Motif ID: NKX2-2,8.p2

Z-value: 0.861

Transcription factors associated with NKX2-2,8.p2:

NameEntrezDescription
Nkx2-2 18088 NK2 transcription factor related, locus 2 (Drosophila)
Nkx2-9 18094 NK2 transcription factor related, locus 9 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Nkx2-2chr2_-_1470119900.144.1e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chrM_+_3913 4.550


chr19_-_5797749 3.641 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chrM_+_3844 3.420


chr12_+_110798661 3.379 Meg3
maternally expressed 3
chr19_+_4711220 2.288 NM_021287
Spnb3
spectrin beta 3
chr16_+_94664089 2.264 Ttc3
tetratricopeptide repeat domain 3
chr6_-_55631085 2.233 Neurod6
neurogenic differentiation 6
chrM_+_409 2.034


chr18_+_69843730 1.883 Tcf4
transcription factor 4
chr17_-_35971913 1.836 Tubb5
tubulin, beta 5
chrM_+_2750 1.814


chr14_+_122879276 1.750 Zic2
zinc finger protein of the cerebellum 2
chr6_+_103461323 1.702 Chl1
cell adhesion molecule with homology to L1CAM
chrM_+_1550 1.676


chrX_-_98615096 1.650 NM_001177985
NM_001177986
Zmym3

zinc finger, MYM-type 3

chr6_+_103460955 1.589 Chl1
cell adhesion molecule with homology to L1CAM
chr9_+_72859850 1.438 Ccpg1
cell cycle progression 1
chr2_+_174171943 1.425


chrX_-_161765324 1.346 Glra2
glycine receptor, alpha 2 subunit
chr18_+_69753146 1.307 Tcf4
transcription factor 4
chr6_-_60778740 1.274 NM_001042451
Snca
synuclein, alpha
chr19_+_45122281 1.267 Sfxn3
sideroflexin 3
chr2_+_163843744 1.179


chr17_+_43705510 1.115 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr2_+_174171525 1.107 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr1_-_37592976 1.078 NM_173870
Mgat4a
mannoside acetylglucosaminyltransferase 4, isoenzyme A
chr5_-_104508289 1.039 Sparcl1
SPARC-like 1
chr19_-_5797068 1.015


chr10_-_89083993 0.997 NM_182959
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr9_-_60497537 0.982 Lrrc49
leucine rich repeat containing 49
chr8_-_87369780 0.956


chr2_-_42508486 0.943 Lrp1b
low density lipoprotein-related protein 1B (deleted in tumors)
chr12_+_30219982 0.933 Myt1l
myelin transcription factor 1-like
chr16_+_57152994 0.928 Tomm70a
translocase of outer mitochondrial membrane 70 homolog A (yeast)
chr5_-_104542751 0.926 Sparcl1
SPARC-like 1
chr8_+_97197870 0.912 Arl2bp
ADP-ribosylation factor-like 2 binding protein
chr6_-_55631039 0.903 Neurod6
neurogenic differentiation 6
chr18_+_63112372 0.898 Apcdd1
adenomatosis polyposis coli down-regulated 1
chr5_-_104542598 0.891 Sparcl1
SPARC-like 1
chr15_+_58247107 0.882 D15Ertd621e
DNA segment, Chr 15, ERATO Doi 621, expressed
chr1_-_79436564 0.863 NM_009129
Scg2
secretogranin II
chr7_+_107789414 0.848 Rab6
RAB6, member RAS oncogene family
chr18_+_37112301 0.847 NM_001174154
NM_007766
Pcdha4-g
Pcdha4
protocadherin alpha 4-gamma
protocadherin alpha 4
chr5_-_104542641 0.838 Sparcl1
SPARC-like 1
chr9_-_21820860 0.836 Elavl3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr5_-_104542729 0.810 Sparcl1
SPARC-like 1
chr4_-_77857753 0.789 Ptprd
protein tyrosine phosphatase, receptor type, D
chr2_+_69708777 0.777 Ssb
Sjogren syndrome antigen B
chr15_-_56526052 0.773 NM_008216
Has2
hyaluronan synthase 2
chr8_-_87297283 0.769 Nfix
nuclear factor I/X
chr9_+_113721698 0.759 NM_001081960
NM_029633
Clasp2

CLIP associating protein 2

chr12_-_84828657 0.749 NM_058212
Dpf3
D4, zinc and double PHD fingers, family 3
chr2_+_61642509 0.745 NM_009322
Tbr1
T-box brain gene 1
chr3_-_146433544 0.723 NM_001164199
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr6_+_103460834 0.720 NM_007697
Chl1
cell adhesion molecule with homology to L1CAM
chr8_+_56122680 0.720 Gpm6a
glycoprotein m6a
chr6_-_51416921 0.713 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr12_+_77182878 0.701 Syne2
synaptic nuclear envelope 2
chr18_+_69753035 0.690 Tcf4
transcription factor 4
chr7_-_29678773 0.683 Actn4
actinin alpha 4
chr1_-_36756687 0.678 Actr1b
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chrM_+_6139 0.661


chr18_+_37133455 0.644 NM_009957
Pcdha7
protocadherin alpha 7
chr7_+_101191200 0.580


chr1_-_72905107 0.566 Igfbp5
insulin-like growth factor binding protein 5
chr14_-_73764361 0.564 Itm2b
integral membrane protein 2B
chr1_-_65169708 0.563 NM_175293
D630023F18Rik
RIKEN cDNA D630023F18 gene
chr8_-_34858230 0.557 2700090O03Rik
RIKEN cDNA 2700090O03 gene
chr11_+_87862035 0.556 Srsf1
serine/arginine-rich splicing factor 1
chr4_+_154932115 0.552


chr10_-_80363606 0.547 NM_013895
Timm13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr17_+_80706746 0.545 NM_001145452
Arhgef33
Rho guanine nucleotide exchange factor (GEF) 33
chr3_+_95463691 0.543 Mcl1
myeloid cell leukemia sequence 1
chr6_+_14851348 0.537 NM_053242
Foxp2
forkhead box P2
chr5_-_92872646 0.536 Scarb2
scavenger receptor class B, member 2
chr2_+_174170886 0.531 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chrX_+_102315680 0.524 NM_053201
Magee1
melanoma antigen, family E, 1
chr2_-_37502738 0.524 NM_009261
Strbp
spermatid perinuclear RNA binding protein
chr4_+_138012860 0.522 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr10_+_69487700 0.522 Ank3
ankyrin 3, epithelial
chr17_-_35971652 0.517 Tubb5
tubulin, beta 5
chr18_-_77870871 0.517 2310007O11Rik
RIKEN cDNA 2310007O11 gene
chr1_-_88253690 0.515 Ncl
nucleolin
chrM_+_15355 0.504


chr6_+_33922645 0.504


chr16_-_84955488 0.503 App
amyloid beta (A4) precursor protein
chr10_+_42550365 0.490 Sec63
SEC63-like (S. cerevisiae)
chr7_+_26682646 0.488 Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
chr7_+_26682681 0.485 NM_009999
Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
chr4_-_137869546 0.484 Pink1
PTEN induced putative kinase 1
chr2_+_59322709 0.484 NM_029723
Dapl1
death associated protein-like 1
chr19_+_22522646 0.484 NM_177341
Trpm3
transient receptor potential cation channel, subfamily M, member 3
chr5_+_125935187 0.479


chr12_+_86474651 0.461 Dlst
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr15_-_79656745 0.459 Cbx6
chromobox homolog 6
chr7_-_140179678 0.450 Ctbp2
C-terminal binding protein 2
chr14_-_65035722 0.447 Msra
methionine sulfoxide reductase A
chr14_-_65716932 0.446 NM_018788
Extl3
exostoses (multiple)-like 3
chr3_-_127111968 0.446 Ank2
ankyrin 2, brain
chr16_+_55973916 0.443 NM_173026
Zbtb11
zinc finger and BTB domain containing 11
chr3_+_75878452 0.438 NM_178673
Fstl5
follistatin-like 5
chr14_-_94287950 0.437 NM_001081377
Pcdh9
protocadherin 9
chr7_-_117509277 0.419 Sbf2
SET binding factor 2
chrX_-_161764912 0.417 NM_183427
Glra2
glycine receptor, alpha 2 subunit
chr11_+_75570317 0.414 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr18_+_37663917 0.411 NM_053145
Pcdhb20
protocadherin beta 20
chr2_+_173901808 0.410 Stx16
syntaxin 16
chr10_+_80102813 0.404 Csnk1g2
casein kinase 1, gamma 2
chr6_-_38075416 0.402 D630045J12Rik
RIKEN cDNA D630045J12 gene
chr17_-_85461840 0.397 Prepl
prolyl endopeptidase-like
chr9_+_3335139 0.392 NM_026303
Alkbh8
alkB, alkylation repair homolog 8 (E. coli)
chr15_+_75534706 0.381 NM_001163465
NM_008164
Rhpn1

rhophilin, Rho GTPase binding protein 1

chr18_-_15562126 0.381 NM_009700
Aqp4
aquaporin 4
chr6_+_104443037 0.380 NM_017383
Cntn6
contactin 6
chr2_+_163843294 0.376 Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr5_+_108796754 0.375 Gm10419
predicted gene 10419
chr18_+_34480612 0.375 Apc
adenomatosis polyposis coli
chrX_+_34142137 0.372


chr14_-_73768214 0.371 Itm2b
integral membrane protein 2B
chr5_-_135096236 0.371 Eif4h
eukaryotic translation initiation factor 4H
chr5_+_117827904 0.370 Wsb2
WD repeat and SOCS box-containing 2
chr3_-_127111869 0.368 Ank2
ankyrin 2, brain
chr1_+_154802144 0.361 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr9_+_123428782 0.359 Limd1
LIM domains containing 1
chr10_+_127927057 0.354


chr2_-_73498303 0.353 NM_001166604
NM_175752
Chn1

chimerin (chimaerin) 1

chr5_+_114185777 0.351 NM_001010825
Ficd
FIC domain containing
chr3_+_95465860 0.348 Mcl1
myeloid cell leukemia sequence 1
chr7_-_35005681 0.342 Gpi1
glucose phosphate isomerase 1
chr9_+_40590943 0.339 9030425E11Rik
RIKEN cDNA 9030425E11 gene
chr2_+_136581861 0.339 Snap25
synaptosomal-associated protein 25
chr4_+_154932761 0.336 Gnb1
guanine nucleotide binding protein (G protein), beta 1
chr2_-_27309917 0.331 Brd3
bromodomain containing 3
chr9_+_120058842 0.330 NM_001039364
NM_001039365
NM_008614
Mobp


myelin-associated oligodendrocytic basic protein


chr4_+_101927543 0.329 NM_019840
Pde4b
phosphodiesterase 4B, cAMP specific
chr13_-_38694739 0.322


chr9_-_71326295 0.322


chr9_+_19426674 0.316 Zfp317
zinc finger protein 317
chr10_-_80363493 0.316 Timm13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr8_+_56040211 0.311 Gpm6a
glycoprotein m6a
chr5_-_135096716 0.309 Eif4h
eukaryotic translation initiation factor 4H
chr16_-_85103501 0.307 App
amyloid beta (A4) precursor protein
chr10_-_6806261 0.306 NM_027391
Iyd
iodotyrosine deiodinase
chr12_+_53800302 0.303 Akap6
A kinase (PRKA) anchor protein 6
chr13_+_110693266 0.300


chr9_+_123429291 0.300 Limd1
LIM domains containing 1
chrX_+_151696991 0.299 NM_019736
Acot9
acyl-CoA thioesterase 9
chr8_+_56040193 0.298 Gpm6a
glycoprotein m6a
chr14_-_104243541 0.298 Ednrb
endothelin receptor type B
chr7_-_148615247 0.295 NM_021316
Cend1
cell cycle exit and neuronal differentiation 1
chr19_-_28838026 0.292 NM_001177391
Gm6788
predicted gene 6788
chr2_-_7002287 0.292 Celf2
CUGBP, Elav-like family member 2
chr7_+_63185457 0.286 Cyfip1
cytoplasmic FMR1 interacting protein 1
chr12_-_93087514 0.285 NM_001039089
NM_011344
Sel1l

sel-1 suppressor of lin-12-like (C. elegans)

chr7_-_52494097 0.277 NM_007645
Cd37
CD37 antigen
chr3_+_85888818 0.273 Sh3d19
SH3 domain protein D19
chr17_-_66234198 0.270 NM_001198949
Ralbp1
ralA binding protein 1
chr5_+_114185982 0.268 Ficd
FIC domain containing
chr12_+_70342818 0.267 NM_178253
Klhdc1
kelch domain containing 1
chr6_-_128384424 0.264 Fkbp4
FK506 binding protein 4
chr3_+_52072302 0.263 Foxo1
forkhead box O1
chr5_-_145952452 0.262 NM_020582
Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr13_-_58228079 0.261 Hnrnpa0
heterogeneous nuclear ribonucleoprotein A0
chr5_-_147396407 0.260 Gpr12
G-protein coupled receptor 12
chr11_-_43649708 0.259 NM_007416
Adra1b
adrenergic receptor, alpha 1b
chr13_+_21570775 0.254 NM_001039115
Zkscan4
zinc finger with KRAB and SCAN domains 4
chr1_-_157264398 0.254 NM_011273
Xpr1
xenotropic and polytropic retrovirus receptor 1
chr2_-_77784222 0.253 NM_030560
Cwc22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr9_-_65402264 0.252


chr3_+_68673489 0.250 NM_001167996
1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr18_+_78016286 0.249 Atp5a1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1
chr13_+_43497279 0.248 Nol7
nucleolar protein 7
chr8_-_88063071 0.246


chr2_-_7002344 0.239 NM_001110229
NM_001110230
NM_001160292
Celf2


CUGBP, Elav-like family member 2


chr4_-_58083082 0.237 Svep1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr18_+_37170365 0.237 NM_009960
Pcdha11
protocadherin alpha 11
chr13_-_41923709 0.237 9530008L14Rik
RIKEN cDNA 9530008L14 gene
chr11_-_6333725 0.236 H2afv
H2A histone family, member V
chr2_+_162762650 0.233


chr2_+_34627836 0.233 Hspa5
heat shock protein 5
chr3_-_108707417 0.232 Prpf38b
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr7_+_97535490 0.232 NM_001040087
NM_001040088
Sytl2

synaptotagmin-like 2

chr5_+_125365789 0.231 Zfp664
zinc finger protein 664
chr14_-_104215770 0.231 Ednrb
endothelin receptor type B
chr19_-_13870096 0.228 NM_146741
Olfr1497
olfactory receptor 1497
chr11_-_120432985 0.226 P4hb
prolyl 4-hydroxylase, beta polypeptide
chr1_-_39608846 0.226 Rnf149
ring finger protein 149
chr7_-_82453166 0.222 Sv2b
synaptic vesicle glycoprotein 2 b
chr7_-_52494453 0.221 Cd37
CD37 antigen
chr8_-_24301206 0.219 Agpat6
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
chr17_+_43705388 0.218 NM_013737
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr9_-_91255831 0.218 Zic1
zinc finger protein of the cerebellum 1
chr12_+_62625477 0.216 NM_178714
Lrfn5
leucine rich repeat and fibronectin type III domain containing 5
chr4_+_123613778 0.215 Rragc
Ras-related GTP binding C
chr17_+_5341444 0.207 Arid1b
AT rich interactive domain 1B (SWI-like)
chr9_-_66883879 0.207 Tpm1
tropomyosin 1, alpha
chr1_+_83156336 0.204 NM_027725
Wdr69
WD repeat domain 69
chr13_+_8202111 0.203 NM_052977
Adarb2
adenosine deaminase, RNA-specific, B2
chr5_+_35104409 0.202 Htt
huntingtin
chr9_-_95390211 0.202 2610101N10Rik
RIKEN cDNA 2610101N10 gene

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.