• All motifs sorted by activity significance
• All samples sorted alphabetically

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: HNF1A.p2

Z-value: 2.351

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Top targets:

Promoter	Score	Refseq	Gene	Description
chr5_+_90889913	63.656	NM_009654	Alb	albumin
chr5_-_89886732	45.362	NM_008096	Gc	group specific component
chr7_+_147949708	39.913	NM_021282	Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1
chr3_-_82853711	27.675	NM_181849	Fgb	fibrinogen beta chain
chr3_+_82830071	26.407	NM_001111048 NM_010196	Fga	fibrinogen alpha chain
chr5_+_90889937	21.365		Alb	albumin
chr2_-_91476551	18.895	NM_010168	F2	coagulation factor II
chr17_+_12571494	14.799		Plg	plasminogen
chr6_+_71149869	14.639	NM_017399	Fabp1	fatty acid binding protein 1, liver
chr17_+_12571455	13.663	NM_008877	Plg	plasminogen
chr6_+_141578016	12.346	NM_020495	Slco1b2	solute carrier organic anion transporter family, member 1b2
chr12_-_105195097	12.222	NM_009247	Serpina1e	serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr8_+_107572489	12.003	NM_001164681 NM_198672	Ces3a	carboxylesterase 3A
chr1_+_90108533	11.692	NM_201645	Ugt1a1	UDP glucuronosyltransferase 1 family, polypeptide A1
chr16_+_22951183	11.180		Hrg	histidine-rich glycoprotein
chr11_+_108256590	10.755	NM_013475	Apoh	apolipoprotein H
chr12_+_105316152	10.205		Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1
chr14_+_51716032	9.365		Ang Rnase4	angiogenin, ribonuclease, RNase A family, 5 ribonuclease, RNase A family 4
chr2_-_34956162	8.875	NM_178885	AI182371	expressed sequence AI182371
chr19_-_14672540	8.531		Tle4	transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr13_+_4433567	8.457	NM_030611	Akr1c6	aldo-keto reductase family 1, member C6
chr3_-_66100663	7.879	NM_145820	Veph1	ventricular zone expressed PH domain homolog 1 (zebrafish)
chr5_-_87335956	7.837	NM_153598	Ugt2b34	UDP glucuronosyltransferase 2 family, polypeptide B34
chr5_+_90947970	7.771	NM_145146	Afm	afamin
chr19_-_14672472	7.390	NM_011600	Tle4	transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr18_+_20823908	6.600		Ttr	transthyretin
chr4_-_33010429	6.562	NM_001012450 NM_080471	Ankrd6	ankyrin repeat domain 6
chrX_+_98572571	6.444	NM_008124	Gjb1	gap junction protein, beta 1
chr1_+_174628164	5.965	NM_007768	Crp	C-reactive protein, pentraxin-related
chr2_-_34916915	5.649	NM_010406	Hc	hemolytic complement
chr11_+_101229029	5.346	NM_008061	G6pc	glucose-6-phosphatase, catalytic
chr12_-_105011767	5.345		Serpina1d	serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr3_+_129539656	5.086	NM_007686	Cfi	complement component factor i
chr5_-_87355527	4.675	NM_152811	Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1
chr11_-_75252976	4.622	NM_008878	Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2
chr8_+_107607652	4.570	NM_001159415 NM_144511	Ces3b	carboxylesterase 3B
chr7_-_31900188	4.263	NM_001110252 NM_008281	Hpn	hepsin
chr5_+_35384213	4.061		Hgfac	hepatocyte growth factor activator
chr1_+_135142673	3.893	NM_001160268 NM_182930	Plekha6	pleckstrin homology domain containing, family A member 6
chr2_-_68310324	3.813		Stk39	serine/threonine kinase 39, STE20/SPS1 homolog (yeast)
chr2_-_134380065	3.743	NM_010403	Hao1	hydroxyacid oxidase 1, liver
chr5_-_87521574	3.707	NM_001029867	Ugt2b36	UDP glucuronosyltransferase 2 family, polypeptide B36
chr12_-_104895307	3.695		Serpina6	serine (or cysteine) peptidase inhibitor, clade A, member 6
chr1_-_132558108	3.524	NM_007576	C4bp	complement component 4 binding protein
chr10_+_76038388	3.321	NM_080845	Ftcd	formiminotransferase cyclodeaminase
chr9_+_99529985	3.301	NM_028258	Dzip1l	DAZ interacting protein 1-like
chr10_+_60552061	3.184	NM_025273	Pcbd1	pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr16_+_22951144	3.144	NM_053176	Hrg	histidine-rich glycoprotein
chr19_+_30307417	2.977		Mbl2	mannose-binding lectin (protein C) 2
chr9_+_44206431	2.697		Slc37a4	solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr1_+_141398282	2.693	NM_031164	F13b	coagulation factor XIII, beta subunit
chr5_+_35384200	2.657	NM_019447	Hgfac	hepatocyte growth factor activator
chr1_-_141755209	2.654	NM_001025575	BC026782	cDNA sequence BC026782
chr2_+_172978566	2.598	NM_011044	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic
chr18_-_33623527	2.513		D0H4S114	DNA segment, human D4S114
chr4_-_96330818	2.241		Cyp2j5	cytochrome P450, family 2, subfamily j, polypeptide 5
chr2_+_13500063	2.161		Vim	vimentin
chr16_-_26755585	2.125
chrM_-_14069	2.117		ND6	NADH dehydrogenase subunit 6
chr5_-_87569342	2.047	NM_009467	Ugt2b5	UDP glucuronosyltransferase 2 family, polypeptide B5
chr13_-_4522566	1.974	NM_054080	Akr1c20	aldo-keto reductase family 1, member C20
chr9_-_71011053	1.948	NM_022026	Aqp9	aquaporin 9
chr9_+_99530246	1.892		Dzip1l	DAZ interacting protein 1-like
chr14_-_71026793	1.801		Epb4.9	erythrocyte protein band 4.9
chr15_-_82624668	1.793	NM_029562	Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26
chr13_+_23898861	1.706	NM_144836	Slc17a2	solute carrier family 17 (sodium phosphate), member 2
chr5_+_87429884	1.658	NM_172881	Ugt2b35	UDP glucuronosyltransferase 2 family, polypeptide B35
chr19_-_47993687	1.650	NM_001001738	Itprip Wdr96	inositol 1,4,5-triphosphate receptor interacting protein WD repeat domain 96
chr9_-_16182674	1.642	NM_001080814	Fat3	FAT tumor suppressor homolog 3 (Drosophila)
chr17_-_35268696	1.628	NM_018816	Apom	apolipoprotein M
chr1_+_89967340	1.590	NM_201644	Ugt1a9	UDP glucuronosyltransferase 1 family, polypeptide A9
chr15_+_9209583	1.555	NM_207216	Ugt3a1	UDP glycosyltransferases 3 family, polypeptide A1
chr2_+_91105271	1.516	NM_001166024 NM_023854	Arfgap2	ADP-ribosylation factor GTPase activating protein 2
chr5_-_149806774	1.486		5930430L01Rik	RIKEN cDNA 5930430L01 gene
chr8_-_124468764	1.484	NM_007608	Car5a	carbonic anhydrase 5a, mitochondrial
chrX_+_137909951	1.472	NM_001163155 NM_007736	Col4a5	collagen, type IV, alpha 5
chr12_-_105011807	1.403	NM_009246	Serpina1d	serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr18_-_33623668	1.352	NM_001109988	D0H4S114	DNA segment, human D4S114
chr4_-_96330805	1.343	NM_010007	Cyp2j5	cytochrome P450, family 2, subfamily j, polypeptide 5
chr19_+_31943250	1.337	NM_001081074	A1cf	APOBEC1 complementation factor
chr3_+_59835700	1.318	NM_023383	Aadac	arylacetamide deacetylase (esterase)
chr2_+_158593806	1.289	NM_027975	Fam83d	family with sequence similarity 83, member D
chr19_-_39815590	1.246	NM_001039555	Cyp2c68	cytochrome P450, family 2, subfamily c, polypeptide 68
chr12_-_105143108	1.217	NM_009245	Serpina1c	serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr7_-_71518926	1.188	NM_177893	Fan1	FANCD2/FANCI-associated nuclease 1
chr4_-_96330738	1.181		Cyp2j5	cytochrome P450, family 2, subfamily j, polypeptide 5
chr14_+_41964744	1.165	NM_010775	Mbl1	mannose-binding lectin (protein A) 1
chr18_-_32297813	1.099	NM_001042768 NM_008934	Proc	protein C
chr13_+_89680240	1.080	NM_013500	Hapln1	hyaluronan and proteoglycan link protein 1
chr6_-_41654290	1.060	NM_032540	Kel	Kell blood group
chr5_+_108494692	1.050	NM_013827	Mtf2	metal response element binding transcription factor 2
chr7_+_74792295	1.041	NM_001168475 NM_001168476 NM_001168477 NM_025905	Ttc23	tetratricopeptide repeat domain 23
chr15_-_103045710	0.954	NM_001110216 NM_007626	Cbx5	chromobox homolog 5 (Drosophila HP1a)
chr2_-_32279522	0.868		Slc25a25	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr13_-_98786061	0.861		Rgnef	Rho-guanine nucleotide exchange factor
chr17_-_65944300	0.827		Vapa	vesicle-associated membrane protein, associated protein A
chr10_-_30562434	0.793	NM_013904	Hey2	hairy/enhancer-of-split related with YRPW motif 2
chr10_-_124765435	0.734	NM_011391	Slc16a7	solute carrier family 16 (monocarboxylic acid transporters), member 7
chr6_-_3444484	0.716	NM_178899	Hepacam2	HEPACAM family member 2
chr10_+_23614493	0.692	NM_011704	Vnn1	vanin 1
chr5_-_87997908	0.683		Sult1d1	sulfotransferase family 1D, member 1
chrX_+_155897136	0.670		Mtap7d2	MAP7 domain containing 2
chrX_+_155897056	0.659		Mtap7d2	MAP7 domain containing 2
chr19_+_43856793	0.636	NM_013806	Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr9_+_51894884	0.598		Rdx	radixin
chr3_-_108707417	0.577		Prpf38b	PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr16_-_11220854	0.573		Gspt1	G1 to S phase transition 1
chr18_-_33623400	0.530	NM_001109989	D0H4S114	DNA segment, human D4S114
chrM_+_8606	0.530		COX3	cytochrome c oxidase subunit III
chr9_+_21639937	0.488	NM_001080940	Gm6484	predicted gene 6484
chr2_-_68309996	0.456	NM_016866	Stk39	serine/threonine kinase 39, STE20/SPS1 homolog (yeast)
chr2_+_162760505	0.439
chr14_+_79915429	0.401		Elf1	E74-like factor 1
chr19_-_55201631	0.390		Gpam	glycerol-3-phosphate acyltransferase, mitochondrial
chr10_+_89280918	0.353		Uhrf1bp1l	UHRF1 (ICBP90) binding protein 1-like
chr4_-_21694265	0.333		2610029I01Rik	RIKEN cDNA 2610029I01 gene
chr6_-_93628981	0.321		Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1
chr5_-_87766219	0.282	NM_028094	Ugt2a3	UDP glucuronosyltransferase 2 family, polypeptide A3
chr10_-_44178474	0.277	NM_007548	Prdm1	PR domain containing 1, with ZNF domain
chr5_+_116010796	0.274		Rplp0	ribosomal protein, large, P0
chr17_-_35183667	0.272	NM_001146215	Msh5	mutS homolog 5 (E. coli)
chr2_-_62249934	0.270	NM_001159543 NM_010074	Dpp4	dipeptidylpeptidase 4
chr15_-_82624638	0.267		Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26
chr19_-_7280741	0.251	NM_134150	Otub1	OTU domain, ubiquitin aldehyde binding 1
chr12_+_90191833	0.236	NM_172544	Nrxn3	neurexin III
chr13_-_91044959	0.208	NM_001145879	Atp6ap1l	ATPase, H+ transporting, lysosomal accessory protein 1-like
chr5_-_137510950	0.204		Ap1s1	adaptor protein complex AP-1, sigma 1
chr2_-_94252368	0.201		Api5	apoptosis inhibitor 5
chr1_+_136321327	0.191		Adipor1	adiponectin receptor 1
chr7_+_109082609	0.188		Numa1	nuclear mitotic apparatus protein 1
chr2_-_62249869	0.164		Dpp4	dipeptidylpeptidase 4
chr2_+_174109820	0.164	NM_019690 NM_022000	Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr13_+_113657736	0.150
chr9_+_51894422	0.121
chr1_+_58852303	0.119		Casp8	caspase 8
chr8_-_18741546	0.117	NM_007426	Angpt2	angiopoietin 2
chr7_+_107789414	0.110		Rab6	RAB6, member RAS oncogene family
chr4_+_8533630	0.101		Rab2a	RAB2A, member RAS oncogene family
chr10_-_77632399	0.097	NM_138601	D10Jhu81e	DNA segment, Chr 10, Johns Hopkins University 81 expressed
chr11_+_79845841	0.096		Suz12	suppressor of zeste 12 homolog (Drosophila)
chr5_-_34517575	0.090
chr13_-_53381426	0.082	NM_013846	Ror2	receptor tyrosine kinase-like orphan receptor 2
chrX_-_165092598	0.076		Msl3	male-specific lethal 3 homolog (Drosophila)
chr7_+_107422781	0.072		Pgm2l1	phosphoglucomutase 2-like 1
chrX_-_22797942	0.063		Klhl13	kelch-like 13 (Drosophila)
chr6_+_55018084	0.057		Gars	glycyl-tRNA synthetase
chr2_+_152891690	0.040	NM_145536	BC020535	cDNA sequence BC020535
chr1_-_177555593	0.038	NM_010209	Fh1	fumarate hydratase 1
chr1_+_17591981	0.037	NM_053191	Pi15	peptidase inhibitor 15
chr8_+_113381876	0.035		Cog4	component of oligomeric golgi complex 4
chr11_-_62206116	0.031		Ncor1	nuclear receptor co-repressor 1
chr1_+_40082070	0.029		Map4k4	mitogen-activated protein kinase kinase kinase kinase 4
chr2_+_44967779	0.013	NM_001177395	Gm13476	predicted gene 13476
chr14_-_32594734	0.007		3110068a07rik	RIKEN cDNA 3110068A07 gene
chr16_+_92086695	0.003		Slc5a3	solute carrier family 5 (inositol transporters), member 3

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
42.98	1.92e-06	GO:0072376	protein activation cascade
151.43	2.55e-06	GO:0051918	negative regulation of fibrinolysis
57.62	8.29e-06	GO:0006958	complement activation, classical pathway
106.00	1.52e-05	GO:0051917	regulation of fibrinolysis
49.08	1.97e-05	GO:0002455	humoral immune response mediated by circulating immunoglobulin
44.18	3.44e-05	GO:0006956	complement activation
41.42	4.83e-05	GO:0030193	regulation of blood coagulation
81.54	5.12e-05	GO:0030194	positive regulation of blood coagulation
66.26	1.29e-04	GO:0050820	positive regulation of coagulation
33.98	1.35e-04	GO:0050818	regulation of coagulation
33.13	1.54e-04	GO:0061041	regulation of wound healing
20.66	1.74e-04	GO:0006639	acylglycerol metabolic process
20.14	2.03e-04	GO:0006638	neutral lipid metabolic process
20.14	2.03e-04	GO:0010951	negative regulation of endopeptidase activity
11.17	2.22e-04	GO:0008202	steroid metabolic process
19.64	2.35e-04	GO:0007596	blood coagulation
19.64	2.35e-04	GO:0050817	coagulation
19.40	2.53e-04	GO:0007599	hemostasis
132.50	4.07e-04	GO:0051818	disruption of cells of other organism involved in symbiotic interaction
132.50	4.07e-04	GO:0051883	killing of cells in other organism involved in symbiotic interaction
26.51	4.82e-04	GO:0006959	humoral immune response
17.11	5.33e-04	GO:0006662	glycerol ether metabolic process
16.75	6.04e-04	GO:0018904	organic ether metabolic process
12.14	6.82e-04	GO:0042060	wound healing
113.57	7.11e-04	GO:0031640	killing of cells of other organism
24.10	7.81e-04	GO:0016064	immunoglobulin mediated immune response
23.26	9.34e-04	GO:0019724	B cell mediated immunity
36.56	1.63e-03	GO:0006805	xenobiotic metabolic process
36.56	1.63e-03	GO:0071466	cellular response to xenobiotic stimulus
19.79	2.09e-03	GO:0006641	triglyceride metabolic process
13.37	2.25e-03	GO:0010466	negative regulation of peptidase activity
33.13	2.44e-03	GO:0009410	response to xenobiotic stimulus
18.94	2.60e-03	GO:0002449	lymphocyte mediated immunity
5.72	3.47e-03	GO:0051336	regulation of hydrolase activity
17.22	4.16e-03	GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
16.37	5.33e-03	GO:0002250	adaptive immune response
264.99	5.66e-03	GO:0051552	flavone metabolic process
264.99	5.66e-03	GO:0070980	biphenyl catabolic process
11.05	6.71e-03	GO:0050878	regulation of body fluid levels
15.07	7.99e-03	GO:0002443	leukocyte mediated immunity
4.14	1.08e-02	GO:0006629	lipid metabolic process
49.70	1.11e-02	GO:0030195	negative regulation of blood coagulation
10.08	1.13e-02	GO:0051346	negative regulation of hydrolase activity
9.95	1.22e-02	GO:0030162	regulation of proteolysis
7.81	1.23e-02	GO:0032101	regulation of response to external stimulus
46.77	1.34e-02	GO:0006094	gluconeogenesis
2.85	1.43e-02	GO:0065008	regulation of biological quality
176.66	1.69e-02	GO:0015712	hexose phosphate transport
176.66	1.69e-02	GO:0015760	glucose-6-phosphate transport
37.87	2.60e-02	GO:0050819	negative regulation of coagulation
5.62	3.35e-02	GO:0009611	response to wounding
132.50	3.38e-02	GO:0018879	biphenyl metabolic process
34.57	3.45e-02	GO:0001906	cell killing
34.57	3.45e-02	GO:0019319	hexose biosynthetic process
8.25	3.46e-02	GO:0052548	regulation of endopeptidase activity
17.11	3.48e-02	GO:0033500	carbohydrate homeostasis
17.11	3.48e-02	GO:0042593	glucose homeostasis
8.08	3.87e-02	GO:0046486	glycerolipid metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
11.27	8.12e-09	GO:0005792	microsome
10.98	1.12e-08	GO:0042598	vesicular fraction
4.03	1.86e-08	GO:0005576	extracellular region
6.47	4.75e-08	GO:0005615	extracellular space
5.46	6.73e-08	GO:0044421	extracellular region part
4.37	2.24e-04	GO:0005624	membrane fraction
3.74	2.99e-04	GO:0000267	cell fraction
4.17	3.80e-04	GO:0005626	insoluble fraction
3.70	1.48e-03	GO:0005783	endoplasmic reticulum

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
72.28	1.88e-08	GO:0015020	glucuronosyltransferase activity
31.56	5.81e-05	GO:0043498	cell surface binding
9.08	6.97e-05	GO:0004857	enzyme inhibitor activity
11.68	2.58e-04	GO:0004866	endopeptidase inhibitor activity
15.15	3.18e-04	GO:0004867	serine-type endopeptidase inhibitor activity
9.03	3.20e-04	GO:0016757	transferase activity, transferring glycosyl groups
22.47	3.25e-04	GO:0033293	monocarboxylic acid binding
11.25	3.30e-04	GO:0061135	endopeptidase regulator activity
11.19	3.44e-04	GO:0031406	carboxylic acid binding
22.09	3.54e-04	GO:0005496	steroid binding
11.05	3.72e-04	GO:0030414	peptidase inhibitor activity
14.73	3.75e-04	GO:0008194	UDP-glycosyltransferase activity
9.48	1.03e-03	GO:0061134	peptidase regulator activity
10.40	2.77e-03	GO:0016758	transferase activity, transferring hexosyl groups
39.76	6.55e-03	GO:0043499	eukaryotic cell surface binding
8.17	1.07e-02	GO:0017171	serine hydrolase activity
5.35	1.38e-02	GO:0008289	lipid binding
10.28	1.46e-02	GO:0004497	monooxygenase activity
106.00	1.65e-02	GO:0032052	bile acid binding
1.79	2.14e-02	GO:0003824	catalytic activity
26.51	2.27e-02	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
3.60	2.43e-02	GO:0030234	enzyme regulator activity
8.96	2.78e-02	GO:0004252	serine-type endopeptidase activity
75.72	3.44e-02	GO:0080030	methyl indole-3-acetate esterase activity
75.72	3.44e-02	GO:0080031	methyl salicylate esterase activity
75.72	3.44e-02	GO:0080032	methyl jasmonate esterase activity