 12.387 3110035E14Rik
RIKEN cDNA 3110035E14 gene
chr3_+_127336055 11.755 NM_009718
Neurog2
neurogenin 2
chr18_-_15309939 11.641 NM_134112
Kctd1
potassium channel tetramerisation domain containing 1
chr5_+_48374328 11.072 NM_178804
Slit2
slit homolog 2 (Drosophila)
chr13_-_56353523 10.788 NM_010896
Neurog1
neurogenin 1
chr10_+_17516024 10.592 NM_138628
Txlnb
taxilin beta
chr18_-_46372017 9.928 NM_178872
Trim36
tripartite motif-containing 36
chr2_-_59963586 9.465 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr2_-_65405546 9.398 NM_018732
Scn3a
sodium channel, voltage-gated, type III, alpha
chr1_-_176851949 8.747 NM_011825
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr2_+_181498036 8.503 NM_001171615
Myt1
myelin transcription factor 1
chr2_-_56967331 8.107 NM_013613
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr11_+_93905557 7.887 Spag9
sperm associated antigen 9
chr1_-_12980994 7.881 NM_172841
Slco5a1
solute carrier organic anion transporter family, member 5A1
chr3_+_101814059 7.867 NM_178777
Nhlh2
nescient helix loop helix 2
chr13_-_60278723 7.864 Gas1
growth arrest specific 1
chr3_-_66100663 7.627 NM_145820
Veph1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr16_+_52031733 7.585 Cblb
Casitas B-lineage lymphoma b
chr9_-_82868992 7.513 Phip
pleckstrin homology domain interacting protein
chr17_+_17539832 7.463 Lix1
limb expression 1 homolog (chicken)
chr4_-_6917964 7.274 Tox
thymocyte selection-associated high mobility group box
chr8_+_46593141 7.250 NM_172752
Sorbs2
sorbin and SH3 domain containing 2
chr1_+_42752608 6.882


chr14_-_109313298 6.832 Slitrk1
SLIT and NTRK-like family, member 1
chr2_+_25036276 6.821 NM_025980
Nrarp
Notch-regulated ankyrin repeat protein
chr18_-_75120759 6.776 NM_010720
Lipg
lipase, endothelial
chr9_+_96159666 6.544 NM_001184710
NM_001184711
Tfdp2

transcription factor Dp 2

chrX_+_104115963 6.530 NM_175271
Lpar4
lysophosphatidic acid receptor 4
chrX_+_139952975 6.508 NM_001195048
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr16_+_52031704 6.388 Cblb
Casitas B-lineage lymphoma b
chr5_+_111846284 6.346 Mn1
meningioma 1
chr7_-_91827857 6.274 NM_022985
Zfand6
zinc finger, AN1-type domain 6
chr3_+_94282235 6.183 Celf3
VCUGBP, Elav-like family member 3
chr10_-_86956393 6.123 NM_008553
Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr6_-_71582871 6.068 NM_001038695
Kdm3a
lysine (K)-specific demethylase 3A
chr4_+_13670582 5.908 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_+_106614513 5.888 NM_028145
Klhl35
kelch-like 35 (Drosophila)
chr12_+_104553168 5.881 NM_001195726
Fam181a
family with sequence similarity 181, member A
chr9_+_64988960 5.877 NM_008988
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr6_+_17699145 5.863 NM_001083315
NM_022332
St7

suppression of tumorigenicity 7

chr10_-_36855292 5.786 Marcks
myristoylated alanine rich protein kinase C substrate
chr14_-_34195326 5.758 Mapk8
mitogen-activated protein kinase 8
chr10_-_117252126 5.750


chr15_-_26825266 5.665 NM_176959
Fbxl7
F-box and leucine-rich repeat protein 7
chr5_+_28492235 5.662 NM_010134
En2
engrailed 2
chr5_-_135028197 5.658 NM_001039162
NM_009990
Clip2

CAP-GLY domain containing linker protein 2

chr5_-_67490295 5.554 NM_008888
Phox2b
paired-like homeobox 2b
chr1_+_19198994 5.552 NM_009334
Tcfap2b
transcription factor AP-2 beta
chr2_-_73613381 5.550 NM_001113246
NM_001166603
Chn1

chimerin (chimaerin) 1

chr16_-_17125198 5.505 NM_183287
2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr19_-_46114019 5.494 NM_010697
Ldb1
LIM domain binding 1
chr4_+_48598013 5.426 NM_021436
Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr2_-_29701764 5.346 Gm3088
predicted gene 3088
chr10_+_57206184 5.330 NM_008297
Hsf2
heat shock factor 2
chr1_-_46910333 5.330 NM_172653
Slc39a10
solute carrier family 39 (zinc transporter), member 10
chr6_-_39156609 5.322 Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr1_-_128634766 5.302 Nckap5
NCK-associated protein 5
chr12_+_30219982 5.301 Myt1l
myelin transcription factor 1-like
chr2_-_59963796 5.261 NM_001001182
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr3_+_34548916 5.254 NM_011443
Sox2
SRY-box containing gene 2
chr5_-_92512683 5.244 NM_001080795
NM_011816
G3bp2

GTPase activating protein (SH3 domain) binding protein 2

chr6_+_64992861 5.236 Smarcad1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr2_-_51004604 5.231 NM_028810
Rnd3
Rho family GTPase 3
chr3_+_5218545 5.228 NM_030708
Zfhx4
zinc finger homeodomain 4
chr16_-_44558929 5.221 NM_172506
Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr1_+_34062720 5.134 Dst
dystonin
chr4_-_21612991 5.128 NM_001080771
Prdm13
PR domain containing 13
chr6_+_64992810 5.111 Smarcad1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr4_-_109960078 5.108 NM_001038698
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr8_-_64238879 5.004 Palld
palladin, cytoskeletal associated protein
chr15_+_98465193 4.962 NM_007581
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr14_-_104867215 4.938 NM_011143
Pou4f1
POU domain, class 4, transcription factor 1
chr18_-_43552694 4.924 NM_009468
Dpysl3
dihydropyrimidinase-like 3
chr11_-_40508405 4.903 Mat2b
methionine adenosyltransferase II, beta
chr7_+_87171113 4.889 NM_175433
Zfp710
zinc finger protein 710
chr10_+_43298969 4.787 NM_009846
Cd24a
CD24a antigen
chr9_+_61220162 4.776 NM_001083927
NM_001083928
NM_009389
Tle3


transducin-like enhancer of split 3, homolog of Drosophila E(spl)


chr10_+_79612410 4.756 Midn
midnolin
chr6_-_51416921 4.739 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr8_-_86760940 4.737 NM_172503
Zswim4
zinc finger, SWIM domain containing 4
chr4_+_122673318 4.733 NM_008506
Mycl1
v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
chr16_-_96349292 4.685 NM_008251
Hmgn1
high mobility group nucleosomal binding domain 1
chr17_-_71199129 4.682 NM_001164076
Tgif1
TGFB-induced factor homeobox 1
chr13_-_54789064 4.680 Rnf44
ring finger protein 44
chr6_-_31513817 4.630 NM_013723
Podxl
podocalyxin-like
chr4_-_91042997 4.608 NM_001177883
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_+_155596555 4.597 NM_011882
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr18_-_16966954 4.562 Cdh2
cadherin 2
chr9_+_55388955 4.529 NM_027397
Isl2
insulin related protein 2 (islet 2)
chr3_+_89019126 4.510 Thbs3
thrombospondin 3
chr2_+_61642509 4.494 NM_009322
Tbr1
T-box brain gene 1
chr18_+_35758269 4.446 NM_026420
Paip2
polyadenylate-binding protein-interacting protein 2
chr9_-_49606959 4.436 Ncam1
neural cell adhesion molecule 1
chr2_+_34631124 4.428 Hspa5
heat shock protein 5
chr8_+_63703064 4.405 Sh3rf1
SH3 domain containing ring finger 1
chr11_-_77707282 4.400 NM_008952
Pipox
pipecolic acid oxidase
chr10_+_68996455 4.383 NM_146005
NM_170688
NM_170689
NM_170690
NM_170728
NM_170729
NM_170730
Ank3






ankyrin 3, epithelial






chr18_+_65048630 4.286 Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr12_+_53800369 4.175 NM_198111
Akap6
A kinase (PRKA) anchor protein 6
chr16_-_32079317 4.092 NM_177326
Pak2
p21 protein (Cdc42/Rac)-activated kinase 2
chr16_+_19760300 4.090 NM_001159407
NM_001159408
NM_054052
B3gnt5


UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5


chr3_-_145312928 4.076 NM_010516
Cyr61
cysteine rich protein 61
chr10_-_61246611 4.064 NM_207000
H2afy2
H2A histone family, member Y2
chr7_-_134758707 4.030 Zfp629
zinc finger protein 629
chr6_+_64992584 3.982 NM_007958
Smarcad1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr9_-_110526866 3.945 NM_026012
Nradd
neurotrophin receptor associated death domain
chr4_-_3865501 3.880 NM_019969
Plag1
pleiomorphic adenoma gene 1
chr9_-_69608633 3.874 NM_022378
Foxb1
forkhead box B1
chr1_-_33871349 3.855 Zfp451
zinc finger protein 451
chr15_-_95358674 3.846 Nell2
NEL-like 2 (chicken)
chr5_-_138721164 3.833 NM_172412
Gpc2
glypican 2 (cerebroglycan)
chr7_+_134376574 3.754 Zfp553
zinc finger protein 553
chr17_-_28046158 3.695 Taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr8_+_130882920 3.690 NM_008737
Nrp1
neuropilin 1
chr12_+_82049290 3.663 Srsf5
serine/arginine-rich splicing factor 5
chr4_+_111087610 3.652 NM_026279
Bend5
BEN domain containing 5
chr14_+_73637697 3.642 NM_175116
Lpar6
lysophosphatidic acid receptor 6
chr13_-_54788995 3.632 Rnf44
ring finger protein 44
chr19_+_40905768 3.553 NM_172839
Ccnj
cyclin J
chr16_+_17070249 3.537 NM_023249
Ypel1
yippee-like 1 (Drosophila)
chr5_+_90889913 3.507 NM_009654
Alb
albumin
chrX_+_93651684 3.489 NM_001159627
NM_181273
Heph

hephaestin

chr5_+_93696566 3.478 NM_007635
Ccng2
cyclin G2
chr4_-_20705698 3.435 NM_172987
Nkain3
Na+/K+ transporting ATPase interacting 3
chr13_+_88961161 3.385 Edil3
EGF-like repeats and discoidin I-like domains 3
chr11_+_20125239 3.370 Rab1
RAB1, member RAS oncogene family
chr1_+_174412343 3.369 NM_001145800
NM_033608
Igsf9

immunoglobulin superfamily, member 9

chr5_-_89104575 3.359 NM_001098476
Grsf1
G-rich RNA sequence binding factor 1
chr5_+_77694506 3.353 NM_011263
Rest
RE1-silencing transcription factor
chr2_+_78709363 3.318 Ube2e3
ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog (yeast)
chr6_-_49164469 3.318 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chrX_-_137077133 3.317 Tsc22d3
TSC22 domain family, member 3
chr4_-_131604821 3.312 NM_001128606
Epb4.1
erythrocyte protein band 4.1
chrX_-_6765768 3.311 NM_016691
Clcn5
chloride channel 5
chr18_+_73732352 3.285 NM_001039214
Mex3c
mex3 homolog C (C. elegans)
chr3_+_121129396 3.284 NM_028044
Cnn3
calponin 3, acidic
chr5_+_13399492 3.281 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr2_+_34631438 3.272 Hspa5
heat shock protein 5
chr3_-_83844042 3.260 NM_172681
D930015E06Rik
RIKEN cDNA D930015E06 gene
chr6_+_120314442 3.253 Kdm5a
lysine (K)-specific demethylase 5A
chr14_-_111154292 3.223 NM_175499
Slitrk6
SLIT and NTRK-like family, member 6
chr4_-_77857594 3.209 Ptprd
protein tyrosine phosphatase, receptor type, D
chr6_-_148893155 3.181 Fam60a
family with sequence similarity 60, member A
chr1_-_195196423 3.173 NM_144817
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr4_-_91066674 3.168 NM_207685
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr5_+_73398142 3.161 NM_173403
Slc10a4
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr4_+_129190877 3.154 Marcksl1
MARCKS-like 1
chr19_-_14672540 3.152 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr3_-_122322556 3.151 NM_001114665
NM_153118
Fnbp1l

formin binding protein 1-like

chr4_+_13670425 3.139 NM_001111026
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr15_-_76983985 3.118 NM_001110828
NM_001110829
NM_001110830
Rbfox2


RNA binding protein, fox-1 homolog (C. elegans) 2


chr3_-_49561168 3.108 NM_130448
Pcdh18
protocadherin 18
chr16_+_5086296 3.102


chr5_+_36236113 3.092 Afap1
actin filament associated protein 1
chr6_+_107479719 3.084 NM_008516
Lrrn1
leucine rich repeat protein 1, neuronal
chr12_-_32398730 3.067 NM_175191
Gpr22
G protein-coupled receptor 22
chr11_+_60513191 3.050 NM_001159404
NM_001159405
NM_008502
Llgl1


lethal giant larvae homolog 1 (Drosophila)


chr2_+_44966657 3.037 NM_001177394
Gm13476
predicted gene 13476
chrX_-_140261831 3.029 Capn6
calpain 6
chr2_+_14976877 3.021 NM_029466
Arl5b
ADP-ribosylation factor-like 5B
chr19_-_14672472 3.005 NM_011600
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr13_+_22036962 3.004 NM_183014
Zfp184
zinc finger protein 184 (Kruppel-like)
chr3_+_17695743 3.001 6430547I21Rik
RIKEN cDNA 6430547I21 gene
chr12_-_35213738 2.995 NM_024124
Hdac9
histone deacetylase 9
chr1_-_153347884 2.995 NM_011277
Rnf2
ring finger protein 2
chrX_-_9793824 2.974 NM_001177950
NM_001177951
NM_001177953
NM_001177954
NM_011285
Rpgr




retinitis pigmentosa GTPase regulator




chr9_-_50535949 2.947 NM_178118
Dixdc1
DIX domain containing 1
chrX_+_98624989 2.926 NM_023144
Nono
non-POU-domain-containing, octamer binding protein
chr2_-_74497475 2.922 NM_007967
Evx2
even skipped homeotic gene 2 homolog
chr4_-_133309484 2.921 NM_001080819
Arid1a
AT rich interactive domain 1A (SWI-like)
chr6_+_17015159 2.920 Tes
testis derived transcript
chr2_+_154262114 2.878 NM_009823
NM_172860
Cbfa2t2

core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)

chr6_-_3444484 2.867 NM_178899
Hepacam2
HEPACAM family member 2
chr8_-_8667108 2.853 Arglu1
arginine and glutamate rich 1
chr7_+_103358652 2.851 Odz4
odd Oz/ten-m homolog 4 (Drosophila)
chr12_-_86113948 2.850 NM_023409
Npc2
Niemann Pick type C2
chr13_-_40829082 2.839 NM_011547
Tcfap2a
transcription factor AP-2, alpha
chr11_+_93905443 2.835 Spag9
sperm associated antigen 9
chr17_+_17539908 2.834 Lix1
limb expression 1 homolog (chicken)
chr10_-_26095736 2.830 L3mbtl3
l(3)mbt-like 3 (Drosophila)
chr9_-_49606862 2.806 Ncam1
neural cell adhesion molecule 1
chr11_-_94154354 2.806 Luc7l3
LUC7-like 3 (S. cerevisiae)
chr17_+_78907402 2.798 NM_001197028
NM_028813
Vit

vitrin

chr14_-_52723590 2.797 NM_001170981
NM_001170982
NM_001170983
NM_001170984
NM_016884
Hnrnpc




heterogeneous nuclear ribonucleoprotein C




chr11_+_44430784 2.763


chr14_-_109313333 2.749 Slitrk1
SLIT and NTRK-like family, member 1
chrX_+_137909951 2.738 NM_001163155
NM_007736
Col4a5

collagen, type IV, alpha 5

chrX_+_35542969 2.716 NM_001079513
NM_020256
Zbtb33

zinc finger and BTB domain containing 33

chr7_-_29086780 2.707 NM_007866
Dll3
delta-like 3 (Drosophila)
chr3_+_37538808 2.707 NM_011896
Spry1
sprouty homolog 1 (Drosophila)
chr1_-_152840432 2.699 NM_001024720
Hmcn1
hemicentin 1
chr4_-_155571450 2.697 Agrn
agrin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.69 2.00e-37 GO:0010468 regulation of gene expression
2.82 8.44e-37 GO:0051252 regulation of RNA metabolic process
2.67 4.50e-34 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.75 2.54e-33 GO:0006355 regulation of transcription, DNA-dependent
2.62 3.60e-33 GO:0010556 regulation of macromolecule biosynthetic process
2.33 7.72e-33 GO:0060255 regulation of macromolecule metabolic process
2.70 3.75e-32 GO:0016070 RNA metabolic process
2.53 6.71e-32 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.50 2.75e-31 GO:0051171 regulation of nitrogen compound metabolic process
2.50 5.55e-31 GO:0031326 regulation of cellular biosynthetic process
2.24 1.29e-30 GO:0031323 regulation of cellular metabolic process
2.47 3.00e-30 GO:0009889 regulation of biosynthetic process
2.23 1.34e-29 GO:0080090 regulation of primary metabolic process
2.45 1.21e-28 GO:0090304 nucleic acid metabolic process
2.46 3.35e-27 GO:0010467 gene expression
2.88 5.68e-27 GO:0006351 transcription, DNA-dependent
2.87 6.84e-27 GO:0032774 RNA biosynthetic process
2.07 7.25e-27 GO:0019222 regulation of metabolic process
2.20 5.89e-25 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.89 3.03e-23 GO:0044260 cellular macromolecule metabolic process
2.11 1.42e-21 GO:0032502 developmental process
2.18 1.99e-21 GO:0007275 multicellular organismal development
2.03 7.28e-21 GO:0034641 cellular nitrogen compound metabolic process
1.99 2.65e-20 GO:0006807 nitrogen compound metabolic process
3.07 2.85e-20 GO:0007399 nervous system development
2.28 3.08e-19 GO:0034645 cellular macromolecule biosynthetic process
1.75 5.44e-19 GO:0043170 macromolecule metabolic process
2.26 6.95e-19 GO:0009059 macromolecule biosynthetic process
2.16 1.74e-18 GO:0048856 anatomical structure development
2.17 3.86e-16 GO:0048731 system development
2.28 5.57e-15 GO:0030154 cell differentiation
2.21 5.64e-14 GO:0048869 cellular developmental process
1.55 8.08e-14 GO:0044237 cellular metabolic process
3.18 1.23e-13 GO:0048699 generation of neurons
1.53 1.70e-13 GO:0044238 primary metabolic process
3.02 8.78e-13 GO:0022008 neurogenesis
1.44 1.62e-12 GO:0050794 regulation of cellular process
1.87 2.00e-12 GO:0044249 cellular biosynthetic process
1.41 8.56e-12 GO:0050789 regulation of biological process
1.82 2.64e-11 GO:0009058 biosynthetic process
1.38 5.16e-11 GO:0065007 biological regulation
3.63 2.51e-10 GO:0007417 central nervous system development
2.33 3.74e-10 GO:0009653 anatomical structure morphogenesis
2.98 4.87e-10 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.91 7.49e-10 GO:0010558 negative regulation of macromolecule biosynthetic process
1.84 7.82e-10 GO:0048518 positive regulation of biological process
2.87 8.85e-10 GO:0031327 negative regulation of cellular biosynthetic process
1.97 1.28e-09 GO:0048523 negative regulation of cellular process
3.07 2.01e-09 GO:0045892 negative regulation of transcription, DNA-dependent
1.41 2.11e-09 GO:0008152 metabolic process
2.80 2.37e-09 GO:0009890 negative regulation of biosynthetic process
2.93 2.71e-09 GO:0010629 negative regulation of gene expression
3.96 3.54e-09 GO:0016568 chromatin modification
3.02 3.58e-09 GO:0051253 negative regulation of RNA metabolic process
2.63 6.27e-09 GO:2000026 regulation of multicellular organismal development
3.67 8.65e-09 GO:0007389 pattern specification process
3.17 8.81e-09 GO:0030182 neuron differentiation
1.85 9.47e-09 GO:0048522 positive regulation of cellular process
3.83 9.61e-09 GO:0007420 brain development
3.64 1.11e-08 GO:0006325 chromatin organization
2.05 1.23e-08 GO:0048513 organ development
2.63 1.42e-08 GO:0048468 cell development
2.81 2.04e-08 GO:0051172 negative regulation of nitrogen compound metabolic process
1.23 2.59e-08 GO:0009987 cellular process
1.91 3.34e-08 GO:0071842 cellular component organization at cellular level
2.80 3.71e-08 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.14 5.95e-08 GO:0051276 chromosome organization
3.43 6.90e-08 GO:0060284 regulation of cell development
2.42 8.97e-08 GO:0031324 negative regulation of cellular metabolic process
2.38 9.73e-08 GO:0050793 regulation of developmental process
1.83 9.83e-08 GO:0048519 negative regulation of biological process
2.41 1.07e-07 GO:0010605 negative regulation of macromolecule metabolic process
4.08 1.20e-07 GO:0003002 regionalization
2.61 1.35e-07 GO:0045595 regulation of cell differentiation
1.85 1.66e-07 GO:0071841 cellular component organization or biogenesis at cellular level
2.40 1.72e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
3.58 4.25e-07 GO:0050767 regulation of neurogenesis
3.50 4.35e-07 GO:0016071 mRNA metabolic process
2.54 9.07e-07 GO:0051254 positive regulation of RNA metabolic process
2.26 1.07e-06 GO:0009892 negative regulation of metabolic process
3.30 1.14e-06 GO:0051093 negative regulation of developmental process
4.53 1.17e-06 GO:0009952 anterior/posterior pattern formation
2.53 1.53e-06 GO:0045893 positive regulation of transcription, DNA-dependent
3.56 1.70e-06 GO:0045596 negative regulation of cell differentiation
3.30 1.96e-06 GO:0051960 regulation of nervous system development
1.67 2.77e-06 GO:0016043 cellular component organization
2.72 3.40e-06 GO:0040011 locomotion
2.41 4.00e-06 GO:0010628 positive regulation of gene expression
2.35 4.52e-06 GO:0009888 tissue development
4.59 4.56e-06 GO:0016055 Wnt receptor signaling pathway
3.69 5.07e-06 GO:0008380 RNA splicing
4.04 5.67e-06 GO:0007409 axonogenesis
3.04 1.00e-05 GO:0048666 neuron development
2.25 1.12e-05 GO:0031328 positive regulation of cellular biosynthetic process
6.57 1.13e-05 GO:0030902 hindbrain development
1.63 1.19e-05 GO:0071840 cellular component organization or biogenesis
2.99 1.46e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
2.30 1.46e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
3.51 1.58e-05 GO:0006397 mRNA processing
3.30 1.95e-05 GO:0031175 neuron projection development
3.37 2.15e-05 GO:0000904 cell morphogenesis involved in differentiation
2.21 2.27e-05 GO:0009891 positive regulation of biosynthetic process
2.29 2.31e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.43 2.41e-05 GO:0032501 multicellular organismal process
3.53 2.49e-05 GO:0045664 regulation of neuron differentiation
3.68 3.73e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
2.31 4.12e-05 GO:0009790 embryo development
2.23 5.34e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.91 5.67e-05 GO:0051239 regulation of multicellular organismal process
1.98 6.62e-05 GO:0010604 positive regulation of macromolecule metabolic process
2.85 7.86e-05 GO:0048598 embryonic morphogenesis
3.52 9.14e-05 GO:0048812 neuron projection morphogenesis
1.95 1.36e-04 GO:0031325 positive regulation of cellular metabolic process
1.91 1.55e-04 GO:0009893 positive regulation of metabolic process
2.08 2.44e-04 GO:0010941 regulation of cell death
2.56 3.22e-04 GO:0051094 positive regulation of developmental process
2.89 3.69e-04 GO:0016477 cell migration
3.57 4.48e-04 GO:0030900 forebrain development
4.53 8.23e-04 GO:0007411 axon guidance
2.05 8.72e-04 GO:0042981 regulation of apoptosis
2.65 1.05e-03 GO:0006928 cellular component movement
2.02 1.26e-03 GO:0043067 regulation of programmed cell death
2.67 1.29e-03 GO:0048870 cell motility
2.67 1.29e-03 GO:0051674 localization of cell
2.68 1.87e-03 GO:0060429 epithelium development
2.37 2.04e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
3.06 2.20e-03 GO:0002009 morphogenesis of an epithelium
2.60 2.40e-03 GO:0000902 cell morphogenesis
6.74 2.98e-03 GO:0045665 negative regulation of neuron differentiation
3.56 3.02e-03 GO:0016570 histone modification
2.91 3.28e-03 GO:0048858 cell projection morphogenesis
3.69 3.38e-03 GO:0045165 cell fate commitment
3.27 3.48e-03 GO:0035239 tube morphogenesis
3.51 3.83e-03 GO:0016569 covalent chromatin modification
2.64 3.87e-03 GO:0045597 positive regulation of cell differentiation
5.33 3.90e-03 GO:0009953 dorsal/ventral pattern formation
2.86 4.68e-03 GO:0032990 cell part morphogenesis
2.42 5.00e-03 GO:0043009 chordate embryonic development
2.46 5.01e-03 GO:0032989 cellular component morphogenesis
1.77 5.01e-03 GO:0006996 organelle organization
2.38 5.15e-03 GO:0048646 anatomical structure formation involved in morphogenesis
28.05 5.42e-03 GO:0070934 CRD-mediated mRNA stabilization
4.42 5.59e-03 GO:0021915 neural tube development
2.39 6.81e-03 GO:0009792 embryo development ending in birth or egg hatching
3.37 7.06e-03 GO:0032582 negative regulation of gene-specific transcription
2.34 7.27e-03 GO:0006396 RNA processing
3.22 7.89e-03 GO:0048732 gland development
2.61 1.04e-02 GO:0048729 tissue morphogenesis
6.44 1.47e-02 GO:0021536 diencephalon development
2.51 1.50e-02 GO:0032583 regulation of gene-specific transcription
4.95 2.14e-02 GO:0001764 neuron migration
4.53 2.21e-02 GO:0007369 gastrulation
2.32 2.27e-02 GO:0030030 cell projection organization
1.65 2.58e-02 GO:0006464 protein modification process
3.63 2.95e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
3.63 2.95e-02 GO:0022604 regulation of cell morphogenesis
2.41 2.99e-02 GO:0040008 regulation of growth
2.62 3.10e-02 GO:0035295 tube development
10.02 3.34e-02 GO:0048640 negative regulation of developmental growth
1.61 4.12e-02 GO:0043412 macromolecule modification
4.21 4.65e-02 GO:0021953 central nervous system neuron differentiation
2.23 4.89e-02 GO:0010942 positive regulation of cell death

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.04 7.73e-36 GO:0005634 nucleus
1.40 1.61e-22 GO:0005622 intracellular
1.41 5.38e-22 GO:0044424 intracellular part
1.45 5.22e-19 GO:0043229 intracellular organelle
1.44 9.32e-19 GO:0043226 organelle
1.48 8.25e-18 GO:0043231 intracellular membrane-bounded organelle
1.48 1.20e-17 GO:0043227 membrane-bounded organelle
2.40 6.42e-17 GO:0044428 nuclear part
2.33 3.95e-12 GO:0031981 nuclear lumen
3.02 4.39e-11 GO:0044451 nucleoplasm part
2.51 4.59e-10 GO:0005654 nucleoplasm
2.07 1.44e-09 GO:0031974 membrane-enclosed lumen
2.07 2.32e-09 GO:0070013 intracellular organelle lumen
2.06 2.58e-09 GO:0043233 organelle lumen
1.15 1.77e-07 GO:0005623 cell
1.15 1.77e-07 GO:0044464 cell part
1.47 1.39e-05 GO:0044446 intracellular organelle part
3.22 1.50e-05 GO:0005667 transcription factor complex
1.46 1.81e-05 GO:0044422 organelle part
1.49 2.39e-04 GO:0032991 macromolecular complex
1.52 7.18e-04 GO:0043234 protein complex
28.05 8.09e-04 GO:0070937 CRD-mediated mRNA stability complex
23.37 2.37e-03 GO:0016342 catenin complex
1.53 2.54e-03 GO:0043228 non-membrane-bounded organelle
1.53 2.54e-03 GO:0043232 intracellular non-membrane-bounded organelle
35.06 5.84e-03 GO:0071664 catenin-TCF7L2 complex
2.15 6.65e-03 GO:0043005 neuron projection
17.53 1.06e-02 GO:0005915 zonula adherens
2.49 1.07e-02 GO:0044297 cell body
1.64 1.49e-02 GO:0005856 cytoskeleton
15.58 1.86e-02 GO:0071564 npBAF complex
1.73 2.06e-02 GO:0042995 cell projection
3.98 2.51e-02 GO:0000790 nuclear chromatin
9.74 2.95e-02 GO:0070603 SWI/SNF-type complex
2.40 3.84e-02 GO:0043025 neuronal cell body
9.23 3.91e-02 GO:0031519 PcG protein complex
12.75 4.66e-02 GO:0071565 nBAF complex

Gene overrepresentation in function category:

enrichment p-value GO term description
2.44 6.02e-28 GO:0003676 nucleic acid binding
1.44 9.29e-27 GO:0005488 binding
2.52 1.17e-19 GO:0003677 DNA binding
1.61 2.13e-15 GO:0005515 protein binding
2.92 4.87e-14 GO:0030528 transcription regulator activity
3.02 1.42e-12 GO:0001071 nucleic acid binding transcription factor activity
3.02 1.42e-12 GO:0003700 sequence-specific DNA binding transcription factor activity
2.76 5.05e-09 GO:0003723 RNA binding
2.15 1.88e-08 GO:0008270 zinc ion binding
2.77 2.50e-08 GO:0043565 sequence-specific DNA binding
3.59 1.43e-07 GO:0016564 transcription repressor activity
1.98 1.52e-07 GO:0046914 transition metal ion binding
3.63 1.18e-04 GO:0003682 chromatin binding
1.49 1.87e-04 GO:0046872 metal ion binding
1.47 3.61e-04 GO:0043169 cation binding
1.46 4.43e-04 GO:0043167 ion binding
2.39 6.24e-04 GO:0019904 protein domain specific binding
28.05 9.91e-04 GO:0042153 RPTP-like protein binding
1.59 1.21e-03 GO:0000166 nucleotide binding
1.92 7.43e-03 GO:0019899 enzyme binding
5.08 7.59e-03 GO:0003704 specific RNA polymerase II transcription factor activity
2.55 8.90e-03 GO:0016563 transcription activator activity
2.80 1.14e-02 GO:0019901 protein kinase binding
2.82 1.55e-02 GO:0003712 transcription cofactor activity
2.81 1.64e-02 GO:0000989 transcription factor binding transcription factor activity
2.78 1.94e-02 GO:0000988 protein binding transcription factor activity
14.02 3.71e-02 GO:0045295 gamma-catenin binding
2.46 4.73e-02 GO:0019900 kinase binding