Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.687

Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

NameEntrezDescription
Lef1 16842 lymphoid enhancer binding factor 1
Tcf7 21414 transcription factor 7, T-cell specific
Tcf7l1 21415 transcription factor 7-like 1 (T-cell specific, HMG box)
Tcf7l2 21416 transcription factor 7-like 2, T-cell specific, HMG-box

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Lef1chr3_+_1308132140.581.9e-04Click!
Tcf7l1chr6_-_72738935-0.421.2e-02Click!
Tcf7l2chr19_+_55816299-0.382.2e-02Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr7_-_56892061 14.002 NM_001005232
Dbx1
developing brain homeobox 1
chr8_+_46593141 13.271 NM_172752
Sorbs2
sorbin and SH3 domain containing 2
chr14_+_27852148 11.541 NM_134437
Il17rd
interleukin 17 receptor D
chr18_-_46372017 9.813 NM_178872
Trim36
tripartite motif-containing 36
chr2_+_157385835 9.178 NM_010923
NM_180960
Nnat

neuronatin

chr2_-_65405546 8.833 NM_018732
Scn3a
sodium channel, voltage-gated, type III, alpha
chr7_+_106614513 8.326 NM_028145
Klhl35
kelch-like 35 (Drosophila)
chr5_-_135028197 7.598 NM_001039162
NM_009990
Clip2

CAP-GLY domain containing linker protein 2

chr3_+_101814059 7.079 NM_178777
Nhlh2
nescient helix loop helix 2
chr1_-_12980994 7.028 NM_172841
Slco5a1
solute carrier organic anion transporter family, member 5A1
chr9_-_99776467 6.951 NM_011440
Sox14
SRY-box containing gene 14
chr10_+_43298969 6.393 NM_009846
Cd24a
CD24a antigen
chr8_+_94881694 6.234 NM_018826
Irx5
Iroquois related homeobox 5 (Drosophila)
chr12_+_53800369 5.714 NM_198111
Akap6
A kinase (PRKA) anchor protein 6
chr1_+_155596555 5.681 NM_011882
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr2_+_37372112 5.675 NM_177383
Gpr21
G protein-coupled receptor 21
chr4_-_91042997 5.628 NM_001177883
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr13_-_54789064 5.420 Rnf44
ring finger protein 44
chr7_-_111001598 5.304 NM_008221
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr9_+_64988960 5.208 NM_008988
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr4_+_33069972 5.190 NM_027491
Rragd
Ras-related GTP binding D
chr12_+_114378688 4.975 Crip2
cysteine rich protein 2
chr7_+_119167048 4.697 Usp47
ubiquitin specific peptidase 47
chr4_-_34830178 4.673 NM_013889
Zfp292
zinc finger protein 292
chr8_-_41596638 4.597 NM_011135
Cnot7
CCR4-NOT transcription complex, subunit 7
chr14_-_98568744 4.592 NM_001038610
NM_007826
Dach1

dachshund 1 (Drosophila)

chr4_+_129190877 4.576 Marcksl1
MARCKS-like 1
chr4_-_155571450 4.437 Agrn
agrin
chr15_-_98783909 4.413 NM_011653
Tuba1a
tubulin, alpha 1A
chr6_-_47763309 4.406 Pdia4
protein disulfide isomerase associated 4
chr9_-_82868992 4.392 Phip
pleckstrin homology domain interacting protein
chr6_-_90732001 4.353 E130314K07Rik
RIKEN cDNA E130314K07 gene
chr4_+_129190872 4.349 Marcksl1
MARCKS-like 1
chr6_+_137200819 4.290 NM_001164401
NM_011216
Ptpro

protein tyrosine phosphatase, receptor type, O

chr1_-_97564064 4.168 St8sia4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr14_-_98568962 4.153 Dach1
dachshund 1 (Drosophila)
chr11_-_86621074 4.149 Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr7_-_91558468 3.959 NM_007488
Arnt2
aryl hydrocarbon receptor nuclear translocator 2
chr6_+_83087016 3.831 NM_009106
NM_133641
Rtkn

rhotekin

chr9_+_90057930 3.818 Adamts7
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7
chr10_+_126500607 3.764 NM_009870
Cdk4
cyclin-dependent kinase 4
chr7_-_112936063 3.746 NM_001162943
Dchs1
dachsous 1 (Drosophila)
chr6_-_148893155 3.639 Fam60a
family with sequence similarity 60, member A
chr1_+_92100572 3.602 NM_007722
Cxcr7
chemokine (C-X-C motif) receptor 7
chr18_+_10325174 3.545 NM_001083628
Greb1l
growth regulation by estrogen in breast cancer-like
chr12_-_42212538 3.513 Lrrn3
leucine rich repeat protein 3, neuronal
chr5_+_89012547 3.469 Rufy3
RUN and FYVE domain containing 3
chr6_+_17015159 3.456 Tes
testis derived transcript
chr2_+_172847371 3.450 NM_019547
Rbm38
RNA binding motif protein 38
chr1_+_159342882 3.385 2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr14_-_50403002 3.336 NM_026142
3632451O06Rik
RIKEN cDNA 3632451O06 gene
chr5_+_65522325 3.272 NM_175174
Klhl5
kelch-like 5 (Drosophila)
chr13_-_108680257 3.230 NM_145456
Zswim6
zinc finger, SWIM domain containing 6
chr1_-_183950050 3.226 NM_001083120
NM_001083121
NM_008680
NM_010135
Enah



enabled homolog (Drosophila)



chr18_-_16967100 3.201 Cdh2
cadherin 2
chr16_+_87699143 3.191 NM_007520
Bach1
BTB and CNC homology 1
chr2_-_179777080 3.160 NM_011969
Psma7
proteasome (prosome, macropain) subunit, alpha type 7
chr9_-_82869034 3.094 Phip
pleckstrin homology domain interacting protein
chr5_+_31014229 3.042 NM_023047
Dpysl5
dihydropyrimidinase-like 5
chr11_+_108781661 3.032 NM_015732
Axin2
axin2
chr8_+_63702967 2.942 NM_021506
Sh3rf1
SH3 domain containing ring finger 1
chr7_+_134376574 2.855 Zfp553
zinc finger protein 553
chr17_-_25570721 2.795 NM_001163691
NM_021415
Cacna1h

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr5_-_5265981 2.732 Cdk14
cyclin-dependent kinase 14
chr8_-_4259126 2.729 NM_183315
Ctxn1
cortexin 1
chr6_-_49214015 2.710 NM_198102
Tra2a
transformer 2 alpha homolog (Drosophila)
chr2_-_59963586 2.708 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr16_+_19760300 2.696 NM_001159407
NM_001159408
NM_054052
B3gnt5


UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5


chr3_+_142428186 2.678 NM_145546
Gtf2b
general transcription factor IIB
chr6_+_17015148 2.668 NM_207176
Tes
testis derived transcript
chr15_+_98462650 2.649 NM_001044741
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr1_-_155334737 2.609 NM_007842
Dhx9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
chr13_-_54789148 2.557 NM_001146025
NM_001146026
NM_134064
Rnf44


ring finger protein 44


chr7_-_91558407 2.531 Arnt2
aryl hydrocarbon receptor nuclear translocator 2
chr13_-_99696254 2.515 NM_178716
Tnpo1
transportin 1
chr9_+_107471447 2.486 NM_010489
Hyal2
hyaluronoglucosaminidase 2
chr2_-_52414072 2.475 NM_146123
Cacnb4
calcium channel, voltage-dependent, beta 4 subunit
chr10_+_126437764 2.475 NM_009635
Avil
advillin
chr14_+_62218348 2.421 NM_023233
Trim13
tripartite motif-containing 13
chr12_-_56087322 2.405 NM_013815
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr4_-_136391849 2.394 NM_010142
Ephb2
Eph receptor B2
chr12_+_25516433 2.385 NM_001083341
NM_026037
Mboat2

membrane bound O-acyltransferase domain containing 2

chr7_+_30088984 2.350 NM_013874
Dpf1
D4, zinc and double PHD fingers family 1
chr11_+_121098532 2.345 NM_026272
Narf
nuclear prelamin A recognition factor
chr9_-_45792865 2.316 NM_008775
Pafah1b2
2610005M20Rik
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
RIKEN cDNA 2610005M20 gene
chr6_-_47544925 2.301 NM_001146689
NM_007971
Ezh2

enhancer of zeste homolog 2 (Drosophila)

chr7_-_125273061 2.275 NM_019419
Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chrX_+_139952975 2.256 NM_001195048
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chrX_+_68916841 2.252 NM_010340
Gpr50
G-protein-coupled receptor 50
chr7_+_133903186 2.202 Mapk3
mitogen-activated protein kinase 3
chr6_-_138371302 2.176 Lmo3
LIM domain only 3
chr8_-_11635688 2.165 Ankrd10
ankyrin repeat domain 10
chr8_+_63703064 2.156 Sh3rf1
SH3 domain containing ring finger 1
chr11_+_80290571 2.151 Cdk5r1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr6_+_71657791 2.132 NM_178608
Reep1
receptor accessory protein 1
chr10_+_5958432 2.127 NM_001033466
Zbtb2
zinc finger and BTB domain containing 2
chr4_-_12015073 2.118 NM_177861
Tmem67
transmembrane protein 67
chr6_+_47194393 2.114 NM_025771
Cntnap2
contactin associated protein-like 2
chr9_+_85736444 2.107 NM_001164792
Tpbg
trophoblast glycoprotein
chr9_+_102620058 2.088 Amotl2
angiomotin-like 2
chr11_-_86887549 2.069 NM_025638
Gdpd1
glycerophosphodiester phosphodiesterase domain containing 1
chr5_-_138596915 2.053 NM_019747
Zfp113
zinc finger protein 113
chr8_+_41597112 2.052 NM_033560
Vps37a
vacuolar protein sorting 37A (yeast)
chrX_-_140367467 2.050 NM_001110222
NM_001110223
NM_001110224
NM_010025
Dcx



doublecortin



chr19_-_5894106 2.022 NM_198634
Tigd3
tigger transposable element derived 3
chr3_-_116126853 2.012 Cdc14a
CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chr11_-_60988419 1.998 Usp22
ubiquitin specific peptidase 22
chr5_+_89012537 1.997 Rufy3
RUN and FYVE domain containing 3
chr5_+_36236113 1.996 Afap1
actin filament associated protein 1
chr11_+_117193732 1.994


chr5_+_34326081 1.983 NM_001033458
Gm1673
predicted gene 1673
chr12_+_96930429 1.979 NM_201518
Flrt2
fibronectin leucine rich transmembrane protein 2
chr2_-_59963796 1.972 NM_001001182
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr4_-_20705698 1.951 NM_172987
Nkain3
Na+/K+ transporting ATPase interacting 3
chr2_-_130985746 1.928 NM_026091
1700037H04Rik
RIKEN cDNA 1700037H04 gene
chr1_-_54614516 1.913 NM_001163314
Pgap1
post-GPI attachment to proteins 1
chr2_+_31805751 1.870 NM_145144
Aif1l
allograft inflammatory factor 1-like
chr16_+_22951183 1.861 Hrg
histidine-rich glycoprotein
chr9_+_21420612 1.845 NM_001174078
NM_001174079
NM_011417
Smarca4


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4


chr3_+_130813214 1.839 NM_010703
Lef1
lymphoid enhancer binding factor 1
chrX_-_6765768 1.837 NM_016691
Clcn5
chloride channel 5
chr19_-_30623890 1.831 NM_010051
Dkk1
dickkopf homolog 1 (Xenopus laevis)
chr13_+_22036962 1.825 NM_183014
Zfp184
zinc finger protein 184 (Kruppel-like)
chr3_-_146432922 1.819 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr8_+_125935441 1.814 NM_023279
Tubb3
tubulin, beta 3
chr12_-_21423383 1.807 Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr5_+_3928053 1.806 Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr18_+_65048630 1.796 Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr6_-_30643681 1.774 NM_031998
Tsga14
testis specific gene A14
chr4_-_69587193 1.757 Gm11223
stathmin 1 pseudogene
chr12_+_70397667 1.748 NM_027117
Klhdc2
kelch domain containing 2
chr5_+_89012596 1.737 NM_027530
Rufy3
RUN and FYVE domain containing 3
chr17_+_74738195 1.735 NM_001162870
NM_016962
Spast

spastin

chr12_+_114378368 1.715 NM_024223
Crip2
cysteine rich protein 2
chr9_-_114690887 1.712 NM_133978
Cmtm7
CKLF-like MARVEL transmembrane domain containing 7
chr1_+_134088010 1.710 NM_001033250
Lemd1
LEM domain containing 1
chr2_+_14976877 1.704 NM_029466
Arl5b
ADP-ribosylation factor-like 5B
chr2_-_11423673 1.699 NM_001177752
NM_001177753
NM_001177754
NM_001177755
NM_001177756
NM_001177757
NM_133232
Pfkfb3






6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3






chr8_+_32222291 1.694 NM_175136
Rnf122
ring finger protein 122
chr10_-_22451093 1.694 Tbpl1
TATA box binding protein-like 1
chr2_+_21127350 1.690 NM_001001297
NM_177588
Thnsl1

threonine synthase-like 1 (bacterial)

chr14_+_22319075 1.661 NM_017479
Myst4
MYST histone acetyltransferase monocytic leukemia 4
chr8_-_49928495 1.660 2900073C17Rik
RIKEN cDNA 2900073C17 gene
chr4_-_91066674 1.657 NM_207685
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr9_+_102620096 1.641 NM_019764
Amotl2
angiomotin-like 2
chr11_-_107050573 1.637 NM_001161329
NM_133702
Nol11

nucleolar protein 11

chr5_-_102498929 1.636 NM_172882
Wdfy3
WD repeat and FYVE domain containing 3
chr5_-_123632567 1.624 NM_008277
Hpd
4-hydroxyphenylpyruvic acid dioxygenase
chr19_+_8914035 1.611 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr7_-_52124950 1.586 Ptov1
prostate tumor over expressed gene 1
chr14_-_80171003 1.577 NM_001042726
NM_021543
Pcdh8

protocadherin 8

chr11_-_86621130 1.562 NM_026191
Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr5_+_89012600 1.558 Rufy3
RUN and FYVE domain containing 3
chr9_-_60535699 1.556 Lrrc49
leucine rich repeat containing 49
chrX_-_147247483 1.551 Maged2
melanoma antigen, family D, 2
chr18_-_89063689 1.540 Socs6
suppressor of cytokine signaling 6
chr9_+_110034489 1.540 NM_009211
Smarcc1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr15_-_10967722 1.526 NM_178717
Rxfp3
relaxin family peptide receptor 3
chr17_+_75404893 1.522 Ltbp1
latent transforming growth factor beta binding protein 1
chr2_-_5863788 1.504 NM_001081131
Dhtkd1
dehydrogenase E1 and transketolase domain containing 1
chr8_-_42140113 1.504 NM_001005864
Mtus1
mitochondrial tumor suppressor 1
chr9_+_72773456 1.503 NM_028116
Pygo1
pygopus 1
chr3_+_121129396 1.496 NM_028044
Cnn3
calponin 3, acidic
chr4_+_95224197 1.482 NM_001113412
Fggy
FGGY carbohydrate kinase domain containing
chr10_+_79612410 1.463 Midn
midnolin
chr15_+_6658368 1.454 NM_030168
Rictor
RPTOR independent companion of MTOR, complex 2
chr17_-_25570112 1.450 Cacna1h
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr11_+_117193738 1.448 Sept9
septin 9
chr11_+_108781772 1.448 Axin2
axin2
chr7_-_4966268 1.439 NM_001110328
NM_001110329
Fiz1

Flt3 interacting zinc finger protein 1

chr8_-_27229485 1.436 NM_207659
Hook3
hook homolog 3 (Drosophila)
chr3_-_75760843 1.427 Golim4
golgi integral membrane protein 4
chr3_-_116126932 1.425 NM_001080818
NM_001173553
Cdc14a

CDC14 cell division cycle 14 homolog A (S. cerevisiae)

chr11_-_76308483 1.416 Abr
active BCR-related gene
chr7_-_81158546 1.412 NM_009181
St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr11_+_29273673 1.412 NM_176841
Ccdc88a
coiled coil domain containing 88A
chr10_+_28863801 1.410 NM_026138
6330407J23Rik
RIKEN cDNA 6330407J23 gene
chr11_-_115674905 1.402 NM_080643
Caskin2
CASK-interacting protein 2
chr4_+_88783273 1.391 NM_024433
Mtap
methylthioadenosine phosphorylase
chr5_-_116738971 1.389 NM_177759
Ccdc60
coiled-coil domain containing 60
chr16_-_91044623 1.380 NM_026110
Gcfc1
GC-rich sequence DNA-binding factor 1
chr10_+_52410306 1.376 NM_178675
Slc35f1
solute carrier family 35, member F1
chr16_+_17452048 1.361 NM_007764
Crkl
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr8_-_41597015 1.361 Cnot7
CCR4-NOT transcription complex, subunit 7
chr18_+_37844927 1.357 NM_033587
Pcdhga4
protocadherin gamma subfamily A, 4
chrX_-_54646073 1.356 NM_001166623
NM_011252
Rbmx

RNA binding motif protein, X chromosome

chr17_-_33170297 1.355 NM_028543
Zfp763
zinc finger protein 763
chr18_-_16966954 1.353 Cdh2
cadherin 2
chr15_-_98748371 1.349 NM_029098
Lmbr1l
limb region 1 like
chr9_-_71743854 1.331 Tcf12
transcription factor 12
chr2_-_103637096 1.328 NM_001111289
NM_001111290
NM_001111292
Caprin1


cell cycle associated protein 1


chr2_+_126378563 1.310 NM_011978
Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
chr6_+_5340417 1.296 Asb4
ankyrin repeat and SOCS box-containing 4
chr16_+_78931190 1.294 NM_139134
Chodl
chondrolectin
chr7_-_27981077 1.277 NM_015782
Snrpa
small nuclear ribonucleoprotein polypeptide A
chr17_-_25570566 1.275 Cacna1h
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr3_-_75760820 1.274 Golim4
golgi integral membrane protein 4
chr6_-_91361356 1.271 NM_009527
Wnt7a
wingless-related MMTV integration site 7A
chr5_-_5265598 1.269 Cdk14
cyclin-dependent kinase 14
chr2_-_91476551 1.266 NM_010168
F2
coagulation factor II

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.90 7.22e-06 GO:0007399 nervous system development
4.36 8.16e-05 GO:0060284 regulation of cell development
2.87 2.07e-03 GO:0022008 neurogenesis
2.94 2.21e-03 GO:0048699 generation of neurons
1.82 2.99e-03 GO:0007275 multicellular organismal development
3.95 3.11e-03 GO:0051960 regulation of nervous system development
4.14 3.60e-03 GO:0050767 regulation of neurogenesis
4.33 1.01e-02 GO:0045664 regulation of neuron differentiation
1.81 1.14e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.88 1.23e-02 GO:0051252 regulation of RNA metabolic process
1.84 1.46e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.79 1.53e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.71 1.90e-02 GO:0032502 developmental process
5.25 2.10e-02 GO:0010975 regulation of neuron projection development
1.66 2.11e-02 GO:0080090 regulation of primary metabolic process
1.65 2.64e-02 GO:0031323 regulation of cellular metabolic process
1.79 2.82e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.66 2.88e-02 GO:0060255 regulation of macromolecule metabolic process
1.84 3.51e-02 GO:0006355 regulation of transcription, DNA-dependent
1.57 4.91e-02 GO:0019222 regulation of metabolic process

Gene overrepresentation in compartment category:

enrichment p-value GO term description
1.33 2.11e-05 GO:0005622 intracellular
1.33 3.57e-05 GO:0044424 intracellular part
1.32 2.11e-03 GO:0043229 intracellular organelle
1.61 2.28e-03 GO:0044446 intracellular organelle part
1.32 2.50e-03 GO:0043226 organelle
1.58 4.42e-03 GO:0044422 organelle part
1.49 8.62e-03 GO:0005634 nucleus
16.98 1.23e-02 GO:0034704 calcium channel complex
1.69 1.74e-02 GO:0043234 protein complex
1.15 2.09e-02 GO:0005623 cell
1.15 2.09e-02 GO:0044464 cell part
2.74 2.69e-02 GO:0015630 microtubule cytoskeleton
24.30 3.34e-02 GO:0071565 nBAF complex
1.30 4.31e-02 GO:0043231 intracellular membrane-bounded organelle
1.85 4.58e-02 GO:0044428 nuclear part
1.29 4.73e-02 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

enrichment p-value GO term description
1.37 6.95e-07 GO:0005488 binding
1.52 6.57e-04 GO:0005515 protein binding