Motif ID: IRF1,2,7.p3

Z-value: 2.410

Transcription factors associated with IRF1,2,7.p3:

NameEntrezDescription
Irf1 16362 interferon regulatory factor 1
Irf2 16363 interferon regulatory factor 2
Irf7 54123 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Irf1chr11_+_535835150.773.3e-08Click!
Irf7chr7_-_1484522990.546.5e-04Click!
Irf2chr8_+_478250720.482.7e-03Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Description
chr6_-_23789259 27.697 NM_153163
Cadps2
Ca2+-dependent activator protein for secretion 2
chr5_-_138404150 17.551 NM_080450
Gjc3
gap junction protein, gamma 3
chr11_-_78798332 14.944 NM_001159301
NM_010708
Lgals9

lectin, galactose binding, soluble 9

chr10_-_24919916 14.906 Akap7
A kinase (PRKA) anchor protein 7
chr14_+_14117313 14.464 Synpr
synaptoporin
chr15_-_8660462 13.315 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_+_122115755 13.250 NM_001110218
NM_176919
Ppm1h

protein phosphatase 1H (PP2C domain containing)

chr2_-_7002287 13.194 Celf2
CUGBP, Elav-like family member 2
chr2_-_7002344 12.234 NM_001110229
NM_001110230
NM_001160292
Celf2


CUGBP, Elav-like family member 2


chr9_+_20673069 11.801 NM_175687
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr3_-_50247306 11.793 NM_011990
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr7_-_148196526 11.107 Ifitm3
interferon induced transmembrane protein 3
chr8_+_24521967 9.662 NM_013834
Sfrp1
secreted frizzled-related protein 1
chr2_+_121973414 8.787 NM_009735
B2m
beta-2 microglobulin
chr6_-_23789048 8.770 Cadps2
Ca2+-dependent activator protein for secretion 2
chrX_+_10062237 8.209 NM_019634
Tspan7
tetraspanin 7
chr15_-_8660442 7.986 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_96361879 7.897 NM_001009935
NM_023719
Txnip

thioredoxin interacting protein

chr6_+_22825464 7.835 NM_001081306
Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr10_-_60294129 7.774 NM_029770
Unc5b
unc-5 homolog B (C. elegans)
chr15_+_3220994 7.671 Sepp1
selenoprotein P, plasma, 1
chr6_-_23789419 7.530 Cadps2
Ca2+-dependent activator protein for secretion 2
chr7_-_148196606 7.299 Ifitm3
interferon induced transmembrane protein 3
chr11_+_100436283 7.236 Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr6_+_141472906 7.184 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chr14_+_14117292 6.975 NM_028052
Synpr
synaptoporin
chr15_-_8660479 6.931 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8660393 6.800 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_+_3220999 6.547 Sepp1
selenoprotein P, plasma, 1
chr15_-_8660729 6.409 NM_148938
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_+_75692745 6.064 NM_026960
Gsdmd
gasdermin D
chr1_-_156731538 5.902 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr5_+_75548337 5.852 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr11_+_3414792 5.502 Selm
selenoprotein M
chr3_+_81736518 5.174 NM_177662
Ctso
cathepsin O
chr8_-_108461909 5.121 Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr13_+_46597271 5.079 NM_026056
Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr18_+_23573908 5.065 NM_010087
NM_207650
Dtna

dystrobrevin alpha

chr1_-_156993820 5.026 NM_008209
Mr1
major histocompatibility complex, class I-related
chr8_-_74061134 4.920 NM_198095
Bst2
bone marrow stromal cell antigen 2
chr8_+_87162885 4.709 Cacna1a
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr19_+_53214934 4.633 NM_001164099
NM_001164101
Add3

adducin 3 (gamma)

chr3_-_107563049 4.551 Csf1
colony stimulating factor 1 (macrophage)
chr15_+_74551611 4.493 NM_198607
4930572J05Rik
RIKEN cDNA 4930572J05 gene
chrM_+_12383 4.229


chr12_+_104672380 4.184 NM_026790
NM_194066
NM_194067
NM_194068
NM_194069
Ifi27l1




interferon, alpha-inducible protein 27 like 1




chr15_+_32850477 4.164 NM_008304
Sdc2
syndecan 2
chr7_-_20282950 4.125 Apoe
apolipoprotein E
chr16_+_23609986 4.009 NM_023386
Rtp4
receptor transporter protein 4
chr10_+_75716647 3.866 S100b
S100 protein, beta polypeptide, neural
chr13_+_23622912 3.751 NM_153173
Hist1h4h
histone cluster 1, H4h
chr10_+_77532065 3.747 NM_015790
Icosl
icos ligand
chr13_+_94541584 3.617 NM_009712
Arsb
arylsulfatase B
chr10_-_75130829 3.562 Cabin1
calcineurin binding protein 1
chr10_-_128356215 3.555 NM_134006
Rdh5
retinol dehydrogenase 5
chr12_+_110783593 3.548 Meg3
maternally expressed 3
chr3_-_117063317 3.544 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr17_+_34056585 3.529 Tapbp
TAP binding protein
chr7_-_148621230 3.498 Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr9_+_118387306 3.442 NM_001164789
NM_010136
Eomes

eomesodermin homolog (Xenopus laevis)

chr9_-_103664100 3.333 NM_178638
Tmem108
transmembrane protein 108
chr11_-_110029368 3.331 NM_147220
Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr7_-_152125661 3.270 Ccnd1
cyclin D1
chr16_+_43619057 3.256 Zbtb20
zinc finger and BTB domain containing 20
chr11_+_119254380 3.244 Rnf213
ring finger protein 213
chr2_-_127347102 3.066 NM_019789
Kcnip3
Kv channel interacting protein 3, calsenilin
chr9_-_58097422 3.007 Pml
promyelocytic leukemia
chr2_-_51790406 2.951 NM_001141981
NM_030243
Rbm43

RNA binding motif protein 43

chr1_-_142079842 2.911 NM_009888
Cfh
complement component factor h
chr11_+_78137699 2.876 NM_009657
Aldoc
aldolase C, fructose-bisphosphate
chr3_+_145421621 2.734 NM_026993
Ddah1
dimethylarginine dimethylaminohydrolase 1
chr9_+_5345475 2.669 NM_009808
Casp12
caspase 12
chr2_-_51828440 2.666 Nmi
N-myc (and STAT) interactor
chr14_-_66452720 2.646 NM_028039
Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr11_-_18918923 2.633 NM_001193271
NM_010789
Meis1

Meis homeobox 1

chrM_+_11812 2.577


chr9_+_80012873 2.574 Myo6
myosin VI
chr11_+_72115129 2.537 NM_001037713
Xaf1
XIAP associated factor 1
chr10_+_7309565 2.526 NM_172784
Lrp11
low density lipoprotein receptor-related protein 11
chr9_+_80012837 2.511 NM_001039546
Myo6
myosin VI
chr4_-_40186722 2.509 NM_172689
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_-_48684659 2.494 NM_008326
Irgm1
immunity-related GTPase family M member 1
chr13_+_24893310 2.410 NM_024473
BC005537
cDNA sequence BC005537
chr10_+_85484631 2.316 NM_153195
Fbxo7
F-box protein 7
chr17_+_57498108 2.312 NM_010130
Emr1
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
chr10_-_30375572 2.294 NM_001111267
Ncoa7
nuclear receptor coactivator 7
chr3_+_113733536 2.285 Col11a1
collagen, type XI, alpha 1
chr8_+_114535258 2.269 NM_020584
Terf2ip
telomeric repeat binding factor 2, interacting protein
chr2_-_180891448 2.263 Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr13_+_37437194 2.230 NM_010745
Ly86
lymphocyte antigen 86
chrX_+_65931956 2.222 Fmr1
fragile X mental retardation syndrome 1 homolog
chr1_+_52176281 2.201 NM_009283
Stat1
signal transducer and activator of transcription 1
chr16_-_85173851 2.200 App
amyloid beta (A4) precursor protein
chr8_-_83262881 2.196 Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr7_+_114710946 2.176 NM_172907
Olfml1
olfactomedin-like 1
chr12_-_103677867 2.160 NM_011175
Lgmn
legumain
chr17_-_90855291 2.152


chr3_-_146433544 2.152 NM_001164199
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr6_-_38304558 2.097 NM_028421
NM_028864
Zc3hav1

zinc finger CCCH type, antiviral 1

chr17_+_34335139 2.057 NM_010724
Psmb8
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
chr16_-_36784864 2.040 NM_001145899
NM_021301
Slc15a2

solute carrier family 15 (H+/peptide transporter), member 2

chr13_+_49600158 2.021 NM_001012324
Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr14_-_79701303 1.997 NM_025427
1190002H23Rik
RIKEN cDNA 1190002H23 gene
chr16_-_44333103 1.986 Sidt1
SID1 transmembrane family, member 1
chr8_-_113329771 1.978 NM_001135100
NM_029646
Il34

interleukin 34

chr5_-_90652790 1.975 Cox18
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr4_-_96220294 1.969 NM_010008
Cyp2j6
cytochrome P450, family 2, subfamily j, polypeptide 6
chr1_-_186556329 1.965 NM_008250
Hlx
H2.0-like homeobox
chr5_+_75548309 1.915 NM_011058
Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr8_-_125075222 1.901 NM_001037298
Fam38a
family with sequence similarity 38, member A
chr8_+_119028873 1.890 NM_029297
Dynlrb2
dynein light chain roadblock-type 2
chr4_-_96220030 1.889 Cyp2j6
cytochrome P450, family 2, subfamily j, polypeptide 6
chr6_+_45010040 1.879 NM_001004357
Cntnap2
contactin associated protein-like 2
chr5_-_143084677 1.866 NM_175217
Mmd2
monocyte to macrophage differentiation-associated 2
chr1_+_173053280 1.860 1700009P17Rik
RIKEN cDNA 1700009P17 gene
chr19_+_4099973 1.857 NM_001136078
Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr16_-_10785590 1.797 NM_009896
Socs1
suppressor of cytokine signaling 1
chr11_+_100436316 1.796 Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr2_-_152157835 1.782 Rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr19_-_57082666 1.775 Afap1l2
actin filament associated protein 1-like 2
chr16_+_35939047 1.725 Parp9
poly (ADP-ribose) polymerase family, member 9
chrM_+_12178 1.718


chr8_-_107850154 1.693 NM_177449
Lrrc29
leucine rich repeat containing 29
chr8_-_46418352 1.623 NM_133969
Cyp4v3
cytochrome P450, family 4, subfamily v, polypeptide 3
chr9_+_72859850 1.614 Ccpg1
cell cycle progression 1
chr10_+_75716580 1.590 NM_009115
S100b
S100 protein, beta polypeptide, neural
chr19_+_22767272 1.584 Trpm3
transient receptor potential cation channel, subfamily M, member 3
chr9_-_57110250 1.582 NM_028820
1700017B05Rik
RIKEN cDNA 1700017B05 gene
chr11_-_42134548 1.565 NM_001099641
NM_008068
Gabra6

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6

chr10_-_75130331 1.559 Cabin1
calcineurin binding protein 1
chr8_-_3672313 1.533 2400009B08Rik
RIKEN cDNA 2400009B08 gene
chr1_-_175810248 1.531 NM_001170853
Mndal
myeloid nuclear differentiation antigen like
chr1_-_172040852 1.511 Ddr2
discoidin domain receptor family, member 2
chr13_+_56710896 1.495 NM_009369
Tgfbi
transforming growth factor, beta induced
chr13_-_25029458 1.485 NM_172532
Aldh5a1
aldhehyde dehydrogenase family 5, subfamily A1
chr8_-_88224811 1.483 Neto2
neuropilin (NRP) and tolloid (TLL)-like 2
chr2_-_32837527 1.475 NM_019488
Slc2a8
solute carrier family 2, (facilitated glucose transporter), member 8
chr10_-_126959397 1.462 Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr14_-_104243541 1.460 Ednrb
endothelin receptor type B
chr11_-_109856977 1.456 NM_013851
Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr17_+_34056367 1.446 NM_001025313
NM_009318
Tapbp

TAP binding protein

chr1_-_66909822 1.438 NM_007381
Acadl
acyl-Coenzyme A dehydrogenase, long-chain
chr4_+_99602038 1.411 NM_028132
Pgm2
phosphoglucomutase 2
chr3_+_27215949 1.397 NM_009425
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
chrX_-_47988434 1.395 6720401G13Rik
RIKEN cDNA 6720401G13 gene
chrX_+_65931715 1.391 NM_008031
Fmr1
fragile X mental retardation syndrome 1 homolog
chr14_-_14117143 1.389 NM_177813
Gm5087
predicted gene 5087
chr7_+_25669603 1.385 NM_023133
Rps19
ribosomal protein S19
chr6_+_128942978 1.383 BC064078
cDNA sequence BC064078
chr1_-_133423902 1.382 NM_001081011
Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr16_-_85173764 1.372 App
amyloid beta (A4) precursor protein
chr10_-_77815056 1.369 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr7_-_134158053 1.364 NM_080638
Mvp
major vault protein
chr12_+_102017289 1.359 NM_145448
9030617O03Rik
RIKEN cDNA 9030617O03 gene
chr7_+_82846863 1.354 Akap13
A kinase (PRKA) anchor protein 13
chr2_+_32502107 1.352 NM_001146348
NM_001146350
NM_007932
Eng


endoglin


chr3_-_96067233 1.346 NM_033596
Hist2h4
histone cluster 2, H4
chr10_-_94407211 1.340 NM_018797
Plxnc1
plexin C1
chr17_-_34324234 1.336 NM_013585
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr3_-_142058595 1.334 NM_001190852
NM_001190853
NM_001190854
NM_001190855
NM_001190856
NM_019808
NM_019809
Pdlim5






PDZ and LIM domain 5






chr10_-_126959446 1.326 NM_028230
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr18_+_23573939 1.314 Dtna
dystrobrevin alpha
chr6_-_120772651 1.286 Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr1_-_172519932 1.285 NM_001109985
Nos1ap
nitric oxide synthase 1 (neuronal) adaptor protein
chr8_+_89997055 1.284 C230036H16Rik
RIKEN cDNA C230036H16 gene
chr13_-_23802635 1.281 NM_010424
Hfe
hemochromatosis
chr15_+_33012972 1.279 Pgcp
plasma glutamate carboxypeptidase
chr5_-_134705423 1.257 NM_010876
Ncf1
neutrophil cytosolic factor 1
chr3_+_142193286 1.252 NM_001083312
NM_145545
Gbp6

guanylate binding protein 6

chr4_+_84851330 1.247 NM_019535
Sh3gl2
SH3-domain GRB2-like 2
chr7_-_53435334 1.240 NM_011510
Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr11_+_43287798 1.238 C1qtnf2
C1q and tumor necrosis factor related protein 2
chr14_+_21895346 1.221 Adk
adenosine kinase
chr8_-_73919683 1.214 NM_181418
Ushbp1
Usher syndrome 1C binding protein 1
chr18_-_33623273 1.207 D0H4S114
DNA segment, human D4S114
chr18_+_37885359 1.207 NM_033591
Pcdhga8
protocadherin gamma subfamily A, 8
chr1_-_74982118 1.198 NM_001039495
Ccdc108
coiled-coil domain containing 108
chr4_+_52452089 1.198 NM_008017
Smc2
structural maintenance of chromosomes 2
chr6_-_112646587 1.193 NM_001167730
NM_021385
Rad18

RAD18 homolog (S. cerevisiae)

chr4_+_45985143 1.191 Tdrd7
tudor domain containing 7
chrX_+_70728939 1.175 NM_007542
Bgn
biglycan
chr7_-_152125823 1.165 NM_007631
Ccnd1
cyclin D1
chr11_+_75327028 1.165 NM_001004157
Scarf1
scavenger receptor class F, member 1
chr11_-_48630854 1.164 NM_145377
Trim41
tripartite motif-containing 41
chr8_+_67471046 1.160 NM_001163747
NM_028427
Tmem192

transmembrane protein 192

chr4_-_41261743 1.155 Dcaf12
DDB1 and CUL4 associated factor 12
chr7_-_148452299 1.127 NM_016850
Irf7
interferon regulatory factor 7
chrX_+_50341236 1.125 NM_013556
Hprt
hypoxanthine guanine phosphoribosyl transferase
chr11_-_116515232 1.125 Cygb
cytoglobin
chr15_+_99223377 1.116 NM_001171034
NM_001171036
NM_026669
Tmbim6


transmembrane BAX inhibitor motif containing 6


chr2_+_166631011 1.113 NM_001085495
Arfgef2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr7_+_96781228 1.109 Me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr10_+_96945972 1.102 Dcn
decorin
chr16_+_49913305 1.095 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr2_-_152158078 1.084


chr11_-_116515361 1.082 Cygb
cytoglobin
chr9_-_52484889 1.077 AI593442
expressed sequence AI593442
chr7_-_148354562 1.072 NM_001172101
NM_145135
Rnh1

ribonuclease/angiogenin inhibitor 1

chr11_-_53293696 1.063 NM_183173
Ankrd43
ankyrin repeat domain 43
chr9_+_5298516 1.052 NM_009807
Casp1
caspase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
3.62 5.97e-06 GO:0002376 immune system process
2.07 8.17e-04 GO:0048518 positive regulation of biological process
2.10 1.95e-03 GO:0048522 positive regulation of cellular process
13.54 4.95e-03 GO:0019882 antigen processing and presentation
4.18 6.82e-03 GO:0009607 response to biotic stimulus
29.32 8.27e-03 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
2.36 1.69e-02 GO:0051239 regulation of multicellular organismal process
4.10 1.79e-02 GO:0006955 immune response
14.66 2.11e-02 GO:0051289 protein homotetramerization
2.55 2.22e-02 GO:0007399 nervous system development
2.25 2.97e-02 GO:0006950 response to stress
13.33 3.39e-02 GO:0016358 dendrite development
3.04 4.60e-02 GO:0008219 cell death
2.28 4.64e-02 GO:0065009 regulation of molecular function
3.99 4.95e-02 GO:0009628 response to abiotic stimulus

Gene overrepresentation in compartment category:

enrichment p-value GO term description
1.48 1.23e-04 GO:0005737 cytoplasm
1.64 2.32e-04 GO:0044444 cytoplasmic part
2.79 1.83e-03 GO:0044421 extracellular region part
2.11 7.70e-03 GO:0044459 plasma membrane part
35.18 1.02e-02 GO:0042612 MHC class I protein complex
2.37 1.46e-02 GO:0000267 cell fraction
4.01 1.47e-02 GO:0043025 neuronal cell body
1.36 1.89e-02 GO:0043227 membrane-bounded organelle
3.82 2.26e-02 GO:0044297 cell body
1.35 3.14e-02 GO:0043231 intracellular membrane-bounded organelle
2.50 3.14e-02 GO:0005626 insoluble fraction
1.63 4.05e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment p-value GO term description
1.53 7.50e-03 GO:0005515 protein binding
11.50 1.33e-02 GO:0004197 cysteine-type endopeptidase activity
117.26 1.34e-02 GO:0005157 macrophage colony-stimulating factor receptor binding
6.04 3.06e-02 GO:0005539 glycosaminoglycan binding