Motif ID: MTF1.p2

Z-value: 2.186

Transcription factors associated with MTF1.p2:

NameEntrezDescription
Mtf1 17764 metal response element binding transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Mtf1chr4_+_124479785-0.372.8e-02Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr7_+_53651811 26.826 NM_008421
NM_001112739
Kcnc1

potassium voltage gated channel, Shaw-related subfamily, member 1

chr8_+_96696677 21.068 Mt2
metallothionein 2
chr11_-_5965626 19.809 Camk2b
calcium/calmodulin-dependent protein kinase II, beta
chr11_-_5965555 17.980 Camk2b
calcium/calmodulin-dependent protein kinase II, beta
chr8_+_96702981 17.977 NM_013602
Mt1
metallothionein 1
chr1_-_33964439 15.384 NM_177235
Bend6
BEN domain containing 6
chr13_+_19040215 13.746 NM_175007
Amph
amphiphysin
chr6_-_23789259 13.190 NM_153163
Cadps2
Ca2+-dependent activator protein for secretion 2
chr11_-_5965743 12.425 NM_001174053
NM_001174054
NM_007595
Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr11_+_77744280 11.298 NM_021286
Sez6
seizure related gene 6
chr16_+_91270009 11.189 NM_016968
Olig1
oligodendrocyte transcription factor 1
chrX_+_162676910 10.287 Gpm6b
glycoprotein m6b
chr7_-_88851798 10.029 NM_001164086
NM_011983
Homer2

homer homolog 2 (Drosophila)

chr4_+_129662110 9.874 Bai2
brain-specific angiogenesis inhibitor 2
chr5_-_8367951 9.613 NM_001007220
NM_001007221
NM_001098225
Adam22


a disintegrin and metallopeptidase domain 22


chr6_+_114081227 9.522 NM_172890
Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr5_-_139801315 9.410 NM_172723
Adap1
ArfGAP with dual PH domains 1
chr6_-_126114938 9.154 NM_001164035
Ntf3
neurotrophin 3
chr13_+_49282844 8.583 NM_013610
Ninj1
ninjurin 1
chr11_+_16652205 8.539 NM_007912
NM_207655
Egfr

epidermal growth factor receptor

chr4_+_129662284 8.441 NM_173071
Bai2
brain-specific angiogenesis inhibitor 2
chr2_-_77654669 8.290 NM_178723
Zfp385b
zinc finger protein 385B
chr14_+_35124004 8.263 Glud1
glutamate dehydrogenase 1
chr11_+_100436283 8.077 Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr10_-_120913138 8.016 NM_138956
Rassf3
Ras association (RalGDS/AF-6) domain family member 3
chr5_-_113006173 7.983 NM_019982
Sez6l
seizure related 6 homolog like
chr4_+_148960604 7.960 NM_023051
Clstn1
calsyntenin 1
chr2_+_146047656 7.826 NM_016889
Insm1
insulinoma-associated 1
chr6_+_38613031 7.658 NM_001101507
Clec2l
C-type lectin domain family, member L
chr14_+_12386094 7.509 Ptprg
protein tyrosine phosphatase, receptor type, G
chr17_+_70318707 7.495 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr1_-_75215798 7.394 NM_009447
Tuba4a
tubulin, alpha 4A
chr9_+_43851477 7.210 Thy1
thymus cell antigen 1, theta
chr13_-_52626065 7.159 NM_001024474
Diras2
DIRAS family, GTP-binding RAS-like 2
chr8_-_125201971 7.081 NM_001109873
NM_177289
Cbfa2t3

core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)

chr15_+_100701360 7.071


chr8_+_96703145 6.887 Mt1
metallothionein 1
chr19_+_5741862 6.730 Ltbp3
latent transforming growth factor beta binding protein 3
chr1_+_63492447 6.603 NM_001177600
NM_011780
Adam23

a disintegrin and metallopeptidase domain 23

chr19_+_6497834 6.570


chr11_-_75609557 6.443 NM_007873
Doc2b
double C2, beta
chr6_+_66846377 6.431 NM_001177556
NM_001177557
NM_001177559
NM_001177560
NM_025278
Gng12




guanine nucleotide binding protein (G protein), gamma 12




chr2_+_90725895 6.425 NM_026161
C1qtnf4
C1q and tumor necrosis factor related protein 4
chr2_+_156439426 6.308 NM_146128
Dlgap4
discs, large homolog-associated protein 4 (Drosophila)
chr5_+_89315839 6.238 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr8_-_101940218 6.200 NM_001039154
NM_007667
Cdh8

cadherin 8

chr9_+_57787915 6.180 NM_011352
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr4_+_130348406 6.142 NM_011520
Sdc3
syndecan 3
chr6_-_137597775 6.096 Eps8
epidermal growth factor receptor pathway substrate 8
chr2_+_156301543 5.889 NM_001006664
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr17_+_86567003 5.816 NM_011104
Prkce
protein kinase C, epsilon
chr16_+_49855786 5.746 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr6_-_113991945 5.699 NM_009723
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr15_+_30102306 5.611 NM_008729
Ctnnd2
catenin (cadherin associated protein), delta 2
chr2_+_155601077 5.590 NM_010808
Mmp24
matrix metallopeptidase 24
chr11_+_68902025 5.474 NM_009497
Vamp2
vesicle-associated membrane protein 2
chr5_+_37259780 5.446 NM_172994
Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr7_-_53435334 5.439 NM_011510
Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr11_-_6375845 5.438 NM_011221
Purb
purine rich element binding protein B
chr1_-_166387998 5.379 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_-_31701432 5.352 NM_178887
Fibcd1
fibrinogen C domain containing 1
chr8_+_73017009 5.313 NM_018827
Crlf1
cytokine receptor-like factor 1
chr4_-_57003214 5.305 NM_001142965
6430704M03Rik
RIKEN cDNA 6430704M03 gene
chr15_+_30102710 5.236 Ctnnd2
catenin (cadherin associated protein), delta 2
chr7_+_120351012 5.186 Arntl
aryl hydrocarbon receptor nuclear translocator-like
chr9_-_123169866 5.142 NM_001002267
Tmem158
transmembrane protein 158
chr11_+_68901989 5.075 Vamp2
vesicle-associated membrane protein 2
chrX_+_7215705 5.067 NM_009305
Syp
synaptophysin
chr1_-_17087915 5.041 Jph1
junctophilin 1
chr2_-_79296732 4.940 NM_010894
Neurod1
neurogenic differentiation 1
chr2_-_162486792 4.911 Ptprt
protein tyrosine phosphatase, receptor type, T
chr15_+_78673024 4.904 NM_027219
Cdc42ep1
CDC42 effector protein (Rho GTPase binding) 1
chr7_+_108496574 4.768 NM_001040111
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr17_+_70318387 4.761 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr11_-_33743416 4.755 NM_001190885
NM_027398
Kcnip1

Kv channel-interacting protein 1

chr10_-_77815056 4.686 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr14_-_73785035 4.677 Itm2b
integral membrane protein 2B
chr10_+_98377759 4.654 NM_026482
Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr9_+_26541302 4.640 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr2_-_181194085 4.596 NM_028125
Zbtb46
zinc finger and BTB domain containing 46
chr19_-_7062118 4.593 NM_001185164
NM_011697
Vegfb

vascular endothelial growth factor B

chr8_-_47296201 4.582 NM_007450
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr16_+_11984205 4.577 NM_001174086
NM_028277
Shisa9

shisa homolog 9 (Xenopus laevis)

chr15_-_89011113 4.575 NM_138749
Plxnb2
plexin B2
chr1_+_187278726 4.569 NM_001033286
Slc30a10
solute carrier family 30, member 10
chr7_+_73007017 4.555 NM_011048
Pcsk6
proprotein convertase subtilisin/kexin type 6
chr8_+_116729508 4.543 NM_173016
Vat1l
vesicle amine transport protein 1 homolog-like (T. californica)
chr19_-_7061958 4.522 Vegfb
vascular endothelial growth factor B
chr5_+_34339258 4.514 Nat8l
N-acetyltransferase 8-like
chr10_-_8238569 4.491 NM_177387
Ust
uronyl-2-sulfotransferase
chr2_-_156904966 4.475 NM_001164663
9830001H06Rik
RIKEN cDNA 9830001H06 gene
chr17_+_70318530 4.396 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr3_-_125641429 4.369 NM_011674
Ugt8a
UDP galactosyltransferase 8A
chr6_+_88674398 4.369 NM_001166249
NM_011844
Mgll

monoglyceride lipase

chr15_-_78034565 4.364 NM_013645
Pvalb
parvalbumin
chr1_-_175297778 4.324 NM_053199
Cadm3
cell adhesion molecule 3
chr9_-_75459125 4.303 NM_016711
Tmod2
tropomodulin 2
chr7_-_30066910 4.297 NM_001082548
NM_011464
Spint2

serine protease inhibitor, Kunitz type 2

chr4_+_148960536 4.294 Clstn1
calsyntenin 1
chr8_+_86939262 4.270 NM_007578
Cacna1a
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr10_+_59569206 4.248 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr4_-_120689813 4.229 NM_133716
Smap2
stromal membrane-associated GTPase-activating protein 2
chr16_+_49855691 4.196 NM_010581
Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr19_+_4100914 4.194 Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr3_+_126299858 4.168 NM_001025438
NM_001025439
NM_023813
Camk2d


calcium/calmodulin-dependent protein kinase II, delta


chr11_+_115024626 4.129 NM_012030
Slc9a3r1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr2_+_28388947 4.093 NM_001145835
NM_001145836
Ralgds

ral guanine nucleotide dissociation stimulator

chr1_-_84692352 4.092 Dner
delta/notch-like EGF-related receptor
chr4_-_154772070 4.059 NM_008072
Gabrd
gamma-aminobutyric acid (GABA) A receptor, subunit delta
chr17_-_50329593 4.039 NM_181397
Rftn1
raftlin lipid raft linker 1
chr4_-_128483355 4.038 NM_001081098
Zfp362
zinc finger protein 362
chr15_-_58913543 3.991 NM_001146180
NM_144800
Mtss1

metastasis suppressor 1

chr10_+_80755738 3.984 Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
chr11_+_70467599 3.971 Pfn1
profilin 1
chr8_-_74195545 3.943 Unc13a
unc-13 homolog A (C. elegans)
chr15_+_78744328 3.916 NM_020271
Pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr17_+_44215761 3.908 NM_032003
NM_001168620
Enpp5

ectonucleotide pyrophosphatase/phosphodiesterase 5

chr9_-_107134182 3.841 NM_153413
Dock3
dedicator of cyto-kinesis 3
chrX_+_158155484 3.833 NM_198409
Rai2
retinoic acid induced 2
chr13_+_55050729 3.833 NM_153131
Unc5a
unc-5 homolog A (C. elegans)
chr7_+_138079669 3.818 NM_019564
Htra1
HtrA serine peptidase 1
chr7_+_147080594 3.802 NM_177261
Kndc1
kinase non-catalytic C-lobe domain (KIND) containing 1
chr11_-_54846882 3.773 NM_001110211
NM_013472
Anxa6

annexin A6

chr8_+_96703174 3.742 Mt1
metallothionein 1
chr10_-_79602040 3.722 Dos
downstream of Stk11
chr5_+_137506122 3.718 NM_001039385
Vgf
VGF nerve growth factor inducible
chr11_-_118770859 3.715 Rbfox3
RNA binding protein, fox-1 homolog (C. elegans) 3
chr16_-_95219189 3.692 NM_001025584
NM_001025585
NM_010606
Kcnj6


potassium inwardly-rectifying channel, subfamily J, member 6


chr4_+_84851330 3.680 NM_019535
Sh3gl2
SH3-domain GRB2-like 2
chr15_-_101966611 3.661 NM_001033277
Spryd3
SPRY domain containing 3
chr14_-_37781899 3.643 Gcap14
granule cell antiserum positive 14
chr7_+_29236897 3.636 NM_030562
Lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr16_-_18348136 3.623 D16H22S680E
DNA segment, Chr 16, human D22S680E, expressed
chr9_+_58430031 3.618 NM_009145
Nptn
neuroplastin
chr14_-_40286236 3.597 NM_001190187
NM_001190188
NM_008734
Nrg3


neuregulin 3


chr5_+_37259906 3.597 Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr9_-_56265833 3.575 NM_172924
C230081A13Rik
RIKEN cDNA C230081A13 gene
chr2_+_28061156 3.574 NM_001038612
NM_019498
Olfm1

olfactomedin 1

chr13_-_59658585 3.572 NM_001048008
NM_023328
Agtpbp1

ATP/GTP binding protein 1

chr4_-_133054355 3.569 NM_001081156
Trnp1
TMF1-regulated nuclear protein 1
chrX_+_158154967 3.540 NM_001103367
Rai2
retinoic acid induced 2
chr2_+_28048592 3.481 NM_001038613
NM_001038614
Olfm1

olfactomedin 1

chr4_+_8617613 3.460 Chd7
chromodomain helicase DNA binding protein 7
chr12_-_112615555 3.452 Cdc42bpb
CDC42 binding protein kinase beta
chr8_-_87323958 3.434 Nfix
nuclear factor I/X
chr2_-_163744663 3.430 Rims4
regulating synaptic membrane exocytosis 4
chrX_-_138740574 3.428 Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr2_-_92241357 3.414 NM_011162
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr9_-_56483379 3.412 Lingo1
leucine rich repeat and Ig domain containing 1
chr9_-_75459046 3.412 Tmod2
tropomodulin 2
chr5_-_72049058 3.411 Gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr19_+_26681759 3.394 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_+_54472705 3.368 NM_009946
Cplx2
complexin 2
chr1_+_137043277 3.363 NM_026823
Arl8a
ADP-ribosylation factor-like 8A
chr13_-_52626022 3.354 Diras2
DIRAS family, GTP-binding RAS-like 2
chr4_-_47004585 3.339 NM_001081141
Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr2_-_168567436 3.339 Atp9a
ATPase, class II, type 9A
chrX_+_162676870 3.337 NM_001177961
NM_001177962
NM_023122
Gpm6b


glycoprotein m6b


chr10_+_80755734 3.335 Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
chr9_-_112137285 3.319 NM_001177619
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr2_-_11423651 3.308 Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr9_-_53823107 3.289 NM_177769
Elmod1
ELMO domain containing 1
chr15_-_78034648 3.281 Pvalb
parvalbumin
chr2_+_157740281 3.274 NM_198627
Vstm2l
V-set and transmembrane domain containing 2-like
chr9_-_14185399 3.273 Endod1
endonuclease domain containing 1
chr10_+_128346900 3.265 NM_007653
Cd63
CD63 antigen
chr17_+_70318760 3.217 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr1_+_193730645 3.206 NM_009579
Slc30a1
solute carrier family 30 (zinc transporter), member 1
chr1_+_89160921 3.204 NM_028889
Efhd1
EF hand domain containing 1
chr9_-_75458954 3.193 Tmod2
tropomodulin 2
chr2_-_152777135 3.119 NM_145744
NM_001159376
Dusp15

dual specificity phosphatase-like 15

chr9_-_89517823 3.118 NM_153509
AF529169
cDNA sequence AF529169
chr1_-_156731538 3.112 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr7_+_51846254 3.106 NM_008422
Kcnc3
potassium voltage gated channel, Shaw-related subfamily, member 3
chr7_-_87547589 3.087 NM_011046
Furin
furin (paired basic amino acid cleaving enzyme)
chr8_+_107064705 3.076 NM_053070
Car7
carbonic anhydrase 7
chr13_+_54472806 3.065 Cplx2
complexin 2
chr3_-_58495986 3.054 Siah2
seven in absentia 2
chr5_-_139470895 3.034 NM_008808
Pdgfa
platelet derived growth factor, alpha
chr17_+_43153516 3.031 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr3_-_87804062 3.029 Bcan
brevican
chr16_-_85173978 3.026 App
amyloid beta (A4) precursor protein
chr9_+_89804723 2.991 Rasgrf1
RAS protein-specific guanine nucleotide-releasing factor 1
chr3_+_54559503 2.976 NM_019483
Smad9
MAD homolog 9 (Drosophila)
chr9_-_53822931 2.974 Elmod1
ELMO domain containing 1
chr10_+_99478457 2.940 NM_013598
Kitl
kit ligand
chr3_-_32515388 2.925 NM_013531
Gnb4
guanine nucleotide binding protein (G protein), beta 4
chr16_-_22657245 2.919 Dgkg
diacylglycerol kinase, gamma
chr11_-_77303157 2.911 NM_172945
Ankrd13b
ankyrin repeat domain 13b
chr7_+_129432585 2.906 NM_008855
Prkcb
protein kinase C, beta
chr1_-_191167231 2.894 NM_001159850
Kcnk2
potassium channel, subfamily K, member 2
chr17_-_24787217 2.892 NM_023055
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr13_+_54472833 2.882 Cplx2
complexin 2
chr5_+_35399712 2.877 NM_172708
Dok7
docking protein 7
chr1_+_95132413 2.868 NM_172463
Sned1
sushi, nidogen and EGF-like domains 1
chrX_+_70748418 2.831 NM_177236
Atp2b3
ATPase, Ca++ transporting, plasma membrane 3
chrX_-_70905062 2.820 NM_012040
Pnck
pregnancy upregulated non-ubiquitously expressed CaM kinase
chrX_-_45388010 2.798 NM_013912
Apln
apelin
chr15_+_74786009 2.794 Ly6e
lymphocyte antigen 6 complex, locus E
chr18_+_69504145 2.775 NM_013685
Tcf4
transcription factor 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.15 3.69e-19 GO:0006810 transport
2.12 2.10e-18 GO:0051234 establishment of localization
1.98 1.57e-17 GO:0051179 localization
2.71 3.74e-15 GO:0007399 nervous system development
4.56 2.48e-14 GO:0019226 transmission of nerve impulse
4.56 2.48e-14 GO:0035637 multicellular organismal signaling
4.86 1.00e-12 GO:0007268 synaptic transmission
3.03 2.47e-12 GO:0051049 regulation of transport
3.15 9.91e-12 GO:0007154 cell communication
2.16 1.08e-11 GO:0065008 regulation of biological quality
2.62 1.34e-11 GO:0032879 regulation of localization
1.94 4.27e-11 GO:0048731 system development
3.73 5.17e-11 GO:0007267 cell-cell signaling
2.81 8.58e-11 GO:0006811 ion transport
3.36 1.85e-10 GO:0030001 metal ion transport
2.25 2.72e-10 GO:0023051 regulation of signaling
3.63 4.72e-10 GO:0044057 regulation of system process
7.62 4.72e-10 GO:0006836 neurotransmitter transport
1.36 6.03e-10 GO:0065007 biological regulation
3.32 1.01e-09 GO:0030030 cell projection organization
2.43 2.37e-09 GO:0010646 regulation of cell communication
1.80 3.24e-09 GO:0048856 anatomical structure development
2.72 3.36e-09 GO:0048699 generation of neurons
2.16 3.79e-09 GO:0051239 regulation of multicellular organismal process
2.64 5.65e-09 GO:0022008 neurogenesis
3.11 5.66e-09 GO:0030182 neuron differentiation
2.95 5.78e-09 GO:0048878 chemical homeostasis
4.82 9.31e-09 GO:0050804 regulation of synaptic transmission
1.73 1.43e-08 GO:0007275 multicellular organismal development
1.57 1.69e-08 GO:0023052 signaling
2.93 1.80e-08 GO:0006812 cation transport
3.73 2.04e-08 GO:0031175 neuron projection development
1.36 2.47e-08 GO:0050794 regulation of cellular process
4.47 5.85e-08 GO:0051969 regulation of transmission of nerve impulse
1.66 7.09e-08 GO:0032502 developmental process
4.26 8.61e-08 GO:0031644 regulation of neurological system process
3.27 8.81e-08 GO:0048666 neuron development
1.22 1.29e-07 GO:0009987 cellular process
1.33 1.42e-07 GO:0050789 regulation of biological process
3.16 1.51e-07 GO:0055082 cellular chemical homeostasis
7.29 1.88e-07 GO:0048167 regulation of synaptic plasticity
3.16 2.48e-07 GO:0006873 cellular ion homeostasis
3.33 2.84e-07 GO:0007610 behavior
3.04 3.01e-07 GO:0050801 ion homeostasis
1.74 2.19e-06 GO:0048519 negative regulation of biological process
3.95 2.23e-06 GO:0032940 secretion by cell
2.78 2.82e-06 GO:0019725 cellular homeostasis
2.29 6.30e-06 GO:0042592 homeostatic process
9.01 7.98e-06 GO:0007269 neurotransmitter secretion
1.98 1.05e-05 GO:0009653 anatomical structure morphogenesis
3.28 1.25e-05 GO:0046903 secretion
2.14 1.37e-05 GO:0035556 intracellular signal transduction
2.57 1.38e-05 GO:0016192 vesicle-mediated transport
4.94 1.60e-05 GO:0007611 learning or memory
2.49 1.70e-05 GO:0019220 regulation of phosphate metabolic process
2.49 1.70e-05 GO:0051174 regulation of phosphorus metabolic process
1.77 2.05e-05 GO:0030154 cell differentiation
4.62 2.13e-05 GO:0006816 calcium ion transport
2.27 2.34e-05 GO:0048468 cell development
1.76 2.35e-05 GO:0048869 cellular developmental process
2.59 2.39e-05 GO:0001932 regulation of protein phosphorylation
2.40 2.54e-05 GO:0055085 transmembrane transport
2.26 2.78e-05 GO:0051649 establishment of localization in cell
3.98 3.22e-05 GO:0043269 regulation of ion transport
4.13 3.31e-05 GO:0070838 divalent metal ion transport
2.47 4.23e-05 GO:0042325 regulation of phosphorylation
4.43 4.35e-05 GO:0006813 potassium ion transport
4.65 4.45e-05 GO:0050890 cognition
4.06 4.51e-05 GO:0072511 divalent inorganic cation transport
4.23 4.53e-05 GO:0060627 regulation of vesicle-mediated transport
2.10 6.58e-05 GO:0051641 cellular localization
3.45 7.54e-05 GO:0048812 neuron projection morphogenesis
2.97 7.86e-05 GO:0051050 positive regulation of transport
6.08 9.83e-05 GO:0001505 regulation of neurotransmitter levels
2.90 1.40e-04 GO:0045859 regulation of protein kinase activity
2.78 1.49e-04 GO:0051338 regulation of transferase activity
2.27 1.53e-04 GO:0031399 regulation of protein modification process
2.82 1.70e-04 GO:0043549 regulation of kinase activity
3.06 2.89e-04 GO:0015672 monovalent inorganic cation transport
1.38 2.93e-04 GO:0032501 multicellular organismal process
1.95 2.95e-04 GO:0009966 regulation of signal transduction
1.66 2.97e-04 GO:0048523 negative regulation of cellular process
4.85 3.10e-04 GO:0003001 generation of a signal involved in cell-cell signaling
4.85 3.10e-04 GO:0023061 signal release
1.83 3.47e-04 GO:0065009 regulation of molecular function
3.89 3.99e-04 GO:0042391 regulation of membrane potential
4.25 4.20e-04 GO:0007626 locomotory behavior
1.92 5.97e-04 GO:0050790 regulation of catalytic activity
7.68 8.07e-04 GO:0048168 regulation of neuronal synaptic plasticity
7.68 8.07e-04 GO:0050885 neuromuscular process controlling balance
2.54 8.81e-04 GO:0032989 cellular component morphogenesis
2.96 9.25e-04 GO:0048858 cell projection morphogenesis
2.11 9.60e-04 GO:0051128 regulation of cellular component organization
2.95 9.88e-04 GO:0000904 cell morphogenesis involved in differentiation
7.50 1.02e-03 GO:0007270 nerve-nerve synaptic transmission
16.51 1.03e-03 GO:0021697 cerebellar cortex formation
2.60 1.05e-03 GO:0000902 cell morphogenesis
2.75 1.12e-03 GO:0051960 regulation of nervous system development
2.86 1.14e-03 GO:0050767 regulation of neurogenesis
3.50 1.15e-03 GO:0031344 regulation of cell projection organization
3.08 1.18e-03 GO:0045664 regulation of neuron differentiation
4.97 1.32e-03 GO:0034765 regulation of ion transmembrane transport
2.91 1.36e-03 GO:0032990 cell part morphogenesis
12.16 1.43e-03 GO:0021696 cerebellar cortex morphogenesis
3.05 1.45e-03 GO:0006140 regulation of nucleotide metabolic process
1.53 1.64e-03 GO:0048518 positive regulation of biological process
3.19 1.78e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
2.63 1.80e-03 GO:0060284 regulation of cell development
1.52 1.99e-03 GO:0016043 cellular component organization
11.56 2.14e-03 GO:0046847 filopodium assembly
5.58 2.30e-03 GO:0050905 neuromuscular process
1.97 3.11e-03 GO:0032268 regulation of cellular protein metabolic process
4.03 3.89e-03 GO:0006814 sodium ion transport
10.51 4.47e-03 GO:0030035 microspike assembly
4.20 4.85e-03 GO:0006887 exocytosis
3.20 5.11e-03 GO:0007409 axonogenesis
2.70 5.44e-03 GO:0007420 brain development
1.90 5.57e-03 GO:0050793 regulation of developmental process
1.53 6.08e-03 GO:0048522 positive regulation of cellular process
7.08 6.35e-03 GO:0048489 synaptic vesicle transport
2.68 6.45e-03 GO:0051130 positive regulation of cellular component organization
2.18 6.53e-03 GO:0043085 positive regulation of catalytic activity
1.47 6.66e-03 GO:0071840 cellular component organization or biogenesis
5.50 7.31e-03 GO:0018209 peptidyl-serine modification
3.50 7.35e-03 GO:0010975 regulation of neuron projection development
2.19 7.72e-03 GO:0007155 cell adhesion
12.38 8.03e-03 GO:0007416 synapse assembly
2.64 8.51e-03 GO:0022603 regulation of anatomical structure morphogenesis
3.77 9.33e-03 GO:0010959 regulation of metal ion transport
2.17 9.42e-03 GO:0022610 biological adhesion
1.38 1.02e-02 GO:0007165 signal transduction
5.90 1.05e-02 GO:0050808 synapse organization
1.86 1.08e-02 GO:0051246 regulation of protein metabolic process
2.45 1.11e-02 GO:0023057 negative regulation of signaling
2.41 1.12e-02 GO:0007417 central nervous system development
3.90 1.22e-02 GO:0043087 regulation of GTPase activity
3.87 1.34e-02 GO:0033124 regulation of GTP catabolic process
8.89 1.55e-02 GO:0021695 cerebellar cortex development
2.24 1.90e-02 GO:0048646 anatomical structure formation involved in morphogenesis
3.27 1.91e-02 GO:0034762 regulation of transmembrane transport
8.56 2.04e-02 GO:0021587 cerebellum morphogenesis
2.37 2.26e-02 GO:0060341 regulation of cellular localization
4.91 2.29e-02 GO:0007612 learning
1.85 2.33e-02 GO:0006796 phosphate metabolic process
4.17 2.40e-02 GO:0030534 adult behavior
1.84 2.47e-02 GO:0006793 phosphorus metabolic process
5.94 2.87e-02 GO:0043547 positive regulation of GTPase activity
2.37 3.13e-02 GO:0010648 negative regulation of cell communication
1.39 3.51e-02 GO:0031323 regulation of cellular metabolic process
2.41 4.35e-02 GO:0009968 negative regulation of signal transduction
2.10 4.43e-02 GO:0040011 locomotion
18.87 4.69e-02 GO:0048172 regulation of short-term neuronal synaptic plasticity
5.61 4.69e-02 GO:0018105 peptidyl-serine phosphorylation
1.88 4.86e-02 GO:2000026 regulation of multicellular organismal development
4.54 4.87e-02 GO:0030902 hindbrain development

Gene overrepresentation in compartment category:

enrichment p-value GO term description
4.85 4.81e-26 GO:0045202 synapse
1.95 5.39e-21 GO:0005886 plasma membrane
1.93 1.15e-20 GO:0071944 cell periphery
1.49 1.32e-19 GO:0016020 membrane
3.75 3.01e-17 GO:0043005 neuron projection
2.35 3.34e-17 GO:0044459 plasma membrane part
2.70 7.72e-15 GO:0042995 cell projection
4.46 9.00e-15 GO:0044456 synapse part
1.46 1.88e-12 GO:0044425 membrane part
4.29 2.25e-11 GO:0030425 dendrite
2.98 1.35e-10 GO:0030054 cell junction
3.71 9.60e-10 GO:0044297 cell body
3.80 9.67e-10 GO:0043025 neuronal cell body
1.16 1.62e-09 GO:0005623 cell
1.16 1.62e-09 GO:0044464 cell part
2.40 4.15e-08 GO:0005624 membrane fraction
2.30 2.57e-07 GO:0005626 insoluble fraction
2.12 2.75e-07 GO:0000267 cell fraction
3.06 2.84e-07 GO:0044463 cell projection part
9.91 3.74e-07 GO:0042734 presynaptic membrane
3.56 1.83e-06 GO:0030424 axon
1.29 3.70e-06 GO:0005737 cytoplasm
4.61 7.96e-06 GO:0019717 synaptosome
2.29 1.00e-05 GO:0031982 vesicle
2.29 2.50e-05 GO:0031410 cytoplasmic vesicle
4.10 2.56e-05 GO:0045211 postsynaptic membrane
5.50 5.75e-05 GO:0030427 site of polarized growth
1.33 7.72e-05 GO:0031224 intrinsic to membrane
5.00 7.76e-05 GO:0008021 synaptic vesicle
5.30 2.45e-04 GO:0030426 growth cone
1.32 3.80e-04 GO:0016021 integral to membrane
2.18 4.19e-04 GO:0031226 intrinsic to plasma membrane
3.59 4.34e-04 GO:0034702 ion channel complex
9.11 4.51e-04 GO:0030672 synaptic vesicle membrane
1.32 5.01e-04 GO:0044444 cytoplasmic part
3.85 5.83e-04 GO:0030136 clathrin-coated vesicle
2.31 6.42e-04 GO:0031988 membrane-bounded vesicle
7.43 6.50e-04 GO:0031594 neuromuscular junction
6.12 1.18e-03 GO:0030665 clathrin coated vesicle membrane
2.30 1.24e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.17 1.34e-03 GO:0005622 intracellular
2.15 1.42e-03 GO:0005887 integral to plasma membrane
1.48 1.87e-03 GO:0043234 protein complex
7.55 2.11e-03 GO:0005834 heterotrimeric G-protein complex
4.56 3.25e-03 GO:0009898 internal side of plasma membrane
3.38 3.34e-03 GO:0030135 coated vesicle
1.17 3.59e-03 GO:0044424 intracellular part
3.25 5.74e-03 GO:0012506 vesicle membrane
1.84 5.85e-03 GO:0005794 Golgi apparatus
3.37 6.36e-03 GO:0030659 cytoplasmic vesicle membrane
33.02 7.58e-03 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex
3.26 9.37e-03 GO:0044433 cytoplasmic vesicle part
1.90 9.89e-03 GO:0012505 endomembrane system
6.00 1.25e-02 GO:0031234 extrinsic to internal side of plasma membrane
4.72 1.27e-02 GO:0030662 coated vesicle membrane
3.50 1.31e-02 GO:0033267 axon part
4.52 1.83e-02 GO:0019897 extrinsic to plasma membrane
3.81 1.98e-02 GO:0034703 cation channel complex
3.77 2.18e-02 GO:0019898 extrinsic to membrane

Gene overrepresentation in function category:

enrichment p-value GO term description
1.63 3.51e-17 GO:0005515 protein binding
1.33 4.02e-15 GO:0005488 binding
2.83 2.56e-11 GO:0022891 substrate-specific transmembrane transporter activity
2.67 8.87e-11 GO:0022857 transmembrane transporter activity
2.62 1.54e-10 GO:0022892 substrate-specific transporter activity
2.85 8.05e-10 GO:0015075 ion transmembrane transporter activity
2.37 2.55e-09 GO:0005215 transporter activity
3.80 4.20e-08 GO:0022836 gated channel activity
2.89 3.31e-07 GO:0008324 cation transmembrane transporter activity
3.10 1.47e-06 GO:0022838 substrate-specific channel activity
5.10 2.26e-06 GO:0005516 calmodulin binding
3.08 2.96e-06 GO:0005216 ion channel activity
3.00 3.33e-06 GO:0015267 channel activity
3.00 3.56e-06 GO:0022803 passive transmembrane transporter activity
1.80 7.90e-06 GO:0032555 purine ribonucleotide binding
1.80 8.12e-06 GO:0032553 ribonucleotide binding
1.71 9.50e-06 GO:0000166 nucleotide binding
1.79 9.61e-06 GO:0017076 purine nucleotide binding
1.77 2.50e-05 GO:0035639 purine ribonucleoside triphosphate binding
3.85 5.62e-05 GO:0005244 voltage-gated ion channel activity
3.85 5.62e-05 GO:0022832 voltage-gated channel activity
6.85 1.80e-04 GO:0016247 channel regulator activity
12.84 2.26e-04 GO:0004683 calmodulin-dependent protein kinase activity
8.74 2.26e-04 GO:0015179 L-amino acid transmembrane transporter activity
2.43 2.73e-04 GO:0005509 calcium ion binding
3.63 2.94e-04 GO:0005543 phospholipid binding
3.16 3.07e-04 GO:0005261 cation channel activity
2.91 3.11e-04 GO:0022804 active transmembrane transporter activity
2.62 3.17e-04 GO:0004674 protein serine/threonine kinase activity
2.38 4.80e-04 GO:0019904 protein domain specific binding
2.71 5.60e-04 GO:0032403 protein complex binding
4.03 9.46e-04 GO:0022843 voltage-gated cation channel activity
1.72 1.58e-03 GO:0032559 adenyl ribonucleotide binding
1.43 1.80e-03 GO:0046872 metal ion binding
1.71 1.89e-03 GO:0030554 adenyl nucleotide binding
12.38 1.96e-03 GO:0005246 calcium channel regulator activity
2.28 2.37e-03 GO:0008092 cytoskeletal protein binding
1.42 2.55e-03 GO:0043167 ion binding
1.41 3.34e-03 GO:0043169 cation binding
2.41 5.25e-03 GO:0008289 lipid binding
1.68 5.68e-03 GO:0005524 ATP binding
5.24 7.60e-03 GO:0015171 amino acid transmembrane transporter activity
3.73 1.00e-02 GO:0005267 potassium channel activity
2.01 1.01e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.92 1.02e-02 GO:0016301 kinase activity
3.67 1.20e-02 GO:0046873 metal ion transmembrane transporter activity
2.11 1.28e-02 GO:0004672 protein kinase activity
6.29 1.35e-02 GO:0000149 SNARE binding
1.78 1.51e-02 GO:0005102 receptor binding
11.01 2.46e-02 GO:0050750 low-density lipoprotein particle receptor binding
3.38 3.04e-02 GO:0008509 anion transmembrane transporter activity
6.60 3.05e-02 GO:0019905 syntaxin binding
4.40 3.56e-02 GO:0005275 amine transmembrane transporter activity
3.95 4.38e-02 GO:0030165 PDZ domain binding
3.67 4.41e-02 GO:0035091 phosphatidylinositol binding
4.29 4.47e-02 GO:0015081 sodium ion transmembrane transporter activity
2.97 4.48e-02 GO:0015291 secondary active transmembrane transporter activity
24.76 4.56e-02 GO:0050321 tau-protein kinase activity
3.91 4.84e-02 GO:0046943 carboxylic acid transmembrane transporter activity