Motif ID: PBX1.p2

Z-value: 0.862

Transcription factors associated with PBX1.p2:

NameEntrezDescription
Pbx1 18514 pre B-cell leukemia transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Pbx1chr1_-_1703622440.618.7e-05Click!


Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr7_-_56892061 9.897 NM_001005232
Dbx1
developing brain homeobox 1
chr18_-_77285981 4.100 Katnal2
katanin p60 subunit A-like 2
chr18_-_77286034 4.085 NM_027721
Katnal2
katanin p60 subunit A-like 2
chr13_-_23775827 3.481 NM_178189
Hist1h2ac
histone cluster 1, H2ac
chr2_-_172195998 3.447 NM_011497
Aurka
aurora kinase A
chr13_+_23666249 3.174 NM_178188
Hist1h2ad
Hist1h2ai
histone cluster 1, H2ad
histone cluster 1, H2ai
chr13_+_23855536 3.010 NM_030609
Hist1h1a
histone cluster 1, H1a
chr13_+_23776066 3.001 NM_023422
Hist1h2bc
histone cluster 1, H2bc
chr2_+_164595415 2.966 NM_026785
Ube2c
ubiquitin-conjugating enzyme E2C
chr18_-_75120759 2.946 NM_010720
Lipg
lipase, endothelial
chrX_+_166317553 2.924 NM_183151
Mid1
midline 1
chr8_-_4779533 2.900 NM_011369
Shcbp1
Shc SH2-domain binding protein 1
chr13_-_23666058 2.842 NM_178195
Hist1h2bf
histone cluster 1, H2bf
chr1_-_170362244 2.632 Pbx1
pre B-cell leukemia transcription factor 1
chr13_-_72101161 2.559 NM_010573
Irx1
Iroquois related homeobox 1 (Drosophila)
chr3_+_102799658 2.497 NM_025679
Sike1
suppressor of IKBKE 1
chr4_+_132324212 2.351 NM_011284
Rpa2
replication protein A2
chr19_-_9973901 2.301 NM_016692
Incenp
inner centromere protein
chr15_-_79604806 2.287 NM_017470
Dnalc4
dynein, axonemal, light chain 4
chr13_-_21808011 2.256 NM_178199
Hist1h2bl
histone cluster 1, H2bl
chr14_-_48037815 2.219 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr4_+_140257340 2.207 NM_173867
Rcc2
regulator of chromosome condensation 2
chr3_+_90097269 2.191 Gatad2b
GATA zinc finger domain containing 2B
chr9_+_109778051 2.188 NM_007658
Cdc25a
cell division cycle 25 homolog A (S. pombe)
chr9_+_65738129 2.110 NM_026515
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chrX_+_97972559 2.081 NM_001177780
Dlg3
discs, large homolog 3 (Drosophila)
chr8_-_86760940 2.033 NM_172503
Zswim4
zinc finger, SWIM domain containing 4
chr5_-_138613028 2.010 NM_008568
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr16_-_15637390 1.994 NM_008565
Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr6_+_34426352 1.969 NM_007563
Bpgm
2,3-bisphosphoglycerate mutase
chr1_-_45559904 1.938 Col5a2
collagen, type V, alpha 2
chr9_-_119231439 1.919 Oxsr1
oxidative-stress responsive 1
chr13_+_23627286 1.918 NM_145073
Hist1h3g
histone cluster 1, H3g
chr1_-_170362278 1.912 Pbx1
pre B-cell leukemia transcription factor 1
chr5_-_111268743 1.912 NM_153571
Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr7_+_3581586 1.890 NM_001159714
NM_027328
Prpf31

PRP31 pre-mRNA processing factor 31 homolog (yeast)

chr6_-_115803305 1.886 NM_010774
Mbd4
methyl-CpG binding domain protein 4
chr6_-_52114644 1.873 NM_010451
Hoxa2
homeobox A2
chr1_+_138521477 1.869 NM_001160251
NM_177643
Zfp281

zinc finger protein 281

chr6_+_34426324 1.813 Bpgm
2,3-bisphosphoglycerate mutase
chr17_+_7374435 1.797 NM_011299
Rps6ka2
ribosomal protein S6 kinase, polypeptide 2
chr2_-_69044179 1.780 NM_025565
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_+_113840232 1.760 Ubp1
upstream binding protein 1
chr3_-_96024766 1.756 NM_175662
Hist2h2ac
histone cluster 2, H2ac
chr13_-_21872421 1.716 NM_020034
Hist1h1b
histone cluster 1, H1b
chr4_-_71861922 1.707 Tle1
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
chr9_-_100446444 1.664 NM_010878
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr11_-_115674905 1.662 NM_080643
Caskin2
CASK-interacting protein 2
chr19_-_41818111 1.654 Slit1
slit homolog 1 (Drosophila)
chr13_+_23646900 1.647 NM_145713
Hist1h1d
histone cluster 1, H1d
chr2_+_164595447 1.600 Ube2c
ubiquitin-conjugating enzyme E2C
chr5_+_111269020 1.574 NM_016681
Chek2
CHK2 checkpoint homolog (S. pombe)
chr3_+_89019126 1.562 Thbs3
thrombospondin 3
chr1_-_176851949 1.547 NM_011825
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr3_+_32607582 1.514 Actl6a
actin-like 6A
chr13_-_23854226 1.490 NM_013550
Hist1h3a
histone cluster 1, H3a
chr13_-_23790310 1.474 NM_178208
Hist1h4c
histone cluster 1, H4c
chr3_-_94846454 1.461 NM_008951
Psmd4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
chr9_-_65972570 1.443 NM_019727
Snx1
sorting nexin 1
chr6_+_83276009 1.438 NM_145571
Mobkl1b
MOB1, Mps One Binder kinase activator-like 1B (yeast)
chr12_+_86114195 1.389 NM_028863
Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr7_-_28835041 1.387 NM_011874
Psmc4
proteasome (prosome, macropain) 26S subunit, ATPase, 4
chr6_-_39370221 1.385 Mkrn1
makorin, ring finger protein, 1
chr15_-_26825266 1.347 NM_176959
Fbxl7
F-box and leucine-rich repeat protein 7
chr15_+_21041206 1.298 NM_001008420
Cdh12
cadherin 12
chr2_-_53937785 1.295 NM_023396
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr13_-_23654226 1.281 NM_178205
Hist1h3e
histone cluster 1, H3e
chr7_-_125676764 1.276 Coq7
demethyl-Q 7
chr2_-_174120889 1.272 Nespas
neuroendocrine secretory protein antisense
chr9_+_44142772 1.250 NM_010436
H2afx
H2A histone family, member X
chr3_+_96073622 1.222 NM_175666
Hist2h2bb
histone cluster 2, H2bb
chr2_-_25080160 1.218 Tubb2c
tubulin, beta 2C
chr8_-_107995282 1.217 NM_026481
Tppp3
tubulin polymerization-promoting protein family member 3
chr2_-_3430013 1.217 NM_015765
Hspa14
heat shock protein 14
chr15_+_102236709 1.217 NM_013672
Sp1
trans-acting transcription factor 1
chr4_-_129318200 1.215 Txlna
taxilin alpha
chr13_+_21879356 1.207 NM_178202
Hist1h2bp
histone cluster 1, H2bp
chr1_-_45559700 1.205 Col5a2
collagen, type V, alpha 2
chr8_+_108424267 1.199 NM_173432
Pskh1
protein serine kinase H1
chrX_-_58146562 1.168 NM_009237
Sox3
SRY-box containing gene 3
chr19_+_45225176 1.150 NM_021901
Tlx1
T-cell leukemia, homeobox 1
chr5_-_115608153 1.139 NM_175403
Mlec
malectin
chr6_+_125045998 1.131 NM_145979
Chd4
chromodomain helicase DNA binding protein 4
chr9_-_13631432 1.126 Cep57
centrosomal protein 57
chr2_-_115890747 1.122 NM_001136072
NM_001159567
NM_001159568
NM_010825
Meis2



Meis homeobox 2



chr4_-_142752030 1.121 Prdm2
PR domain containing 2, with ZNF domain
chr2_-_155652383 1.113 Eif6
eukaryotic translation initiation factor 6
chr4_-_62815137 1.110 NM_007443
Ambp
alpha 1 microglobulin/bikunin
chr9_-_13631482 1.097 NM_026665
Cep57
centrosomal protein 57
chr2_+_144381976 1.072 NM_019787
Sec23b
SEC23B (S. cerevisiae)
chr11_+_115794942 1.070 NM_020483
Sap30bp
SAP30 binding protein
chr11_+_103635438 1.064 NM_009521
Wnt3
wingless-related MMTV integration site 3
chr11_-_120434181 1.058 P4hb
prolyl 4-hydroxylase, beta polypeptide
chr2_+_164595389 1.057 Ube2c
ubiquitin-conjugating enzyme E2C
chr1_-_191511950 1.034 NM_001081363
Cenpf
centromere protein F
chr3_-_127256215 1.030 NM_138593
Larp7
La ribonucleoprotein domain family, member 7
chr15_-_83295010 1.025 NM_001159509
Pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr11_-_96691198 0.999 Nfe2l1
nuclear factor, erythroid derived 2,-like 1
chr17_-_25864310 0.994 NM_145409
Chtf18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr7_-_125676808 0.979 Coq7
demethyl-Q 7
chr2_-_84615535 0.952 NM_009776
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr3_-_100773571 0.950 NM_001013026
Ttf2
transcription termination factor, RNA polymerase II
chr14_+_47451869 0.946 NM_026832
Cgrrf1
cell growth regulator with ring finger domain 1
chr16_+_36828464 0.928 NM_177128
Iqcb1
IQ calmodulin-binding motif containing 1
chr8_+_109459623 0.911 NM_009229
Sntb2
syntrophin, basic 2
chr5_-_123271283 0.907 NM_001042491
NM_021505
Anapc5

anaphase-promoting complex subunit 5

chrX_+_98624989 0.897 NM_023144
Nono
non-POU-domain-containing, octamer binding protein
chr9_+_4376532 0.895 8430410K20Rik
RIKEN cDNA 8430410K20 gene
chr10_-_67741461 0.885 NM_023598
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr5_+_116295259 0.864 Cit
citron
chr11_+_55283201 0.856 NM_013716
G3bp1
Ras-GTPase-activating protein SH3-domain binding protein 1
chr11_+_108781661 0.834 NM_015732
Axin2
axin2
chr2_-_80287218 0.828 Frzb
frizzled-related protein
chr19_-_8893759 0.826 NM_027412
Ttc9c
tetratricopeptide repeat domain 9C
chr11_-_120434075 0.824 P4hb
prolyl 4-hydroxylase, beta polypeptide
chr15_-_96529998 0.816 NM_175121
Slc38a2
solute carrier family 38, member 2
chr12_+_109572514 0.812 NM_010010
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr2_-_164705231 0.804 4930445K14Rik
RIKEN cDNA 4930445K14 gene
chr7_+_82600419 0.795 NM_029332
Akap13
A kinase (PRKA) anchor protein 13
chr13_-_23837389 0.778 NM_175653
Hist1h3c
histone cluster 1, H3c
chr5_+_100947327 0.764 NM_012001
Cops4
COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
chr8_+_59990639 0.758 NM_008252
Hmgb2
high mobility group box 2
chr4_+_95633972 0.751 Hook1
hook homolog 1 (Drosophila)
chr11_+_87895626 0.743 Vezf1
vascular endothelial zinc finger 1
chr12_-_86113948 0.732 NM_023409
Npc2
Niemann Pick type C2
chr15_-_99200868 0.732 NM_011711
Fmnl3
formin-like 3
chr11_-_40568710 0.720 NM_009831
Ccng1
cyclin G1
chr12_-_81213930 0.719 NM_007564
Zfp36l1
zinc finger protein 36, C3H type-like 1
chr5_+_100947447 0.709 Cops4
COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
chr3_-_27052733 0.708 NM_001177625
NM_007900
Ect2

ect2 oncogene

chrX_+_19941606 0.707 NM_133669
Rp2h
retinitis pigmentosa 2 homolog (human)
chr12_-_103196366 0.706 NM_001167914
NM_029705
Atxn3

ataxin 3

chr12_+_77471506 0.704 Zbtb1
zinc finger and BTB domain containing 1
chr6_-_41654290 0.697 NM_032540
Kel
Kell blood group
chr12_-_86113816 0.693 Npc2
Niemann Pick type C2
chr1_-_128634766 0.693 Nckap5
NCK-associated protein 5
chr7_+_117205194 0.692 NM_009281
Zfp143
zinc finger protein 143
chr6_+_34426288 0.692 Bpgm
2,3-bisphosphoglycerate mutase
chr2_-_165980462 0.688 Sulf2
sulfatase 2
chr5_-_89886732 0.688 NM_008096
Gc
group specific component
chr13_-_120197722 0.678 NM_008710
Nnt
nicotinamide nucleotide transhydrogenase
chr6_+_17699145 0.675 NM_001083315
NM_022332
St7

suppression of tumorigenicity 7

chr6_-_8209105 0.671 Rpa3
replication protein A3
chr14_-_104243474 0.670 Ednrb
endothelin receptor type B
chr5_-_46248719 0.662 NM_001163073
NM_178142
Lcorl

ligand dependent nuclear receptor corepressor-like

chr1_+_58052814 0.661 NM_199007
Sgol2
shugoshin-like 2 (S. pombe)
chr2_+_119853216 0.658 NM_001114637
Pla2g4b
Jmjd7
phospholipase A2, group IVB (cytosolic)
jumonji domain containing 7
chr1_-_170362388 0.655 NM_008783
NM_183355
Pbx1

pre B-cell leukemia transcription factor 1

chr16_+_30065419 0.650 NM_008235
Hes1
hairy and enhancer of split 1 (Drosophila)
chr15_-_24957039 0.649 Gm2824
predicted gene 2824
chr6_+_64679118 0.646 NM_007500
Atoh1
atonal homolog 1 (Drosophila)
chr11_-_97023157 0.644 Kpnb1
karyopherin (importin) beta 1
chr2_+_164705533 0.638


chr13_+_21809496 0.635 NM_178206
Hist1h3h
histone cluster 1, H3h
chr4_-_22415444 0.624 Pou3f2
POU domain, class 3, transcription factor 2
chr14_-_31942057 0.622 2010107H07Rik
RIKEN cDNA 2010107H07 gene
chr3_-_65196395 0.621 NM_026155
Ssr3
signal sequence receptor, gamma
chr19_-_14672540 0.614 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr4_-_3865501 0.612 NM_019969
Plag1
pleiomorphic adenoma gene 1
chr11_+_59021811 0.611 NM_024210
2310033P09Rik
RIKEN cDNA 2310033P09 gene
chr18_+_85020742 0.602 Cyb5
cytochrome b-5
chr1_+_93146860 0.598 NM_026454
Ube2f
ubiquitin-conjugating enzyme E2F (putative)
chr9_+_110558996 0.592 NM_028312
Ccdc12
coiled-coil domain containing 12
chr3_-_95622554 0.584 NM_001081293
Rprd2
regulation of nuclear pre-mRNA domain containing 2
chr8_-_86628606 0.584 NM_172502
Dcaf15
DDB1 and CUL4 associated factor 15
chr11_+_103828032 0.574 Arf2
ADP-ribosylation factor 2
chr7_+_80536124 0.574 Rgma
RGM domain family, member A
chr11_-_50105794 0.574 NM_175334
Maml1
mastermind like 1 (Drosophila)
chr11_+_75300330 0.565 Prpf8
pre-mRNA processing factor 8
chr1_-_120950111 0.563 NM_001081125
Gli2
GLI-Kruppel family member GLI2
chr3_+_66789621 0.563 Rsrc1
arginine/serine-rich coiled-coil 1
chr9_+_56924152 0.562 NM_001110350
NM_011378
Sin3a

transcriptional regulator, SIN3A (yeast)

chr12_+_66176588 0.557 NM_178912
Fancm
Fanconi anemia, complementation group M
chr8_-_107995252 0.552 Tppp3
tubulin polymerization-promoting protein family member 3
chr4_+_124428773 0.549 Inpp5b
inositol polyphosphate-5-phosphatase B
chr5_-_73647814 0.546 Fryl
furry homolog-like (Drosophila)
chr3_-_127256181 0.546 Larp7
La ribonucleoprotein domain family, member 7
chr11_-_106860803 0.538 NM_010655
Kpna2
karyopherin (importin) alpha 2
chr18_+_67959756 0.538 NM_027556
Cep192
centrosomal protein 192
chr17_+_47027617 0.538 Tbcc
tubulin-specific chaperone C
chr13_+_23663264 0.535 NM_178196
Hist1h2bg
histone cluster 1, H2bg
chr7_+_29595894 0.534 NM_177301
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr9_+_37015872 0.530 NM_025464
Tmem218
transmembrane protein 218
chr19_-_4811507 0.528 NM_019869
Rbm4
Rbm14
RNA binding motif protein 4
RNA binding motif protein 14
chr13_-_23663006 0.518 NM_178187
Hist1h2ae
histone cluster 1, H2ae
chr3_+_127256406 0.516 NM_197997
4930422G04Rik
RIKEN cDNA 4930422G04 gene
chrX_-_137491205 0.512 NM_001164177
NM_016883
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr3_+_96404978 0.510 NM_001163170
Lix1l
Lix1-like
chr16_+_14705932 0.506 NM_011415
Snai2
snail homolog 2 (Drosophila)
chr4_-_129317873 0.502 NM_001005506
Txlna
taxilin alpha
chr4_-_129318264 0.498 Txlna
taxilin alpha
chr5_-_73647663 0.495 Fryl
furry homolog-like (Drosophila)
chr8_+_113557763 0.494 NM_146217
Aars
alanyl-tRNA synthetase
chr6_-_98978185 0.494 NM_001197322
Foxp1
forkhead box P1
chr11_+_96212945 0.492 NM_134032
Hoxb2
homeobox B2
chr12_-_32398730 0.487 NM_175191
Gpr22
G protein-coupled receptor 22
chr17_-_47147441 0.487 NM_001177374
NM_146078
Ubr2

ubiquitin protein ligase E3 component n-recognin 2

chr13_-_104564553 0.485 Srsf12
serine/arginine-rich splicing factor 12
chr14_+_105658063 0.484 Ndfip2
Nedd4 family interacting protein 2
chr12_-_119539840 0.481 Sp4
trans-acting transcription factor 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
17.22 8.32e-06 GO:0071103 DNA conformation change
28.15 2.78e-05 GO:0006334 nucleosome assembly
25.14 5.58e-05 GO:0031497 chromatin assembly
24.70 6.21e-05 GO:0034728 nucleosome organization
24.27 6.90e-05 GO:0065004 protein-DNA complex assembly
8.70 8.84e-05 GO:0034622 cellular macromolecular complex assembly
23.08 9.38e-05 GO:0071824 protein-DNA complex subunit organization
22.35 1.14e-04 GO:0006333 chromatin assembly or disassembly
6.95 1.99e-04 GO:0000278 mitotic cell cycle
5.50 2.38e-04 GO:0022402 cell cycle process
7.70 2.71e-04 GO:0034621 cellular macromolecular complex subunit organization
4.60 2.86e-04 GO:0007049 cell cycle
2.82 7.15e-04 GO:0071842 cellular component organization at cellular level
16.19 7.81e-04 GO:0006323 DNA packaging
2.68 1.79e-03 GO:0071841 cellular component organization or biogenesis at cellular level
8.39 2.05e-03 GO:0000087 M phase of mitotic cell cycle
5.66 4.21e-03 GO:0022403 cell cycle phase
3.15 4.49e-03 GO:0006996 organelle organization
6.37 4.76e-03 GO:0000279 M phase
4.75 7.61e-03 GO:0071844 cellular component assembly at cellular level
2.28 1.17e-02 GO:0016043 cellular component organization
4.28 1.98e-02 GO:0043933 macromolecular complex subunit organization
2.19 2.51e-02 GO:0071840 cellular component organization or biogenesis
1.35 3.72e-02 GO:0009987 cellular process
4.23 4.98e-02 GO:0065003 macromolecular complex assembly

Gene overrepresentation in compartment category:

enrichment p-value GO term description
24.06 1.19e-07 GO:0032993 protein-DNA complex
8.02 1.55e-07 GO:0044427 chromosomal part
2.24 3.85e-07 GO:0005634 nucleus
7.41 4.28e-07 GO:0005694 chromosome
28.73 5.12e-06 GO:0000786 nucleosome
2.26 1.23e-05 GO:0044422 organelle part
1.54 1.26e-05 GO:0044424 intracellular part
2.25 2.45e-05 GO:0044446 intracellular organelle part
1.51 3.40e-05 GO:0005622 intracellular
2.40 5.69e-05 GO:0032991 macromolecular complex
1.58 1.43e-04 GO:0043226 organelle
8.95 2.65e-04 GO:0000785 chromatin
1.56 3.68e-04 GO:0043229 intracellular organelle
2.56 5.04e-04 GO:0043228 non-membrane-bounded organelle
2.56 5.04e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.59 1.18e-03 GO:0043227 membrane-bounded organelle
7.12 1.41e-03 GO:0005874 microtubule
4.68 1.84e-03 GO:0015630 microtubule cytoskeleton
1.56 2.83e-03 GO:0043231 intracellular membrane-bounded organelle
3.41 4.40e-03 GO:0005654 nucleoplasm
2.89 5.01e-03 GO:0031981 nuclear lumen
3.43 7.88e-03 GO:0044430 cytoskeletal part
10.39 1.05e-02 GO:0005819 spindle
93.82 1.57e-02 GO:0042555 MCM complex
78.18 2.35e-02 GO:0031616 spindle pole centrosome
2.51 2.81e-02 GO:0070013 intracellular organelle lumen
2.51 2.87e-02 GO:0043233 organelle lumen
2.46 3.64e-02 GO:0031974 membrane-enclosed lumen
2.05 4.04e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

enrichment p-value GO term description
3.06 1.04e-04 GO:0003677 DNA binding
2.48 4.56e-04 GO:0003676 nucleic acid binding
1.44 1.17e-03 GO:0005488 binding