Motif ID: IKZF1.p2

Z-value: 1.178

Transcription factors associated with IKZF1.p2:

NameEntrezDescription
Ikzf1 22778 IKAROS family zinc finger 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Ikzf1chr11_+_115862730.298.3e-02Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr8_-_127093601 10.294 NM_007428
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_17652669 8.365 NM_028757
Nebl
nebulette
chr2_-_170232008 8.041 Bcas1
breast carcinoma amplified sequence 1
chr15_+_91881593 7.842 NM_001159648
Cntn1
contactin 1
chr12_-_11443284 7.672 NM_012038
Vsnl1
visinin-like 1
chr14_-_104242892 7.198 NM_007904
Ednrb
endothelin receptor type B
chr13_+_54472806 7.119 Cplx2
complexin 2
chr13_+_54472833 5.840 Cplx2
complexin 2
chr8_+_56040445 5.811 Gpm6a
glycoprotein m6a
chr13_+_54472705 5.297 NM_009946
Cplx2
complexin 2
chr4_-_25727109 5.262 NM_010243
Fut9
fucosyltransferase 9
chr11_-_102758340 5.038 Gfap
glial fibrillary acidic protein
chr10_+_122116066 4.988 Ppm1h
protein phosphatase 1H (PP2C domain containing)
chr15_+_83998239 4.964 NM_054088
Pnpla3
patatin-like phospholipase domain containing 3
chr5_-_151397024 4.696 NM_133898
N4bp2l1
NEDD4 binding protein 2-like 1
chr2_-_25325248 4.633 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr10_+_57514349 4.617 NM_020561
Smpdl3a
sphingomyelin phosphodiesterase, acid-like 3A
chr4_+_84851330 3.917 NM_019535
Sh3gl2
SH3-domain GRB2-like 2
chr18_+_63137573 3.893 Napg
N-ethylmaleimide sensitive fusion protein attachment protein gamma
chr16_-_20621287 3.876 NM_028420
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr19_+_53214934 3.858 NM_001164099
NM_001164101
Add3

adducin 3 (gamma)

chr7_+_120909680 3.815 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr7_-_30066910 3.704 NM_001082548
NM_011464
Spint2

serine protease inhibitor, Kunitz type 2

chr1_-_157883515 3.673 NM_001160018
NM_144791
Tor1aip1

torsin A interacting protein 1

chr1_-_79436564 3.655 NM_009129
Scg2
secretogranin II
chr1_+_36364557 3.626 NM_001172205
NM_001172206
NM_145996
Arid5a


AT rich interactive domain 5A (MRF1-like)


chr19_-_5085487 3.409 Tmem151a
transmembrane protein 151A
chr7_-_20282950 3.336 Apoe
apolipoprotein E
chr18_+_35020859 3.292 NM_007913
Egr1
early growth response 1
chr16_+_91270009 3.292 NM_016968
Olig1
oligodendrocyte transcription factor 1
chr6_+_88674398 3.286 NM_001166249
NM_011844
Mgll

monoglyceride lipase

chr2_-_92241357 3.255 NM_011162
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr7_+_100228374 3.215 NM_021427
Fam181b
family with sequence similarity 181, member B
chrX_+_7455387 3.186 NM_138606
Pim2
proviral integration site 2
chr6_+_88674821 3.174 Mgll
monoglyceride lipase
chr8_+_11758376 3.148 Arhgef7
Rho guanine nucleotide exchange factor (GEF7)
chr3_-_80606500 3.076 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr5_-_21850490 3.072 NM_011261
Reln
reelin
chr10_+_115738429 3.037 NM_029928
Ptprb
protein tyrosine phosphatase, receptor type, B
chr19_+_23833310 3.003 NM_177034
Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr4_-_128798481 2.990 NM_010471
Hpca
hippocalcin
chr2_-_181194085 2.907 NM_028125
Zbtb46
zinc finger and BTB domain containing 46
chr5_+_37259780 2.791 NM_172994
Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr3_-_107320881 2.783 NM_172271
Slc6a17
solute carrier family 6 (neurotransmitter transporter), member 17
chr7_+_35971403 2.765 NM_017394
Slc7a10
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
chr8_+_56040553 2.748 Gpm6a
glycoprotein m6a
chr8_+_56040211 2.713 Gpm6a
glycoprotein m6a
chr17_-_67703726 2.698 NM_008984
Ptprm
protein tyrosine phosphatase, receptor type, M
chr8_+_113245378 2.657 NM_198625
Mtss1l
metastasis suppressor 1-like
chr11_-_119878383 2.646 Aatk
apoptosis-associated tyrosine kinase
chr11_-_90548862 2.632 NM_028011
Tom1l1
target of myb1-like 1 (chicken)
chr11_-_102758460 2.612 NM_001131020
NM_010277
Gfap

glial fibrillary acidic protein

chr1_+_10983542 2.571 NM_029525
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr7_-_53435334 2.541 NM_011510
Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr2_+_158436493 2.534 NM_009508
Slc32a1
solute carrier family 32 (GABA vesicular transporter), member 1
chr19_+_23215704 2.500 NM_010638
Klf9
Kruppel-like factor 9
chr4_-_133443662 2.485 NM_009097
Rps6ka1
ribosomal protein S6 kinase polypeptide 1
chr18_+_63137550 2.483 Napg
N-ethylmaleimide sensitive fusion protein attachment protein gamma
chrX_+_7234519 2.476 Prickle3
prickle homolog 3 (Drosophila)
chr4_+_126287086 2.447 NM_001013755
NM_001145950
5730409E04Rik

RIKEN cDNA 5730409E04Rik gene

chr15_-_66801198 2.404 NM_008681
Ndrg1
N-myc downstream regulated gene 1
chr12_+_16660521 2.402 Ntsr2
neurotensin receptor 2
chr17_+_35960291 2.388 NM_008027
Flot1
flotillin 1
chr9_-_53822931 2.367 Elmod1
ELMO domain containing 1
chr6_+_66846377 2.335 NM_001177556
NM_001177557
NM_001177559
NM_001177560
NM_025278
Gng12




guanine nucleotide binding protein (G protein), gamma 12




chr6_+_88674697 2.271 NM_001166250
NM_001166251
Mgll

monoglyceride lipase

chr13_-_61037894 2.162 NM_001145799
Ctla2a
cytotoxic T lymphocyte-associated protein 2 alpha
chr12_-_77811119 2.148 Spnb1
spectrin beta 1
chr9_-_95650735 2.129 NM_011643
Trpc1
transient receptor potential cation channel, subfamily C, member 1
chr1_-_134036041 2.092 NM_008795
Cdk18
cyclin-dependent kinase 18
chr8_+_56040193 2.070 Gpm6a
glycoprotein m6a
chr11_+_94871181 2.033 NM_146025
Samd14
sterile alpha motif domain containing 14
chr3_-_80606598 2.029 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr1_-_84692750 2.019 NM_152915
Dner
delta/notch-like EGF-related receptor
chr17_-_24306262 2.000 NM_009729
Atp6v0c-ps2
Atp6v0c
ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 2
ATPase, H+ transporting, lysosomal V0 subunit C
chr8_-_67171805 1.999 NM_013494
Cpe
carboxypeptidase E
chr11_+_77992224 1.981 NM_026708
Tlcd1
TLC domain containing 1
chr13_-_19711409 1.971 NM_134065
Epdr1
ependymin related protein 1 (zebrafish)
chr2_-_104250490 1.915 NM_001033347
D430041D05Rik
RIKEN cDNA D430041D05 gene
chr15_-_36538288 1.862 Pabpc1
poly(A) binding protein, cytoplasmic 1
chr15_+_39491073 1.856 Rims2
regulating synaptic membrane exocytosis 2
chr19_-_10315199 1.828 NM_001033481
Gm98
predicted gene 98
chr18_+_63137566 1.827 NM_028017
Napg
N-ethylmaleimide sensitive fusion protein attachment protein gamma
chr10_-_67011689 1.822 NM_001005419
Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr16_+_41533317 1.803 NM_175548
Lsamp
limbic system-associated membrane protein
chrX_+_149574541 1.795 Rragb
Ras-related GTP binding B
chr18_+_63137498 1.792 Napg
N-ethylmaleimide sensitive fusion protein attachment protein gamma
chr15_-_77137301 1.775 Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr16_+_38089536 1.758 Gsk3b
glycogen synthase kinase 3 beta
chr8_-_112692071 1.725 NM_007586
Calb2
calbindin 2
chr15_-_94234549 1.699 Adamts20
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
chr3_-_31209216 1.670 NM_172861
Slc7a14
solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
chr2_-_17652725 1.651 Nebl
nebulette
chr7_+_80885175 1.649 NM_001162532
Fam174b
family with sequence similarity 174, member B
chr1_+_95582188 1.647 NM_016778
Bok
BCL2-related ovarian killer protein
chr12_+_75385267 1.635 1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr14_+_119254123 1.594 NM_001160099
NM_021386
Cldn10

claudin 10

chrX_+_10294707 1.578 Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr8_+_48072271 1.573 NM_177304
Enpp6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr17_+_8476638 1.552 NM_018819
Brp44l
brain protein 44-like
chr7_+_80885223 1.551 Fam174b
family with sequence similarity 174, member B
chr6_-_137597775 1.539 Eps8
epidermal growth factor receptor pathway substrate 8
chr1_+_74283381 1.528 Arpc2
actin related protein 2/3 complex, subunit 2
chr1_+_174271397 1.525 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr13_+_31898612 1.523 Foxc1
forkhead box C1
chr7_+_97535490 1.520 NM_001040087
NM_001040088
Sytl2

synaptotagmin-like 2

chr7_+_120909625 1.519 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr18_+_63137563 1.505 Napg
N-ethylmaleimide sensitive fusion protein attachment protein gamma
chr3_+_53267587 1.505 2810046L04Rik
RIKEN cDNA 2810046L04 gene
chr9_+_86465577 1.504 NM_001145969
NM_001145968
NM_027100
Rwdd2a


RWD domain containing 2A


chr7_-_112781902 1.496 NM_018880
Trim3
tripartite motif-containing 3
chr4_+_84851440 1.486 Sh3gl2
SH3-domain GRB2-like 2
chr6_-_125444722 1.464 NM_007657
Cd9
CD9 antigen
chr12_-_113146259 1.438 NM_011625
Ppp1r13b
protein phosphatase 1, regulatory (inhibitor) subunit 13B
chr9_-_114842996 1.426 Gpd1l
glycerol-3-phosphate dehydrogenase 1-like
chr16_+_96689322 1.417


chr12_+_12268901 1.413 NM_001146119
NM_029758
Fam49a

family with sequence similarity 49, member A

chr1_-_75260687 1.411 NM_008985
Ptprn
protein tyrosine phosphatase, receptor type, N
chr5_-_104542729 1.397 Sparcl1
SPARC-like 1
chr2_+_157740281 1.392 NM_198627
Vstm2l
V-set and transmembrane domain containing 2-like
chr9_-_53823107 1.384 NM_177769
Elmod1
ELMO domain containing 1
chr5_-_24083072 1.381 Abcf2
ATP-binding cassette, sub-family F (GCN20), member 2
chr2_-_148558110 1.347 NM_019632
Napb
N-ethylmaleimide sensitive fusion protein attachment protein beta
chr11_-_95936914 1.343 NM_001161419
NM_007506
Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr15_+_81977766 1.342 Srebf2
sterol regulatory element binding factor 2
chr5_+_98683202 1.340 NM_010203
Fgf5
fibroblast growth factor 5
chr14_+_55502261 1.340 NM_007537
Bcl2l2
BCL2-like 2
chrX_-_9240025 1.331 NM_025975
Dynlt3
dynein light chain Tctex-type 3
chr10_-_108447996 1.295 Syt1
synaptotagmin I
chr14_+_21895418 1.284 Adk
adenosine kinase
chr17_+_31194623 1.282 NM_009593
Abcg1
ATP-binding cassette, sub-family G (WHITE), member 1
chr3_+_152009483 1.271 Usp33
ubiquitin specific peptidase 33
chr15_-_8584897 1.267 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_+_4133370 1.265 NM_001159536
NM_001159537
Adcy3

adenylate cyclase 3

chr11_+_109511803 1.263 Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
chr1_+_89160921 1.253 NM_028889
Efhd1
EF hand domain containing 1
chr11_-_118216625 1.252 Timp2
tissue inhibitor of metalloproteinase 2
chr11_-_6344445 1.244 NM_029938
H2afv
H2A histone family, member V
chr18_+_33098694 1.244 NM_009793
Camk4
calcium/calmodulin-dependent protein kinase IV
chrX_+_39502588 1.241 NM_001077712
Stag2
stromal antigen 2
chr18_-_24688558 1.233 Rprd1a
regulation of nuclear pre-mRNA domain containing 1A
chr18_+_38456315 1.206 Rnf14
ring finger protein 14
chr1_-_136131399 1.198 Adora1
adenosine A1 receptor
chr11_+_92959670 1.193 Car10
carbonic anhydrase 10
chr6_-_97437749 1.193 Frmd4b
FERM domain containing 4B
chr2_+_132088957 1.164 Cds2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chrX_+_33652066 1.145 NM_133990
Il13ra1
interleukin 13 receptor, alpha 1
chr3_+_87723608 1.139 Mrpl24
mitochondrial ribosomal protein L24
chr9_-_61762220 1.130 NM_018853
Rplp1
ribosomal protein, large, P1
chr7_-_112717810 1.130 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr11_-_74739106 1.124 Srr
serine racemase
chr18_+_23468655 1.123 Dtna
dystrobrevin alpha
chr2_-_155340538 1.121 NM_144786
Ggt7
gamma-glutamyltransferase 7
chr2_+_127073631 1.121 NM_175145
Tmem127
transmembrane protein 127
chr4_+_126287109 1.114 5730409E04Rik
RIKEN cDNA 5730409E04Rik gene
chr3_-_126865105 1.099 Ank2
ankyrin 2, brain
chr11_-_69479553 1.082 NM_009853
Cd68
CD68 antigen
chr12_+_79327630 1.074 NM_145965
NM_172952
Gphn

gephyrin

chr11_-_94335350 1.071 NM_001112813
NM_001177888
NM_001177890
NM_009783
Cacna1g



calcium channel, voltage-dependent, T type, alpha 1G subunit



chr19_+_6341137 1.061 NM_009006
Map4k2
mitogen-activated protein kinase kinase kinase kinase 2
chr2_-_92241282 1.057 Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr12_+_85626260 1.043 NM_029880
Ptgr2
prostaglandin reductase 2
chr14_+_21895346 1.037 Adk
adenosine kinase
chr19_-_5118229 1.031 NM_008451
Klc2
kinesin light chain 2
chr19_+_23215725 1.029 Klf9
Kruppel-like factor 9
chr4_-_43591258 1.024 Gba2
glucosidase beta 2
chr1_-_52874501 1.023 NM_008384
Inpp1
inositol polyphosphate-1-phosphatase
chr15_+_40486577 1.013 NM_011766
Zfpm2
zinc finger protein, multitype 2
chr15_-_99602827 1.012 NM_028015
Lass5
LAG1 homolog, ceramide synthase 5
chr11_-_17111582 1.009 NM_025443
Pno1
partner of NOB1 homolog (S. cerevisiae)
chr5_-_69732792 1.007 Kctd8
potassium channel tetramerisation domain containing 8
chr5_+_98758322 1.006 NM_001024614
1700007G11Rik
RIKEN cDNA 1700007G11 gene
chr1_+_174271338 1.001 NM_001039484
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr4_-_147310804 1.000 NM_011122
Plod1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr3_-_80606704 0.996 NM_001039195
NM_001083806
NM_013540
Gria2


glutamate receptor, ionotropic, AMPA2 (alpha 2)


chr8_+_127316918 0.992 NM_198632
Trim67
tripartite motif-containing 67
chr8_-_101940218 0.992 NM_001039154
NM_007667
Cdh8

cadherin 8

chr4_+_49072138 0.977 E130309F12Rik
RIKEN cDNA E130309F12 gene
chr10_+_89336253 0.970 NM_001128086
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_-_149329097 0.969 NM_029035
Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
chr18_+_23468585 0.965 Dtna
dystrobrevin alpha
chr1_+_7079042 0.963 Pcmtd1
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr4_+_106926486 0.960 NM_028394
Hspb11
heat shock protein family B (small), member 11
chr17_+_35068258 0.956 Neu1
neuraminidase 1
chrX_-_154481213 0.952


chr12_+_79327673 0.948 Gphn
gephyrin
chr15_+_74551611 0.947 NM_198607
4930572J05Rik
RIKEN cDNA 4930572J05 gene
chr3_+_141128527 0.945 NM_009472
Unc5c
unc-5 homolog C (C. elegans)
chr3_+_152009470 0.936 Usp33
ubiquitin specific peptidase 33
chrX_+_133371611 0.936 Plp1
proteolipid protein (myelin) 1
chr3_+_117278144 0.934 NM_029425
4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr12_+_56499902 0.932 Psma6
proteasome (prosome, macropain) subunit, alpha type 6
chr13_-_8870975 0.919 NM_001039388
Wdr37
WD repeat domain 37
chr9_-_79566271 0.917 NM_007730
Col12a1
collagen, type XII, alpha 1
chr10_+_79127318 0.904 NM_013591
Madcam1
mucosal vascular addressin cell adhesion molecule 1
chr2_+_155102040 0.903 NM_025735
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr15_-_43002356 0.901 NM_172815
Rspo2
R-spondin 2 homolog (Xenopus laevis)
chr7_+_52112742 0.894 Pnkp
polynucleotide kinase 3'- phosphatase
chr7_+_127245860 0.887 NM_145586
Tmem159
transmembrane protein 159
chr18_+_65960170 0.884 NM_025468
Sec11c
SEC11 homolog C (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
7.26 8.83e-05 GO:0031644 regulation of neurological system process
11.71 3.51e-04 GO:0042063 gliogenesis
5.43 7.23e-04 GO:0019226 transmission of nerve impulse
5.43 7.23e-04 GO:0035637 multicellular organismal signaling
2.04 9.64e-04 GO:0051179 localization
4.88 9.71e-04 GO:0044057 regulation of system process
12.06 1.56e-03 GO:0010001 glial cell differentiation
14.85 2.57e-03 GO:0050880 regulation of blood vessel size
6.58 2.60e-03 GO:0051969 regulation of transmission of nerve impulse
5.81 2.76e-03 GO:0007268 synaptic transmission
14.58 2.86e-03 GO:0035150 regulation of tube size
2.07 6.10e-03 GO:0006810 transport
12.19 8.24e-03 GO:0003018 vascular process in circulatory system
12.19 8.24e-03 GO:0043270 positive regulation of ion transport
2.04 9.00e-03 GO:0051234 establishment of localization
6.38 1.05e-02 GO:0050804 regulation of synaptic transmission
4.59 1.07e-02 GO:0051050 positive regulation of transport
3.16 1.33e-02 GO:0022008 neurogenesis
10.61 1.84e-02 GO:0048167 regulation of synaptic plasticity
2.84 2.04e-02 GO:0051641 cellular localization
45.35 2.70e-02 GO:0010872 regulation of cholesterol esterification
4.10 3.30e-02 GO:0007267 cell-cell signaling
8.98 4.77e-02 GO:0006836 neurotransmitter transport
2.58 4.93e-02 GO:0007399 nervous system development

Gene overrepresentation in compartment category:

enrichment p-value GO term description
5.14 2.08e-06 GO:0045202 synapse
6.69 3.69e-06 GO:0030425 dendrite
4.42 2.05e-05 GO:0043005 neuron projection
5.24 1.95e-04 GO:0044297 cell body
2.98 3.70e-04 GO:0042995 cell projection
11.34 4.25e-04 GO:0030427 site of polarized growth
1.89 6.31e-04 GO:0005886 plasma membrane
1.85 1.12e-03 GO:0071944 cell periphery
4.65 3.98e-03 GO:0043025 neuronal cell body
10.08 4.43e-03 GO:0030426 growth cone
2.21 7.70e-03 GO:0044459 plasma membrane part
136.03 8.27e-03 GO:0044292 dendrite terminus
18.77 8.79e-03 GO:0030672 synaptic vesicle membrane
1.56 1.05e-02 GO:0044444 cytoplasmic part
1.40 1.79e-02 GO:0005737 cytoplasm
1.39 2.47e-02 GO:0016020 membrane
4.09 2.70e-02 GO:0044456 synapse part
13.61 3.18e-02 GO:0042734 presynaptic membrane

Gene overrepresentation in function category:

enrichment p-value GO term description
1.80 4.26e-06 GO:0005515 protein binding
1.39 1.27e-04 GO:0005488 binding