Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.930

Transcription factors associated with NKX2-3_NKX2-5.p2:

NameEntrezDescription
Nkx2-3 18089 NK2 transcription factor related, locus 3 (Drosophila)
Nkx2-5 18091 NK2 transcription factor related, locus 5 (Drosophila)



Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr1_-_180259336 5.517 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr3_+_101814059 4.982 NM_178777
Nhlh2
nescient helix loop helix 2
chr1_+_6720153 4.771 St18
suppression of tumorigenicity 18
chr3_+_17695743 4.597 6430547I21Rik
RIKEN cDNA 6430547I21 gene
chr3_-_126701320 4.568 Ank2
ankyrin 2, brain
chr9_+_96159123 4.001 NM_001184709
Tfdp2
transcription factor Dp 2
chr12_+_53800369 3.648 NM_198111
Akap6
A kinase (PRKA) anchor protein 6
chr10_-_116786025 3.542 Cpsf6
cleavage and polyadenylation specific factor 6
chr1_+_19198994 3.501 NM_009334
Tcfap2b
transcription factor AP-2 beta
chr2_+_73110010 3.215 Sp9
trans-acting transcription factor 9
chr11_+_75578548 3.182 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr3_+_133899454 3.099 Cxxc4
CXXC finger 4
chr11_-_77707282 3.064 NM_008952
Pipox
pipecolic acid oxidase
chr15_+_92427539 2.917 NM_001164594
Pdzrn4
PDZ domain containing RING finger 4
chr1_+_45368443 2.814 Col3a1
collagen, type III, alpha 1
chr5_-_92483744 2.732 G3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr14_-_118450875 2.662 NM_010024
Dct
dopachrome tautomerase
chr1_-_42749940 2.638 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr1_+_19202046 2.638 NM_001025305
Tcfap2b
transcription factor AP-2 beta
chr3_-_126701367 2.510 NM_178655
Ank2
ankyrin 2, brain
chr1_+_6720087 2.448 NM_173868
St18
suppression of tumorigenicity 18
chr4_-_33010429 2.359 NM_001012450
NM_080471
Ankrd6

ankyrin repeat domain 6

chr6_-_51413182 2.270 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr1_+_19093102 2.260 NM_153154
Tcfap2d
transcription factor AP-2, delta
chr5_-_89886732 2.010 NM_008096
Gc
group specific component
chr2_-_44968508 1.995 Zeb2
zinc finger E-box binding homeobox 2
chr7_-_26506741 1.951


chr17_+_17539832 1.928 Lix1
limb expression 1 homolog (chicken)
chr1_-_55044032 1.909 Sf3b1
splicing factor 3b, subunit 1
chr4_-_109960078 1.886 NM_001038698
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr15_-_96861590 1.852 Slc38a4
solute carrier family 38, member 4
chr15_-_24957039 1.818 Gm2824
predicted gene 2824
chr2_-_44968728 1.756 NM_015753
Zeb2
zinc finger E-box binding homeobox 2
chr12_+_39510297 1.754 NM_001163154
Etv1
ets variant gene 1
chr11_+_93905443 1.718 Spag9
sperm associated antigen 9
chr13_-_76081244 1.712 NM_028493
Rhobtb3
Rho-related BTB domain containing 3
chr15_+_80629020 1.685 NM_177124
Tnrc6b
trinucleotide repeat containing 6b
chr2_+_51893618 1.559 NM_009398
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr9_+_54758322 1.511 Ireb2
iron responsive element binding protein 2
chr1_+_66368409 1.495 Mtap2
microtubule-associated protein 2
chr11_+_93905557 1.482 Spag9
sperm associated antigen 9
chr5_-_122906470 1.454 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr11_-_94154354 1.394 Luc7l3
LUC7-like 3 (S. cerevisiae)
chr15_-_103045710 1.390 NM_001110216
NM_007626
Cbx5

chromobox homolog 5 (Drosophila HP1a)

chr10_-_20444654 1.377 NM_013875
Pde7b
phosphodiesterase 7B
chr19_+_39361574 1.369 NM_007815
Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
chr19_-_14672540 1.348 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr11_+_75578120 1.346 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr11_+_96212945 1.295 NM_134032
Hoxb2
homeobox B2
chr11_-_101828286 1.267 NM_024449
Sost
sclerostin
chr2_+_73109981 1.208 NM_001005343
Sp9
trans-acting transcription factor 9
chr3_-_86978431 1.206 NM_001170985
NM_130867
Kirrel

kin of IRRE like (Drosophila)

chr13_+_42776161 1.179 Phactr1
phosphatase and actin regulator 1
chr17_+_17539908 1.173 Lix1
limb expression 1 homolog (chicken)
chr6_-_87793898 1.158 Cnbp
cellular nucleic acid binding protein
chr6_+_64679118 1.146 NM_007500
Atoh1
atonal homolog 1 (Drosophila)
chrM_+_5462 1.131


chr10_-_117252126 1.131


chr16_+_7069927 1.113 NM_183188
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr13_-_53568111 1.113 NM_013601
Msx2
homeobox, msh-like 2
chr9_-_44610921 1.073 Ttc36
tetratricopeptide repeat domain 36
chr2_+_27020999 1.066 NM_138942
Dbh
dopamine beta hydroxylase
chr8_-_49928495 1.048 2900073C17Rik
RIKEN cDNA 2900073C17 gene
chr16_+_20692792 1.043


chr1_-_173957316 1.025 NM_033509
Vangl2
vang-like 2 (van gogh, Drosophila)
chr2_-_84490827 1.013 NM_001085448
NM_001085449
NM_001085450
NM_007615
Ctnnd1



catenin (cadherin associated protein), delta 1



chr14_-_111154292 1.013 NM_175499
Slitrk6
SLIT and NTRK-like family, member 6
chr11_-_119971500 1.011 Slc38a10
solute carrier family 38, member 10
chr2_+_74707394 1.005 Mtx2
metaxin 2
chr9_-_78326946 1.004 Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr7_-_77511242 0.995 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr3_+_90097269 0.993 Gatad2b
GATA zinc finger domain containing 2B
chr3_+_159502646 0.983 NM_026582
Wls
wntless homolog (Drosophila)
chr2_+_34631438 0.974 Hspa5
heat shock protein 5
chr13_-_23714425 0.974 NM_015787
Hist1h1e
histone cluster 1, H1e
chr5_-_122907002 0.973 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr5_-_100391613 0.967 Hnrnpd
heterogeneous nuclear ribonucleoprotein D
chr6_-_99216494 0.963 NM_001197321
Foxp1
forkhead box P1
chr16_-_63863905 0.957 NM_010140
Epha3
Eph receptor A3
chr4_-_109959366 0.941 NM_001163399
NM_010488
Elavl4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr5_-_100465086 0.934 Hnrpdl
heterogeneous nuclear ribonucleoprotein D-like
chr9_-_16182674 0.923 NM_001080814
Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr14_+_75855788 0.896 NM_001128093
Siah3
seven in absentia homolog 3 (Drosophila)
chr10_-_45189997 0.885 NM_001031772
Lin28b
lin-28 homolog B (C. elegans)
chr3_-_49561168 0.883 NM_130448
Pcdh18
protocadherin 18
chr1_-_154472199 0.875 NM_016846
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr2_+_13501725 0.874 Vim
vimentin
chr9_-_113563906 0.833 Pdcd6ip
programmed cell death 6 interacting protein
chrM_+_5398 0.824


chrM_+_8606 0.811 COX3
cytochrome c oxidase subunit III
chr10_+_101621712 0.798 NM_001162369
Mgat4c
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr6_-_127075853 0.795 Ccnd2
cyclin D2
chr1_+_158769044 0.784 NM_028333
Angptl1
angiopoietin-like 1
chr5_+_91197542 0.777 NM_023785
Ppbp
pro-platelet basic protein
chr2_+_34631124 0.773 Hspa5
heat shock protein 5
chr5_-_108304062 0.773 NM_007964
Evi5
ecotropic viral integration site 5
chr2_+_162760505 0.770


chr10_+_56097078 0.770 NM_010288
Gja1
gap junction protein, alpha 1
chr6_-_41654290 0.768 NM_032540
Kel
Kell blood group
chr7_-_80686630 0.766 NM_001081345
Chd2
chromodomain helicase DNA binding protein 2
chr1_+_45368568 0.762 Col3a1
collagen, type III, alpha 1
chr2_-_7317824 0.761 NM_001110231
Celf2
CUGBP, Elav-like family member 2
chr10_+_97110043 0.760 Epyc
epiphycan
chr19_+_26822892 0.759 NM_026003
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr11_-_75114563 0.748 Rpa1
replication protein A1
chr3_-_78949796 0.746 NM_001099624
Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr1_+_58052814 0.744 NM_199007
Sgol2
shugoshin-like 2 (S. pombe)
chr9_+_35024031 0.740 Srpr
signal recognition particle receptor ('docking protein')
chr1_+_162917586 0.733 Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr6_+_15135505 0.731 NM_212435
Foxp2
forkhead box P2
chr19_-_14672472 0.720 NM_011600
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chrM_+_9458 0.718 ND3
NADH dehydrogenase subunit 3
chr2_+_34631709 0.716 Hspa5
heat shock protein 5
chr9_+_19426528 0.711 NM_172918
Zfp317
zinc finger protein 317
chr6_+_17699145 0.704 NM_001083315
NM_022332
St7

suppression of tumorigenicity 7

chr7_+_138712015 0.697 Bub3
budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae)
chr3_-_86352170 0.696 NM_011839
Mab21l2
mab-21-like 2 (C. elegans)
chr1_+_162917640 0.684 Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chrX_+_155897136 0.682 Mtap7d2
MAP7 domain containing 2
chr4_+_8533630 0.680 Rab2a
RAB2A, member RAS oncogene family
chr2_+_35413977 0.676 NM_001114125
Dab2ip
disabled homolog 2 (Drosophila) interacting protein
chr11_-_69229653 0.675 Kdm6b
KDM1 lysine (K)-specific demethylase 6B
chr17_+_78907402 0.674 NM_001197028
NM_028813
Vit

vitrin

chr6_-_3444484 0.662 NM_178899
Hepacam2
HEPACAM family member 2
chr18_+_38476622 0.658


chr14_+_65569108 0.657 Ints9
integrator complex subunit 9
chr3_+_55265654 0.654 NM_001111051
NM_001111052
NM_001195539
NM_001195540
Dclk1



doublecortin-like kinase 1



chr17_+_12571455 0.652 NM_008877
Plg
plasminogen
chr19_+_8876985 0.651 NM_133759
NM_001098237
Zbtb3

zinc finger and BTB domain containing 3

chr4_-_109959185 0.649 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr4_+_57907032 0.649 Akap2
A kinase (PRKA) anchor protein 2
chr1_-_180264067 0.639 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr4_-_43536296 0.639 Tpm2
tropomyosin 2, beta
chr1_+_84836413 0.637 NM_025386
Fbxo36
F-box protein 36
chr8_+_56040080 0.632 NM_153581
Gpm6a
glycoprotein m6a
chr1_-_173957407 0.632 Vangl2
vang-like 2 (van gogh, Drosophila)
chr7_-_11242322 0.631 NM_001110020
Gm6900
predicted gene 6900
chr1_-_128727208 0.631 NM_001081756
NM_176957
Nckap5

NCK-associated protein 5

chr16_+_37580303 0.627 Hgd
homogentisate 1, 2-dioxygenase
chr8_+_4238862 0.619 Map2k7
mitogen-activated protein kinase kinase 7
chr9_-_44611055 0.605 Ttc36
tetratricopeptide repeat domain 36
chr8_+_91115856 0.599 Nkd1
naked cuticle 1 homolog (Drosophila)
chr11_+_94189303 0.596 NM_027799
NM_146024
Ankrd40

ankyrin repeat domain 40

chr8_+_4238838 0.595 Map2k7
mitogen-activated protein kinase kinase 7
chr19_-_12841737 0.595 Zfp91
zinc finger protein 91
chr2_-_17970075 0.590 NM_028317
2810030E01Rik
RIKEN cDNA 2810030E01 gene
chr15_-_13103346 0.589 NM_007666
Cdh6
cadherin 6
chr6_-_128380651 0.587


chr10_+_87323855 0.586 NM_001111274
NM_001111276
NM_184052
Igf1


insulin-like growth factor 1


chr1_-_168058009 0.583 NM_001033344
NM_001160049
Dusp27

dual specificity phosphatase 27 (putative)

chr16_-_11137100 0.581 Zc3h7a
zinc finger CCCH type containing 7 A
chr1_-_165243608 0.581 Prrx1
paired related homeobox 1
chr17_+_12571494 0.579 Plg
plasminogen
chr10_+_40657980 0.576 Wasf1
WASP family 1
chr11_+_102254816 0.576 Rundc3a
RUN domain containing 3A
chr10_+_28863801 0.574 NM_026138
6330407J23Rik
RIKEN cDNA 6330407J23 gene
chr17_+_34729159 0.573 Pbx2
pre B-cell leukemia transcription factor 2
chr11_-_74491006 0.570 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr14_-_34195326 0.569 Mapk8
mitogen-activated protein kinase 8
chr18_+_35750406 0.569 Matr3
matrin 3
chr9_+_96159666 0.568 NM_001184710
NM_001184711
Tfdp2

transcription factor Dp 2

chr11_+_32646291 0.568 Fbxw11
F-box and WD-40 domain protein 11
chrX_+_156278399 0.563 NM_001135728
Sh3kbp1
SH3-domain kinase binding protein 1
chr1_-_37973274 0.561 NM_001033427
Lyg2
lysozyme G-like 2
chrX_+_155897056 0.559 Mtap7d2
MAP7 domain containing 2
chrX_-_16488889 0.557 NM_010883
Ndp
Norrie disease (pseudoglioma) (human)
chr15_+_78860623 0.554


chr5_-_122907269 0.553 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr18_-_77285981 0.544 Katnal2
katanin p60 subunit A-like 2
chrX_-_163645313 0.540 Tmsb4x
thymosin, beta 4, X chromosome
chr3_+_68376319 0.533 Schip1
schwannomin interacting protein 1
chr15_+_25682945 0.529 Myo10
myosin X
chr6_+_83087016 0.523 NM_009106
NM_133641
Rtkn

rhotekin

chr10_-_116782524 0.517 Cpsf6
cleavage and polyadenylation specific factor 6
chr3_-_122241909 0.512 Fnbp1l
formin binding protein 1-like
chr11_+_52202137 0.510 Vdac1
voltage-dependent anion channel 1
chr7_+_119253816 0.510 Usp47
ubiquitin specific peptidase 47
chr5_-_135096236 0.509 Eif4h
eukaryotic translation initiation factor 4H
chr4_+_6321713 0.509 Sdcbp
syndecan binding protein
chrM_-_622 0.508


chr2_+_162759398 0.508 Srsf6
serine/arginine-rich splicing factor 6
chr15_+_3230053 0.504


chr8_-_95721654 0.500 Ces1d
carboxylesterase 1D
chr2_+_13504271 0.496


chr6_+_34659440 0.496 NM_145575
Cald1
caldesmon 1
chr3_+_84781329 0.492


chr12_+_82049290 0.490 Srsf5
serine/arginine-rich splicing factor 5
chr3_-_82853711 0.486 NM_181849
Fgb
fibrinogen beta chain
chr1_-_151808361 0.486 NM_008869
Pla2g4a
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr11_+_79845841 0.482 Suz12
suppressor of zeste 12 homolog (Drosophila)
chr6_+_30400873 0.477


chr2_-_155999858 0.477 Rbm39
RNA binding motif protein 39
chr14_+_79915429 0.467 Elf1
E74-like factor 1
chr16_-_16560240 0.466 NM_139232
NM_139234
Fgd4

FYVE, RhoGEF and PH domain containing 4

chr2_-_79969429 0.465 NM_001159582
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr1_+_166081951 0.458 NM_007976
F5
coagulation factor V
chr6_-_119988624 0.457 NM_001185020
NM_001185021
NM_198703
Wnk1


WNK lysine deficient protein kinase 1


chr15_+_80453912 0.453 NM_010815
Grap2
GRB2-related adaptor protein 2
chr11_+_60351469 0.453 Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chrX_-_92853721 0.447 NM_001003916
Zc4h2
zinc finger, C4H2 domain containing

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.64 2.18e-04 GO:0006807 nitrogen compound metabolic process
2.60 5.30e-04 GO:0034641 cellular nitrogen compound metabolic process
3.02 5.40e-04 GO:0010467 gene expression
3.15 5.45e-04 GO:0016070 RNA metabolic process
2.73 4.83e-03 GO:0090304 nucleic acid metabolic process
2.53 5.11e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.28 2.72e-02 GO:0031323 regulation of cellular metabolic process
10.31 4.40e-02 GO:0016055 Wnt receptor signaling pathway

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment p-value GO term description
3.24 6.23e-06 GO:0003676 nucleic acid binding
5.55 2.14e-04 GO:0003723 RNA binding
1.56 4.32e-04 GO:0005488 binding
3.28 9.07e-04 GO:0003677 DNA binding
3.96 1.13e-02 GO:0030528 transcription regulator activity
4.27 1.41e-02 GO:0001071 nucleic acid binding transcription factor activity
4.27 1.41e-02 GO:0003700 sequence-specific DNA binding transcription factor activity