Motif ID: HIC1.p2

Z-value: 1.402

Transcription factors associated with HIC1.p2:

NameEntrezDescription
Hic1 15248 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Hic1chr11_-_749825510.325.7e-02Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr5_+_37259780 4.982 NM_172994
Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr11_-_5965626 4.657 Camk2b
calcium/calmodulin-dependent protein kinase II, beta
chr11_+_6963421 4.645 NM_009622
Adcy1
adenylate cyclase 1
chr5_+_37259906 3.917 Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr11_+_49715292 3.418 NM_029004
Rasgef1c
RasGEF domain family, member 1C
chr19_-_5085487 3.362 Tmem151a
transmembrane protein 151A
chr10_+_79179326 3.352 NM_008226
Hcn2
hyperpolarization-activated, cyclic nucleotide-gated K+ 2
chr11_-_75609557 3.195 NM_007873
Doc2b
double C2, beta
chr7_+_120351012 3.114 Arntl
aryl hydrocarbon receptor nuclear translocator-like
chr9_+_26541302 3.076 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr5_-_21850490 3.006 NM_011261
Reln
reelin
chr11_-_5965743 3.003 NM_001174053
NM_001174054
NM_007595
Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr4_-_136512727 2.923 NM_007939
Epha8
Eph receptor A8
chr2_+_155601077 2.923 NM_010808
Mmp24
matrix metallopeptidase 24
chr11_-_5965555 2.695 Camk2b
calcium/calmodulin-dependent protein kinase II, beta
chr2_+_156439426 2.388 NM_146128
Dlgap4
discs, large homolog-associated protein 4 (Drosophila)
chr7_+_73007017 2.363 NM_011048
Pcsk6
proprotein convertase subtilisin/kexin type 6
chr2_-_77654669 2.350 NM_178723
Zfp385b
zinc finger protein 385B
chr12_+_3806955 2.338 NM_007872
Dnmt3a
DNA methyltransferase 3A
chr14_+_35124004 2.300 Glud1
glutamate dehydrogenase 1
chr8_+_119780918 2.235 NM_001163262
4933407C03Rik
RIKEN cDNA 4933407C03 gene
chr2_+_28061156 2.094 NM_001038612
NM_019498
Olfm1

olfactomedin 1

chr9_+_60560923 2.025 NM_026235
Larp6
La ribonucleoprotein domain family, member 6
chr12_+_109793151 1.978 Evl
Ena-vasodilator stimulated phosphoprotein
chr4_-_134260127 1.967 NM_207237
Man1c1
mannosidase, alpha, class 1C, member 1
chr1_-_33964439 1.956 NM_177235
Bend6
BEN domain containing 6
chr5_-_139801315 1.900 NM_172723
Adap1
ArfGAP with dual PH domains 1
chr2_-_32702610 1.826 Stxbp1
syntaxin binding protein 1
chr2_+_135485242 1.821 Plcb4
phospholipase C, beta 4
chr3_-_9833502 1.799 NM_001195031
NM_053182
Pag1

phosphoprotein associated with glycosphingolipid microdomains 1

chr10_+_99478457 1.773 NM_013598
Kitl
kit ligand
chr6_+_38613031 1.763 NM_001101507
Clec2l
C-type lectin domain family, member L
chr14_-_103381744 1.750 NM_177715
Kctd12
potassium channel tetramerisation domain containing 12
chrX_+_66613505 1.632 NM_008032
Aff2
AF4/FMR2 family, member 2
chr19_+_10463540 1.628 NM_018801
NM_173067
NM_173068
Syt7


synaptotagmin VII


chr2_+_124436031 1.582 NM_172537
NM_199238
NM_199239
NM_199240
NM_199241
Sema6d




sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D




chr6_+_88674821 1.572 Mgll
monoglyceride lipase
chr8_-_88224652 1.532 Neto2
neuropilin (NRP) and tolloid (TLL)-like 2
chr5_-_125659422 1.526 NM_011424
Ncor2
nuclear receptor co-repressor 2
chr6_+_115084919 1.519 NM_001111015
NM_013681
Syn2

synapsin II

chr8_-_17535279 1.505 NM_053171
Csmd1
CUB and Sushi multiple domains 1
chr5_+_37633178 1.486 Crmp1
collapsin response mediator protein 1
chr9_-_42752453 1.479 NM_175481
Grik4
glutamate receptor, ionotropic, kainate 4
chr5_+_37633353 1.478 Crmp1
collapsin response mediator protein 1
chr5_+_37633317 1.478 NM_001136058
Crmp1
collapsin response mediator protein 1
chr17_-_67703726 1.467 NM_008984
Ptprm
protein tyrosine phosphatase, receptor type, M
chr6_-_137597775 1.457 Eps8
epidermal growth factor receptor pathway substrate 8
chr13_-_49063376 1.445 Fam120a
family with sequence similarity 120, member A
chr17_+_86567003 1.431 NM_011104
Prkce
protein kinase C, epsilon
chr12_+_72410755 1.431 NM_001190466
NM_021532
Dact1

dapper homolog 1, antagonist of beta-catenin (xenopus)

chr2_-_130867226 1.428 Gfra4
glial cell line derived neurotrophic factor family receptor alpha 4
chr1_-_137584672 1.424 Nav1
neuron navigator 1
chr19_+_47253484 1.417 Neurl1a
neuralized homolog 1A (Drosophila)
chr6_+_114081227 1.410 NM_172890
Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr4_-_45543623 1.404 NM_001033306
Shb
src homology 2 domain-containing transforming protein B
chr9_+_45238375 1.399 NM_001081270
Dscaml1
Down syndrome cell adhesion molecule-like 1
chr16_+_49855691 1.389 NM_010581
Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr13_-_52626065 1.385 NM_001024474
Diras2
DIRAS family, GTP-binding RAS-like 2
chr11_-_69419419 1.379 NM_013415
Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr8_+_24521967 1.371 NM_013834
Sfrp1
secreted frizzled-related protein 1
chr14_+_122874598 1.369 NM_009574
Zic2
zinc finger protein of the cerebellum 2
chr4_+_84851330 1.355 NM_019535
Sh3gl2
SH3-domain GRB2-like 2
chr9_+_110147867 1.334 Cspg5
chondroitin sulfate proteoglycan 5
chr2_-_168567436 1.331 Atp9a
ATPase, class II, type 9A
chr1_-_23389950 1.323 NM_001081079
Ogfrl1
opioid growth factor receptor-like 1
chr4_-_151235758 1.321 Camta1
calmodulin binding transcription activator 1
chr8_-_47296201 1.308 NM_007450
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr18_-_62071451 1.306 NM_198649
Ablim3
actin binding LIM protein family, member 3
chr18_-_62071494 1.283 NM_001164491
Ablim3
actin binding LIM protein family, member 3
chr12_+_75098739 1.280 NM_172804
Syt16
synaptotagmin XVI
chr11_-_30168153 1.277 Spnb2
spectrin beta 2
chr1_+_59970358 1.275 Fam117b
family with sequence similarity 117, member B
chr14_+_122874625 1.263 Zic2
zinc finger protein of the cerebellum 2
chr9_-_97933599 1.261 Clstn2
calsyntenin 2
chr6_-_131338282 1.243 Csda
cold shock domain protein A
chr8_-_87324043 1.241 NM_001081982
NM_010906
Nfix

nuclear factor I/X

chr17_-_26338106 1.229 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr2_-_181406313 1.209 NM_009236
Sox18
SRY-box containing gene 18
chr2_+_164311755 1.204 NM_026797
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr2_+_124436328 1.201 Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr7_+_53651811 1.198 NM_008421
NM_001112739
Kcnc1

potassium voltage gated channel, Shaw-related subfamily, member 1

chr13_-_54712629 1.194 NM_028870
Cltb
clathrin, light polypeptide (Lcb)
chr16_-_52453104 1.190 NM_009655
Alcam
activated leukocyte cell adhesion molecule
chr19_+_6497834 1.183


chr16_-_85173944 1.183 NM_001198823
NM_001198824
NM_001198825
NM_001198826
NM_007471
App




amyloid beta (A4) precursor protein




chr17_+_70318707 1.168 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr4_-_154417257 1.167 Plch2
phospholipase C, eta 2
chr11_-_30168142 1.160 Spnb2
spectrin beta 2
chr6_+_88674697 1.158 NM_001166250
NM_001166251
Mgll

monoglyceride lipase

chr19_+_53403902 1.148 NM_010847
Mxi1
Max interacting protein 1
chr2_+_28048592 1.142 NM_001038613
NM_001038614
Olfm1

olfactomedin 1

chr8_-_13494457 1.141 NM_019521
Gas6
growth arrest specific 6
chr19_+_45063750 1.136 NM_011976
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr10_-_80306743 1.126 NM_001013758
Lingo3
leucine rich repeat and Ig domain containing 3
chr3_+_105507516 1.126 NM_175398
6530418L21Rik
RIKEN cDNA 6530418L21 gene
chr2_-_32702729 1.110 NM_009295
NM_001113569
Stxbp1

syntaxin binding protein 1

chr17_-_63849928 1.107 NM_015794
Fbxl17
F-box and leucine-rich repeat protein 17
chr15_+_94459521 1.106 NM_178789
Tmem117
transmembrane protein 117
chr10_-_83111346 1.094 NM_145220
Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr2_-_162486792 1.073 Ptprt
protein tyrosine phosphatase, receptor type, T
chr1_+_89160921 1.073 NM_028889
Efhd1
EF hand domain containing 1
chr8_+_73017009 1.071 NM_018827
Crlf1
cytokine receptor-like factor 1
chr9_-_53916173 1.069 NM_001033535
Tnfaip8l3
tumor necrosis factor, alpha-induced protein 8-like 3
chr19_-_17912073 1.066 NM_001163144
NM_001190483
Pcsk5

proprotein convertase subtilisin/kexin type 5

chr4_+_97444312 1.062 NM_001122953
NM_010905
Nfia

nuclear factor I/A

chr17_-_24787217 1.061 NM_023055
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr5_-_113006173 1.055 NM_019982
Sez6l
seizure related 6 homolog like
chr10_+_122115755 1.053 NM_001110218
NM_176919
Ppm1h

protein phosphatase 1H (PP2C domain containing)

chr13_-_59658585 1.047 NM_001048008
NM_023328
Agtpbp1

ATP/GTP binding protein 1

chr7_+_29236897 1.045 NM_030562
Lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr16_+_49855786 1.040 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr8_-_112692071 1.039 NM_007586
Calb2
calbindin 2
chr8_+_86423968 1.034 NM_181039
Lphn1
latrophilin 1
chr18_+_58038278 1.034 NM_009194
Slc12a2
solute carrier family 12, member 2
chr7_+_147080594 1.030 NM_177261
Kndc1
kinase non-catalytic C-lobe domain (KIND) containing 1
chr1_+_87942437 1.026 NM_001144992
NM_001144993
2810459M11Rik

RIKEN cDNA 2810459M11 gene

chr15_+_88890140 0.997 NM_001002005
Panx2
pannexin 2
chr9_+_68501551 0.993 NM_013646
Rora
RAR-related orphan receptor alpha
chr7_+_150238626 0.992 NM_133655
Cd81
CD81 antigen
chr7_-_145589409 0.991 NM_183289
Tcerg1l
transcription elongation regulator 1-like
chr10_-_75807976 0.988 NM_001081419
Dip2a
DIP2 disco-interacting protein 2 homolog A (Drosophila)
chr4_-_138648762 0.985 NM_008675
Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr14_-_102007883 0.983 Tbc1d4
TBC1 domain family, member 4
chr1_-_31006599 0.982 NM_011200
Ptp4a1
protein tyrosine phosphatase 4a1
chr15_+_7079540 0.981 NM_001113386
Lifr
leukemia inhibitory factor receptor
chr13_+_38436987 0.969 Bmp6
bone morphogenetic protein 6
chr11_+_19824417 0.967 NM_033523
Spred2
sprouty-related, EVH1 domain containing 2
chr6_+_22825464 0.963 NM_001081306
Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr13_+_55050729 0.947 NM_153131
Unc5a
unc-5 homolog A (C. elegans)
chr5_-_147396407 0.944 Gpr12
G-protein coupled receptor 12
chr5_+_141717487 0.943 NM_177879
Sdk1
sidekick homolog 1 (chicken)
chr16_-_85173978 0.941 App
amyloid beta (A4) precursor protein
chr15_-_31460752 0.936 NM_172606
March6
membrane-associated ring finger (C3HC4) 6
chr17_+_27792487 0.936 Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr9_+_107302196 0.931 NM_001174047
NM_001174048
NM_001174049
NM_001174050
NM_020263
Cacna2d2




calcium channel, voltage-dependent, alpha 2/delta subunit 2




chr2_-_130867149 0.931 Gfra4
glial cell line derived neurotrophic factor family receptor alpha 4
chr16_+_31428887 0.926 Bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr12_+_113960379 0.919 NM_001024602
AW555464
expressed sequence AW555464
chr15_-_94234549 0.909 Adamts20
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
chr11_-_115128540 0.905 NM_010350
Grin2c
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
chr6_-_131338465 0.901 NM_011733
NM_139117
Csda

cold shock domain protein A

chr4_-_8166182 0.899 NM_007592
Car8
carbonic anhydrase 8
chr8_+_88016492 0.898 NM_173866
Gpt2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr17_+_70318387 0.894 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chrX_+_162676910 0.893 Gpm6b
glycoprotein m6b
chr3_-_127540408 0.892 NM_145964
Ap1ar
adaptor-related protein complex 1 associated regulatory protein
chr12_+_113960424 0.889 AW555464
expressed sequence AW555464
chr4_+_129662110 0.888 Bai2
brain-specific angiogenesis inhibitor 2
chr18_-_60908267 0.887 Ndst1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr6_-_115944822 0.886 NM_026376
Plxnd1
plexin D1
chr11_-_118216625 0.881 Timp2
tissue inhibitor of metalloproteinase 2
chr6_-_125444722 0.881 NM_007657
Cd9
CD9 antigen
chr2_-_32208737 0.880 NM_010065
Dnm1
dynamin 1
chr7_-_31514527 0.878 NM_027215
Tmem147
transmembrane protein 147
chr11_-_119908236 0.878 NM_001198785
NM_007377
Aatk

apoptosis-associated tyrosine kinase

chr17_-_26056379 0.874 NM_139154
Rab40c
Rab40c, member RAS oncogene family
chr5_+_110973321 0.872 NM_198306
Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr2_+_32462471 0.870 NM_001025310
NM_016973
St6galnac6

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

chr15_-_79635156 0.868 Nptxr
neuronal pentraxin receptor
chr9_-_123169866 0.864 NM_001002267
Tmem158
transmembrane protein 158
chr4_-_47004585 0.864 NM_001081141
Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr11_+_83223154 0.860 Rasl10b
RAS-like, family 10, member B
chr4_+_151712739 0.853 NM_001081376
NM_029216
Chd5

chromodomain helicase DNA binding protein 5

chr12_-_4484059 0.847 NM_010881
Ncoa1
nuclear receptor coactivator 1
chr10_+_61245998 0.846


chr19_-_60019520 0.841 NM_001164367
Rab11fip2
RAB11 family interacting protein 2 (class I)
chr14_-_70689083 0.840 NM_008915
Ppp3cc
protein phosphatase 3, catalytic subunit, gamma isoform
chr6_-_124706435 0.840 NM_007881
Atn1
atrophin 1
chr8_+_113245378 0.839 NM_198625
Mtss1l
metastasis suppressor 1-like
chr10_-_80945445 0.839 NM_176954
Celf5
CUGBP, Elav-like family member 5
chr9_+_43552046 0.838 Pvrl1
poliovirus receptor-related 1
chr19_+_10116104 0.833 Fads3
fatty acid desaturase 3
chr17_-_48061354 0.831 Foxp4
forkhead box P4
chr4_+_42930076 0.828 NM_172690
N28178
expressed sequence N28178
chr13_-_54850954 0.827 NM_012014
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr5_-_69732792 0.825 Kctd8
potassium channel tetramerisation domain containing 8
chr13_-_52626022 0.825 Diras2
DIRAS family, GTP-binding RAS-like 2
chr8_+_97056910 0.823 NM_153507
Cpne2
copine II
chr5_-_106887469 0.816 Barhl2
BarH-like 2 (Drosophila)
chr19_+_3323339 0.815 Cpt1a
carnitine palmitoyltransferase 1a, liver
chr8_+_11312828 0.808 NM_009932
Col4a2
collagen, type IV, alpha 2
chr9_-_31019234 0.806 Aplp2
amyloid beta (A4) precursor-like protein 2
chr14_-_40286236 0.806 NM_001190187
NM_001190188
NM_008734
Nrg3


neuregulin 3


chr10_+_128370814 0.803 NM_008398
Itga7
integrin alpha 7
chr3_-_10440061 0.802 NM_001127191
NM_029068
Snx16

sorting nexin 16

chr4_+_97444326 0.800 Nfia
nuclear factor I/A
chr15_-_90509751 0.795 NM_001033851
NM_025815
Cpne8

copine VIII

chr17_+_46390828 0.795 NM_001111142
Gm88
predicted gene 88
chr2_-_163744663 0.794 Rims4
regulating synaptic membrane exocytosis 4
chr2_-_151458299 0.794 Snph
syntaphilin
chr19_-_40588255 0.788 Sorbs1
sorbin and SH3 domain containing 1
chr2_+_4322447 0.785 Frmd4a
FERM domain containing 4A
chr8_-_88224811 0.782 Neto2
neuropilin (NRP) and tolloid (TLL)-like 2
chr12_-_4483975 0.778 Ncoa1
nuclear receptor coactivator 1
chr11_-_80593259 0.775 NM_177390
Myo1d
myosin ID
chr5_-_135028113 0.774 Clip2
CAP-GLY domain containing linker protein 2
chr12_-_113146259 0.772 NM_011625
Ppp1r13b
protein phosphatase 1, regulatory (inhibitor) subunit 13B
chr4_-_68615382 0.767 NM_019967
Dbc1
deleted in bladder cancer 1 (human)
chr7_-_25084361 0.764 Zfp61
zinc finger protein 61
chr10_-_79602040 0.764 Dos
downstream of Stk11

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
3.41 1.32e-03 GO:0007399 nervous system development
4.38 4.65e-03 GO:0007155 cell adhesion
4.34 5.09e-03 GO:0022610 biological adhesion
4.68 5.54e-03 GO:0030182 neuron differentiation
7.31 8.24e-03 GO:0007409 axonogenesis
3.82 9.60e-03 GO:0048699 generation of neurons
5.91 1.28e-02 GO:0000904 cell morphogenesis involved in differentiation
6.67 1.60e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
2.14 1.63e-02 GO:0007275 multicellular organismal development
5.60 1.97e-02 GO:0031175 neuron projection development
3.58 1.97e-02 GO:0022008 neurogenesis
2.48 1.97e-02 GO:0030154 cell differentiation
4.91 2.15e-02 GO:0048666 neuron development
6.37 2.21e-02 GO:0048812 neuron projection morphogenesis
2.28 2.26e-02 GO:0048731 system development
9.59 2.30e-02 GO:0007411 axon guidance
3.47 2.74e-02 GO:0048468 cell development
12.71 2.75e-02 GO:0050796 regulation of insulin secretion
2.41 3.15e-02 GO:0048869 cellular developmental process
2.79 3.73e-02 GO:0009653 anatomical structure morphogenesis
11.66 4.16e-02 GO:0090276 regulation of peptide hormone secretion
11.26 4.90e-02 GO:0002791 regulation of peptide secretion
11.26 4.90e-02 GO:0090087 regulation of peptide transport

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.86 1.02e-11 GO:0005886 plasma membrane
2.81 2.32e-11 GO:0071944 cell periphery
6.24 1.73e-06 GO:0045202 synapse
1.69 5.81e-06 GO:0016020 membrane
6.55 1.03e-04 GO:0044456 synapse part
1.25 6.44e-04 GO:0005623 cell
1.25 6.44e-04 GO:0044464 cell part
2.42 1.27e-02 GO:0044459 plasma membrane part
4.93 2.49e-02 GO:0043025 neuronal cell body
3.58 2.75e-02 GO:0030054 cell junction
4.70 3.45e-02 GO:0044297 cell body

Gene overrepresentation in function category:

enrichment p-value GO term description
1.99 1.56e-06 GO:0005515 protein binding
1.50 1.02e-05 GO:0005488 binding