Motif ID: NFATC1..3.p2

Z-value: 1.090

Transcription factors associated with NFATC1..3.p2:

NameEntrezDescription
Nfatc1 18018 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Nfatc2 18019 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Nfatc3 18021 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Nfatc1chr18_-_809048520.261.3e-01Click!
Nfatc2chr2_-_1684156900.202.3e-01Click!
Nfatc3chr8_+_1085834490.029.2e-01Click!


Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr6_+_135313010 2.689 Emp1
epithelial membrane protein 1
chr1_-_171677653 2.652 NM_009062
Rgs4
regulator of G-protein signaling 4
chr9_-_10904725 2.045 NM_001033359
NM_001170787
Cntn5

contactin 5

chr6_+_135312948 1.937 NM_010128
Emp1
epithelial membrane protein 1
chr8_-_109927080 1.922 NM_008706
Nqo1
NAD(P)H dehydrogenase, quinone 1
chr17_-_24826812 1.889 Syngr3
synaptogyrin 3
chr8_+_115093942 1.849 NM_130457
Cntnap4
contactin associated protein-like 4
chr13_-_100670595 1.807 NM_001081493
NM_013732
Cartpt

CART prepropeptide

chr18_-_43552694 1.774 NM_009468
Dpysl3
dihydropyrimidinase-like 3
chr18_+_20823908 1.717 Ttr
transthyretin
chr5_+_13125413 1.674 LOC100503462
hypothetical LOC100503462
chr9_+_37175190 1.659 NM_175189
Hepacam
hepatocyte cell adhesion molecule
chr9_-_117161564 1.615 NM_001172122
NM_001172123
NM_001172124
NM_001172126
NM_178660
Rbms3




RNA binding motif, single stranded interacting protein




chr9_-_29770699 1.611 NM_172290
Ntm
neurotrimin
chr3_+_45182311 1.588 NM_001098170
NM_001098171
NM_001098172
NM_011043
Pcdh10



protocadherin 10



chr1_+_45368443 1.553 Col3a1
collagen, type III, alpha 1
chr6_+_49772688 1.531 NM_023456
Npy
neuropeptide Y
chr17_-_14831095 1.521 Thbs2
thrombospondin 2
chr1_+_174430359 1.444 NM_178598
Tagln2
transgelin 2
chr14_+_69647294 1.432 NM_009285
Stc1
stanniocalcin 1
chr8_-_105308910 1.425 NM_009866
Cdh11
cadherin 11
chr1_-_75274936 1.414 NM_009049
Resp18
regulated endocrine-specific protein 18
chrX_+_70728939 1.381 NM_007542
Bgn
biglycan
chr1_+_43787692 1.334 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr3_+_98084352 1.312 NM_008256
Hmgcs2
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
chrX_+_140098931 1.277


chr10_-_60846055 1.275 NM_013753
X99384
cDNA sequence X99384
chr19_+_22767272 1.178 Trpm3
transient receptor potential cation channel, subfamily M, member 3
chr15_-_96886327 1.177 NM_027052
Slc38a4
solute carrier family 38, member 4
chr10_-_108447996 1.154 Syt1
synaptotagmin I
chr6_-_58974400 1.119 NM_153574
Fam13a
family with sequence similarity 13, member A
chr6_-_112896894 1.091 Srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr13_-_6647924 1.049 NM_019703
Pfkp
phosphofructokinase, platelet
chr3_-_86352170 1.038 NM_011839
Mab21l2
mab-21-like 2 (C. elegans)
chr15_+_61817102 1.022 Myc
myelocytomatosis oncogene
chr16_-_31314534 1.019 NM_007470
Apod
apolipoprotein D
chr5_+_67067477 1.013 Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr15_+_3220994 1.011 Sepp1
selenoprotein P, plasma, 1
chr6_+_135313056 0.969 Emp1
epithelial membrane protein 1
chr14_+_84843366 0.960 NM_001013753
Pcdh17
protocadherin 17
chr5_-_90312358 0.934 NM_001081401
NM_177872
Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr10_+_52410306 0.930 NM_178675
Slc35f1
solute carrier family 35, member F1
chr12_+_30219982 0.908 Myt1l
myelin transcription factor 1-like
chr1_-_173126368 0.872 NM_025557
Pcp4l1
Purkinje cell protein 4-like 1
chr14_-_102007883 0.871 Tbc1d4
TBC1 domain family, member 4
chr2_+_28061156 0.870 NM_001038612
NM_019498
Olfm1

olfactomedin 1

chr2_-_73052356 0.862 Ola1
Obg-like ATPase 1
chr11_+_93905501 0.857 NM_001025428
NM_001025429
NM_001025430
Spag9


sperm associated antigen 9


chr5_-_51945054 0.823 NM_008904
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr18_-_38129384 0.819 NM_175684
Fchsd1
FCH and double SH3 domains 1
chr9_-_52484889 0.799 AI593442
expressed sequence AI593442
chr2_-_66248146 0.788


chr7_+_54102451 0.787 NM_001136069
Ldha
lactate dehydrogenase A
chr2_-_148269170 0.783 NM_010740
Cd93
CD93 antigen
chr1_-_55283618 0.765 NM_028713
Rftn2
raftlin family member 2
chrX_-_100678555 0.758 Xist
inactive X specific transcripts
chr10_-_108447674 0.755 NM_009306
Syt1
synaptotagmin I
chr18_+_37098858 0.748 NM_198117
Pcdha2
protocadherin alpha 2
chr3_-_105804304 0.746 NM_029604
1700027A23Rik
RIKEN cDNA 1700027A23 gene
chr15_-_98783909 0.744 NM_011653
Tuba1a
tubulin, alpha 1A
chr6_-_121423633 0.737 Iqsec3
IQ motif and Sec7 domain 3
chr18_+_37127284 0.735 NM_007767
Pcdha6
protocadherin alpha 6
chr11_-_78349594 0.723 NM_001159392
NM_009395
Tnfaip1

tumor necrosis factor, alpha-induced protein 1 (endothelial)

chr3_+_121670737 0.712 Arhgap29
Rho GTPase activating protein 29
chr1_-_66909822 0.711 NM_007381
Acadl
acyl-Coenzyme A dehydrogenase, long-chain
chr2_+_157385835 0.704 NM_010923
NM_180960
Nnat

neuronatin

chr15_-_91403581 0.698 Slc2a13
solute carrier family 2 (facilitated glucose transporter), member 13
chr1_+_92100572 0.697 NM_007722
Cxcr7
chemokine (C-X-C motif) receptor 7
chr14_-_122138082 0.697 NM_001128307
NM_001128308
Dock9

dedicator of cytokinesis 9

chr17_-_66868909 0.694 NM_024448
Rab12
RAB12, member RAS oncogene family
chr3_+_96404978 0.692 NM_001163170
Lix1l
Lix1-like
chr16_-_45408997 0.688 NM_010818
Cd200
2300009N04Rik
CD200 antigen
RIKEN cDNA 2300009N04 gene
chr15_-_37389073 0.688 NM_001170867
NM_001170868
Ncald

neurocalcin delta

chr14_+_79248971 0.686 NM_027906
NM_173758
1300010F03Rik

RIKEN cDNA 1300010F03 gene

chr3_+_67696141 0.685 NM_001113419
NM_177585
Iqcj-schip1
Iqcj
IQ motif containing J-schwannomin interacting protein 1 read-through transcript
IQ motif containing J
chr18_+_66618186 0.681 NM_021451
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr6_+_48487648 0.677 Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr12_+_30219769 0.676 NM_001093776
Myt1l
myelin transcription factor 1-like
chr15_+_6336747 0.673 NM_001037905
NM_001102400
NM_023118
Dab2


disabled homolog 2 (Drosophila)


chr15_+_3220766 0.669 NM_001042613
NM_001042614
NM_009155
Sepp1


selenoprotein P, plasma, 1


chr9_-_58006311 0.650 NM_001195431
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr15_+_3220999 0.645 Sepp1
selenoprotein P, plasma, 1
chr2_-_104689616 0.644 NM_178695
Prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr6_-_13789847 0.643 NM_145066
Gpr85
G protein-coupled receptor 85
chr18_-_31476721 0.628 NM_009065
Rit2
Ras-like without CAAX 2
chr3_+_106524599 0.624 NM_001039488
NM_028081
4933421E11Rik

RIKEN cDNA 4933421E11 gene

chr11_-_98590680 0.622 NM_011869
Med24
mediator complex subunit 24
chr3_-_107820766 0.622 NM_010358
Gstm1
glutathione S-transferase, mu 1
chr10_+_97028409 0.619 Lum
lumican
chrX_-_98463514 0.617 NM_013563
Il2rg
interleukin 2 receptor, gamma chain
chr11_-_106077657 0.609 NM_026009
Ccdc47
coiled-coil domain containing 47
chr5_+_67067497 0.604 Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr12_+_87702066 0.599 NM_001159500
Esrrb
estrogen related receptor, beta
chr3_-_116126853 0.591 Cdc14a
CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chr11_-_107656007 0.591 Cacng4
calcium channel, voltage-dependent, gamma subunit 4
chr18_+_37649118 0.585 NM_053143
Pcdhb18
protocadherin beta 18
chr12_+_30213224 0.581 NM_001093775
NM_001093778
NM_008666
Myt1l


myelin transcription factor 1-like


chr10_-_127188724 0.579 Gpr182
G protein-coupled receptor 182
chr14_-_20796411 0.575 NM_001038637
NM_010315
Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr11_-_106077627 0.575 Ccdc47
coiled-coil domain containing 47
chr11_-_69734709 0.569 NM_001166595
Eif5a
eukaryotic translation initiation factor 5A
chr16_-_85550617 0.567 NM_144853
Cyyr1
cysteine and tyrosine-rich protein 1
chr10_+_89207730 0.565 NM_029166
Uhrf1bp1l
UHRF1 (ICBP90) binding protein 1-like
chrX_+_21061748 0.561 NM_007429
Agtr2
angiotensin II receptor, type 2
chr16_-_28929698 0.548 NM_177718
1600021P15Rik
RIKEN cDNA 1600021P15 gene
chr10_-_101953046 0.547 NM_024435
Nts
neurotensin
chr4_+_102432943 0.544 NM_144906
Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr11_-_121065928 0.543 NM_025402
1110031I02Rik
RIKEN cDNA 1110031I02 gene
chrX_+_130842701 0.538 NM_145924
Cenpi
centromere protein I
chr13_+_20564928 0.537 NM_198093
Elmo1
engulfment and cell motility 1, ced-12 homolog (C. elegans)
chr18_+_37637421 0.523 NM_053141
Pcdhb16
protocadherin beta 16
chr7_+_127883556 0.522 Vwa3a
von Willebrand factor A domain containing 3A
chr12_+_96930429 0.521 NM_201518
Flrt2
fibronectin leucine rich transmembrane protein 2
chr9_-_97933599 0.516 Clstn2
calsyntenin 2
chr7_-_117758413 0.509 NM_177324
Sbf2
SET binding factor 2
chr10_+_7387285 0.506 NM_145706
Nup43
nucleoporin 43
chr15_+_44027680 0.504 NM_013696
Trhr
thyrotropin releasing hormone receptor
chrX_-_131285919 0.504 NM_001007578
Armcx6
armadillo repeat containing, X-linked 6
chr18_+_37885359 0.503 NM_033591
Pcdhga8
protocadherin gamma subfamily A, 8
chr9_-_31019234 0.502 Aplp2
amyloid beta (A4) precursor-like protein 2
chr4_-_43536296 0.499 Tpm2
tropomyosin 2, beta
chr3_+_135488617 0.499 NM_001135149
NM_001135150
Slc39a8

solute carrier family 39 (metal ion transporter), member 8

chr3_+_95303177 0.498 NM_007802
Ctsk
cathepsin K
chr5_-_76374399 0.493 NM_010612
Kdr
kinase insert domain protein receptor
chr3_+_8509479 0.492 NM_025285
Stmn2
stathmin-like 2
chr3_+_131748252 0.488 NM_020265
Dkk2
dickkopf homolog 2 (Xenopus laevis)
chr7_+_62090867 0.486 Luzp2
leucine zipper protein 2
chrX_-_6765768 0.484 NM_016691
Clcn5
chloride channel 5
chr11_-_100831909 0.483 NM_008986
Ptrf
polymerase I and transcript release factor
chr2_-_120365581 0.482 Zfp106
zinc finger protein 106
chrX_+_131252456 0.473 NM_001166377
NM_001166378
NM_001166379
NM_001166380
NM_030066
Armcx1




armadillo repeat containing, X-linked 1




chr2_-_25325248 0.471 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr1_-_14299936 0.465 NM_010164
Eya1
eyes absent 1 homolog (Drosophila)
chr16_-_19983049 0.464 NM_183390
Klhl6
kelch-like 6 (Drosophila)
chr3_-_33743185 0.461 NM_026222
Ccdc39
coiled-coil domain containing 39
chr3_-_81878554 0.460 NM_001161796
NM_017469
Gucy1b3

guanylate cyclase 1, soluble, beta 3

chrX_-_69901382 0.460 NM_008067
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr5_-_28793627 0.459 NM_009170
Shh
sonic hedgehog
chr3_+_13946371 0.458 NM_001163329
NM_001163330
Ralyl

RALY RNA binding protein-like

chr4_+_111392586 0.456 NM_026470
Spata6
spermatogenesis associated 6
chr19_-_5688608 0.451 Pcnxl3
pecanex-like 3 (Drosophila)
chr5_+_100947327 0.447 NM_012001
Cops4
COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
chr12_-_81213930 0.446 NM_007564
Zfp36l1
zinc finger protein 36, C3H type-like 1
chr15_-_57966551 0.445 NM_027435
Atad2
ATPase family, AAA domain containing 2
chr2_-_42508486 0.442 Lrp1b
low density lipoprotein-related protein 1B (deleted in tumors)
chr1_-_172040852 0.442 Ddr2
discoidin domain receptor family, member 2
chr19_+_34266716 0.442 NM_029682
Stambpl1
STAM binding protein like 1
chr5_+_3343861 0.441 Cdk6
cyclin-dependent kinase 6
chr3_+_135488454 0.432 NM_026228
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr6_-_35489703 0.430 Mtpn
myotrophin
chr18_-_31476626 0.430 Rit2
Ras-like without CAAX 2
chr6_+_104443037 0.429 NM_017383
Cntn6
contactin 6
chr10_+_38685309 0.427 NM_010681
Lama4
laminin, alpha 4
chr14_+_65568881 0.427 NM_153414
Ints9
integrator complex subunit 9
chr1_+_9538119 0.425 NM_175236
Adhfe1
alcohol dehydrogenase, iron containing, 1
chrX_+_131135770 0.421 NM_019868
Hnrnph2
heterogeneous nuclear ribonucleoprotein H2
chr4_+_154998982 0.420 Cdk11b
cyclin-dependent kinase 11B
chr4_+_108551674 0.419 NM_023537
Rab3b
RAB3B, member RAS oncogene family
chr4_+_97248556 0.416 NM_001122952
Nfia
D130039L10Rik
nuclear factor I/A
RIKEN cDNA D130039L10 gene
chr8_-_86118291 0.416 Tecr
trans-2,3-enoyl-CoA reductase
chr12_+_73543228 0.414 NM_001142729
Lrrc9
leucine rich repeat containing 9
chr7_-_52765714 0.414 NM_001163662
NM_008749
Nucb1

nucleobindin 1

chr2_+_97307652 0.413 NM_178725
Lrrc4c
leucine rich repeat containing 4C
chr17_+_80526993 0.411 Galm
galactose mutarotase
chr1_-_75206018 0.410 Glb1l
galactosidase, beta 1-like
chr14_-_65568677 0.410 NM_177338
Hmbox1
homeobox containing 1
chr2_+_135485242 0.407 Plcb4
phospholipase C, beta 4
chrX_+_111587911 0.405 NM_172781
Klhl4
kelch-like 4 (Drosophila)
chrX_-_161765324 0.403 Glra2
glycine receptor, alpha 2 subunit
chrX_+_82819294 0.402 NM_025729
Tab3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr15_-_79635156 0.401 Nptxr
neuronal pentraxin receptor
chr6_+_145882641 0.393 NM_010656
Sspn
sarcospan
chr2_+_174155592 0.390 NM_001077510
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr17_+_75835208 0.387 NM_001166493
Rasgrp3
RAS, guanyl releasing protein 3
chr17_-_30713158 0.386 NM_027060
NM_172618
Btbd9

BTB (POZ) domain containing 9

chr6_+_97160749 0.384 NM_022992
Arl6ip5
ADP-ribosylation factor-like 6 interacting protein 5
chr8_+_74685098 0.383 NM_023126
Rab8a
RAB8A, member RAS oncogene family
chr1_-_173164404 0.380 NM_010185
Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr3_-_116671720 0.380 Palmd
palmdelphin
chr7_+_30644997 0.380 NM_172740
Zfp420
zinc finger protein 420
chr8_-_39724524 0.379 NM_145841
Sgcz
sarcoglycan zeta
chr3_-_145312928 0.377 NM_010516
Cyr61
cysteine rich protein 61
chr10_-_61970481 0.375 NM_011157
Srgn
serglycin
chr7_-_52467196 0.375 NM_015789
Dkkl1
dickkopf-like 1
chr16_-_88290458 0.374 NM_010348
NM_146072
Grik1

glutamate receptor, ionotropic, kainate 1

chr15_+_25682945 0.373 Myo10
myosin X
chr2_-_180869947 0.373 Kcnq2
potassium voltage-gated channel, subfamily Q, member 2
chr11_-_106243873 0.369 NM_010494
Icam2
intercellular adhesion molecule 2
chr1_-_60099916 0.367 NM_027407
Ica1l
islet cell autoantigen 1-like
chr14_-_75347637 0.367 NM_001033439
Lrch1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr18_+_37170365 0.366 NM_009960
Pcdha11
protocadherin alpha 11
chr9_+_108594526 0.366 Prkar2a
protein kinase, cAMP dependent regulatory, type II alpha
chr18_+_37644674 0.366 NM_053142
Pcdhb17
protocadherin beta 17
chr4_-_118162385 0.364 NM_011587
Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr1_-_156993820 0.363 NM_008209
Mr1
major histocompatibility complex, class I-related
chr14_+_56223001 0.362 Irf9
interferon regulatory factor 9
chr6_-_36759929 0.362 Ptn
pleiotrophin
chr8_+_72315061 0.359 NM_133224
Atp13a1
ATPase type 13A1
chr19_-_58935470 0.358 NM_175199
Hspa12a
heat shock protein 12A
chr3_-_146433544 0.357 NM_001164199
Prkacb
protein kinase, cAMP dependent, catalytic, beta

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
7.73 9.70e-04 GO:0007155 cell adhesion
7.66 1.03e-03 GO:0022610 biological adhesion
141.72 1.42e-02 GO:0008343 adult feeding behavior
94.49 3.32e-02 GO:0032098 regulation of appetite

Gene overrepresentation in compartment category:

enrichment p-value GO term description
6.77 1.52e-05 GO:0044421 extracellular region part
7.34 1.22e-04 GO:0005615 extracellular space
4.32 1.61e-04 GO:0005576 extracellular region
7.18 2.32e-03 GO:0043005 neuron projection
27.45 1.03e-02 GO:0030133 transport vesicle

Gene overrepresentation in function category:

enrichment p-value GO term description
19.74 1.49e-03 GO:0005179 hormone activity
4.64 7.12e-03 GO:0005102 receptor binding
7.60 1.42e-02 GO:0030246 carbohydrate binding