Motif ID: JUN.p2

Z-value: 1.148

Transcription factors associated with JUN.p2:

NameEntrezDescription
Jun 16476 Jun oncogene
Junb 16477 Jun-B oncogene
Jund 16478 Jun proto-oncogene related gene d

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Junchr4_-_947188460.447.0e-03Click!
Jundchr8_+_732228410.153.8e-01Click!
Junbchr8_-_875025920.028.9e-01Click!


Activity profile for motif JUN.p2.

activity profile for motif JUN.p2


Sorted Z-values histogram for motif JUN.p2

Sorted Z-values for motif JUN.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of JUN.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr15_-_83936038 16.680 Sult4a1
sulfotransferase family 4A, member 1
chr5_-_124482223 10.571 NM_177876
Vps37b
vacuolar protein sorting 37B (yeast)
chr2_+_155102040 10.473 NM_025735
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr4_+_84851330 8.860 NM_019535
Sh3gl2
SH3-domain GRB2-like 2
chr5_+_137506122 8.722 NM_001039385
Vgf
VGF nerve growth factor inducible
chr1_-_79436564 7.835 NM_009129
Scg2
secretogranin II
chr3_-_117063090 7.407 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr19_-_61302538 7.276 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chrX_+_162676910 6.624 Gpm6b
glycoprotein m6b
chr19_-_5085487 6.343 Tmem151a
transmembrane protein 151A
chr2_-_93797176 6.200 NM_001145034
Gm13889
predicted gene 13889
chr17_+_37187550 6.187 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr7_-_149280946 6.083 Dusp8
dual specificity phosphatase 8
chr14_+_66963139 6.037 NM_019675
Stmn4
stathmin-like 4
chr8_+_46970814 5.928 NM_016798
Pdlim3
PDZ and LIM domain 3
chr1_-_133421746 5.925 Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr6_-_124414668 5.833 NM_153508
Clstn3
calsyntenin 3
chrX_-_20498021 5.212 NM_001110780
NM_013680
Syn1

synapsin I

chr3_-_117063317 5.171 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr8_-_73011217 5.141 NM_182991
Tmem59l
transmembrane protein 59-like
chr8_-_70342105 5.134 NM_027626
Psd3
pleckstrin and Sec7 domain containing 3
chr12_-_56922146 5.121 NM_001003719
NM_001112714
NM_019994
Ralgapa1


Ral GTPase activating protein, alpha subunit 1


chr2_+_136539202 5.120 Snap25
synaptosomal-associated protein 25
chr5_-_69732792 4.873 Kctd8
potassium channel tetramerisation domain containing 8
chr9_+_69137694 4.718 Rora
RAR-related orphan receptor alpha
chr9_-_31019234 4.718 Aplp2
amyloid beta (A4) precursor-like protein 2
chr12_+_103793130 4.628 NM_007693
Chga
chromogranin A
chr18_-_35374663 4.378 NM_178005
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr19_+_23215704 4.288 NM_010638
Klf9
Kruppel-like factor 9
chr9_-_31019392 4.281 NM_001102455
NM_001102456
NM_009691
Aplp2


amyloid beta (A4) precursor-like protein 2


chr17_-_46624611 4.259 NM_001162864
Ttbk1
tau tubulin kinase 1
chr1_+_179374783 4.218 NM_001012330
Zfp238
zinc finger protein 238
chr15_+_81767188 4.102 NM_145473
Csdc2
cold shock domain containing C2, RNA binding
chr10_+_59568976 4.032 NM_052994
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr1_+_37356745 3.951 Inpp4a
inositol polyphosphate-4-phosphatase, type I
chr16_-_20621287 3.936 NM_028420
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr9_-_31019412 3.916 Aplp2
amyloid beta (A4) precursor-like protein 2
chr5_-_106887469 3.841 Barhl2
BarH-like 2 (Drosophila)
chr18_+_36508277 3.840 NM_001081365
0610010O12Rik
RIKEN cDNA 0610010O12 gene
chr11_-_6375845 3.781 NM_011221
Purb
purine rich element binding protein B
chr6_-_55631085 3.777 Neurod6
neurogenic differentiation 6
chr17_-_24306262 3.754 NM_009729
Atp6v0c-ps2
Atp6v0c
ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 2
ATPase, H+ transporting, lysosomal V0 subunit C
chr1_-_33964439 3.723 NM_177235
Bend6
BEN domain containing 6
chr5_+_33361479 3.677 Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr10_+_80695899 3.595 NM_001034895
Zfr2
zinc finger RNA binding protein 2
chr9_-_97933599 3.533 Clstn2
calsyntenin 2
chr6_+_54631644 3.474 NM_026629
2410066E13Rik
RIKEN cDNA 2410066E13 gene
chr7_+_62090867 3.439 Luzp2
leucine zipper protein 2
chr8_+_68141935 3.407 NM_001166372
March1
membrane-associated ring finger (C3HC4) 1
chr1_-_75260687 3.367 NM_008985
Ptprn
protein tyrosine phosphatase, receptor type, N
chr1_+_145487825 3.300 NM_020025
B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr2_+_136539143 3.174 NM_011428
Snap25
synaptosomal-associated protein 25
chr13_-_34169854 3.148 NM_009450
Tubb2a
tubulin, beta 2A
chr16_+_91225794 3.114 NM_016967
Olig2
oligodendrocyte transcription factor 2
chr13_+_13876570 3.072 Gng4
guanine nucleotide binding protein (G protein), gamma 4
chr4_-_150026205 3.063 NM_173774
Slc45a1
solute carrier family 45, member 1
chr5_+_25265761 3.059 NM_001004365
Actr3b
ARP3 actin-related protein 3 homolog B (yeast)
chr4_-_150482562 3.057 Camta1
calmodulin binding transcription activator 1
chr7_-_116925058 3.027 NM_020610
Nrip3
nuclear receptor interacting protein 3
chr11_-_41995688 2.988 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr16_-_95219189 2.956 NM_001025584
NM_001025585
NM_010606
Kcnj6


potassium inwardly-rectifying channel, subfamily J, member 6


chr10_+_59569052 2.924 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr11_-_41995934 2.897 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr13_-_54712629 2.880 NM_028870
Cltb
clathrin, light polypeptide (Lcb)
chr17_-_56615784 2.857 Ptprs
protein tyrosine phosphatase, receptor type, S
chr16_-_23890909 2.850 NM_009215
Sst
somatostatin
chr8_-_63461923 2.847 Clcn3
chloride channel 3
chr12_+_110783593 2.837 Meg3
maternally expressed 3
chr15_+_83998239 2.799 NM_054088
Pnpla3
patatin-like phospholipase domain containing 3
chr8_-_82581887 2.750 NM_020259
Hhip
Hedgehog-interacting protein
chr17_+_35226172 2.742 NM_178592
Abhd16a
abhydrolase domain containing 16A
chr9_-_75531734 2.733 NM_001164790
NM_009130
Scg3

secretogranin III

chr19_-_61303137 2.695 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr13_-_94269673 2.677 Jmy
junction-mediating and regulatory protein
chr6_+_71443847 2.660 Rnf103
ring finger protein 103
chr18_+_36440748 2.659 NM_008989
Pura
purine rich element binding protein A
chr5_+_33361386 2.640 NM_011738
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr7_+_146574969 2.621 NM_001127363
NM_183144
Inpp5a

inositol polyphosphate-5-phosphatase A

chr6_-_55631039 2.610 Neurod6
neurogenic differentiation 6
chr4_-_100937800 2.608 NM_146145
Jak1
Janus kinase 1
chr15_+_61869529 2.588 Pvt1
plasmacytoma variant translocation 1
chr2_+_28048592 2.550 NM_001038613
NM_001038614
Olfm1

olfactomedin 1

chr11_-_90252228 2.517 NM_172563
Hlf
hepatic leukemia factor
chr1_+_37356722 2.487 NM_030266
Inpp4a
inositol polyphosphate-4-phosphatase, type I
chr10_-_101953046 2.476 NM_024435
Nts
neurotensin
chr8_+_73278577 2.466 NM_001166399
NM_009001
Rab3a

RAB3A, member RAS oncogene family

chr14_-_73785035 2.440 Itm2b
integral membrane protein 2B
chr1_-_94998418 2.422 NM_001110315
NM_008440
Kif1a

kinesin family member 1A

chr13_+_58909168 2.394 NM_001025074
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr13_+_58909236 2.383 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr16_-_10313963 2.377 Emp2
epithelial membrane protein 2
chr7_+_26052714 2.376 Cic
capicua homolog (Drosophila)
chr2_+_49474775 2.356 NM_008449
Kif5c
kinesin family member 5C
chr11_-_74537303 2.343 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr19_-_6235784 2.325 NM_198168
Ppp2r5b
protein phosphatase 2, regulatory subunit B (B56), beta isoform
chr6_+_129483295 2.321 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr8_-_63462080 2.304 NM_007711
NM_173873
NM_173874
Clcn3


chloride channel 3


chr11_-_70501430 2.300 Camta2
calmodulin binding transcription activator 2
chr15_-_33617572 2.279 NM_001085421
Tspyl5
testis-specific protein, Y-encoded-like 5
chr17_+_44090192 2.248 Rcan2
regulator of calcineurin 2
chr11_+_6191622 2.244 Ogdh
oxoglutarate dehydrogenase (lipoamide)
chr15_-_37389073 2.242 NM_001170867
NM_001170868
Ncald

neurocalcin delta

chr11_+_52578152 2.227 NM_177059
Fstl4
follistatin-like 4
chr17_-_24826812 2.227 Syngr3
synaptogyrin 3
chr4_+_84851440 2.217 Sh3gl2
SH3-domain GRB2-like 2
chr5_+_107926763 2.208 NM_001007574
NM_001168557
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr9_-_45763300 2.196 NM_172257
Sidt2
SID1 transmembrane family, member 2
chr18_-_31476721 2.177 NM_009065
Rit2
Ras-like without CAAX 2
chr4_-_126430511 2.173 NM_011986
Ncdn
neurochondrin
chr4_+_43455122 2.167 NM_011571
Tesk1
testis specific protein kinase 1
chr6_-_8728094 2.163 Ica1
islet cell autoantigen 1
chr6_-_30254273 2.149 NM_001170345
NM_001169576
NM_009459
Gm2058
Ube2h

predicted gene 2058
ubiquitin-conjugating enzyme E2H

chr6_+_112223751 2.120 NM_144799
Lmcd1
LIM and cysteine-rich domains 1
chr15_+_91991704 2.113 NM_001159647
Cntn1
contactin 1
chr2_-_170232008 2.109 Bcas1
breast carcinoma amplified sequence 1
chr2_+_143371807 2.106 NM_008792
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr17_-_56615861 2.099 Ptprs
protein tyrosine phosphatase, receptor type, S
chrX_-_7722800 2.081 NM_001166409
NM_001166410
NM_001166411
NM_016809
Rbm3



RNA binding motif protein 3



chr8_+_119780918 2.076 NM_001163262
4933407C03Rik
RIKEN cDNA 4933407C03 gene
chr12_+_110779204 2.061 Meg3
maternally expressed 3
chr1_-_94998392 2.034 Kif1a
kinesin family member 1A
chr2_-_160698705 2.031 NM_177263
Zhx3
zinc fingers and homeoboxes 3
chr10_+_13685579 2.024 2900084C01Rik
RIKEN cDNA 2900084C01 gene
chr18_+_45719101 2.018 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr8_+_96334452 2.001 NM_001113384
NM_010308
Gnao1

guanine nucleotide binding protein, alpha O

chr11_-_72609306 1.994 NM_001024926
Cyb5d2
cytochrome b5 domain containing 2
chr17_+_79451501 1.990 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr19_+_26679649 1.973 NM_011416
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_+_155221507 1.954 NM_010091
Dvl1
dishevelled, dsh homolog 1 (Drosophila)
chr11_-_41814008 1.925 NM_008073
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr9_+_113721698 1.925 NM_001081960
NM_029633
Clasp2

CLIP associating protein 2

chr16_-_95218980 1.921 Kcnj6
potassium inwardly-rectifying channel, subfamily J, member 6
chr19_+_21346734 1.913 NM_009551
Zfand5
zinc finger, AN1-type domain 5
chr18_-_35374531 1.913 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr17_+_86567003 1.905 NM_011104
Prkce
protein kinase C, epsilon
chr8_+_46970860 1.899 Pdlim3
PDZ and LIM domain 3
chr1_+_24685377 1.864 NM_026719
Lmbrd1
LMBR1 domain containing 1
chr2_+_177876635 1.861 NM_028806
Phactr3
phosphatase and actin regulator 3
chr10_+_34017221 1.846 NM_030203
Tspyl4
TSPY-like 4
chr18_+_36441115 1.833 Pura
purine rich element binding protein A
chr9_-_50817077 1.814 NM_178710
Sik2
salt inducible kinase 2
chr7_-_7251473 1.811 Clcn4-2
chloride channel 4-2
chr5_-_69732915 1.810 NM_175519
Kctd8
potassium channel tetramerisation domain containing 8
chr5_-_75073816 1.808 NM_001159578
NM_001159579
NM_001159580
NM_010727
Lnx1



ligand of numb-protein X 1



chr15_-_58913543 1.784 NM_001146180
NM_144800
Mtss1

metastasis suppressor 1

chr2_-_160698733 1.781


chr11_-_54846882 1.775 NM_001110211
NM_013472
Anxa6

annexin A6

chr4_+_151712739 1.774 NM_001081376
NM_029216
Chd5

chromodomain helicase DNA binding protein 5

chr17_-_24826873 1.757 NM_011522
Syngr3
synaptogyrin 3
chr11_-_118947424 1.754 NM_007625
Cbx4
chromobox homolog 4 (Drosophila Pc class)
chr10_+_59569206 1.751 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr18_-_24688558 1.750 Rprd1a
regulation of nuclear pre-mRNA domain containing 1A
chr10_+_20672352 1.742 NM_026203
Ahi1
Abelson helper integration site 1
chr12_-_68323528 1.738 NM_001193266
NM_207010
Mdga2

MAM domain containing glycosylphosphatidylinositol anchor 2

chr18_+_66618186 1.735 NM_021451
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr17_+_43153516 1.731 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr17_-_56615875 1.728 NM_011218
Ptprs
protein tyrosine phosphatase, receptor type, S
chr7_+_6683288 1.694 NM_021323
Usp29
ubiquitin specific peptidase 29
chr15_+_79921725 1.686 NM_009303
NM_207708
Syngr1

synaptogyrin 1

chr2_+_28388947 1.676 NM_001145835
NM_001145836
Ralgds

ral guanine nucleotide dissociation stimulator

chr2_+_132607013 1.660 NM_007694
Chgb
chromogranin B
chr15_+_99223622 1.658 NM_001171035
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr5_-_148537561 1.657 NM_010228
Flt1
FMS-like tyrosine kinase 1
chrX_+_162676870 1.653 NM_001177961
NM_001177962
NM_023122
Gpm6b


glycoprotein m6b


chr18_-_31476626 1.653 Rit2
Ras-like without CAAX 2
chr5_-_92471603 1.650 Cdkl2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr1_+_75476106 1.635 NM_177056
Tmem198
transmembrane protein 198
chr3_+_89518943 1.616 NM_001038587
Adar
adenosine deaminase, RNA-specific
chr3_+_82162091 1.613 Mtap9
microtubule-associated protein 9
chr8_-_72240381 1.594 NM_181274
Zfp869
zinc finger protein 869
chr3_-_127111968 1.592 Ank2
ankyrin 2, brain
chr6_+_125165597 1.591 NM_001080557
NM_009496
Vamp1

vesicle-associated membrane protein 1

chr12_+_80231774 1.588 NM_009705
Arg2
arginase type II
chr7_-_51751770 1.575 NM_197991
2310044H10Rik
RIKEN cDNA 2310044H10 gene
chr7_-_134041745 1.569 NM_026827
NM_028389
Tmem219

transmembrane protein 219

chr3_+_82162037 1.564 Mtap9
microtubule-associated protein 9
chr2_+_112295120 1.554 NM_133749
2900064A13Rik
RIKEN cDNA 2900064A13 gene
chr10_+_72117619 1.554 NM_025635
Zwint
ZW10 interactor
chr4_-_138648762 1.523 NM_008675
Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr4_-_94718846 1.512 NM_010591
Jun
Jun oncogene
chr7_+_107756292 1.512 Rab6
RAB6, member RAS oncogene family
chr6_-_90378423 1.508 NM_173775
Ccdc37
coiled-coil domain containing 37
chr16_+_49699314 1.503 NM_028680
Ift57
intraflagellar transport 57 homolog (Chlamydomonas)
chr3_+_125106995 1.499 NM_022565
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr1_+_174430359 1.490 NM_178598
Tagln2
transgelin 2
chr8_+_23868194 1.486 NM_008872
Plat
plasminogen activator, tissue
chr3_+_65470149 1.483 NM_001166659
NM_001037923
Lekr1

leucine, glutamate and lysine rich 1

chr8_-_109620286 1.481 Terf2
telomeric repeat binding factor 2
chr6_-_113481546 1.480 NM_175101
Tmem111
transmembrane protein 111
chr6_+_53523365 1.480 NM_172728
Creb5
cAMP responsive element binding protein 5
chr12_-_73509668 1.465 Rtn1
reticulon 1
chr11_-_101032604 1.464 NM_146030
Plekhh3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr19_-_59150001 1.463 4930506M07Rik
RIKEN cDNA 4930506M07 gene
chr11_-_118902219 1.459 NM_013926
Cbx8
chromobox homolog 8 (Drosophila Pc class)
chr3_+_7366586 1.458 NM_008862
Pkia
protein kinase inhibitor, alpha
chr4_+_8617613 1.458 Chd7
chromodomain helicase DNA binding protein 7
chr2_+_31951149 1.456 NM_145521
Ppapdc3
phosphatidic acid phosphatase type 2 domain containing 3
chr6_-_113481340 1.449 Tmem111
transmembrane protein 111
chr18_-_23200150 1.440 NM_199024
Nol4
nucleolar protein 4
chr4_-_149148173 1.439 NM_027460
Slc25a33
solute carrier family 25, member 33

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.46 2.22e-03 GO:0007399 nervous system development
3.34 2.53e-03 GO:0030182 neuron differentiation
3.70 3.88e-03 GO:0044057 regulation of system process
2.48 8.58e-03 GO:0051641 cellular localization
2.64 9.20e-03 GO:0051649 establishment of localization in cell
1.92 1.40e-02 GO:0071842 cellular component organization at cellular level
2.69 1.63e-02 GO:0048699 generation of neurons
2.52 4.48e-02 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

enrichment p-value GO term description
3.93 9.07e-06 GO:0045202 synapse
3.19 3.25e-05 GO:0031410 cytoplasmic vesicle
2.79 6.56e-05 GO:0005794 Golgi apparatus
3.00 1.05e-04 GO:0031982 vesicle
4.09 3.78e-04 GO:0044456 synapse part
3.21 8.33e-04 GO:0031988 membrane-bounded vesicle
1.33 9.58e-04 GO:0043229 intracellular organelle
1.33 1.14e-03 GO:0043226 organelle
1.37 1.15e-03 GO:0005737 cytoplasm
3.22 1.39e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
5.83 1.56e-03 GO:0030136 clathrin-coated vesicle
1.27 1.78e-03 GO:0005622 intracellular
1.27 2.50e-03 GO:0044424 intracellular part
5.13 4.76e-03 GO:0030135 coated vesicle
9.45 6.86e-03 GO:0030665 clathrin coated vesicle membrane
1.45 8.92e-03 GO:0044444 cytoplasmic part
1.32 9.58e-03 GO:0043231 intracellular membrane-bounded organelle
1.32 1.06e-02 GO:0043227 membrane-bounded organelle
3.39 1.28e-02 GO:0005625 soluble fraction
6.02 2.90e-02 GO:0008021 synaptic vesicle
7.29 2.98e-02 GO:0030662 coated vesicle membrane
5.00 3.59e-02 GO:0019717 synaptosome
4.43 3.67e-02 GO:0012506 vesicle membrane

Gene overrepresentation in function category:

enrichment p-value GO term description
1.69 1.39e-07 GO:0005515 protein binding
3.02 6.71e-03 GO:0008092 cytoskeletal protein binding
1.25 7.18e-03 GO:0005488 binding
17.90 1.29e-02 GO:0005184 neuropeptide hormone activity