Motif ID: NKX6-1,2.p2

Z-value: 1.105

Transcription factors associated with NKX6-1,2.p2:

NameEntrezDescription
Nkx6-1 18096 NK6 homeobox 1
Nkx6-2 14912 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Nkx6-2chr7_-_1467686330.554.5e-04Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr7_-_111001598 20.590 NM_008221
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr5_+_90889913 11.154 NM_009654
Alb
albumin
chrX_+_108009728 9.538 NM_008901
Pou3f4
POU domain, class 3, transcription factor 4
chr6_-_127075853 7.569 Ccnd2
cyclin D2
chr9_+_96159123 5.812 NM_001184709
Tfdp2
transcription factor Dp 2
chr19_-_14672472 4.968 NM_011600
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr9_+_96159666 4.650 NM_001184710
NM_001184711
Tfdp2

transcription factor Dp 2

chr19_-_14672540 4.631 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr1_-_42749940 4.292 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr5_+_90889937 4.175 Alb
albumin
chr14_+_73637697 3.569 NM_175116
Lpar6
lysophosphatidic acid receptor 6
chr1_-_180259336 2.838 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr11_+_75565381 2.550 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr1_+_66368409 2.504 Mtap2
microtubule-associated protein 2
chr14_+_67254087 2.501 NM_013461
Adra1a
adrenergic receptor, alpha 1a
chr15_-_13103346 2.397 NM_007666
Cdh6
cadherin 6
chr7_-_69609363 2.393 NM_013788
Peg12
paternally expressed 12
chr4_-_116855158 2.321 NM_134471
Kif2c
kinesin family member 2C
chr3_+_96405063 2.305 Lix1l
Lix1-like
chr2_+_79547936 2.277 NM_172420
Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr3_-_49561168 2.184 NM_130448
Pcdh18
protocadherin 18
chr3_+_40439675 2.179 NM_175515
Intu
inturned planar cell polarity effector homolog (Drosophila)
chr3_+_66023808 2.129 NM_008987
Ptx3
pentraxin related gene
chr5_+_123592177 2.127 Setd1b
SET domain containing 1B
chr11_-_101828286 2.123 NM_024449
Sost
sclerostin
chr6_+_137703029 2.112 NM_172733
Dera
2-deoxyribose-5-phosphate aldolase homolog (C. elegans)
chr1_-_176851918 2.110 Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr1_-_173957407 2.106 Vangl2
vang-like 2 (van gogh, Drosophila)
chr15_-_103045710 2.057 NM_001110216
NM_007626
Cbx5

chromobox homolog 5 (Drosophila HP1a)

chr11_-_86517662 2.054 Cltc
clathrin, heavy polypeptide (Hc)
chr5_+_93238413 1.978 NM_001077595
Shroom3
shroom family member 3
chr12_-_81861527 1.864 NM_001008423
Gm1568
predicted gene 1568
chr1_-_176851949 1.842 NM_011825
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr19_-_58529766 1.821 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr3_+_66023884 1.746 Ptx3
pentraxin related gene
chr5_-_23536487 1.734 NM_053090
Fam126a
family with sequence similarity 126, member A
chr5_-_52576002 1.733


chr4_+_140257340 1.664 NM_173867
Rcc2
regulator of chromosome condensation 2
chr7_-_106987766 1.637 Spcs2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr2_-_84490827 1.623 NM_001085448
NM_001085449
NM_001085450
NM_007615
Ctnnd1



catenin (cadherin associated protein), delta 1



chr3_+_135101248 1.612 Ube2d3
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
chrX_+_34142137 1.560


chrX_-_48371127 1.542 NM_172413
Rap2c
RAP2C, member of RAS oncogene family
chr2_+_90858663 1.476 Celf1
CUGBP, Elav-like family member 1
chr11_-_17853850 1.427 NM_026576
Etaa1
Ewing's tumor-associated antigen 1
chr8_+_116657473 1.400 NM_024437
NM_024446
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr4_-_154010868 1.376 NM_001177995
NM_027504
Prdm16

PR domain containing 16

chr12_-_74147698 1.338 NM_009189
Six1
sine oculis-related homeobox 1 homolog (Drosophila)
chr7_-_25873560 1.324


chr2_+_13501725 1.297 Vim
vimentin
chr12_+_82049290 1.246 Srsf5
serine/arginine-rich splicing factor 5
chr3_+_145541951 1.204


chr15_-_96861590 1.197 Slc38a4
solute carrier family 38, member 4
chr7_+_16633755 1.178 2010004M13Rik
RIKEN cDNA 2010004M13 gene
chr1_-_93295259 1.171 Ilkap
integrin-linked kinase-associated serine/threonine phosphatase 2C
chr3_+_123149830 1.154 NM_008939
Prss12
protease, serine, 12 neurotrypsin (motopsin)
chr4_-_3865501 1.134 NM_019969
Plag1
pleiomorphic adenoma gene 1
chr2_+_174171943 1.134


chr1_-_179178874 1.132 NM_011785
Akt3
thymoma viral proto-oncogene 3
chr18_-_89063689 1.130 Socs6
suppressor of cytokine signaling 6
chr2_+_69699618 1.128 NM_001110145
NM_009278
Ssb

Sjogren syndrome antigen B

chr15_+_80629020 1.116 NM_177124
Tnrc6b
trinucleotide repeat containing 6b
chr12_+_119082333 1.106 NM_146040
Cdca7l
cell division cycle associated 7 like
chr8_-_88077181 1.102 Dnaja2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr1_-_140743779 1.099 Lhx9
LIM homeobox protein 9
chr5_+_53225253 1.095 Anapc4
anaphase promoting complex subunit 4
chr2_-_125450836 1.072 NM_001081091
Cep152
centrosomal protein 152
chr9_-_71743854 1.044 Tcf12
transcription factor 12
chr3_+_82859422 1.037 NM_016784
Plrg1
pleiotropic regulator 1, PRL1 homolog (Arabidopsis)
chr10_+_87663839 1.020 NM_001122960
NM_026070
NM_027487
Ccdc53


coiled-coil domain containing 53


chr2_-_91771882 1.017 Mdk
midkine
chr10_+_68996455 1.015 NM_146005
NM_170688
NM_170689
NM_170690
NM_170728
NM_170729
NM_170730
Ank3






ankyrin 3, epithelial






chr19_-_44181897 0.999 NM_001162410
NM_007700
Chuk

conserved helix-loop-helix ubiquitous kinase

chr9_+_78039786 0.991 Gsta4
glutathione S-transferase, alpha 4
chr10_-_126748678 0.987 Mars
methionine-tRNA synthetase
chr9_+_72584532 0.976 Nedd4
neural precursor cell expressed, developmentally down-regulated 4
chr6_-_51413182 0.962 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr6_-_82724366 0.956 NM_013820
Hk2
hexokinase 2
chr16_-_52268571 0.951 Alcam
activated leukocyte cell adhesion molecule
chr11_-_116711807 0.948 Srsf2
serine/arginine-rich splicing factor 2
chr11_+_93905557 0.939 Spag9
sperm associated antigen 9
chr11_-_119971500 0.922 Slc38a10
solute carrier family 38, member 10
chr16_-_30267577 0.917 NM_027904
Cpn2
carboxypeptidase N, polypeptide 2
chr16_-_16560240 0.899 NM_139232
NM_139234
Fgd4

FYVE, RhoGEF and PH domain containing 4

chr11_+_62692976 0.890 NM_026210
Fam18b
family with sequence similarity 18, member B
chr17_-_48572043 0.889 NM_009694
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr18_+_32996878 0.888 NM_001110015
NM_001110016
NM_144863
Wdr36


WD repeat domain 36


chr2_-_37502738 0.884 NM_009261
Strbp
spermatid perinuclear RNA binding protein
chr13_+_23830944 0.856 Hist1h1c
histone cluster 1, H1c
chr2_-_65405546 0.856 NM_018732
Scn3a
sodium channel, voltage-gated, type III, alpha
chr7_+_74792295 0.854 NM_001168475
NM_001168476
NM_001168477
NM_025905
Ttc23



tetratricopeptide repeat domain 23



chr11_+_115794942 0.846 NM_020483
Sap30bp
SAP30 binding protein
chr4_-_21694265 0.844 2610029I01Rik
RIKEN cDNA 2610029I01 gene
chr14_-_104921839 0.835 NM_026047
Rnf219
ring finger protein 219
chr19_+_8876985 0.834 NM_133759
NM_001098237
Zbtb3

zinc finger and BTB domain containing 3

chr10_-_79373177 0.833 C030046I01Rik
RIKEN cDNA C030046I01 gene
chr18_-_74367400 0.811 NM_001164355
NM_025581
Ska1

spindle and kinetochore associated complex subunit 1

chr1_-_84741605 0.809 Trip12
thyroid hormone receptor interactor 12
chr14_+_65885454 0.808 NM_015795
Fbxo16
F-box protein 16
chr4_-_34754469 0.799 Zfp292
zinc finger protein 292
chr5_-_84846348 0.798 NM_007937
Epha5
Eph receptor A5
chr5_-_136384495 0.786


chr10_+_24315247 0.777 NM_010217
Ctgf
connective tissue growth factor
chr6_+_51494591 0.770 Snx10
sorting nexin 10
chr15_-_81222718 0.768 St13
suppression of tumorigenicity 13
chr11_+_93905443 0.767 Spag9
sperm associated antigen 9
chrM_+_1550 0.751


chr8_+_131256428 0.749 Itgb1
integrin beta 1 (fibronectin receptor beta)
chrY_-_582062 0.748 NM_009484
Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr2_-_131005549 0.743 NM_007682
Cenpb
centromere protein B
chr2_-_79969095 0.738 NM_016744
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr11_-_53097625 0.736 Hspa4
heat shock protein 4
chr1_+_174249713 0.735


chr18_+_25224729 0.735 Fhod3
formin homology 2 domain containing 3
chr1_+_174628164 0.733 NM_007768
Crp
C-reactive protein, pentraxin-related
chr7_+_58877199 0.726 NM_080853
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_+_63223689 0.722 Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr1_-_12980994 0.722 NM_172841
Slco5a1
solute carrier organic anion transporter family, member 5A1
chr1_-_128727208 0.721 NM_001081756
NM_176957
Nckap5

NCK-associated protein 5

chr5_+_90890764 0.720 Alb
albumin
chr9_-_55983967 0.710 Tspan3
tetraspanin 3
chr4_+_32504409 0.709 NM_001109661
Bach2
BTB and CNC homology 2
chr3_+_89586320 0.709 Ube2q1
ubiquitin-conjugating enzyme E2Q (putative) 1
chr1_+_19202046 0.708 NM_001025305
Tcfap2b
transcription factor AP-2 beta
chr11_+_102254949 0.701 Rundc3a
RUN domain containing 3A
chr12_-_85262786 0.695 Numb
numb gene homolog (Drosophila)
chrM_-_13886 0.693


chr12_-_56087322 0.688 NM_013815
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr6_+_51494521 0.687 NM_001127348
NM_028035
Snx10

sorting nexin 10

chr14_+_66424675 0.679 NM_023209
Pbk
PDZ binding kinase
chr15_-_76476688 0.676 Cyhr1
cysteine and histidine rich 1
chr1_+_43502537 0.673 NM_010879
Nck2
non-catalytic region of tyrosine kinase adaptor protein 2
chrX_-_147248815 0.666 NM_030700
Maged2
melanoma antigen, family D, 2
chr3_+_90097269 0.655 Gatad2b
GATA zinc finger domain containing 2B
chr10_-_84590718 0.653 NM_028832
Mterfd3
MTERF domain containing 3
chr5_+_149114763 0.653 Mtus2
microtubule associated tumor suppressor candidate 2
chr2_-_114001033 0.650 NM_009702
Aqr
aquarius
chr16_-_84955086 0.645 App
amyloid beta (A4) precursor protein
chr17_+_40948047 0.645 NM_011269
Rhag
Rhesus blood group-associated A glycoprotein
chr7_+_25055436 0.641 NM_009567
Zfp93
zinc finger protein 93
chr3_-_41546402 0.635 NM_001081411
Sclt1
sodium channel and clathrin linker 1
chr13_-_64376186 0.629 NM_172587
Cdc14b
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr11_+_26287083 0.628 NM_025923
Fancl
Fanconi anemia, complementation group L
chr13_-_99660903 0.627 NM_001048267
Tnpo1
transportin 1
chr12_-_47919695 0.627 NM_021361
Nova1
neuro-oncological ventral antigen 1
chr7_+_46773116 0.620 NM_001004139
Zfp619
zinc finger protein 619
chr9_+_107790457 0.619 NM_028369
Mon1a
MON1 homolog A (yeast)
chr5_-_123270999 0.617 Anapc5
anaphase-promoting complex subunit 5
chr11_+_75578120 0.608 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr6_-_115626589 0.607 NM_029780
Raf1
v-raf-leukemia viral oncogene 1
chr4_-_147183894 0.606 NM_001127189
Gm13157
2610036A22Rik
predicted gene 13157
RIKEN cDNA 2610036A22 gene
chr2_+_37307786 0.605 Rabgap1
RAB GTPase activating protein 1
chr5_-_123271283 0.604 NM_001042491
NM_021505
Anapc5

anaphase-promoting complex subunit 5

chr14_-_67627598 0.596 NM_009761
Bnip3l
BCL2/adenovirus E1B interacting protein 3-like
chrX_+_130593867 0.595 NM_133196
Cstf2
cleavage stimulation factor, 3' pre-RNA subunit 2
chr17_+_12571455 0.591 NM_008877
Plg
plasminogen
chr9_+_35024031 0.583 Srpr
signal recognition particle receptor ('docking protein')
chr13_-_76081244 0.576 NM_028493
Rhobtb3
Rho-related BTB domain containing 3
chr6_-_48036471 0.576


chr4_+_140258090 0.574 Rcc2
regulator of chromosome condensation 2
chr3_-_86352170 0.568 NM_011839
Mab21l2
mab-21-like 2 (C. elegans)
chr2_+_69627711 0.564 NM_028521
Phospho2
phosphatase, orphan 2
chr14_-_111154292 0.562 NM_175499
Slitrk6
SLIT and NTRK-like family, member 6
chr18_+_23910833 0.561 NM_001162942
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr2_+_174167321 0.559


chr7_-_30945790 0.556 8430406M14Rik
RIKEN cDNA 8430406M14 gene
chr2_-_9800211 0.555 NM_008091
Gata3
GATA binding protein 3
chr1_-_141456740 0.546 NM_015780
Cfhr1
complement factor H-related 1
chr7_-_150835497 0.544 NM_023680
Tnfrsf22
tumor necrosis factor receptor superfamily, member 22
chr6_+_17699145 0.544 NM_001083315
NM_022332
St7

suppression of tumorigenicity 7

chr5_+_130292873 0.543 Cct6a
chaperonin containing Tcp1, subunit 6a (zeta)
chr11_-_86400309 0.540 Tmem49
transmembrane protein 49
chr1_+_88024759 0.535 Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr2_-_74497475 0.532 NM_007967
Evx2
even skipped homeotic gene 2 homolog
chr2_+_13504271 0.529


chr10_-_128397928 0.519 NM_027853
Mettl7b
methyltransferase like 7B
chr13_-_4608352 0.518 NM_018859
Akr1e1
aldo-keto reductase family 1, member E1
chr6_+_5340417 0.517 Asb4
ankyrin repeat and SOCS box-containing 4
chr5_-_123271207 0.511 Anapc5
anaphase-promoting complex subunit 5
chr5_+_151325197 0.510 NM_009765
NM_001081001
Brca2

breast cancer 2

chr15_-_56526052 0.506 NM_008216
Has2
hyaluronan synthase 2
chr13_+_4433567 0.506 NM_030611
Akr1c6
aldo-keto reductase family 1, member C6
chr11_-_94515034 0.503 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr3_-_113277601 0.503 NM_007446
Amy1
amylase 1, salivary
chr14_-_109313298 0.495 Slitrk1
SLIT and NTRK-like family, member 1
chr10_-_126719287 0.492 Mbd6
methyl-CpG binding domain protein 6
chr9_-_115152895 0.492 Stt3b
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr14_+_57287083 0.486 NM_023773
Mphosph8
M-phase phosphoprotein 8
chr14_-_34195326 0.483 Mapk8
mitogen-activated protein kinase 8
chr4_-_138469861 0.480 NM_028453
Otud3
OTU domain containing 3
chr7_+_24960063 0.480 NM_001029933
Zfp114
zinc finger protein 114
chr10_+_97028409 0.480 Lum
lumican
chr8_+_73053287 0.480 Fkbp8
FK506 binding protein 8
chr1_-_134439500 0.478 NM_177129
Cntn2
contactin 2
chr4_+_15211137 0.476 Tmem64
transmembrane protein 64
chr17_+_30272123 0.475 Zfand3
zinc finger, AN1-type domain 3
chr4_-_88368313 0.474 NM_172871
Klhl9
kelch-like 9 (Drosophila)
chr2_-_84490666 0.471 NM_001085453
Ctnnd1
catenin (cadherin associated protein), delta 1
chr7_-_110962416 0.470 NM_008220
NM_016956
Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr8_-_96496001 0.458 Amfr
autocrine motility factor receptor

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.68 8.92e-04 GO:0043234 protein complex
2.47 1.12e-03 GO:0032991 macromolecular complex

Gene overrepresentation in function category:

enrichment p-value GO term description
1.81 1.48e-02 GO:0005515 protein binding