Motif ID: NFE2L2.p2

Z-value: 1.069

Transcription factors associated with NFE2L2.p2:

NameEntrezDescription
Nfe2l2 18024 nuclear factor, erythroid derived 2, like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Nfe2l2chr2_-_75542535-0.616.6e-05Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr2_+_134611879 8.621 NM_001145830
NM_019677
Plcb1

phospholipase C, beta 1

chr1_-_79436564 8.403 NM_009129
Scg2
secretogranin II
chr2_+_164773719 8.246 NM_013599
Mmp9
matrix metallopeptidase 9
chr1_-_33964439 7.568 NM_177235
Bend6
BEN domain containing 6
chr2_+_156301543 6.166 NM_001006664
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr8_+_98226914 5.858 NM_001195006
NM_145602
Ndrg4

N-myc downstream regulated gene 4

chr10_-_88067758 5.783 NM_175418
Mybpc1
myosin binding protein C, slow-type
chr10_+_128370814 5.376 NM_008398
Itga7
integrin alpha 7
chr15_-_90509751 4.630 NM_001033851
NM_025815
Cpne8

copine VIII

chr5_-_136410488 4.540 NM_018871
Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr15_-_56526052 4.224 NM_008216
Has2
hyaluronan synthase 2
chr5_+_43625165 4.167 Cpeb2
cytoplasmic polyadenylation element binding protein 2
chr5_+_67067497 3.801 Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr9_-_86589782 3.777 NM_008615
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr13_-_54712629 3.757 NM_028870
Cltb
clathrin, light polypeptide (Lcb)
chr19_-_6235784 3.735 NM_198168
Ppp2r5b
protein phosphatase 2, regulatory subunit B (B56), beta isoform
chr10_+_59740430 3.625 Psap
prosaposin
chr1_+_138028025 3.589 Kif21b
kinesin family member 21B
chr7_-_30980042 3.516 NM_009795
Capns1
calpain, small subunit 1
chr18_-_31476721 3.492 NM_009065
Rit2
Ras-like without CAAX 2
chr11_-_50024275 3.380 NM_011018
Sqstm1
sequestosome 1
chr2_+_136539202 3.365 Snap25
synaptosomal-associated protein 25
chrX_+_35954355 3.321 Mcts1
malignant T cell amplified sequence 1
chr6_+_129483154 3.315 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr2_+_136539143 3.261 NM_011428
Snap25
synaptosomal-associated protein 25
chr1_-_175297778 3.144 NM_053199
Cadm3
cell adhesion molecule 3
chrX_-_35605544 3.061 Fam70a
family with sequence similarity 70, member A
chr7_-_112630662 3.058 NM_028444
Prkcdbp
protein kinase C, delta binding protein
chrX_-_163647088 3.028 NM_021278
Tmsb4x
thymosin, beta 4, X chromosome
chr7_-_133942605 2.998 NM_001177307
Aldoa
aldolase A, fructose-bisphosphate
chr11_-_41995934 2.835 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr2_+_25284190 2.693 NM_007379
Abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr18_-_31476626 2.664 Rit2
Ras-like without CAAX 2
chr11_-_30549383 2.610 NM_029344
Acyp2
acylphosphatase 2, muscle type
chr1_+_138027943 2.493 NM_001039472
Kif21b
kinesin family member 21B
chr9_-_21043375 2.491 Keap1
kelch-like ECH-associated protein 1
chr1_-_171677653 2.403 NM_009062
Rgs4
regulator of G-protein signaling 4
chr7_-_16507637 2.358 Sepw1
selenoprotein W, muscle 1
chr4_+_101180580 2.348 NM_001164584
NM_001164585
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chrX_-_100381973 2.289 NM_008671
Nap1l2
nucleosome assembly protein 1-like 2
chr3_-_9833502 2.210 NM_001195031
NM_053182
Pag1

phosphoprotein associated with glycosphingolipid microdomains 1

chr5_+_43625194 2.178 Cpeb2
cytoplasmic polyadenylation element binding protein 2
chr15_+_54402914 2.160 NM_178920
Mal2
mal, T-cell differentiation protein 2
chr6_-_124719465 2.137 NM_013509
Eno2
enolase 2, gamma neuronal
chr12_+_112997057 2.118 NM_001025360
NM_001081959
NM_008450
Klc1


kinesin light chain 1


chr1_-_175297624 2.104 Cadm3
cell adhesion molecule 3
chr11_+_67466129 2.077 Gas7
growth arrest specific 7
chr11_+_87394543 2.063 Sept4
septin 4
chr19_-_7557553 2.059 Rtn3
reticulon 3
chr8_+_128519295 2.051 Kcnk1
potassium channel, subfamily K, member 1
chr18_+_61204798 2.043 NM_001146268
NM_008809
Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr6_+_129483295 2.036 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr1_+_109486582 1.983 NM_001159748
NM_011459
Serpinb8

serine (or cysteine) peptidase inhibitor, clade B, member 8

chr3_+_146515330 1.954 NM_027594
Ttll7
tubulin tyrosine ligase-like family, member 7
chr14_-_37781899 1.948 Gcap14
granule cell antiserum positive 14
chr14_-_22668093 1.892 NM_026965
Comtd1
catechol-O-methyltransferase domain containing 1
chr19_-_7557678 1.822 Rtn3
reticulon 3
chr10_+_115580947 1.821 Ptprr
protein tyrosine phosphatase, receptor type, R
chr7_-_16507700 1.800 NM_009156
Sepw1
selenoprotein W, muscle 1
chr10_+_128346900 1.756 NM_007653
Cd63
CD63 antigen
chr2_+_163245523 1.751 2900093K20Rik
RIKEN cDNA 2900093K20 gene
chr2_-_102241053 1.748 NM_020267
Trim44
tripartite motif-containing 44
chr10_+_59740373 1.733 NM_001146120
NM_001146121
NM_001146122
NM_001146123
NM_011179
Psap




prosaposin




chr11_-_74537303 1.720 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr13_-_19711409 1.697 NM_134065
Epdr1
ependymin related protein 1 (zebrafish)
chr2_+_112102082 1.675 NM_025403
Nop10
NOP10 ribonucleoprotein homolog (yeast)
chr11_+_67466072 1.673 Gas7
growth arrest specific 7
chr7_-_116925058 1.579 NM_020610
Nrip3
nuclear receptor interacting protein 3
chr7_+_134388006 1.557 NM_177362
Zfp771
zinc finger protein 771
chr4_-_43013064 1.541


chr13_+_13876570 1.484 Gng4
guanine nucleotide binding protein (G protein), gamma 4
chr2_+_145686377 1.454 Rin2
Ras and Rab interactor 2
chrX_-_35605626 1.453 NM_172930
Fam70a
family with sequence similarity 70, member A
chr14_+_14286471 1.451 NM_001163032
Synpr
synaptoporin
chrX_-_100381703 1.426 Nap1l2
nucleosome assembly protein 1-like 2
chr15_+_81767188 1.413 NM_145473
Csdc2
cold shock domain containing C2, RNA binding
chr7_+_91677480 1.411 Gm2115
predicted gene 2115
chr6_+_90500776 1.359 NM_027406
Aldh1l1
aldehyde dehydrogenase 1 family, member L1
chr4_-_150026205 1.359 NM_173774
Slc45a1
solute carrier family 45, member 1
chrX_+_148578716 1.345 NM_001114664
Iqsec2
IQ motif and Sec7 domain 2
chr19_-_4037895 1.342 NM_013541
Gstp1
glutathione S-transferase, pi 1
chr5_-_140212063 1.336 NM_174850
Micall2
MICAL-like 2
chr17_-_57226987 1.298 NM_009451
Tubb4
tubulin, beta 4
chr12_+_113960379 1.281 NM_001024602
AW555464
expressed sequence AW555464
chr3_+_121948399 1.277 NM_008129
Gclm
glutamate-cysteine ligase, modifier subunit
chr16_-_22439642 1.219 NM_023794
Etv5
ets variant gene 5
chr2_+_151931424 1.207 Srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
chr18_+_12802276 1.201 Ttc39c
tetratricopeptide repeat domain 39C
chr5_-_139960431 1.159 NM_001159908
NM_133349
Zfand2a

zinc finger, AN1-type domain 2A

chr7_-_90883999 1.152 NM_010551
Il16
interleukin 16
chr10_-_127935725 1.124 NM_172259
Myl6b
myosin, light polypeptide 6B
chr2_+_118489015 1.112 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr8_+_128519001 1.094 NM_008430
Kcnk1
potassium channel, subfamily K, member 1
chr2_-_25080099 1.085 Tubb2c
tubulin, beta 2C
chr7_-_51926142 1.082 Myh14
myosin, heavy polypeptide 14
chr10_-_80889856 1.049 NM_008688
NM_026756
Nfic

nuclear factor I/C

chr9_+_60560923 1.039 NM_026235
Larp6
La ribonucleoprotein domain family, member 6
chr7_+_139158135 1.026 NM_173410
Gpr26
G protein-coupled receptor 26
chr8_+_125372273 1.025 NM_007662
Cdh15
cadherin 15
chr8_-_109927080 1.015 NM_008706
Nqo1
NAD(P)H dehydrogenase, quinone 1
chr10_-_127057998 1.010 Lrp1
low density lipoprotein receptor-related protein 1
chr18_+_37673305 1.002 NM_053146
Pcdhb21
protocadherin beta 21
chrX_-_149078963 0.993 Shroom2
shroom family member 2
chr14_-_37781912 0.976 Gcap14
granule cell antiserum positive 14
chr5_+_72091188 0.960 NM_008069
Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr11_+_87394609 0.948 NM_011129
Sept4
septin 4
chr11_-_115158717 0.940 NM_178035
Fads6
fatty acid desaturase domain family, member 6
chr7_+_51565563 0.925 NM_001034115
Shank1
SH3/ankyrin domain gene 1
chr12_+_72075637 0.918 Psma3
proteasome (prosome, macropain) subunit, alpha type 3
chrX_+_90920450 0.907 NM_211138
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr11_-_3814666 0.907 NM_153142
Slc35e4
solute carrier family 35, member E4
chr4_-_41516463 0.898 NM_001159583
NM_027993
2310028H24Rik

RIKEN cDNA 2310028H24 gene

chr3_-_84063605 0.895 Trim2
tripartite motif-containing 2
chr19_-_6915038 0.893 NM_019924
Rps6ka4
ribosomal protein S6 kinase, polypeptide 4
chr18_+_65048630 0.883 Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr7_+_52419289 0.860 NM_182993
Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr9_-_108962219 0.852 NM_011637
Trex1
three prime repair exonuclease 1
chr14_-_20796411 0.846 NM_001038637
NM_010315
Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr6_-_122692526 0.845 Slc2a3
solute carrier family 2 (facilitated glucose transporter), member 3
chr8_-_110112368 0.843 NM_010817
Psmd7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr2_+_179777363 0.835 Ss18l1
synovial sarcoma translocation gene on chromosome 18-like 1
chr9_-_21043503 0.832 Keap1
kelch-like ECH-associated protein 1
chr8_-_63433528 0.832 NM_173876
Clcn3
chloride channel 3
chr10_+_69169221 0.826 Ank3
ankyrin 3, epithelial
chr10_+_4424140 0.825 NM_001161822
NM_019958
Rgs17

regulator of G-protein signaling 17

chr11_-_41996099 0.822 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr4_+_101180625 0.819 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr17_+_29089357 0.819 Kctd20
potassium channel tetramerisation domain containing 20
chr19_+_29038321 0.816 NM_028922
Ppapdc2
phosphatidic acid phosphatase type 2 domain containing 2
chrX_-_72823345 0.804 NM_175122
Rab39b
RAB39B, member RAS oncogene family
chr6_-_72312366 0.801 NM_025607
Rnf181
ring finger protein 181
chr12_+_113960424 0.800 AW555464
expressed sequence AW555464
chr12_-_92828896 0.797 NM_175335
Gtf2a1
general transcription factor II A, 1
chr3_+_27081918 0.795 NM_178772
Nceh1
arylacetamide deacetylase-like 1
chr12_-_82881995 0.790 NM_001174107
NM_177395
Map3k9

mitogen-activated protein kinase kinase kinase 9

chr8_+_97056910 0.786 NM_153507
Cpne2
copine II
chr2_+_71291369 0.785 NM_025633
Metap1d
methionyl aminopeptidase type 1D (mitochondrial)
chr2_+_90730089 0.779 C1qtnf4
C1q and tumor necrosis factor related protein 4
chr6_+_66986592 0.773 E230016M11Rik
RIKEN cDNA E230016M11 gene
chr2_-_102241003 0.771 Trim44
tripartite motif-containing 44
chr5_-_69983484 0.737 NM_001038015
Gnpda2
glucosamine-6-phosphate deaminase 2
chr14_-_37781943 0.737 NM_027045
Gcap14
granule cell antiserum positive 14
chrX_+_50911075 0.737 NM_028375
Cxx1c
CAAX box 1 homolog C (human)
chr7_-_31514527 0.728 NM_027215
Tmem147
transmembrane protein 147
chr11_-_119089774 0.728 NM_172443
Tbc1d16
TBC1 domain family, member 16
chr12_-_113205172 0.711 NM_027360
2010107E04Rik
RIKEN cDNA 2010107E04 gene
chr7_+_52419317 0.710 Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr9_-_107569654 0.698 NM_023805
Slc38a3
solute carrier family 38, member 3
chr17_+_35978442 0.692 NM_001010833
Mdc1
mediator of DNA damage checkpoint 1
chr5_+_112684838 0.677 NM_023695
Crybb1
crystallin, beta B1
chr1_+_167391318 0.669 NM_027430
Brp44
brain protein 44
chr12_+_72075602 0.665 NM_011184
Psma3
proteasome (prosome, macropain) subunit, alpha type 3
chr9_+_40609317 0.661 NM_031165
Hspa8
heat shock protein 8
chr3_-_108059902 0.655 1700010K24Rik
RIKEN cDNA 1700010K24 gene
chr9_+_45646611 0.653 NM_001145947
NM_011792
Bace1

beta-site APP cleaving enzyme 1

chr15_-_31460752 0.651 NM_172606
March6
membrane-associated ring finger (C3HC4) 6
chr4_-_125998912 0.647 NM_133883
Adprhl2
ADP-ribosylhydrolase like 2
chr5_+_109058788 0.637 NM_001163531
NM_001163532
NM_028223
Tmem175


transmembrane protein 175


chr4_+_99768413 0.632 Ror1
receptor tyrosine kinase-like orphan receptor 1
chr5_+_19413335 0.629 NM_001170745
NM_015823
Magi2

membrane associated guanylate kinase, WW and PDZ domain containing 2

chr13_-_12553652 0.624 Lgals8
lectin, galactose binding, soluble 8
chr18_+_61204953 0.609 Pdgfrb
platelet derived growth factor receptor, beta polypeptide
chr19_-_5661634 0.608 Sipa1
signal-induced proliferation associated gene 1
chr17_-_32487506 0.606 NM_017476
Akap8l
A kinase (PRKA) anchor protein 8-like
chr8_-_87296172 0.593 Nfix
nuclear factor I/X
chr6_+_38868942 0.592 NM_011539
Tbxas1
thromboxane A synthase 1, platelet
chr12_+_35731888 0.586 Snx13
sorting nexin 13
chr2_-_102741483 0.576 Cd44
CD44 antigen
chr18_+_34407238 0.569 Apc
adenomatosis polyposis coli
chr10_-_61573705 0.564 NM_027251
2010107G23Rik
RIKEN cDNA 2010107G23 gene
chr2_+_25251393 0.563 NM_009849
Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr7_-_35015309 0.562 NM_008155
Gpi1
glucose phosphate isomerase 1
chr17_-_45729199 0.561 NM_022880
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr7_-_29965655 0.557 NM_026545
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr3_+_124023954 0.552 NM_146140
Tram1l1
translocation associated membrane protein 1-like 1
chr13_+_40982534 0.549 NM_008105
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr1_+_72354084 0.541 Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr5_+_109058850 0.540 Tmem175
transmembrane protein 175
chr14_-_37948251 0.537 NM_078478
Ghitm
growth hormone inducible transmembrane protein
chr4_+_99768482 0.537 Ror1
receptor tyrosine kinase-like orphan receptor 1
chr10_-_70807521 0.535 NM_134007
Cisd1
CDGSH iron sulfur domain 1
chr6_+_90412566 0.534 NM_023184
Klf15
Kruppel-like factor 15
chrX_+_136145155 0.524 NM_023270
Rnf128
ring finger protein 128
chr18_-_31476527 0.523 Rit2
Ras-like without CAAX 2
chr11_+_72774670 0.521 NM_001163336
NM_001163337
NM_016745
Atp2a3


ATPase, Ca++ transporting, ubiquitous


chr6_-_146450669 0.515 Itpr2
inositol 1,4,5-triphosphate receptor 2
chr6_-_126594757 0.508 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr4_-_132768403 0.507 NM_008154
Gpr3
G-protein coupled receptor 3
chr13_+_75977323 0.507 NM_053108
Glrx
glutaredoxin
chr16_+_18812381 0.506 NM_011672
Ufd1l
ubiquitin fusion degradation 1 like
chr13_-_61037894 0.499 NM_001145799
Ctla2a
cytotoxic T lymphocyte-associated protein 2 alpha
chr3_-_89716963 0.498 NM_010559
Il6ra
interleukin 6 receptor, alpha
chr3_+_108060061 0.497 Psma5
proteasome (prosome, macropain) subunit, alpha type 5
chr2_-_29980091 0.490 Zer1
zer-1 homolog (C. elegans)
chr12_+_73637330 0.487 NM_026327
1810048J11Rik
RIKEN cDNA 1810048J11 gene
chr15_+_54577256 0.486 NM_010930
Nov
nephroblastoma overexpressed gene
chr18_+_40416615 0.482 2900055J20Rik
RIKEN cDNA 2900055J20 gene
chr11_-_5661971 0.472 Urgcp
upregulator of cell proliferation
chr13_-_100286521 0.466 NM_008634
Mtap1b
microtubule-associated protein 1B
chr9_-_64101138 0.464 Map2k1
mitogen-activated protein kinase kinase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
16.38 7.72e-04 GO:0007018 microtubule-based movement
57.97 7.33e-03 GO:0008088 axon cargo transport

Gene overrepresentation in compartment category:

enrichment p-value GO term description
3.17 5.05e-04 GO:0005856 cytoskeleton
1.40 5.33e-03 GO:0005622 intracellular
1.54 6.73e-03 GO:0005737 cytoplasm
1.97 8.95e-03 GO:0071944 cell periphery
3.39 9.89e-03 GO:0044430 cytoskeletal part
6.16 1.36e-02 GO:0005874 microtubule
1.36 3.44e-02 GO:0044424 intracellular part
1.88 3.93e-02 GO:0005886 plasma membrane
2.88 4.98e-02 GO:0042995 cell projection

Nothing significant found in function category.