Motif ID: PAX4.p2

Z-value: 1.286

Transcription factors associated with PAX4.p2:

NameEntrezDescription
Pax4 18506 paired box gene 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Pax4chr6_-_283992480.325.6e-02Click!


Activity profile for motif PAX4.p2.

activity profile for motif PAX4.p2


Sorted Z-values histogram for motif PAX4.p2

Sorted Z-values for motif PAX4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chrM_+_13320 8.904


chr19_+_53214934 8.886 NM_001164099
NM_001164101
Add3

adducin 3 (gamma)

chr8_-_87297283 6.342 Nfix
nuclear factor I/X
chr9_-_58006851 5.839 NM_012043
Islr
immunoglobulin superfamily containing leucine-rich repeat
chrM_+_13543 5.158


chrM_+_13998 5.138


chr2_+_138104219 4.961 NM_145534
Btbd3
BTB (POZ) domain containing 3
chr17_+_70871444 4.728 NM_001128180
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr1_-_83404659 4.510 NM_172430
Sphkap
SPHK1 interactor, AKAP domain containing
chr4_+_97248556 4.462 NM_001122952
Nfia
D130039L10Rik
nuclear factor I/A
RIKEN cDNA D130039L10 gene
chr9_+_37175190 4.362 NM_175189
Hepacam
hepatocyte cell adhesion molecule
chrM_+_14143 4.166


chr10_+_75716647 3.911 S100b
S100 protein, beta polypeptide, neural
chr15_-_78994753 3.902 NM_011437
Sox10
SRY-box containing gene 10
chrM_-_13886 3.701


chr9_+_43851477 3.612 Thy1
thymus cell antigen 1, theta
chr9_-_52484889 3.541 AI593442
expressed sequence AI593442
chrM_+_11027 3.486


chr11_+_78312621 3.445 NM_011707
Vtn
vitronectin
chr17_+_43705510 3.435 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr9_-_91260619 3.383 NM_009573
Zic1
zinc finger protein of the cerebellum 1
chr12_+_110783593 3.364 Meg3
maternally expressed 3
chr6_+_141472906 3.240 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chrM_-_16187 3.196


chr11_-_99105293 3.016 NM_172946
Krt222
keratin 222
chr17_-_90487479 2.948 Nrxn1
neurexin I
chr1_+_155756310 2.839 Glul
glutamate-ammonia ligase (glutamine synthetase)
chr4_+_15808409 2.802 NM_009788
Calb1
calbindin 1
chr5_+_75548337 2.801 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr10_-_80893737 2.682 Nfic
nuclear factor I/C
chr2_-_79296732 2.624 NM_010894
Neurod1
neurogenic differentiation 1
chrX_-_9240025 2.610 NM_025975
Dynlt3
dynein light chain Tctex-type 3
chrM_+_3913 2.585


chr4_+_153516477 2.576 NM_021499
Wdr8
WD repeat domain 8
chr3_-_90318178 2.571 NM_011309
S100a1
S100 calcium binding protein A1
chrM_+_11812 2.561


chr10_-_63552994 2.515 NM_178678
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr18_-_38760921 2.437 NM_011898
Spry4
sprouty homolog 4 (Drosophila)
chr3_+_90341208 2.429 S100a16
S100 calcium binding protein A16
chr6_+_113433507 2.422 NM_133930
Creld1
cysteine-rich with EGF-like domains 1
chr5_-_121459496 2.276 NM_011286
Rph3a
rabphilin 3A
chr19_+_28909559 2.255 NM_009199
Slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr18_+_36441115 2.251 Pura
purine rich element binding protein A
chr9_-_112137285 2.220 NM_001177619
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr1_-_53841997 2.195 NM_133810
Stk17b
serine/threonine kinase 17b (apoptosis-inducing)
chr10_-_127986187 2.078 NM_018860
Rpl41
ribosomal protein L41
chr2_-_147011990 2.019 NM_001077632
NM_010919
Nkx2-2

NK2 transcription factor related, locus 2 (Drosophila)

chr15_-_78034648 1.979 Pvalb
parvalbumin
chr4_-_151665770 1.961 NM_008237
Hes3
hairy and enhancer of split 3 (Drosophila)
chr15_+_99556127 1.937 2310016M24Rik
RIKEN cDNA 2310016M24 gene
chr16_-_36666078 1.912 NM_019388
Cd86
CD86 antigen
chr6_+_134874663 1.906 Cdkn1b
cyclin-dependent kinase inhibitor 1B
chr12_-_91976586 1.906 NM_010050
Dio2
deiodinase, iodothyronine, type II
chr10_+_75716580 1.896 NM_009115
S100b
S100 protein, beta polypeptide, neural
chr10_-_76086045 1.891 Col6a2
collagen, type VI, alpha 2
chr5_+_91201521 1.870 Pf4
platelet factor 4
chr5_-_123582394 1.861 Rhof
ras homolog gene family, member f
chr18_-_64676090 1.775 Nars
asparaginyl-tRNA synthetase
chr10_+_21714491 1.761 Sgk1
serum/glucocorticoid regulated kinase 1
chr17_+_43705388 1.745 NM_013737
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chrM_+_11741 1.743 ND5
NADH dehydrogenase subunit 5
chrX_+_138662725 1.687 NM_172782
Nxt2
nuclear transport factor 2-like export factor 2
chr11_-_69761489 1.667 NM_009204
Slc2a4
solute carrier family 2 (facilitated glucose transporter), member 4
chr15_+_33012972 1.631 Pgcp
plasma glutamate carboxypeptidase
chr19_+_46471385 1.623 NM_001025391
NM_015752
Sufu

suppressor of fused homolog (Drosophila)

chr11_+_121296252 1.595 NM_001038699
NM_022014
Fn3k

fructosamine 3 kinase

chr3_+_87723608 1.592 Mrpl24
mitochondrial ribosomal protein L24
chr11_+_54128404 1.563 NM_001033599
Acsl6
acyl-CoA synthetase long-chain family member 6
chr2_+_153171730 1.534 NM_001039939
Asxl1
additional sex combs like 1 (Drosophila)
chr2_+_158492854 1.523 NM_001159662
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr11_-_106642357 1.522 Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr15_-_78034565 1.517 NM_013645
Pvalb
parvalbumin
chr4_-_82150687 1.491 Nfib
nuclear factor I/B
chr7_+_51502089 1.475 NM_025880
2410002F23Rik
RIKEN cDNA 2410002F23 gene
chrX_-_20194385 1.469 Ndufb11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11
chr7_-_91234908 1.457 NM_030728
9930013L23Rik
RIKEN cDNA 9930013L23 gene
chr15_-_34608458 1.453 NM_145469
Nipal2
NIPA-like domain containing 2
chr2_+_125860377 1.448 NM_008008
Fgf7
fibroblast growth factor 7
chrM_+_3844 1.442


chrM_-_14069 1.432 ND6
NADH dehydrogenase subunit 6
chr5_-_138042267 1.412 NM_030037
Mospd3
motile sperm domain containing 3
chr4_+_130469187 1.395 NM_010686
Laptm5
lysosomal-associated protein transmembrane 5
chr10_+_78243274 1.392 Slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr13_+_21809496 1.363 NM_178206
Hist1h3h
histone cluster 1, H3h
chr9_-_91260597 1.355 Zic1
zinc finger protein of the cerebellum 1
chr3_+_95733228 1.352 Anp32e
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr3_+_96361879 1.352 NM_001009935
NM_023719
Txnip

thioredoxin interacting protein

chr6_-_126114938 1.342 NM_001164035
Ntf3
neurotrophin 3
chr12_+_81744869 1.334 Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr19_+_4100914 1.310 Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr16_+_96689322 1.297


chr10_+_77532065 1.287 NM_015790
Icosl
icos ligand
chr10_+_97028409 1.286 Lum
lumican
chr7_-_119301920 1.276 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr17_+_35195979 1.264 NM_001190449
NM_016765
Ddah2

dimethylarginine dimethylaminohydrolase 2

chr10_+_21714471 1.258 NM_011361
Sgk1
serum/glucocorticoid regulated kinase 1
chr2_-_144096164 1.256 Snx5
sorting nexin 5
chr7_+_19576593 1.246 NM_145579
Mypop
Myb-related transcription factor, partner of profilin
chr8_-_47292863 1.233


chr16_+_31428887 1.224 Bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr6_-_131338282 1.222 Csda
cold shock domain protein A
chr11_+_22872062 1.209 Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr9_+_43851466 1.201 NM_009382
Thy1
thymus cell antigen 1, theta
chr10_+_87321789 1.191 NM_001111275
NM_010512
Igf1

insulin-like growth factor 1

chr11_+_70460758 1.186 Rnf167
ring finger protein 167
chr11_-_109334465 1.181 NM_134038
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr2_-_84490666 1.176 NM_001085453
Ctnnd1
catenin (cadherin associated protein), delta 1
chr14_-_104243541 1.171 Ednrb
endothelin receptor type B
chr4_+_126698539 1.168 NM_023603
Sfpq
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr3_+_89240625 1.151 NM_146131
Pbxip1
pre-B-cell leukemia transcription factor interacting protein 1
chr6_-_136752898 1.148 NM_175652
Hist4h4
histone cluster 4, H4
chr2_-_102741483 1.142 Cd44
CD44 antigen
chr5_+_145888588 1.129 Arpc1b
actin related protein 2/3 complex, subunit 1B
chr11_+_94797565 1.102 NM_007742
Col1a1
collagen, type I, alpha 1
chr17_-_66121883 1.096 NM_133685
Rab31
RAB31, member RAS oncogene family
chr11_+_100277007 1.096 NM_001163481
NM_010221
Fkbp10

FK506 binding protein 10

chr1_-_133964485 1.084 Mfsd4
major facilitator superfamily domain containing 4
chr1_+_63492447 1.077 NM_001177600
NM_011780
Adam23

a disintegrin and metallopeptidase domain 23

chr3_+_121426422 1.076 NM_010171
F3
coagulation factor III
chr7_-_135137189 1.073 Pycard
PYD and CARD domain containing
chr7_-_87857062 1.066


chr11_+_92960603 1.043 NM_028296
Car10
carbonic anhydrase 10
chr9_+_92352215 1.027 NM_178711
Plscr4
phospholipid scramblase 4
chr17_-_23782209 1.007 NM_001033339
Mmp25
matrix metallopeptidase 25
chr10_-_79209301 0.979 NM_172551
Polrmt
polymerase (RNA) mitochondrial (DNA directed)
chr5_-_120953567 0.967 NM_023625
Plbd2
phospholipase B domain containing 2
chr11_+_92959670 0.959 Car10
carbonic anhydrase 10
chr1_-_67085155 0.951 Lancl1
LanC (bacterial lantibiotic synthetase component C)-like 1
chr17_+_35196041 0.949 Ddah2
dimethylarginine dimethylaminohydrolase 2
chr12_-_11443284 0.947 NM_012038
Vsnl1
visinin-like 1
chrM_+_3320 0.939


chr19_+_4099973 0.936 NM_001136078
Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr18_+_21159829 0.934 NM_019706
NM_207623
Rnf138

ring finger protein 138

chr16_-_4559511 0.925 NM_031182
Tcfap4
transcription factor AP4
chr5_+_44260035 0.919 NM_007646
Cd38
CD38 antigen
chr14_-_30534966 0.908 NM_009785
Cacna2d3
calcium channel, voltage-dependent, alpha2/delta subunit 3
chr2_+_174167321 0.903


chrX_-_20194364 0.888 Ndufb11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11
chr5_+_124889925 0.886 NM_030241
Setd8
SET domain containing (lysine methyltransferase) 8
chr8_+_107951514 0.875 NM_001033371
NM_001170789
Lrrc36

leucine rich repeat containing 36

chr19_-_10557362 0.873 NM_133689
4930579J09Rik
RIKEN cDNA 4930579J09 gene
chr10_+_101974855 0.869 NM_146240
Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr11_-_119908236 0.864 NM_001198785
NM_007377
Aatk

apoptosis-associated tyrosine kinase

chr4_+_130168140 0.864 Nkain1
Na+/K+ transporting ATPase interacting 1
chr10_-_30375572 0.857 NM_001111267
Ncoa7
nuclear receptor coactivator 7
chr5_-_115140869 0.853 NM_019821
Gltp
glycolipid transfer protein
chr19_+_4125894 0.851 NM_001078649
NM_025889
Tmem134

transmembrane protein 134

chr18_+_61715202 0.849 NM_146087
Csnk1a1
casein kinase 1, alpha 1
chr7_-_112900699 0.847 NM_009906
Tpp1
tripeptidyl peptidase I
chr8_-_88063071 0.847


chr7_-_53435334 0.843 NM_011510
Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr12_-_88541151 0.830 NM_001033475
Tmed8
transmembrane emp24 domain containing 8
chr19_-_6015778 0.826 NM_001110504
Capn1
calpain 1
chr1_-_80272987 0.819


chr6_-_60779848 0.800 NM_009221
Snca
synuclein, alpha
chr9_-_57006034 0.799 NM_025417
Commd4
COMM domain containing 4
chr11_+_98769162 0.796 NM_001025779
Cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr3_+_137806778 0.791 2010015P12Rik
RIKEN cDNA 2010015P12 gene
chr7_-_24993103 0.784 NM_019940
Zfp111
zinc finger protein 111
chr8_-_47292973 0.781 Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr2_-_163470826 0.773 Serinc3
serine incorporator 3
chr3_-_116671869 0.772 NM_023245
Palmd
palmdelphin
chr8_-_113329771 0.770 NM_001135100
NM_029646
Il34

interleukin 34

chr5_+_118292144 0.765 Nos1
nitric oxide synthase 1, neuronal
chr10_+_80720191 0.761 Matk
megakaryocyte-associated tyrosine kinase
chr13_-_22133203 0.753 NM_175656
Hist1h4i
histone cluster 1, H4i
chrX_+_20271802 0.752 Cdk16
cyclin-dependent kinase 16
chr19_+_8692485 0.745 NM_008766
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr3_+_32428424 0.742 Mfn1
mitofusin 1
chr14_+_60997104 0.735 NM_001164705
NM_028113
Fam123a

family with sequence similarity 123, member A

chr19_+_37450854 0.734 NM_010615
Kif11
kinesin family member 11
chr16_-_18426446 0.731 Comt
catechol-O-methyltransferase
chr17_+_53706556 0.730 Kat2b
K(lysine) acetyltransferase 2B
chr15_+_78427476 0.729 NM_028195
Cyth4
cytohesin 4
chr2_-_37502738 0.726 NM_009261
Strbp
spermatid perinuclear RNA binding protein
chr15_-_98593505 0.726 NM_007478
Arf3
ADP-ribosylation factor 3
chr5_-_143665474 0.722


chrX_+_20374922 0.718 Araf
v-raf murine sarcoma 3611 viral oncogene homolog
chr12_-_32893074 0.718 NM_001146201
NM_020272
NM_001146200
Pik3cg


phosphoinositide-3-kinase, catalytic, gamma polypeptide


chr13_-_23790310 0.717 NM_178208
Hist1h4c
histone cluster 1, H4c
chr4_+_98590565 0.716 Usp1
ubiquitin specific peptidase 1
chr19_+_7631935 0.711 NM_139269
Pla2g16
phospholipase A2, group XVI
chr15_+_78757148 0.707 NM_008495
Lgals1
lectin, galactose binding, soluble 1
chr1_-_74982118 0.707 NM_001039495
Ccdc108
coiled-coil domain containing 108
chr16_-_4879787 0.702 NM_145359
Fam100a
family with sequence similarity 100, member A
chr5_-_104450856 0.697 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr16_+_45158943 0.697 Atg3
autophagy-related 3 (yeast)
chr12_-_88488272 0.694 Pomt2
protein-O-mannosyltransferase 2
chr4_-_63707964 0.692 Tnc
tenascin C
chr14_+_60997156 0.683 Fam123a
family with sequence similarity 123, member A
chr5_+_75548309 0.661 NM_011058
Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr11_+_120094240 0.656 NM_198423
Bahcc1
BAH domain and coiled-coil containing 1
chr13_-_30637108 0.655 NM_025710
Uqcrfs1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr8_-_113824073 0.653 NM_146218
Rfwd3
ring finger and WD repeat domain 3
chr7_-_4704436 0.652 NM_183406
NM_183405
Cox6b2

cytochrome c oxidase subunit VIb polypeptide 2

chr4_+_138012860 0.646 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr15_-_82074765 0.641 NM_001080158
Cenpm
centromere protein M
chr17_-_10512217 0.639 NM_001159516
NM_001159517
NM_021881
Qk


quaking


chr1_-_165242744 0.632 Prrx1
paired related homeobox 1
chr7_-_105509797 0.632 NM_001024619
NM_001168540
NM_001168541
NM_001168539
Tsku



tsukushin




Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
2.68 5.90e-05 GO:0048522 positive regulation of cellular process
4.27 1.03e-04 GO:2000026 regulation of multicellular organismal development
2.48 2.03e-04 GO:0048518 positive regulation of biological process
3.25 2.24e-04 GO:0051239 regulation of multicellular organismal process
3.64 1.09e-03 GO:0050793 regulation of developmental process
2.62 1.22e-03 GO:0048523 negative regulation of cellular process
5.99 1.38e-03 GO:0051960 regulation of nervous system development
2.48 2.22e-03 GO:0048519 negative regulation of biological process
2.26 5.89e-03 GO:0009889 regulation of biosynthetic process
1.97 6.49e-03 GO:0019222 regulation of metabolic process
3.43 9.28e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
26.17 9.83e-03 GO:0048483 autonomic nervous system development
2.35 9.86e-03 GO:0048731 system development
3.79 1.10e-02 GO:0009890 negative regulation of biosynthetic process
2.26 1.30e-02 GO:0010556 regulation of macromolecule biosynthetic process
2.21 1.32e-02 GO:0031326 regulation of cellular biosynthetic process
196.19 1.63e-02 GO:0003312 pancreatic PP cell differentiation
196.19 1.63e-02 GO:0003326 pancreatic A cell fate commitment
196.19 1.63e-02 GO:0003329 pancreatic PP cell fate commitment
196.19 1.63e-02 GO:0045653 negative regulation of megakaryocyte differentiation
5.05 1.79e-02 GO:0060284 regulation of cell development
1.99 1.86e-02 GO:0031323 regulation of cellular metabolic process
2.02 2.03e-02 GO:0060255 regulation of macromolecule metabolic process
2.82 2.03e-02 GO:0009893 positive regulation of metabolic process
45.28 2.23e-02 GO:0048484 enteric nervous system development
2.90 2.36e-02 GO:0010604 positive regulation of macromolecule metabolic process
5.48 2.47e-02 GO:0050767 regulation of neurogenesis
3.73 2.70e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
2.85 3.01e-02 GO:0031325 positive regulation of cellular metabolic process
3.61 3.78e-02 GO:0031327 negative regulation of cellular biosynthetic process
2.49 4.76e-02 GO:0048513 organ development

Gene overrepresentation in compartment category:

enrichment p-value GO term description
1.36 1.11e-02 GO:0044424 intracellular part
1.21 1.45e-02 GO:0005623 cell
1.21 1.45e-02 GO:0044464 cell part
1.34 2.50e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment p-value GO term description
1.65 1.58e-02 GO:0005515 protein binding
3.14 1.84e-02 GO:0030528 transcription regulator activity
98.10 2.09e-02 GO:0048154 S100 beta binding
3.92 3.16e-02 GO:0005509 calcium ion binding
3.11 3.56e-02 GO:0019899 enzyme binding
4.77 3.76e-02 GO:0016563 transcription activator activity