Motif ID: HSF1,2.p2

Z-value: 1.087

Transcription factors associated with HSF1,2.p2:

NameEntrezDescription
Hsf1 15499 heat shock factor 1
Hsf2 15500 heat shock factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Hsf1chr15_+_76307820-0.372.5e-02Click!
Hsf2chr10_+_572061840.251.4e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr18_+_20823908 3.679 Ttr
transthyretin
chr10_-_6011993 3.600


chr7_-_35597470 3.441 NM_175140
Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr2_+_29917543 3.392 NM_023871
Set
SET nuclear oncogene
chr9_+_64988960 3.378 NM_008988
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr15_+_78757148 3.266 NM_008495
Lgals1
lectin, galactose binding, soluble 1
chr5_-_67490295 2.941 NM_008888
Phox2b
paired-like homeobox 2b
chr1_+_55144949 2.884 NM_008303
Hspe1
heat shock protein 1 (chaperonin 10)
chr4_+_154335029 2.712 NM_010419
Hes5
hairy and enhancer of split 5 (Drosophila)
chr11_+_43342241 2.651 NM_001045530
Ccnjl
cyclin J-like
chr13_-_112280018 2.630 NM_001122963
NM_028487
Gpbp1

GC-rich promoter binding protein 1

chr19_+_6363686 2.496 NM_001110791
NM_011750
Sf1

splicing factor 1

chr9_+_74709673 2.495 NM_008262
Onecut1
one cut domain, family member 1
chr6_-_128388673 2.218 Fkbp4
FK506 binding protein 4
chr13_+_99124196 2.178 NM_008242
Foxd1
forkhead box D1
chr1_+_55145132 2.004 Hspe1
heat shock protein 1 (chaperonin 10)
chr6_-_90732001 1.988 E130314K07Rik
RIKEN cDNA E130314K07 gene
chr1_+_173155184 1.971 NM_013474
Apoa2
apolipoprotein A-II
chr17_-_71199129 1.936 NM_001164076
Tgif1
TGFB-induced factor homeobox 1
chr13_-_99696254 1.895 NM_178716
Tnpo1
transportin 1
chr19_+_5366812 1.825 NM_027236
Eif1ad
eukaryotic translation initiation factor 1A domain containing
chr6_-_128388502 1.806 NM_010219
Fkbp4
FK506 binding protein 4
chr15_-_95358674 1.712 Nell2
NEL-like 2 (chicken)
chr4_-_133101802 1.706 Nudc
nuclear distribution gene C homolog (Aspergillus)
chr5_+_17080553 1.703 NM_013657
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chrM_+_12383 1.700


chr8_-_73386905 1.656 Kcnn1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr3_-_115832327 1.633 Vcam1
vascular cell adhesion molecule 1
chr1_+_140860285 1.623 NM_001166501
Dennd1b
DENN/MADD domain containing 1B
chr14_+_67853446 1.585 Ebf2
early B-cell factor 2
chr1_-_140743779 1.542 Lhx9
LIM homeobox protein 9
chr13_+_89680457 1.534 Hapln1
hyaluronan and proteoglycan link protein 1
chr2_-_91771882 1.531 Mdk
midkine
chr1_-_55144637 1.526 Hspd1
heat shock protein 1 (chaperonin)
chr11_-_77707282 1.521 NM_008952
Pipox
pipecolic acid oxidase
chr18_+_9707574 1.516 NM_130449
Colec12
collectin sub-family member 12
chr4_-_139388882 1.514 NM_011039
Pax7
paired box gene 7
chr2_+_34629622 1.494 Hspa5
heat shock protein 5
chr15_-_81230497 1.471


chr5_+_91201521 1.458 Pf4
platelet factor 4
chr4_-_33010429 1.439 NM_001012450
NM_080471
Ankrd6

ankyrin repeat domain 6

chr16_+_44139908 1.393 NM_028108
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr14_-_21000972 1.386 NM_021542
Kcnk5
potassium channel, subfamily K, member 5
chr13_-_37141055 1.383 NM_028784
F13a1
coagulation factor XIII, A1 subunit
chr7_-_106501620 1.376 Serpinh1
serine (or cysteine) peptidase inhibitor, clade H, member 1
chr13_+_89680240 1.372 NM_013500
Hapln1
hyaluronan and proteoglycan link protein 1
chr8_+_86132073 1.372 NM_018808
Dnajb1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr13_+_51740600 1.369 NM_025415
Cks2
CDC28 protein kinase regulatory subunit 2
chr13_+_95645581 1.342 NM_011021
Otp
orthopedia homolog (Drosophila)
chr7_-_106501642 1.337 NM_001111043
NM_001111044
NM_009825
Serpinh1


serine (or cysteine) peptidase inhibitor, clade H, member 1


chr13_-_3917356 1.316 NM_019671
Net1
neuroepithelial cell transforming gene 1
chr7_+_147949708 1.306 NM_021282
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr16_-_45844409 1.270 NM_153412
Phldb2
pleckstrin homology-like domain, family B, member 2
chr12_+_112776424 1.269 Eif5
eukaryotic translation initiation factor 5
chr17_-_25933867 1.263 Metrn
meteorin, glial cell differentiation regulator
chr7_-_106630812 1.242 Rps3
ribosomal protein S3
chr2_+_71227270 1.228 NM_026115
Hat1
histone aminotransferase 1
chr2_-_91771836 1.223 NM_001012335
Mdk
midkine
chr3_+_79395280 1.221 NM_026352
Ppid
peptidylprolyl isomerase D (cyclophilin D)
chr4_+_57858096 1.221 NM_001035532
NM_009649
Akap2

A kinase (PRKA) anchor protein 2

chr4_+_140566594 1.190 Mfap2
microfibrillar-associated protein 2
chr9_+_18096674 1.184 NM_025844
Chordc1
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
chr10_+_58786043 1.182 NM_011030
P4ha1
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
chr5_-_137592066 1.180 NM_201373
Trim56
tripartite motif-containing 56
chr1_-_129998984 1.172 NM_027678
Zranb3
zinc finger, RAN-binding domain containing 3
chr7_+_119822831 1.170 NM_001166584
NM_009346
Tead1

TEA domain family member 1

chr4_+_48552806 1.152 NM_001145925
NM_001145924
5730528L13Rik

RIKEN cDNA 5730528L13 gene

chr7_+_99710002 1.143 Ccdc90b
coiled-coil domain containing 90B
chr3_+_151873407 1.134 NM_057172
Fubp1
far upstream element (FUSE) binding protein 1
chr19_-_3686441 1.134 NM_008513
Lrp5
low density lipoprotein receptor-related protein 5
chr15_-_81230036 1.108 NM_133726
St13
suppression of tumorigenicity 13
chr16_-_87496048 1.099 NM_009840
Cct8
chaperonin containing Tcp1, subunit 8 (theta)
chrM_+_12178 1.094


chr5_-_116872852 1.089 NM_030704
Hspb8
heat shock protein 8
chr13_+_89680393 1.071 Hapln1
hyaluronan and proteoglycan link protein 1
chrX_-_99266499 1.067 NM_183318
Rgag4
retrotransposon gag domain containing 4
chr12_-_29320713 1.066 Rps7
ribosomal protein S7
chr1_+_70772288 1.063 NM_177164
Vwc2l
von Willebrand factor C domain-containing protein 2-like
chr19_+_36908682 1.058 NM_001163635
Tnks2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr1_-_45559904 1.051 Col5a2
collagen, type V, alpha 2
chr16_-_22265901 1.046 NM_009186
Tra2b
transformer 2 beta homolog (Drosophila)
chr2_+_164388211 1.040 NM_026323
Wfdc2
WAP four-disulfide core domain 2
chr5_-_138613028 1.036 NM_008568
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr1_-_55144687 1.032 NM_010477
Hspd1
heat shock protein 1 (chaperonin)
chr10_-_86168115 1.021 NM_011631
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr9_-_114690887 0.990 NM_133978
Cmtm7
CKLF-like MARVEL transmembrane domain containing 7
chr6_-_136890189 0.989 NM_007486
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr4_+_40669478 0.984 NM_008298
Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr12_-_28027541 0.983 NM_009234
Sox11
SRY-box containing gene 11
chr2_+_181498036 0.946 NM_001171615
Myt1
myelin transcription factor 1
chr1_-_121970345 0.936 NM_019432
Tmem37
transmembrane protein 37
chr3_-_66100663 0.934 NM_145820
Veph1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr17_-_34764290 0.921 Ppt2
palmitoyl-protein thioesterase 2
chr2_+_44966657 0.920 NM_001177394
Gm13476
predicted gene 13476
chr9_+_55388955 0.915 NM_027397
Isl2
insulin related protein 2 (islet 2)
chr12_+_112776539 0.911 Eif5
eukaryotic translation initiation factor 5
chr16_+_44173356 0.911 NM_001029889
Gm608
predicted gene 608
chr12_-_28027272 0.906 Sox11
SRY-box containing gene 11
chr15_-_25343351 0.901


chr15_-_78603701 0.898 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_-_96886327 0.896 NM_027052
Slc38a4
solute carrier family 38, member 4
chr7_-_26035683 0.894 NM_010155
Erf
Ets2 repressor factor
chr11_+_34214821 0.878 NM_001025382
Fam196b
family with sequence similarity 196, member B
chr7_-_4467556 0.878 NM_011618
Tnnt1
troponin T1, skeletal, slow
chr17_-_3557712 0.858 NM_146074
Tfb1m
transcription factor B1, mitochondrial
chr10_+_5958432 0.853 NM_001033466
Zbtb2
zinc finger and BTB domain containing 2
chr10_+_80642620 0.853 Eef2
eukaryotic translation elongation factor 2
chr2_-_91771919 0.853 NM_001012336
Mdk
midkine
chr19_+_36908807 0.849 Tnks2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr14_-_52723590 0.841 NM_001170981
NM_001170982
NM_001170983
NM_001170984
NM_016884
Hnrnpc




heterogeneous nuclear ribonucleoprotein C




chr2_-_121097017 0.840 NM_013735
Trp53bp1
transformation related protein 53 binding protein 1
chr6_+_133985717 0.839 NM_007961
Etv6
ets variant gene 6 (TEL oncogene)
chr1_-_78193381 0.836 NM_001159520
NM_008781
Pax3

paired box gene 3

chr6_+_29685467 0.831 NM_176996
Smo
smoothened homolog (Drosophila)
chr5_+_124933122 0.827 NM_029532
Snrnp35
small nuclear ribonucleoprotein 35 (U11/U12)
chr4_-_43536296 0.825 Tpm2
tropomyosin 2, beta
chr17_-_25933989 0.825 NM_133719
Metrn
meteorin, glial cell differentiation regulator
chr19_-_10278231 0.824 NM_007999
Fen1
flap structure specific endonuclease 1
chr16_-_63863905 0.815 NM_010140
Epha3
Eph receptor A3
chr3_-_83844042 0.813 NM_172681
D930015E06Rik
RIKEN cDNA D930015E06 gene
chr5_-_150438856 0.812 NM_013559
Hsph1
heat shock 105kDa/110kDa protein 1
chr7_+_90780446 0.810 NM_023377
Stard5
StAR-related lipid transfer (START) domain containing 5
chr6_+_15135505 0.789 NM_212435
Foxp2
forkhead box P2
chr8_+_94881694 0.782 NM_018826
Irx5
Iroquois related homeobox 5 (Drosophila)
chr2_+_5872500 0.779 NM_001081132
Upf2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr9_-_107888185 0.776 6230427J02Rik
RIKEN cDNA 6230427J02 gene
chr14_-_48037874 0.773 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr6_-_51419893 0.772 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr14_-_48037815 0.771 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr11_-_119971500 0.768 Slc38a10
solute carrier family 38, member 10
chr16_-_55934909 0.764 NM_001159364
NM_001159365
NM_001159366
NM_028815
Cep97



centrosomal protein 97



chr4_-_117169519 0.760 NM_025739
Rnf220
ring finger protein 220
chr11_-_89864036 0.760 NM_008796
Pctp
phosphatidylcholine transfer protein
chr10_+_126437764 0.758 NM_009635
Avil
advillin
chrX_+_93651684 0.756 NM_001159627
NM_181273
Heph

hephaestin

chrX_+_104115963 0.751 NM_175271
Lpar4
lysophosphatidic acid receptor 4
chr15_+_100135219 0.740 NM_027334
Mettl7a1
methyltransferase like 7A1
chr5_+_129526311 0.740 Ran
RAN, member RAS oncogene family
chr15_+_78757171 0.735 Lgals1
lectin, galactose binding, soluble 1
chr2_+_13501725 0.734 Vim
vimentin
chr6_+_64679118 0.731 NM_007500
Atoh1
atonal homolog 1 (Drosophila)
chr9_-_46043339 0.726 NM_023114
Apoc3
apolipoprotein C-III
chr5_+_97222355 0.722 NM_013470
Anxa3
annexin A3
chr6_-_39156609 0.720 Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr11_+_97177029 0.711 NM_025927
Mrpl45
mitochondrial ribosomal protein L45
chr15_-_78603874 0.705 NM_008595
Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_-_51004604 0.702 NM_028810
Rnd3
Rho family GTPase 3
chr18_+_35750406 0.697 Matr3
matrin 3
chr7_+_25292105 0.694 NM_146183
Zfp428
zinc finger protein 428
chr2_+_152561983 0.688 NM_010495
Id1
inhibitor of DNA binding 1
chr6_-_21802087 0.678 Tspan12
tetraspanin 12
chr12_+_82127791 0.667 NM_001146217
NM_022316
Smoc1

SPARC related modular calcium binding 1

chr4_+_41082861 0.660 Ube2r2
ubiquitin-conjugating enzyme E2R 2
chr17_-_35971652 0.659 Tubb5
tubulin, beta 5
chr6_-_39156706 0.653 NM_001033430
Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chrM_+_1550 0.650


chr17_-_47147441 0.647 NM_001177374
NM_146078
Ubr2

ubiquitin protein ligase E3 component n-recognin 2

chrX_-_45947549 0.642 NM_001166648
NM_001166649
Zfp280c

zinc finger protein 280C

chr6_+_133985988 0.642 Etv6
ets variant gene 6 (TEL oncogene)
chr2_+_172978566 0.629 NM_011044
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr1_-_121970308 0.629 Tmem37
transmembrane protein 37
chr6_+_4697305 0.624 NM_001040611
NM_130877
Peg10

paternally expressed 10

chr16_+_30065419 0.621 NM_008235
Hes1
hairy and enhancer of split 1 (Drosophila)
chr19_+_8963366 0.620 NM_025463
1810009A15Rik
RIKEN cDNA 1810009A15 gene
chr12_-_56921993 0.615 Ralgapa1
Ral GTPase activating protein, alpha subunit 1
chr1_-_157882999 0.615 Tor1aip1
torsin A interacting protein 1
chr16_+_72663393 0.615 NM_019413
Robo1
roundabout homolog 1 (Drosophila)
chr10_+_80642285 0.610 Eef2
eukaryotic translation elongation factor 2
chr8_-_72498210 0.609 NM_001113346
Gatad2a
GATA zinc finger domain containing 2A
chr11_+_120810346 0.605 NM_001038653
NM_001038654
Slc16a3

solute carrier family 16 (monocarboxylic acid transporters), member 3

chr7_-_52071027 0.601 NM_030693
Atf5
activating transcription factor 5
chr11_-_11832366 0.598 Grb10
growth factor receptor bound protein 10
chr2_+_13504271 0.596


chr5_+_103854200 0.595 NM_011204
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr12_+_110691637 0.594 NM_001190703
NM_001190704
NM_001190705
NM_010052
Dlk1



delta-like 1 homolog (Drosophila)



chr8_+_48618988 0.594 NM_203507
Rwdd4a
RWD domain containing 4A
chr2_+_27020999 0.594 NM_138942
Dbh
dopamine beta hydroxylase
chr11_-_94103862 0.593 NM_181819
Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr19_-_30623890 0.592 NM_010051
Dkk1
dickkopf homolog 1 (Xenopus laevis)
chr2_-_30329737 0.586 Ier5l
immediate early response 5-like
chr7_+_29135727 0.585 Rps16
ribosomal protein S16
chr15_-_81229961 0.583 St13
suppression of tumorigenicity 13
chr5_-_5514787 0.583 NM_001193660
NM_001193659
NM_001193661
NM_022890
Cldn12



claudin 12



chr4_-_124614072 0.581 NM_026560
Cdca8
cell division cycle associated 8
chr2_-_30329717 0.578 NM_030244
Ier5l
immediate early response 5-like
chr7_+_50699457 0.578 NM_026695
Etfb
electron transferring flavoprotein, beta polypeptide
chrX_-_71491851 0.572 NM_010227
Flna
filamin, alpha
chr1_-_180264067 0.569 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr19_+_29596741 0.569 NM_001081319
C030046E11Rik
RIKEN cDNA C030046E11 gene
chr18_-_53577625 0.568 NM_008908
Ppic
peptidylprolyl isomerase C
chr1_-_72921098 0.567 Igfbp5
insulin-like growth factor binding protein 5
chr14_-_102039655 0.567 NM_001033132
NM_001168592
Commd6

COMM domain containing 6

chr10_-_78054639 0.565 NM_027875
Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr8_-_47292973 0.565 Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr4_+_140566551 0.564 NM_008546
Mfap2
microfibrillar-associated protein 2
chr10_-_44178474 0.563 NM_007548
Prdm1
PR domain containing 1, with ZNF domain
chr6_+_29383152 0.561 NM_001081185
Flnc
filamin C, gamma
chr9_+_107471447 0.561 NM_010489
Hyal2
hyaluronoglucosaminidase 2
chr2_+_117937623 0.560 NM_011580
Thbs1
thrombospondin 1
chr6_-_127075853 0.557 Ccnd2
cyclin D2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
18.39 6.53e-08 GO:0006457 protein folding
57.28 2.69e-04 GO:0061077 chaperone-mediated protein folding
2.17 4.00e-04 GO:0044260 cellular macromolecule metabolic process
2.01 1.64e-03 GO:0043170 macromolecule metabolic process
90.69 1.72e-03 GO:0042026 protein refolding
3.12 2.33e-03 GO:0048513 organ development
2.75 4.76e-03 GO:0044267 cellular protein metabolic process
2.65 4.88e-03 GO:0048731 system development
2.49 8.36e-03 GO:0019538 protein metabolic process
2.38 2.71e-02 GO:0048856 anatomical structure development
1.74 2.78e-02 GO:0044237 cellular metabolic process
2.26 4.00e-02 GO:0007275 multicellular organismal development
1.70 4.56e-02 GO:0044238 primary metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment p-value GO term description
19.22 7.18e-05 GO:0051082 unfolded protein binding
16.02 1.59e-03 GO:0031072 heat shock protein binding
1.83 3.92e-03 GO:0005515 protein binding
1.43 8.28e-03 GO:0005488 binding