Motif ID: HMGA1,2.p2

Z-value: 1.201

Transcription factors associated with HMGA1,2.p2:

NameEntrezDescription
Hmga1 15361 high mobility group AT-hook 1
Hmga2 15364 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Hmga2chr10_-_119913319-0.642.6e-05Click!
Hmga1chr17_+_27693518-0.539.1e-04Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr8_-_87297283 19.457 Nfix
nuclear factor I/X
chr15_-_8660462 8.756 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_-_79317471 8.276 Omg
oligodendrocyte myelin glycoprotein
chrX_-_100678555 7.875 Xist
inactive X specific transcripts
chr15_-_8660442 7.847 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_107926763 6.183 NM_001007574
NM_001168557
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr12_+_110783593 4.900 Meg3
maternally expressed 3
chr7_-_67149962 4.741 NM_013670
NM_033174
Snrpn
Snurf
small nuclear ribonucleoprotein N
SNRPN upstream reading frame
chr1_+_45368443 4.587 Col3a1
collagen, type III, alpha 1
chrX_-_132738383 4.571 NM_177919
Tceal5
transcription elongation factor A (SII)-like 5
chr8_+_59934719 4.464 NM_009136
Scrg1
scrapie responsive gene 1
chr15_-_8660479 4.326 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_84265422 4.249 NM_018782
Calcrl
calcitonin receptor-like
chr10_+_99478457 4.033 NM_013598
Kitl
kit ligand
chr9_-_29770699 3.914 NM_172290
Ntm
neurotrimin
chr9_+_37175190 3.884 NM_175189
Hepacam
hepatocyte cell adhesion molecule
chr1_-_156993820 3.853 NM_008209
Mr1
major histocompatibility complex, class I-related
chr9_+_113721698 3.700 NM_001081960
NM_029633
Clasp2

CLIP associating protein 2

chr15_+_91991704 3.651 NM_001159647
Cntn1
contactin 1
chr6_+_22825464 3.618 NM_001081306
Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr1_-_142079842 3.609 NM_009888
Cfh
complement component factor h
chr4_-_96258099 3.603 NM_028979
Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr8_+_96702981 3.484 NM_013602
Mt1
metallothionein 1
chr2_+_136539202 3.468 Snap25
synaptosomal-associated protein 25
chrX_-_149078963 3.286 Shroom2
shroom family member 2
chr10_+_57351786 3.278 NM_001039051
NM_008863
Pkib

protein kinase inhibitor beta, cAMP dependent, testis specific

chr3_-_50247306 3.267 NM_011990
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr9_-_60497537 3.259 Lrrc49
leucine rich repeat containing 49
chr10_+_87321789 3.190 NM_001111275
NM_010512
Igf1

insulin-like growth factor 1

chr15_-_8660393 3.083 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_74583382 2.993 NM_011838
Lynx1
Ly6/neurotoxin 1
chr17_+_70871444 2.923 NM_001128180
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr19_+_8692485 2.890 NM_008766
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr18_+_37607310 2.886 NM_053139
Pcdhb14
protocadherin beta 14
chr5_-_75073816 2.835 NM_001159578
NM_001159579
NM_001159580
NM_010727
Lnx1



ligand of numb-protein X 1



chr10_-_127188724 2.806 Gpr182
G protein-coupled receptor 182
chr15_-_8660729 2.798 NM_148938
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_79436564 2.793 NM_009129
Scg2
secretogranin II
chr9_-_117161564 2.782 NM_001172122
NM_001172123
NM_001172124
NM_001172126
NM_178660
Rbms3




RNA binding motif, single stranded interacting protein




chr5_-_104542751 2.718 Sparcl1
SPARC-like 1
chr18_-_15562126 2.651 NM_009700
Aqp4
aquaporin 4
chr7_+_97535490 2.607 NM_001040087
NM_001040088
Sytl2

synaptotagmin-like 2

chr18_+_20823908 2.554 Ttr
transthyretin
chr10_+_122115755 2.525 NM_001110218
NM_176919
Ppm1h

protein phosphatase 1H (PP2C domain containing)

chr15_+_82105322 2.509 NM_011889
Sept3
septin 3
chr5_-_104542641 2.479 Sparcl1
SPARC-like 1
chr8_+_115093942 2.478 NM_130457
Cntnap4
contactin associated protein-like 4
chr10_+_80614066 2.468 Zbtb7a
zinc finger and BTB domain containing 7a
chr15_-_8584897 2.410 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_-_5802596 2.391 Ramp2
Malat1
receptor (calcitonin) activity modifying protein 2
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr2_+_136539143 2.249 NM_011428
Snap25
synaptosomal-associated protein 25
chr11_-_99105293 2.241 NM_172946
Krt222
keratin 222
chr5_-_104542598 2.206 Sparcl1
SPARC-like 1
chr7_+_96780900 2.158 Me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr10_-_101953046 2.106 NM_024435
Nts
neurotensin
chr10_+_69169221 2.102 Ank3
ankyrin 3, epithelial
chr3_+_117278144 2.062 NM_029425
4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr19_+_53214934 2.045 NM_001164099
NM_001164101
Add3

adducin 3 (gamma)

chr16_-_85173978 2.029 App
amyloid beta (A4) precursor protein
chr5_-_104542729 2.007 Sparcl1
SPARC-like 1
chr16_-_31314534 2.006 NM_007470
Apod
apolipoprotein D
chr16_-_22657245 2.004 Dgkg
diacylglycerol kinase, gamma
chr10_+_90039435 1.980 NM_001177396
NM_001177398
NM_181398
Ipw
Anks1b


imprinted gene in the Prader-Willi syndrome region
ankyrin repeat and sterile alpha motif domain containing 1B


chr7_-_27966073 1.966 Mia1
melanoma inhibitory activity 1
chr7_+_108496574 1.959 NM_001040111
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_-_55631085 1.935 Neurod6
neurogenic differentiation 6
chr3_+_45182311 1.912 NM_001098170
NM_001098171
NM_001098172
NM_011043
Pcdh10



protocadherin 10



chr17_+_70318387 1.910 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr5_-_124053691 1.908 Clip1
CAP-GLY domain containing linker protein 1
chr11_-_28484265 1.843 NM_001166661
NM_001166662
NM_181577
Ccdc85a


coiled-coil domain containing 85A


chr4_+_101927543 1.829 NM_019840
Pde4b
phosphodiesterase 4B, cAMP specific
chr1_+_81073778 1.818 NM_172849
9430031J16Rik
RIKEN cDNA 9430031J16 gene
chr16_+_91270009 1.794 NM_016968
Olig1
oligodendrocyte transcription factor 1
chr18_+_37127284 1.786 NM_007767
Pcdha6
protocadherin alpha 6
chr3_+_54165028 1.766 NM_001198765
NM_001198766
NM_015784
Postn


periostin, osteoblast specific factor


chr15_+_82086506 1.755 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr17_+_35373506 1.715 NM_023179
Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr7_-_82453166 1.704 Sv2b
synaptic vesicle glycoprotein 2 b
chr19_-_8797689 1.671 NM_001161413
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr10_-_127188787 1.661 NM_007412
Gpr182
G protein-coupled receptor 182
chr15_+_51871652 1.611 NM_175503
Aard
alanine and arginine rich domain containing protein
chr4_-_86876311 1.611 Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr7_-_110976439 1.603 Hbb-b1
hemoglobin, beta adult major chain
chr12_+_110783786 1.603 Meg3
maternally expressed 3
chr12_-_25780932 1.546 NM_010496
Id2
inhibitor of DNA binding 2
chr9_+_123371135 1.545 Lars2
leucyl-tRNA synthetase, mitochondrial
chr2_-_113839354 1.542 NM_010290
Gjd2
gap junction protein, delta 2
chr5_-_136410488 1.524 NM_018871
Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr1_+_43787692 1.515 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr11_+_78312621 1.502 NM_011707
Vtn
vitronectin
chr16_+_41532938 1.473 Lsamp
limbic system-associated membrane protein
chr18_+_69753035 1.469 Tcf4
transcription factor 4
chr9_-_4796141 1.466 NM_001113180
NM_001113181
NM_019691
Gria4


glutamate receptor, ionotropic, AMPA4 (alpha 4)


chr15_+_3220999 1.440 Sepp1
selenoprotein P, plasma, 1
chr5_+_75548337 1.431 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr1_+_63492447 1.431 NM_001177600
NM_011780
Adam23

a disintegrin and metallopeptidase domain 23

chr17_-_14831095 1.430 Thbs2
thrombospondin 2
chrX_+_21061748 1.423 NM_007429
Agtr2
angiotensin II receptor, type 2
chr2_+_65683823 1.413 NM_153409
NM_178634
Csrnp3

cysteine-serine-rich nuclear protein 3

chr11_-_116060026 1.401 Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chr4_-_86876328 1.398 NM_172426
Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chrX_-_147091911 1.388 NM_001002272
NM_019548
Tro

trophinin

chr11_-_69479553 1.380 NM_009853
Cd68
CD68 antigen
chr3_+_125106995 1.378 NM_022565
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr10_+_125403274 1.377 NM_177152
Lrig3
leucine-rich repeats and immunoglobulin-like domains 3
chr10_-_63552994 1.374 NM_178678
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr14_+_54878898 1.374 NM_134076
Abhd4
abhydrolase domain containing 4
chr15_+_3220994 1.373 Sepp1
selenoprotein P, plasma, 1
chr9_-_52484889 1.372 AI593442
expressed sequence AI593442
chr2_-_73498303 1.372 NM_001166604
NM_175752
Chn1

chimerin (chimaerin) 1

chr3_+_66789587 1.362 NM_025822
Rsrc1
arginine/serine-rich coiled-coil 1
chr4_+_138012860 1.360 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chrX_-_7709907 1.360 NM_026137
Wdr13
WD repeat domain 13
chr5_-_51945054 1.360 NM_008904
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr10_-_10802102 1.333 NM_001114333
NM_016976
Grm1

glutamate receptor, metabotropic 1

chr11_+_92959670 1.307 Car10
carbonic anhydrase 10
chr14_+_14286471 1.296 NM_001163032
Synpr
synaptoporin
chrX_-_94572488 1.290 NM_001161432
NM_001161433
NM_175540
Eda2r


ectodysplasin A2 receptor


chr5_-_106887469 1.288 Barhl2
BarH-like 2 (Drosophila)
chr2_-_66248146 1.286


chr10_-_61970481 1.279 NM_011157
Srgn
serglycin
chr9_-_123760992 1.278 NM_001110253
Fyco1
FYVE and coiled-coil domain containing 1
chr16_+_31428833 1.272 NM_001122683
Bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr8_-_34858230 1.271 2700090O03Rik
RIKEN cDNA 2700090O03 gene
chr15_+_97614772 1.268 NM_026353
Slc48a1
solute carrier family 48 (heme transporter), member 1
chr11_+_97702591 1.265 B230217C12Rik
RIKEN cDNA B230217C12 gene
chr19_+_27291507 1.259 NM_001161420
NM_013703
Vldlr

very low density lipoprotein receptor

chr4_+_97444312 1.243 NM_001122953
NM_010905
Nfia

nuclear factor I/A

chr15_-_54751515 1.243 NM_001136077
NM_015744
Enpp2

ectonucleotide pyrophosphatase/phosphodiesterase 2

chr10_-_83111346 1.241 NM_145220
Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chrM_+_11741 1.230 ND5
NADH dehydrogenase subunit 5
chr3_-_27795287 1.226 NM_001164437
Tmem212
transmembrane protein 212
chrX_+_150266835 1.214 NM_001005370
Spin2
spindlin family, member 2
chr16_+_49913305 1.211 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr5_+_115392192 1.210 NM_028211
2210016L21Rik
RIKEN cDNA 2210016L21 gene
chr15_+_91881593 1.203 NM_001159648
Cntn1
contactin 1
chr13_+_83663817 1.202 Mef2c
myocyte enhancer factor 2C
chr11_+_31900378 1.186 NM_008741
Nsg2
neuron specific gene family member 2
chrM_+_1091 1.174


chr15_-_42508294 1.168 NM_009640
Angpt1
angiopoietin 1
chr3_+_19857053 1.161 NM_001042611
NM_007752
Cp

ceruloplasmin

chr7_+_51640108 1.140 Syt3
synaptotagmin III
chr1_-_174259356 1.139 NM_008429
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr9_+_94570310 1.134 NM_177909
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr3_+_89006938 1.127 Gba
glucosidase, beta, acid
chr8_+_86939262 1.122 NM_007578
Cacna1a
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr4_-_124742875 1.121 NM_175223
Dnali1
dynein, axonemal, light intermediate polypeptide 1
chr2_-_60801248 1.106 NM_020296
Rbms1
RNA binding motif, single stranded interacting protein 1
chr14_-_78488780 1.106 NM_177629
AU021034
expressed sequence AU021034
chr9_+_20673069 1.097 NM_175687
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr6_-_55631039 1.095 Neurod6
neurogenic differentiation 6
chr6_-_82889694 1.093 NM_001113481
NM_011350
Sema4f

sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain

chr2_-_92886300 1.090 NM_001177536
Prdm11
PR domain containing 11
chr10_+_57504720 1.076 NM_021272
Fabp7
fatty acid binding protein 7, brain
chr18_-_23197156 1.074 NM_001161483
Nol4
nucleolar protein 4
chr5_-_5265598 1.053 Cdk14
cyclin-dependent kinase 14
chr5_+_25265761 1.052 NM_001004365
Actr3b
ARP3 actin-related protein 3 homolog B (yeast)
chr11_-_41995688 1.052 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr4_+_101180580 1.029 NM_001164584
NM_001164585
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr5_-_124482223 1.027 NM_177876
Vps37b
vacuolar protein sorting 37B (yeast)
chr1_+_148344816 1.015 NM_001145807
Fam5c
family with sequence similarity 5, member C
chr11_-_29925939 1.014 NM_146016
Eml6
echinoderm microtubule associated protein like 6
chr10_+_81038028 1.011 NM_019725
Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr10_-_88067758 0.991 NM_175418
Mybpc1
myosin binding protein C, slow-type
chr2_+_177876635 0.988 NM_028806
Phactr3
phosphatase and actin regulator 3
chr2_+_97307652 0.967 NM_178725
Lrrc4c
leucine rich repeat containing 4C
chr16_+_30599808 0.966 NM_177632
Fam43a
family with sequence similarity 43, member A
chr3_+_89866717 0.952 NM_028567
1700094D03Rik
RIKEN cDNA 1700094D03 gene
chr6_+_141472906 0.951 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chr2_+_131317581 0.947 NM_001177833
NM_001177834
NM_001177835
NM_001177836
NM_001177837
NM_001177838
NM_001177839
NM_001177840
NM_145533
Smox








spermine oxidase








chr15_-_48623520 0.943 NM_001081391
Csmd3
CUB and Sushi multiple domains 3
chr1_+_163072784 0.934 NM_028664
Ankrd45
ankyrin repeat domain 45
chr7_+_94735020 0.934 C030032F19Rik
RIKEN cDNA C030032F19 gene
chr1_-_195068455 0.932 NM_001044751
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
chr8_+_73993084 0.928 NM_025600
Dda1
DET1 and DDB1 associated 1
chr10_+_74500008 0.927 Rab36
RAB36, member RAS oncogene family
chr6_-_124719465 0.922 NM_013509
Eno2
enolase 2, gamma neuronal
chr13_-_89881804 0.920 Vcan
versican
chr11_+_67466129 0.918 Gas7
growth arrest specific 7
chr2_-_10052196 0.910 NM_010582
Itih2
inter-alpha trypsin inhibitor, heavy chain 2
chr16_-_85173944 0.907 NM_001198823
NM_001198824
NM_001198825
NM_001198826
NM_007471
App




amyloid beta (A4) precursor protein




chr1_+_111880313 0.906 NM_172853
Cdh7
cadherin 7, type 2
chr18_+_37637421 0.903 NM_053141
Pcdhb16
protocadherin beta 16
chr16_+_7409879 0.896 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_-_131006068 0.894 NM_027816
Cyp2u1
cytochrome P450, family 2, subfamily u, polypeptide 1
chr10_-_8238569 0.890 NM_177387
Ust
uronyl-2-sulfotransferase
chr19_+_24748487 0.887 NM_183160
E030010A14Rik
RIKEN cDNA E030010A14 gene
chr9_+_54434140 0.880 NM_029573
Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr16_-_85901306 0.878 Adamts5
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
chr8_+_3587675 0.876 2310057J16Rik
RIKEN cDNA 2310057J16 gene
chr10_-_120913138 0.857 NM_138956
Rassf3
Ras association (RalGDS/AF-6) domain family member 3
chr1_+_169528492 0.850 NM_009107
Rxrg
retinoid X receptor gamma
chr2_-_148269170 0.842 NM_010740
Cd93
CD93 antigen
chr10_+_125403223 0.841 Lrig3
leucine-rich repeats and immunoglobulin-like domains 3
chr1_-_37592976 0.839 NM_173870
Mgat4a
mannoside acetylglucosaminyltransferase 4, isoenzyme A
chr15_+_75692745 0.830 NM_026960
Gsdmd
gasdermin D
chr5_+_151062363 0.828 NM_172887
Fry
furry homolog (Drosophila)
chr9_+_58430031 0.815 NM_009145
Nptn
neuroplastin
chr15_+_39491073 0.815 Rims2
regulating synaptic membrane exocytosis 2
chr18_+_37906668 0.813 Pcdhga10
protocadherin gamma subfamily A, 10

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
4.51 2.71e-05 GO:0007155 cell adhesion
4.48 3.10e-05 GO:0022610 biological adhesion
1.96 5.46e-03 GO:0051179 localization
5.42 1.11e-02 GO:0007268 synaptic transmission
4.72 1.51e-02 GO:0019226 transmission of nerve impulse
4.72 1.51e-02 GO:0035637 multicellular organismal signaling
1.99 2.22e-02 GO:0051234 establishment of localization
6.43 2.40e-02 GO:0043062 extracellular structure organization
2.25 3.38e-02 GO:0065008 regulation of biological quality

Gene overrepresentation in compartment category:

enrichment p-value GO term description
5.28 1.11e-06 GO:0045202 synapse
2.06 8.97e-06 GO:0071944 cell periphery
2.06 1.24e-05 GO:0005886 plasma membrane
104.82 1.81e-04 GO:0030285 integral to synaptic vesicle membrane
5.04 6.16e-04 GO:0044456 synapse part
3.03 1.16e-03 GO:0044421 extracellular region part
2.29 3.37e-03 GO:0005576 extracellular region
2.19 1.01e-02 GO:0044459 plasma membrane part
3.21 1.52e-02 GO:0030054 cell junction
3.01 1.78e-02 GO:0005615 extracellular space
6.08 2.01e-02 GO:0045211 postsynaptic membrane
2.67 2.66e-02 GO:0005626 insoluble fraction
6.46 4.34e-02 GO:0031225 anchored to membrane
2.63 4.85e-02 GO:0005624 membrane fraction

Gene overrepresentation in function category:

enrichment p-value GO term description
2.89 1.69e-03 GO:0005215 transporter activity
1.61 2.32e-03 GO:0005515 protein binding