Motif ID: NANOG.p2

Z-value: 0.767

Transcription factors associated with NANOG.p2:

NameEntrezDescription
Nanog 71950 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Nanogchr6_+_1226575060.202.4e-01Click!


Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr8_-_3625251 5.306 NM_008790
Pcp2
Purkinje cell protein 2 (L7)
chr10_-_24919916 4.886 Akap7
A kinase (PRKA) anchor protein 7
chr1_+_6720153 3.579 St18
suppression of tumorigenicity 18
chrX_+_133357268 2.948 NM_011123
Plp1
proteolipid protein (myelin) 1
chr10_+_96942263 2.946 Dcn
decorin
chr17_+_80706746 2.445 NM_001145452
Arhgef33
Rho guanine nucleotide exchange factor (GEF) 33
chr5_+_27588462 2.375 NM_001136060
Dpp6
dipeptidylpeptidase 6
chr7_-_20284370 2.081 Apoe
apolipoprotein E
chr2_-_127346987 1.972 Kcnip3
Kv channel interacting protein 3, calsenilin
chr10_+_73284612 1.813 NM_001142735
NM_001142736
NM_001142737
NM_001142738
NM_001142739
NM_001142740
NM_001142741
NM_001142742
NM_001142743
NM_001142746
NM_001142747
NM_001142748
NM_001142760
NM_023115
Pcdh15













protocadherin 15













chr6_+_125502979 1.745 NM_011708
Vwf
Von Willebrand factor homolog
chr2_+_125860377 1.741 NM_008008
Fgf7
fibroblast growth factor 7
chr18_+_23573908 1.605 NM_010087
NM_207650
Dtna

dystrobrevin alpha

chr8_-_87297283 1.589 Nfix
nuclear factor I/X
chr8_-_3624988 1.564 NM_001129804
Pcp2
Purkinje cell protein 2 (L7)
chr15_+_3220994 1.525 Sepp1
selenoprotein P, plasma, 1
chrM_+_3913 1.512


chr1_+_106665395 1.427 NM_011800
Cdh20
cadherin 20
chr3_+_68376289 1.398 NM_013928
Schip1
schwannomin interacting protein 1
chrM_+_12383 1.262


chr4_+_119486921 1.242 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr15_+_3220999 1.169 Sepp1
selenoprotein P, plasma, 1
chr7_+_86418127 1.121 NM_018811
Abhd2
abhydrolase domain containing 2
chr2_+_70312979 1.074 NM_022435
Sp5
trans-acting transcription factor 5
chrM_+_13998 1.044


chr7_+_86418082 1.023 Abhd2
abhydrolase domain containing 2
chr12_+_110783593 1.012 Meg3
maternally expressed 3
chr9_+_45178521 0.976 Fxyd6
FXYD domain-containing ion transport regulator 6
chr6_-_53770406 0.968 Tril
TLR4 interactor with leucine-rich repeats
chr14_+_122879276 0.950 Zic2
zinc finger protein of the cerebellum 2
chr6_+_88674697 0.948 NM_001166250
NM_001166251
Mgll

monoglyceride lipase

chr1_+_6720087 0.946 NM_173868
St18
suppression of tumorigenicity 18
chr15_+_39491073 0.931 Rims2
regulating synaptic membrane exocytosis 2
chr10_+_96942181 0.924 Dcn
decorin
chr14_-_104215770 0.923 Ednrb
endothelin receptor type B
chr7_+_134094045 0.913 NM_144926
Sez6l2
seizure related 6 homolog like 2
chr13_+_20564928 0.905 NM_198093
Elmo1
engulfment and cell motility 1, ced-12 homolog (C. elegans)
chr9_+_118387306 0.884 NM_001164789
NM_010136
Eomes

eomesodermin homolog (Xenopus laevis)

chr18_-_32109233 0.866 NM_001025381
Gpr17
G protein-coupled receptor 17
chr10_-_27336648 0.858 NM_008481
Lama2
laminin, alpha 2
chr9_+_75623153 0.816 NM_007555
Bmp5
bone morphogenetic protein 5
chr12_+_110783786 0.814 Meg3
maternally expressed 3
chrM_+_13320 0.807


chr19_-_34329804 0.806 NM_007392
Acta2
actin, alpha 2, smooth muscle, aorta
chr1_-_79436564 0.793 NM_009129
Scg2
secretogranin II
chr9_-_29770699 0.790 NM_172290
Ntm
neurotrimin
chr1_-_165243777 0.772 NM_001025570
NM_011127
NM_175686
Prrx1


paired related homeobox 1


chr11_-_33103458 0.763 NM_019916
Tlx3
T-cell leukemia, homeobox 3
chr15_+_78757148 0.750 NM_008495
Lgals1
lectin, galactose binding, soluble 1
chr2_-_147011990 0.735 NM_001077632
NM_010919
Nkx2-2

NK2 transcription factor related, locus 2 (Drosophila)

chr2_-_127347102 0.724 NM_019789
Kcnip3
Kv channel interacting protein 3, calsenilin
chr1_+_155756310 0.713 Glul
glutamate-ammonia ligase (glutamine synthetase)
chr6_+_125502943 0.711 Vwf
Von Willebrand factor homolog
chr8_+_24780132 0.706 NM_177086
Zmat4
zinc finger, matrin type 4
chr1_-_166368439 0.704 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr15_-_42508294 0.671 NM_009640
Angpt1
angiopoietin 1
chr11_+_29618696 0.666 Rtn4
reticulon 4
chr12_+_110798661 0.665 Meg3
maternally expressed 3
chr3_-_108236057 0.656 Sars
seryl-aminoacyl-tRNA synthetase
chr10_+_57351786 0.655 NM_001039051
NM_008863
Pkib

protein kinase inhibitor beta, cAMP dependent, testis specific

chr11_+_93905443 0.653 Spag9
sperm associated antigen 9
chr10_+_98725871 0.649 Dusp6
dual specificity phosphatase 6
chr1_-_165243608 0.649 Prrx1
paired related homeobox 1
chr1_+_111880313 0.647 NM_172853
Cdh7
cadherin 7, type 2
chr16_-_85550617 0.642 NM_144853
Cyyr1
cysteine and tyrosine-rich protein 1
chr2_-_79296732 0.631 NM_010894
Neurod1
neurogenic differentiation 1
chr10_-_101953046 0.631 NM_024435
Nts
neurotensin
chr3_+_89324085 0.625 NM_080466
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr18_+_42713035 0.618 Tcerg1
transcription elongation regulator 1 (CA150)
chr11_+_3230733 0.610 NM_178149
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_+_164595447 0.604 Ube2c
ubiquitin-conjugating enzyme E2C
chr3_-_88214230 0.598 NM_025928
Pmf1
polyamine-modulated factor 1
chr11_+_94871643 0.588 Samd14
sterile alpha motif domain containing 14
chr18_+_57628139 0.583 NM_001134697
Ctxn3
cortexin 3
chr6_+_134874663 0.579 Cdkn1b
cyclin-dependent kinase inhibitor 1B
chr8_+_4238862 0.576 Map2k7
mitogen-activated protein kinase kinase 7
chrX_-_85360961 0.573 NM_001160403
Il1rapl1
interleukin 1 receptor accessory protein-like 1
chr9_+_56712850 0.562 NM_139001
Cspg4
chondroitin sulfate proteoglycan 4
chr16_-_37385024 0.556 NM_001114611
NM_001114612
NM_001114613
NM_172440
Stxbp5l



syntaxin binding protein 5-like



chr2_+_10075242 0.553 Itih5
inter-alpha (globulin) inhibitor H5
chr19_-_7044198 0.545 NM_008874
Plcb3
phospholipase C, beta 3
chr11_-_69479553 0.541 NM_009853
Cd68
CD68 antigen
chr19_-_55177562 0.539 Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
chr8_+_122190264 0.534 NM_023395
Wfdc1
WAP four-disulfide core domain 1
chr2_-_6642489 0.531 Celf2
CUGBP, Elav-like family member 2
chr18_-_72367655 0.529


chr2_+_84574217 0.526 NM_001005342
Ypel4
yippee-like 4 (Drosophila)
chrX_-_73120447 0.524 Pls3
plastin 3 (T-isoform)
chr3_-_50247306 0.523 NM_011990
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr13_-_53568111 0.513 NM_013601
Msx2
homeobox, msh-like 2
chr5_+_23870625 0.509 NM_008713
Nos3
nitric oxide synthase 3, endothelial cell
chr17_+_70871444 0.492 NM_001128180
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr11_-_33893151 0.491 NM_001190886
Kcnip1
Kv channel-interacting protein 1
chr7_-_86531587 0.490 Rlbp1
retinaldehyde binding protein 1
chr1_-_195068455 0.489 NM_001044751
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
chr10_+_97028409 0.488 Lum
lumican
chrX_-_73120485 0.476 NM_001166453
Pls3
plastin 3 (T-isoform)
chr15_+_78860623 0.461


chr19_+_8692485 0.453 NM_008766
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chrM_+_3844 0.452


chr9_+_14305055 0.434 NM_023153
Cwc15
CWC15 homolog (S. cerevisiae)
chr3_+_54165028 0.432 NM_001198765
NM_001198766
NM_015784
Postn


periostin, osteoblast specific factor


chr5_-_135223110 0.429 NM_007925
Eln
elastin
chr11_-_94902584 0.428 NM_133667
Pdk2
pyruvate dehydrogenase kinase, isoenzyme 2
chr2_+_84976516 0.427 NM_011784
Aplnr
apelin receptor
chr6_+_83129579 0.420 NM_007835
Dctn1
dynactin 1
chr5_-_63157309 0.418 NM_178407
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_+_97535490 0.416 NM_001040087
NM_001040088
Sytl2

synaptotagmin-like 2

chr6_-_136890189 0.416 NM_007486
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr17_+_34176412 0.412 Col11a2
collagen, type XI, alpha 2
chr6_-_53770687 0.410 NM_025817
Tril
TLR4 interactor with leucine-rich repeats
chr15_+_39490991 0.401 Rims2
regulating synaptic membrane exocytosis 2
chr1_-_129998984 0.399 NM_027678
Zranb3
zinc finger, RAN-binding domain containing 3
chr10_-_20880559 0.396 NM_001198914
NM_010848
Myb

myeloblastosis oncogene

chr11_-_97372344 0.396 Srcin1
SRC kinase signaling inhibitor 1
chr17_-_90487479 0.395 Nrxn1
neurexin I
chr4_-_82151180 0.394 NM_001113209
NM_001113210
NM_008687
Nfib


nuclear factor I/B


chr2_+_10075220 0.387 Itih5
inter-alpha (globulin) inhibitor H5
chr15_+_91991704 0.386 NM_001159647
Cntn1
contactin 1
chr9_+_56712829 0.370 Cspg4
chondroitin sulfate proteoglycan 4
chr8_-_37631772 0.362 Dlc1
deleted in liver cancer 1
chr6_-_99216494 0.355 NM_001197321
Foxp1
forkhead box P1
chr11_-_99105293 0.355 NM_172946
Krt222
keratin 222
chr9_+_45178485 0.347 Fxyd6
FXYD domain-containing ion transport regulator 6
chr16_+_45093784 0.343 Ccdc80
coiled-coil domain containing 80
chr7_-_106289635 0.337 Uvrag
UV radiation resistance associated gene
chr5_-_121459496 0.332 NM_011286
Rph3a
rabphilin 3A
chr4_+_130378728 0.331 Sdc3
syndecan 3
chr19_+_8665743 0.328 NM_001164634
NM_031194
Slc22a8

solute carrier family 22 (organic anion transporter), member 8

chr1_-_14299936 0.325 NM_010164
Eya1
eyes absent 1 homolog (Drosophila)
chr4_-_58219368 0.319 NM_022814
Svep1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr17_+_27693821 0.318 Hmga1
high mobility group AT-hook 1
chr19_+_7631935 0.317 NM_139269
Pla2g16
phospholipase A2, group XVI
chr6_-_60778740 0.314 NM_001042451
Snca
synuclein, alpha
chr9_-_96531911 0.313 NM_053268
Rasa2
RAS p21 protein activator 2
chr8_+_26830480 0.311 NM_028000
Ppapdc1b
phosphatidic acid phosphatase type 2 domain containing 1B
chr13_+_22135065 0.310 NM_178198
Hist1h2bj
histone cluster 1, H2bj
chr2_+_44967779 0.303 NM_001177395
Gm13476
predicted gene 13476
chr5_+_27588579 0.303 Dpp6
dipeptidylpeptidase 6
chr2_+_55288297 0.289 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr5_-_24348240 0.289 Rheb
Ras homolog enriched in brain
chrM_+_11027 0.284


chr3_+_137004089 0.284 Emcn
endomucin
chr7_-_106289616 0.283 Uvrag
UV radiation resistance associated gene
chrM_+_14143 0.278


chr2_+_125860507 0.263 Fgf7
fibroblast growth factor 7
chr7_-_123182257 0.263 NM_001025559
Sox6
SRY-box containing gene 6
chr3_-_57098670 0.258 Tm4sf1
transmembrane 4 superfamily member 1
chr6_-_71390481 0.255 Rmnd5a
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr16_+_6349108 0.253 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr18_+_69753035 0.247 Tcf4
transcription factor 4
chr4_+_8617550 0.246 Chd7
chromodomain helicase DNA binding protein 7
chr16_-_85043886 0.242 App
amyloid beta (A4) precursor protein
chr18_+_37979199 0.239 NM_033583
Pcdhgb4
Pcdhgc5
protocadherin gamma subfamily B, 4
protocadherin gamma subfamily C, 5
chr8_+_46970814 0.238 NM_016798
Pdlim3
PDZ and LIM domain 3
chr5_-_122906470 0.236 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr3_-_88214215 0.236 Pmf1
polyamine-modulated factor 1
chr5_-_121459315 0.234 Rph3a
rabphilin 3A
chr12_+_87702066 0.233 NM_001159500
Esrrb
estrogen related receptor, beta
chr18_+_61265225 0.232 NM_001037859
Csf1r
colony stimulating factor 1 receptor
chr7_-_106289639 0.232 Uvrag
UV radiation resistance associated gene
chrM_-_14069 0.229 ND6
NADH dehydrogenase subunit 6
chr18_+_56591785 0.227 NM_026240
Gramd3
GRAM domain containing 3
chr18_-_38443954 0.225 NM_017378
Pcdh12
protocadherin 12
chr3_+_89586320 0.221 Ube2q1
ubiquitin-conjugating enzyme E2Q (putative) 1
chr5_-_143579060 0.215 NM_001122730
NM_178242
Tnrc18

trinucleotide repeat containing 18

chr4_+_138012860 0.214 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr8_+_96561097 0.213 NM_001093757
NM_177767
Ogfod1

2-oxoglutarate and iron-dependent oxygenase domain containing 1

chr11_+_75578548 0.211 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr11_+_102254816 0.209 Rundc3a
RUN domain containing 3A
chr15_-_77950450 0.209 Cacng2
calcium channel, voltage-dependent, gamma subunit 2
chr15_+_58770843 0.207 Ndufb9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chr15_+_8918001 0.205 NM_198024
Ranbp3l
RAN binding protein 3-like
chr17_+_69788665 0.202 NM_001145192
A330050F15Rik
RIKEN cDNA A330050F15 gene
chr7_+_3596861 0.201 NM_146176
Cnot3
CCR4-NOT transcription complex, subunit 3
chrM_+_7714 0.201 Gm10925
ATP6
predicted gene 10925
ATP synthase F0 subunit 6
chr2_-_120070817 0.191 NM_177845
Pla2g4e
phospholipase A2, group IVE
chr17_-_79281817 0.190 NM_011163
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chr5_+_13125413 0.188 LOC100503462
hypothetical LOC100503462
chr9_-_15162159 0.188 NM_176976
5830418K08Rik
RIKEN cDNA 5830418K08 gene
chr7_+_3596827 0.186 Cnot3
CCR4-NOT transcription complex, subunit 3
chr10_-_90616085 0.183 Tmpo
thymopoietin
chrM_-_13886 0.183


chr2_-_165709697 0.182 Zmynd8
zinc finger, MYND-type containing 8
chrX_+_97170927 0.182 NM_001177937
NM_001177938
NM_001177939
NM_001177940
NM_001177941
NM_001177942
NM_001177943
NM_001177944
NM_010099
Eda








ectodysplasin-A








chr4_-_132066370 0.180 NM_144907
Sesn2
sestrin 2
chr9_-_119977358 0.179 NM_009987
Cx3cr1
chemokine (C-X3-C) receptor 1
chr11_+_75578120 0.178 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr13_+_55546808 0.177 Grk6
G protein-coupled receptor kinase 6
chr14_-_118450875 0.172 NM_010024
Dct
dopachrome tautomerase
chr18_+_23573977 0.170 Dtna
dystrobrevin alpha
chr6_-_35258102 0.168 NM_172892
Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr3_+_28162135 0.162 NM_001163007
NM_001163008
NM_001163009
NM_026910
Tnik



TRAF2 and NCK interacting kinase



chr18_+_23573939 0.161 Dtna
dystrobrevin alpha
chr9_+_98325217 0.161 Rbp1
retinol binding protein 1, cellular
chr11_+_94189303 0.157 NM_027799
NM_146024
Ankrd40

ankyrin repeat domain 40

chr16_-_92400226 0.156 NM_019466
Rcan1
regulator of calcineurin 1
chr13_+_81022644 0.153 NM_001042591
Arrdc3
arrestin domain containing 3
chr5_-_122907269 0.152 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr18_+_37467108 0.152 NM_053129
Pcdhb4
protocadherin beta 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
30.41 2.21e-02 GO:0009791 post-embryonic development
14.66 2.36e-02 GO:0040007 growth

Gene overrepresentation in compartment category:

enrichment p-value GO term description
6.35 8.44e-03 GO:0044421 extracellular region part
7.01 2.06e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment p-value GO term description
19.22 1.64e-02 GO:0030247 polysaccharide binding
52.56 2.32e-02 GO:0005518 collagen binding