Motif ID: NR1H4.p2

Z-value: 1.568

Transcription factors associated with NR1H4.p2:

NameEntrezDescription
Nr1h4 20186 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Nr1h4chr10_-_889963140.105.6e-01Click!


Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chrX_+_133357268 18.731 NM_011123
Plp1
proteolipid protein (myelin) 1
chr7_+_3303657 10.133 NM_011102
Prkcc
protein kinase C, gamma
chr11_-_75236018 9.542 Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr17_-_27650285 8.291 Grm4
glutamate receptor, metabotropic 4
chr19_-_38199291 8.267 NM_011255
Rbp4
retinol binding protein 4, plasma
chr14_+_14117313 7.782 Synpr
synaptoporin
chr11_+_101329457 6.796 Rnd2
Rho family GTPase 2
chr10_-_76188683 6.493 NM_009933
Col6a1
collagen, type VI, alpha 1
chr14_+_14117292 5.983 NM_028052
Synpr
synaptoporin
chr2_-_25325248 4.664 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr11_+_101329615 4.356 NM_009708
Rnd2
Rho family GTPase 2
chr7_-_31840647 4.114 NM_019503
NM_052992
Fxyd1

FXYD domain-containing ion transport regulator 1

chr11_-_53882433 4.047 NM_019417
Pdlim4
PDZ and LIM domain 4
chr5_-_138052555 4.044 NM_008788
Pcolce
procollagen C-endopeptidase enhancer protein
chr8_-_73905790 4.041 NM_010150
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr3_+_90341208 3.868 S100a16
S100 calcium binding protein A16
chr11_+_67399999 3.642 NM_001109657
Gas7
growth arrest specific 7
chr3_+_68808879 3.197 NM_133786
Smc4
structural maintenance of chromosomes 4
chr1_+_67169588 3.084 NM_001080809
Cps1
carbamoyl-phosphate synthetase 1
chr9_+_43851477 3.053 Thy1
thymus cell antigen 1, theta
chr7_+_3303770 3.019 Prkcc
protein kinase C, gamma
chr19_+_9004106 2.924 NM_144872
Eml3
echinoderm microtubule associated protein like 3
chr14_-_31736727 2.754 NM_008407
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr9_+_20673069 2.753 NM_175687
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr11_-_72080066 2.638 NM_001004148
Slc13a5
solute carrier family 13 (sodium-dependent citrate transporter), member 5
chr19_-_10315199 2.575 NM_001033481
Gm98
predicted gene 98
chr1_-_51535232 2.373 NM_028696
Obfc2a
oligonucleotide/oligosaccharide-binding fold containing 2A
chr9_+_123371135 2.332 Lars2
leucyl-tRNA synthetase, mitochondrial
chr16_+_30599808 2.312 NM_177632
Fam43a
family with sequence similarity 43, member A
chr6_+_134879160 2.288 1190002F15Rik
RIKEN cDNA 1190002F15 gene
chr10_+_115738429 2.264 NM_029928
Ptprb
protein tyrosine phosphatase, receptor type, B
chr1_+_174271397 2.167 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr7_-_31839825 2.165 NM_052991
NM_194321
Fxyd1

FXYD domain-containing ion transport regulator 1

chr6_+_83299439 2.151 NM_175277
Bola3
bolA-like 3 (E. coli)
chr14_+_66424675 2.078 NM_023209
Pbk
PDZ binding kinase
chr1_-_173987681 2.020 NM_010916
Nhlh1
nescient helix loop helix 1
chrX_+_98469429 2.006 NM_021521
Med12
mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
chr2_-_181194085 1.987 NM_028125
Zbtb46
zinc finger and BTB domain containing 46
chr6_+_134879109 1.956 1190002F15Rik
RIKEN cDNA 1190002F15 gene
chr10_-_88906629 1.903 NM_001033331
NM_001079876
Gas2l3

growth arrest-specific 2 like 3

chr1_+_174271338 1.890 NM_001039484
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr1_+_141351340 1.889 NM_009791
Aspm
asp (abnormal spindle)-like, microcephaly associated (Drosophila)
chr3_-_108029499 1.876 NM_008596
Sypl2
synaptophysin-like 2
chr2_+_121973414 1.874 NM_009735
B2m
beta-2 microglobulin
chr17_-_45729199 1.866 NM_022880
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr8_-_72519966 1.841 NM_001113345
NM_145596
Gatad2a

GATA zinc finger domain containing 2A

chr4_-_125879832 1.823 NM_146153
Thrap3
thyroid hormone receptor associated protein 3
chr7_+_3293008 1.694 NM_001093766
Myadm
myeloid-associated differentiation marker
chr17_-_27165478 1.645 NM_007523
Bak1
BCL2-antagonist/killer 1
chr18_-_67800869 1.581 Cep76
centrosomal protein 76
chr18_-_67800968 1.516 NM_001081073
Cep76
centrosomal protein 76
chr11_-_3763899 1.506 NM_152818
Osbp2
oxysterol binding protein 2
chr7_+_129432810 1.504 Prkcb
protein kinase C, beta
chr10_-_127984766 1.473 NM_134003
Zc3h10
zinc finger CCCH type containing 10
chr6_-_116623789 1.455 NM_178045
Rassf4
Ras association (RalGDS/AF-6) domain family member 4
chr13_+_75844950 1.442 Ell2
elongation factor RNA polymerase II 2
chr11_-_76384852 1.433 NM_198895
Abr
active BCR-related gene
chr4_-_62815137 1.417 NM_007443
Ambp
alpha 1 microglobulin/bikunin
chr7_-_29086780 1.396 NM_007866
Dll3
delta-like 3 (Drosophila)
chr15_-_77672472 1.386 NM_022410
Myh9
myosin, heavy polypeptide 9, non-muscle
chr7_-_133819870 1.370 NM_133670
Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr4_+_134420419 1.344 NM_011270
Rhd
Rh blood group, D antigen
chr7_-_112748624 1.337 NM_017371
Hpx
hemopexin
chr2_-_170232008 1.329 Bcas1
breast carcinoma amplified sequence 1
chr8_+_131209787 1.303 Itgb1
integrin beta 1 (fibronectin receptor beta)
chr7_+_29573191 1.257 Sirt2
sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
chr7_+_129432585 1.255 NM_008855
Prkcb
protein kinase C, beta
chr11_+_100931369 1.235 NM_013792
Naglu
alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
chr7_-_91754236 1.221 Fah
fumarylacetoacetate hydrolase
chr10_+_79451332 1.187 NM_007725
Cnn2
calponin 2
chr10_+_79451369 1.182 Cnn2
calponin 2
chr1_+_162917640 1.170 Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr5_-_123632567 1.165 NM_008277
Hpd
4-hydroxyphenylpyruvic acid dioxygenase
chr4_-_129852030 1.151 NM_001168333
Tinagl1
tubulointerstitial nephritis antigen-like 1
chr14_-_66743271 1.141 NM_007940
Ephx2
epoxide hydrolase 2, cytoplasmic
chr5_+_89316245 1.128 NM_001136260
NM_001197147
NM_018760
Slc4a4


solute carrier family 4 (anion exchanger), member 4


chr13_-_94407455 1.114 Bhmt
betaine-homocysteine methyltransferase
chr5_+_113919352 1.113 NM_177292
Wscd2
WSC domain containing 2
chr5_+_144125586 1.107 NM_133355
Grid2ip
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
chr7_-_90883999 1.104 NM_010551
Il16
interleukin 16
chr7_+_87171113 1.094 NM_175433
Zfp710
zinc finger protein 710
chr17_+_87153083 1.075 NM_010137
Epas1
endothelial PAS domain protein 1
chr12_+_86814822 1.068 NM_010234
Fos
FBJ osteosarcoma oncogene
chr5_-_148537561 1.060 NM_010228
Flt1
FMS-like tyrosine kinase 1
chr2_-_127346987 1.059 Kcnip3
Kv channel interacting protein 3, calsenilin
chr11_-_98636538 1.047 NM_145434
Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr6_+_129130632 1.046 NM_053109
Clec2d
C-type lectin domain family 2, member d
chr14_+_62950904 1.045 NM_026001
Rnaseh2b
ribonuclease H2, subunit B
chr1_+_162917586 1.045 Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr8_+_11312828 1.039 NM_009932
Col4a2
collagen, type IV, alpha 2
chr1_-_156993820 1.035 NM_008209
Mr1
major histocompatibility complex, class I-related
chr15_-_10644312 1.021 NM_001166408
Rai14
retinoic acid induced 14
chr7_-_26506741 1.018


chr17_+_68046597 1.016 NM_008480
Lama1
laminin, alpha 1
chr6_+_5675638 1.009 NM_001191023
NM_001191025
NM_001191026
NM_001191027
NM_010063
Dync1i1




dynein cytoplasmic 1 intermediate chain 1




chr19_+_6085096 1.004 NM_026410
Cdca5
cell division cycle associated 5
chr2_-_25324650 1.003 Ptgds
prostaglandin D2 synthase (brain)
chr2_+_3630817 0.997 Fam107b
family with sequence similarity 107, member B
chr7_+_86644936 0.986 AI854517
expressed sequence AI854517
chr7_+_114514258 0.976 NM_021889
Syt9
synaptotagmin IX
chr15_-_75900118 0.973 NM_134089
Scrib
scribbled homolog (Drosophila)
chr5_+_65194749 0.951 NM_008453
Klf3
Kruppel-like factor 3 (basic)
chr11_-_76391228 0.918 NM_198894
Abr
active BCR-related gene
chr4_+_53453302 0.917 Slc44a1
solute carrier family 44, member 1
chr3_+_96531649 0.917 Rnf115
ring finger protein 115
chr17_+_34727032 0.871 Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr2_+_3630729 0.866 NM_025626
Fam107b
family with sequence similarity 107, member B
chr5_+_65194627 0.863 Klf3
Kruppel-like factor 3 (basic)
chr1_-_34876794 0.860 Fam168b
family with sequence similarity 168, member B
chr14_-_14117143 0.854 NM_177813
Gm5087
predicted gene 5087
chr11_-_3995299 0.851 NM_026443
Mtfp1
mitochondrial fission process 1
chr5_-_124637176 0.849 Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr9_+_92145094 0.845 Plscr1
phospholipid scramblase 1
chr6_-_48522660 0.844 NM_027852
Rarres2
retinoic acid receptor responder (tazarotene induced) 2
chr11_-_106134024 0.836 NM_001130187
Smarcd2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr7_-_108112785 0.831 NM_183168
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr5_+_114580397 0.829 NM_001040691
Ung
uracil DNA glycosylase
chr7_+_29572956 0.824 Sirt2
sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
chr3_-_68808386 0.807 NM_026641
Ift80
intraflagellar transport 80 homolog (Chlamydomonas)
chr14_+_57194455 0.803 NM_001145978
Parp4
poly (ADP-ribose) polymerase family, member 4
chr15_-_93167238 0.802 Yaf2
YY1 associated factor 2
chr3_+_121670737 0.799 Arhgap29
Rho GTPase activating protein 29
chr9_+_5345475 0.798 NM_009808
Casp12
caspase 12
chr2_+_109739389 0.797 Lin7c
lin-7 homolog C (C. elegans)
chr9_-_22193627 0.781 NM_028390
Anln
anillin, actin binding protein
chr1_+_193645351 0.780 NM_010892
Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
chr15_-_81230497 0.776


chr11_+_87569075 0.766 A430104N18Rik
RIKEN cDNA A430104N18 gene
chr4_-_62186055 0.753 Pole3
polymerase (DNA directed), epsilon 3 (p17 subunit)
chr1_-_132994302 0.753


chr10_-_118677059 0.752 NM_027994
Cand1
cullin associated and neddylation disassociated 1
chr17_+_71168939 0.749 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr15_+_10994444 0.748 NM_175501
Adamts12
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
chr1_-_92740468 0.747 Col6a3
collagen, type VI, alpha 3
chr14_-_55482884 0.744 NM_001177705
Homez
homeodomain leucine zipper-encoding gene
chr16_+_32430986 0.727 NM_009981
NM_001163159
Pcyt1a

phosphate cytidylyltransferase 1, choline, alpha isoform

chr8_+_123012667 0.718 NM_198671
Gse1
genetic suppressor element 1
chr2_+_90687308 0.710 NM_019758
Mtch2
mitochondrial carrier homolog 2 (C. elegans)
chr2_+_32583221 0.709 Sh2d3c
SH2 domain containing 3C
chr8_-_112102961 0.708 Hp
haptoglobin
chr11_-_75236085 0.707 NM_011340
Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr3_-_120874549 0.703 NM_025637
NM_028456
Rwdd3

RWD domain containing 3

chr7_-_38892432 0.703 NM_007633
Ccne1
cyclin E1
chr8_-_116372637 0.700 NM_172466
Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr10_+_98725871 0.698 Dusp6
dual specificity phosphatase 6
chr8_-_11312729 0.693 NM_009931
Col4a1
collagen, type IV, alpha 1
chr7_-_112900699 0.690 NM_009906
Tpp1
tripeptidyl peptidase I
chr3_+_96531494 0.686 NM_026406
Rnf115
ring finger protein 115
chr5_-_115569276 0.683 NM_007383
Acads
acyl-Coenzyme A dehydrogenase, short chain
chr1_-_53353810 0.677 NM_153556
Pms1
postmeiotic segregation increased 1 (S. cerevisiae)
chr9_-_22193577 0.677 Anln
anillin, actin binding protein
chr13_-_93564652 0.676 NM_011582
Thbs4
thrombospondin 4
chr19_+_6084982 0.671 Cdca5
cell division cycle associated 5
chr10_+_17516024 0.663 NM_138628
Txlnb
taxilin beta
chr2_+_163843294 0.655 Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr4_-_128639595 0.649 NM_172875
Adc
arginine decarboxylase
chr6_-_128312524 0.644 5930416I19Rik
RIKEN cDNA 5930416I19 gene
chr16_+_55966387 0.635 NM_024218
Rpl24
ribosomal protein L24
chr10_-_76086045 0.635 Col6a2
collagen, type VI, alpha 2
chr15_-_93166789 0.635 Yaf2
YY1 associated factor 2
chr13_-_21872421 0.633 NM_020034
Hist1h1b
histone cluster 1, H1b
chr9_+_108393006 0.629 NM_001168371
NM_001168372
NM_001168373
NM_027804
NM_145407
Usp19




ubiquitin specific peptidase 19




chr17_-_27076365 0.626 NM_026307
NM_026948
Cuta

cutA divalent cation tolerance homolog (E. coli)

chr6_-_126595818 0.625 NM_010595
Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr2_-_155463821 0.624 Trpc4ap
transient receptor potential cation channel, subfamily C, member 4 associated protein
chr1_-_121401236 0.621 NM_022327
Ralb
v-ral simian leukemia viral oncogene homolog B (ras related)
chr9_+_43851466 0.619 NM_009382
Thy1
thymus cell antigen 1, theta
chr5_-_135103569 0.613


chr7_+_86537223 0.612 NM_145946
Fanci
Fanconi anemia, complementation group I
chr5_-_75440460 0.609 Chic2
cysteine-rich hydrophobic domain 2
chr11_-_116060026 0.607 Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chr1_+_74552794 0.600 Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr17_+_88840048 0.597 NM_180974
Foxn2
forkhead box N2
chrX_-_49518428 0.597 Gpc4
glypican 4
chr12_-_111829789 0.595 9430024F10Rik
RIKEN cDNA 9430024F10 gene
chr17_-_45707358 0.594 Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr19_+_7631935 0.594 NM_139269
Pla2g16
phospholipase A2, group XVI
chr17_-_24357560 0.590 NM_028056
1600002H07Rik
RIKEN cDNA 1600002H07 gene
chr7_+_109214226 0.578 NM_011644
Trpc2
transient receptor potential cation channel, subfamily C, member 2
chr6_-_23789048 0.577 Cadps2
Ca2+-dependent activator protein for secretion 2
chr2_+_35111861 0.567 Gsn
gelsolin
chr17_+_34726750 0.564 NM_134116
Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr9_-_54582260 0.563 NM_001025375
NM_001025376
NM_023191
Wdr61


WD repeat domain 61


chr5_+_65194784 0.563 Klf3
Kruppel-like factor 3 (basic)
chr11_+_78139476 0.562 Aldoc
aldolase C, fructose-bisphosphate
chr9_+_85739048 0.558 Tpbg
trophoblast glycoprotein
chr9_-_35007458 0.556 NM_001177847
NM_001177846
NM_054096
Tirap


toll-interleukin 1 receptor (TIR) domain-containing adaptor protein


chrX_-_133527570 0.553 NM_001114179
Mcart6
mitochondrial carrier triple repeat 6
chr16_-_22657245 0.551 Dgkg
diacylglycerol kinase, gamma
chr5_+_145875080 0.549 NM_023142
Arpc1b
actin related protein 2/3 complex, subunit 1B
chr11_-_54846882 0.549 NM_001110211
NM_013472
Anxa6

annexin A6

chr11_-_97521633 0.547 LOC432596
similar to Als2 protein
chr4_+_59594569 0.545 Hsdl2
hydroxysteroid dehydrogenase like 2
chr9_+_37209586 0.545 NM_028783
Robo4
roundabout homolog 4 (Drosophila)
chr5_-_45841382 0.545 NM_024236
Qdpr
quinoid dihydropteridine reductase
chr10_+_127795461 0.545 Cs
citrate synthase
chr13_+_20182408 0.542 Elmo1
engulfment and cell motility 1, ced-12 homolog (C. elegans)
chr11_+_80623859 0.542 NM_029537
Tmem98
transmembrane protein 98
chr4_-_151401689 0.538 Zbtb48
zinc finger and BTB domain containing 48
chr1_+_155756310 0.528 Glul
glutamate-ammonia ligase (glutamine synthetase)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
5.30 5.24e-04 GO:0048878 chemical homeostasis
5.72 1.91e-03 GO:0050801 ion homeostasis
7.35 2.17e-03 GO:0001568 blood vessel development
6.75 4.33e-03 GO:0001944 vasculature development
7.95 4.39e-03 GO:0048514 blood vessel morphogenesis
9.39 5.77e-03 GO:0001525 angiogenesis
1.58 5.78e-03 GO:0065007 biological regulation
64.71 7.06e-03 GO:0022010 central nervous system myelination
64.71 7.06e-03 GO:0032291 axon ensheathment in central nervous system
2.83 9.04e-03 GO:0065008 regulation of biological quality
5.75 1.55e-02 GO:0051093 negative regulation of developmental process
2.42 2.32e-02 GO:0048731 system development
4.81 2.45e-02 GO:0072358 cardiovascular system development
4.81 2.45e-02 GO:0072359 circulatory system development
2.85 2.51e-02 GO:0048583 regulation of response to stimulus
3.70 2.54e-02 GO:0042592 homeostatic process
4.75 2.76e-02 GO:0048646 anatomical structure formation involved in morphogenesis
3.22 3.03e-02 GO:0007399 nervous system development
2.91 3.27e-02 GO:0051239 regulation of multicellular organismal process
5.12 3.82e-02 GO:0006873 cellular ion homeostasis
4.99 4.66e-02 GO:0055082 cellular chemical homeostasis

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.26 5.69e-03 GO:0043234 protein complex
8.73 3.06e-02 GO:0019717 synaptosome

Gene overrepresentation in function category:

enrichment p-value GO term description
1.73 1.28e-02 GO:0005515 protein binding