Motif ID: NKX2-1,4.p2

Z-value: 0.625

Transcription factors associated with NKX2-1,4.p2:

NameEntrezDescription
Nkx2-1 21869 NK2 homeobox 1
Nkx2-4 228731 NK2 transcription factor related, locus 4 (Drosophila)



Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Description
chr2_-_157392026 2.361 NM_016916
Blcap
bladder cancer associated protein homolog (human)
chr6_+_7505070 1.940 NM_009311
Tac1
tachykinin 1
chr1_-_42749940 1.870 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr10_-_108448003 1.604 Syt1
synaptotagmin I
chr10_-_108447996 1.601 Syt1
synaptotagmin I
chr2_+_61642509 1.566 NM_009322
Tbr1
T-box brain gene 1
chr15_+_98885599 1.545 NM_001163588
NM_001163589
NM_013639
Prph


peripherin


chr18_+_37133455 1.529 NM_009957
Pcdha7
protocadherin alpha 7
chr6_+_96063137 1.302 NM_182808
Fam19a1
family with sequence similarity 19, member A1
chr3_+_125106995 1.168 NM_022565
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr13_+_54472705 1.102 NM_009946
Cplx2
complexin 2
chrM_+_3913 1.099


chr14_+_14286471 1.001 NM_001163032
Synpr
synaptoporin
chr4_+_13670425 0.973 NM_001111026
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr15_+_21041206 0.894 NM_001008420
Cdh12
cadherin 12
chr2_+_139996381 0.877 NM_027093
2310003L22Rik
RIKEN cDNA 2310003L22 gene
chr19_-_5797068 0.771


chr13_+_40982534 0.669 NM_008105
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chrX_+_98494487 0.651 NM_172932
Nlgn3
neuroligin 3
chrM_+_12178 0.619


chr9_-_71743854 0.595 Tcf12
transcription factor 12
chr1_-_135817867 0.582


chr3_+_89324085 0.580 NM_080466
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr10_-_108447894 0.532 Syt1
synaptotagmin I
chrX_+_35954355 0.523 Mcts1
malignant T cell amplified sequence 1
chrX_-_140367467 0.490 NM_001110222
NM_001110223
NM_001110224
NM_010025
Dcx



doublecortin



chr8_+_56040193 0.489 Gpm6a
glycoprotein m6a
chr1_+_174051888 0.484


chr2_-_38499436 0.481 Psmb7
proteasome (prosome, macropain) subunit, beta type 7
chr1_-_135817945 0.441 NM_054077
Prelp
proline arginine-rich end leucine-rich repeat
chr1_+_122498985 0.432 En1
engrailed 1
chr6_-_91757386 0.416 NM_001159507
Grip2
glutamate receptor interacting protein 2
chr2_-_34610751 0.412 NM_025709
Gapvd1
GTPase activating protein and VPS9 domains 1
chr9_+_122481617 0.410 9530059O14Rik
RIKEN cDNA 9530059O14 gene
chr7_-_91827857 0.403 NM_022985
Zfand6
zinc finger, AN1-type domain 6
chr2_-_38499375 0.385 NM_011187
Psmb7
proteasome (prosome, macropain) subunit, beta type 7
chr17_-_90436488 0.383 Nrxn1
neurexin I
chr9_-_122220036 0.368


chrX_-_100381973 0.365 NM_008671
Nap1l2
nucleosome assembly protein 1-like 2
chr3_+_116564564 0.342 NM_009146
Frrs1
ferric-chelate reductase 1
chr16_-_23520662 0.326 NM_008555
Masp1
mannan-binding lectin serine peptidase 1
chr1_-_181682859 0.325 Ahctf1
AT hook containing transcription factor 1
chr18_+_37112301 0.323 NM_001174154
NM_007766
Pcdha4-g
Pcdha4
protocadherin alpha 4-gamma
protocadherin alpha 4
chr4_+_13678443 0.289 NM_001111027
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_-_7709907 0.275 NM_026137
Wdr13
WD repeat domain 13
chr7_-_29551532 0.273 NM_010908
Nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr6_-_136121885 0.266 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr10_-_33344405 0.261 NM_175448
Clvs2
clavesin 2
chr2_+_119851954 0.260 Mapkbp1
mitogen-activated protein kinase binding protein 1
chr8_+_56040211 0.253 Gpm6a
glycoprotein m6a
chrM_+_11812 0.250


chrM_+_12383 0.239


chr2_-_77541328 0.217 NM_001113399
Zfp385b
zinc finger protein 385B
chr11_+_67090625 0.216 NM_177369
Myh8
myosin, heavy polypeptide 8, skeletal muscle, perinatal
chr9_+_96159666 0.208 NM_001184710
NM_001184711
Tfdp2

transcription factor Dp 2

chr17_+_88382830 0.206 Msh6
mutS homolog 6 (E. coli)
chr2_+_169459145 0.198 NM_080455
Tshz2
teashirt zinc finger family member 2
chr3_-_107734481 0.191 NM_026672
Gstm7
glutathione S-transferase, mu 7
chr2_+_139996419 0.188 2310003L22Rik
RIKEN cDNA 2310003L22 gene
chr7_+_148654681 0.183 NM_001111050
Cd151
CD151 antigen
chr7_-_148040227 0.181 Bet1l
blocked early in transport 1 homolog (S. cerevisiae)-like
chr16_+_49906392 0.181


chr7_-_125263314 0.171 Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chr4_-_136891931 0.162 Cdc42
cell division cycle 42 homolog (S. cerevisiae)
chr9_-_58050340 0.161 NM_001161538
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr8_-_47292863 0.161


chr7_+_26086377 0.160 NM_001081294
Prr19
proline rich 19
chr8_+_119983664 0.159


chr4_-_58083082 0.155 Svep1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr7_+_3336653 0.149 NM_133189
Cacng7
calcium channel, voltage-dependent, gamma subunit 7
chr16_-_38445988 0.146 Adprh
ADP-ribosylarginine hydrolase
chr5_+_22988226 0.143


chr12_+_17285392 0.141 Pdia6
protein disulfide isomerase associated 6
chr9_-_21035212 0.139 Keap1
kelch-like ECH-associated protein 1
chr11_-_101139357 0.136


chr11_+_117864696 0.135 Pgs1
phosphatidylglycerophosphate synthase 1
chr1_-_177422520 0.131 Rgs7
regulator of G protein signaling 7
chr16_+_49913305 0.128 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr2_-_120365581 0.128 Zfp106
zinc finger protein 106
chr3_-_129035406 0.126 NM_007934
Enpep
glutamyl aminopeptidase
chr16_+_23520391 0.125


chr10_-_75227029 0.119 NM_172549
Cabin1
calcineurin binding protein 1
chr18_+_78021267 0.113


chr7_+_28018002 0.106 NM_133770
Adck4
aarF domain containing kinase 4
chr2_+_79547936 0.106 NM_172420
Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr17_+_37210011 0.104 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr5_+_147762106 0.102 Gtf3a
general transcription factor III A
chr2_+_91512033 0.095 Atg13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr8_-_87369780 0.093


chr2_+_38441497 0.093 Nek6
NIMA (never in mitosis gene a)-related expressed kinase 6
chr3_+_95465860 0.093 Mcl1
myeloid cell leukemia sequence 1
chr9_+_57369044 0.093 Cox5a
cytochrome c oxidase, subunit Va
chr16_-_88648032 0.092 NM_027105
Krtap26-1
keratin associated protein 26-1
chr1_+_98920975 0.091


chr9_+_38185467 0.091 NM_146874
NM_207553
Olfr900
Olfr251
olfactory receptor 900
olfactory receptor 251
chr9_+_72596925 0.091 Nedd4
neural precursor cell expressed, developmentally down-regulated 4
chr4_+_154927385 0.090 Gnb1
guanine nucleotide binding protein (G protein), beta 1
chr9_-_119835967 0.088 Gorasp1
golgi reassembly stacking protein 1
chr1_-_184246785 0.088 Fbxo28
F-box protein 28
chr13_+_55827167 0.087 Txndc15
thioredoxin domain containing 15
chr18_+_34475207 0.087 Apc
adenomatosis polyposis coli
chr2_-_91516101 0.083 Atg13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chrX_-_108810630 0.082 NM_001080549
Hdx
highly divergent homeobox
chr16_-_87486487 0.082 Cct8
chaperonin containing Tcp1, subunit 8 (theta)
chr10_+_80645192 0.081


chr3_-_108365049 0.080 Tmem167b
transmembrane protein 167B
chr1_-_157626552 0.075 Qsox1
quiescin Q6 sulfhydryl oxidase 1
chr4_-_120597563 0.075 NM_001160043
NM_028457
Dem1

defects in morphology 1 homolog (S. cerevisiae)

chr4_+_154932761 0.074 Gnb1
guanine nucleotide binding protein (G protein), beta 1
chrX_-_137491205 0.073 NM_001164177
NM_016883
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr5_-_138362822 0.070 NM_007819
Cyp3a13
cytochrome P450, family 3, subfamily a, polypeptide 13
chr17_+_49754460 0.068 NM_177052
Kif6
kinesin family member 6
chr9_+_123428782 0.068 Limd1
LIM domains containing 1
chr1_+_174048400 0.067 Copa
coatomer protein complex subunit alpha
chr13_+_100897826 0.067 Smn1
survival motor neuron 1
chr4_+_123613778 0.066 Rragc
Ras-related GTP binding C
chr5_-_33996918 0.066 Tmem129
transmembrane protein 129
chr3_-_58984006 0.063 NM_032399
Gpr87
G protein-coupled receptor 87
chr9_-_110018085 0.063 NM_133347
Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr11_+_98630271 0.063 Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr1_-_36864987 0.062 Tmem131
transmembrane protein 131
chr10_+_74980744 0.062 NM_026095
Snrpd3
small nuclear ribonucleoprotein D3
chr9_+_123429291 0.061 Limd1
LIM domains containing 1
chr7_-_112706892 0.060


chr17_+_64245366 0.060 NM_001037997
Fert2
fer (fms/fps related) protein kinase, testis specific 2
chr7_+_19791687 0.059 Eml2
echinoderm microtubule associated protein like 2
chr17_+_31432427 0.058 NM_153062
Slc37a1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr11_+_75578120 0.057 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr1_+_75165201 0.057 NM_001159905
NM_001159906
NM_026846
Zfand2b


zinc finger, AN1 type domain 2B


chr2_+_26203297 0.056 Gpsm1
G-protein signalling modulator 1 (AGS3-like, C. elegans)
chr7_-_108971734 0.056


chr12_+_111879117 0.055 Dync1h1
dynein cytoplasmic 1 heavy chain 1
chr17_+_71596413 0.054 Lpin2
lipin 2
chr6_-_38074549 0.053 NM_080467
Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr7_+_135273060 0.052 NM_021334
Itgax
integrin alpha X
chr17_+_35263978 0.051 NM_033477
D17H6S53E
DNA segment, Chr 17, human D6S53E
chr2_+_162760505 0.050


chr3_-_103545641 0.049 Hipk1
homeodomain interacting protein kinase 1
chr15_-_102062331 0.048 NM_013566
Itgb7
integrin beta 7
chr7_-_107475377 0.048


chr9_+_114624257 0.048 Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr4_-_142718290 0.047 Prdm2
PR domain containing 2, with ZNF domain
chr10_-_24647173 0.046 Arg1
arginase, liver
chr7_-_87245668 0.046 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr8_+_131237118 0.045 Itgb1
integrin beta 1 (fibronectin receptor beta)
chr12_+_17285655 0.045 Pdia6
protein disulfide isomerase associated 6
chr7_+_54110791 0.044


chr16_+_48816968 0.043 NM_023881
Retnlb
resistin like beta
chr10_+_80644982 0.042


chr17_-_74242984 0.040 Xdh
xanthine dehydrogenase
chr8_+_113381876 0.040 Cog4
component of oligomeric golgi complex 4
chr3_-_108365251 0.039 Tmem167b
transmembrane protein 167B
chr3_-_108707417 0.038 Prpf38b
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr18_-_60760086 0.037 Synpo
synaptopodin
chr11_-_119971500 0.036 Slc38a10
solute carrier family 38, member 10
chr2_-_85036855 0.036 NM_001033346
Lrrc55
leucine rich repeat containing 55
chr4_+_115761660 0.036 Lrrc41
leucine rich repeat containing 41
chr3_+_95091630 0.035 Fam63a
family with sequence similarity 63, member A
chr6_-_126485370 0.035 NM_145983
Kcna5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr18_+_25224729 0.034 Fhod3
formin homology 2 domain containing 3
chr1_-_75132977 0.034 1810031K17Rik
RIKEN cDNA 1810031K17 gene
chr1_-_136700389 0.033 Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr1_-_188573165 0.033 NM_026041
Rrp15
ribosomal RNA processing 15 homolog (S. cerevisiae)
chr16_+_17331463 0.033 NM_008223
Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr5_-_134718500 0.033 Gtf2i
general transcription factor II I
chr17_+_87762817 0.033 Ttc7
tetratricopeptide repeat domain 7
chr7_-_52870858 0.032 NM_020013
Fgf21
fibroblast growth factor 21
chr18_-_61874531 0.032 Grpel2
GrpE-like 2, mitochondrial
chr17_+_24641034 0.032 Caskin1
CASK interacting protein 1
chr11_-_68825972 0.032


chr6_+_123179860 0.030 NM_001190320
NM_001190321
NM_020001
Clec4n


C-type lectin domain family 4, member n


chr9_+_108849434 0.029 Uqcrc1
ubiquinol-cytochrome c reductase core protein 1
chr2_+_14978339 0.029


chr18_+_32416881 0.028 Ercc3
excision repair cross-complementing rodent repair deficiency, complementation group 3
chr9_-_7932402 0.028 Yap1
yes-associated protein 1
chr12_-_110098804 0.028 Wars
tryptophanyl-tRNA synthetase
chr4_+_95246111 0.028 NM_029347
Fggy
FGGY carbohydrate kinase domain containing
chr2_-_167469448 0.028 Tmem189
transmembrane protein 189
chr6_+_115189004 0.027 Syn2
synapsin II
chr7_+_54110679 0.027


chr15_+_66723067 0.026 Wisp1
WNT1 inducible signaling pathway protein 1
chr10_+_80642090 0.026 Eef2
eukaryotic translation elongation factor 2
chr14_-_51550327 0.026 NM_001033271
Tmem55b
transmembrane protein 55b
chr8_-_95603838 0.026 NM_001081372
Ces1b
carboxylesterase 1B
chr2_+_4897196 0.025 Ucma
upper zone of growth plate and cartilage matrix associated
chr6_+_29325052 0.025 Calu
calumenin
chr2_-_32279522 0.025 Slc25a25
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr1_-_175696989 0.023 NM_008329
Ifi204
interferon activated gene 204
chr8_+_74676812 0.023


chr4_+_155246871 0.022 Cpsf3l
cleavage and polyadenylation specific factor 3-like
chr7_+_51031646 0.022 NM_019974
Klk11
kallikrein related-peptidase 11
chr17_+_29839370 0.021


chr6_+_135313056 0.021 Emp1
epithelial membrane protein 1
chr11_-_94900779 0.021 Pdk2
pyruvate dehydrogenase kinase, isoenzyme 2
chr3_+_95965959 0.020 Mtmr11
myotubularin related protein 11
chr9_-_71326295 0.020


chr13_-_41923709 0.020 9530008L14Rik
RIKEN cDNA 9530008L14 gene
chr16_+_17331507 0.020 Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr8_+_108703203 0.019


chr17_-_23981121 0.019 NM_027644
Prss41
protease, serine, 41

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
147.93 2.79e-03 GO:0016079 synaptic vesicle exocytosis
15.73 2.55e-02 GO:0035637 multicellular organismal signaling
44.83 3.10e-02 GO:0001505 regulation of neurotransmitter levels
12.87 4.58e-02 GO:0007267 cell-cell signaling

Gene overrepresentation in compartment category:

enrichment p-value GO term description
117.34 5.11e-03 GO:0030672 synaptic vesicle membrane
12.34 7.38e-03 GO:0043005 neuron projection
63.06 1.79e-02 GO:0030665 clathrin coated vesicle membrane
15.92 2.81e-02 GO:0043025 neuronal cell body
48.66 3.00e-02 GO:0030662 coated vesicle membrane
15.17 3.24e-02 GO:0044297 cell body

Nothing significant found in function category.