Motif ID: RREB1.p2

Z-value: 0.998

Transcription factors associated with RREB1.p2:

NameEntrezDescription
Rreb1 68750 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Rreb1chr13_+_379179060.124.7e-01Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr12_+_110783593 6.360 Meg3
maternally expressed 3
chr1_-_125942073 4.599 NM_199021
Dpp10
dipeptidylpeptidase 10
chr4_-_82151180 3.160 NM_001113209
NM_001113210
NM_008687
Nfib


nuclear factor I/B


chr7_-_31836457 3.051 NM_022007
Fxyd7
FXYD domain-containing ion transport regulator 7
chr12_+_110783786 2.938 Meg3
maternally expressed 3
chr11_-_59263437 2.712 NM_144521
Snap47
synaptosomal-associated protein, 47
chr2_-_33226980 2.446 NM_175211
Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr6_+_65621583 2.406 NM_172399
A930038C07Rik
RIKEN cDNA A930038C07 gene
chrX_-_70905062 2.253 NM_012040
Pnck
pregnancy upregulated non-ubiquitously expressed CaM kinase
chr2_-_63022140 2.252 NM_133207
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr2_+_92439758 2.203 NM_023850
Chst1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr6_-_124813922 2.199 NM_013533
Gpr162
G protein-coupled receptor 162
chr19_-_4125776 2.193 NM_016666
Aip
aryl-hydrocarbon receptor-interacting protein
chr4_+_120527397 2.178 Rims3
regulating synaptic membrane exocytosis 3
chr3_+_105507516 2.168 NM_175398
6530418L21Rik
RIKEN cDNA 6530418L21 gene
chr6_-_126690651 2.140 NM_013568
Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr3_+_95985065 2.126 NM_022030
Sv2a
synaptic vesicle glycoprotein 2 a
chr1_-_83404659 2.107 NM_172430
Sphkap
SPHK1 interactor, AKAP domain containing
chr10_-_108447674 2.105 NM_009306
Syt1
synaptotagmin I
chr8_-_3625251 2.087 NM_008790
Pcp2
Purkinje cell protein 2 (L7)
chr17_+_35960291 1.945 NM_008027
Flot1
flotillin 1
chr4_-_150482562 1.912 Camta1
calmodulin binding transcription activator 1
chr10_+_59568976 1.910 NM_052994
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chrX_+_133200982 1.886 Tceal3
transcription elongation factor A (SII)-like 3
chr8_+_119780918 1.841 NM_001163262
4933407C03Rik
RIKEN cDNA 4933407C03 gene
chr8_-_82581887 1.830 NM_020259
Hhip
Hedgehog-interacting protein
chr10_-_126971614 1.825 NM_183297
Nxph4
neurexophilin 4
chr8_+_96334452 1.793 NM_001113384
NM_010308
Gnao1

guanine nucleotide binding protein, alpha O

chr2_-_33226946 1.783 Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr4_-_82151004 1.771 Nfib
nuclear factor I/B
chr12_+_12268901 1.751 NM_001146119
NM_029758
Fam49a

family with sequence similarity 49, member A

chr17_+_56904233 1.744 Dus3l
dihydrouridine synthase 3-like (S. cerevisiae)
chr17_+_44090192 1.734 Rcan2
regulator of calcineurin 2
chr8_-_3624988 1.719 NM_001129804
Pcp2
Purkinje cell protein 2 (L7)
chr2_-_93797176 1.705 NM_001145034
Gm13889
predicted gene 13889
chr6_-_48395691 1.689 NM_001085417
NM_020589
Zfp467

zinc finger protein 467

chr2_-_90420626 1.676 NM_008982
Ptprj
protein tyrosine phosphatase, receptor type, J
chr6_-_113841295 1.670 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chrX_-_131745187 1.649 NM_025355
Tceal6
transcription elongation factor A (SII)-like 6
chr8_+_124254462 1.640 NM_020605
Jph3
junctophilin 3
chr9_-_58050091 1.618 NM_001161536
NM_177193
NM_001161539
Islr2


immunoglobulin superfamily containing leucine-rich repeat 2


chr18_-_33623287 1.594 NM_053078
D0H4S114
DNA segment, human D4S114
chr15_+_81767188 1.559 NM_145473
Csdc2
cold shock domain containing C2, RNA binding
chr2_+_55289530 1.557 NM_008426
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr11_-_98190774 1.550 NM_010895
Neurod2
neurogenic differentiation 2
chr5_-_139605617 1.538 NM_008923
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr10_+_105907394 1.524 NM_177373
Ppfia2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr18_-_34532974 1.505 NM_007874
Reep5
receptor accessory protein 5
chr17_+_29230715 1.494 NM_007669
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr17_-_24826812 1.492 Syngr3
synaptogyrin 3
chr2_-_152202301 1.490 NM_001009948
Nrsn2
neurensin 2
chr4_+_97444563 1.461 Nfia
nuclear factor I/A
chr2_-_79296732 1.428 NM_010894
Neurod1
neurogenic differentiation 1
chr6_+_79968948 1.413 Lrrtm4
leucine rich repeat transmembrane neuronal 4
chr12_+_25659777 1.402 NM_001081378
Kidins220
kinase D-interacting substrate 220
chr2_+_121184334 1.396 NM_009897
Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
chr4_-_128798939 1.357 NM_001130419
Hpca
hippocalcin
chr8_+_74092790 1.353 NM_011977
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr11_-_59263508 1.352 Snap47
synaptosomal-associated protein, 47
chrX_+_7215705 1.348 NM_009305
Syp
synaptophysin
chr14_+_68701838 1.346 NM_010910
Nefl
neurofilament, light polypeptide
chr2_+_70400179 1.332 NM_008077
Gad1
glutamic acid decarboxylase 1
chr8_+_96676506 1.331 NM_013603
Mt3
metallothionein 3
chr17_+_44215761 1.327 NM_032003
NM_001168620
Enpp5

ectonucleotide pyrophosphatase/phosphodiesterase 5

chr10_-_61802889 1.323 NM_001146100
Hk1
hexokinase 1
chr10_+_59569052 1.316 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr10_+_60638341 1.294 Tbata
thymus, brain and testes associated
chr6_-_55631085 1.292 Neurod6
neurogenic differentiation 6
chr5_-_46030523 1.287 NM_021416
Fam184b
family with sequence similarity 184, member B
chr3_-_18143265 1.280 NM_007825
Cyp7b1
cytochrome P450, family 7, subfamily b, polypeptide 1
chr9_+_37175190 1.278 NM_175189
Hepacam
hepatocyte cell adhesion molecule
chr11_+_119804400 1.236 NM_001037754
NM_001037755
NM_130862
Baiap2


brain-specific angiogenesis inhibitor 1-associated protein 2


chr17_+_55585011 1.235 NM_172829
St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr9_+_26541302 1.234 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr4_-_15076093 1.228 NM_178617
Necab1
N-terminal EF-hand calcium binding protein 1
chr15_+_32174546 1.214 NM_009154
Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr11_+_59476181 1.191 Mprip
myosin phosphatase Rho interacting protein
chr16_-_67621054 1.175 NM_001145977
NM_178721
Cadm2

cell adhesion molecule 2

chr18_+_64425037 1.162 St8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr8_+_98201984 1.160


chr5_-_135223110 1.146 NM_007925
Eln
elastin
chr8_-_30330079 1.145 NM_153135
Unc5d
unc-5 homolog D (C. elegans)
chr4_+_97444494 1.141 Nfia
nuclear factor I/A
chr16_-_95219189 1.135 NM_001025584
NM_001025585
NM_010606
Kcnj6


potassium inwardly-rectifying channel, subfamily J, member 6


chr4_+_126287086 1.133 NM_001013755
NM_001145950
5730409E04Rik

RIKEN cDNA 5730409E04Rik gene

chrX_+_133200913 1.116 NM_001029978
Tceal3
transcription elongation factor A (SII)-like 3
chr10_+_127162447 1.113 NM_009312
Tac2
tachykinin 2
chr17_-_24826873 1.108 NM_011522
Syngr3
synaptogyrin 3
chr16_-_50732795 1.101 5330426P16Rik
RIKEN cDNA 5330426P16 gene
chr4_+_61947463 1.100 NM_025286
Slc31a2
solute carrier family 31, member 2
chr4_+_147534729 1.093 Fbxo2
F-box protein 2
chr6_-_60778740 1.089 NM_001042451
Snca
synuclein, alpha
chr7_-_17200285 1.083 NM_172739
Grlf1
glucocorticoid receptor DNA binding factor 1
chr4_-_128798481 1.078 NM_010471
Hpca
hippocalcin
chr19_-_4283047 1.073 Ankrd13d
ankyrin repeat domain 13 family, member D
chr9_-_53916173 1.073 NM_001033535
Tnfaip8l3
tumor necrosis factor, alpha-induced protein 8-like 3
chr8_+_65430028 1.070 NM_023689
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr1_-_79855209 1.060 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr5_+_151062363 1.051 NM_172887
Fry
furry homolog (Drosophila)
chr9_-_91260619 1.035 NM_009573
Zic1
zinc finger protein of the cerebellum 1
chr7_-_119301920 1.011 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr6_+_45010040 1.011 NM_001004357
Cntnap2
contactin associated protein-like 2
chr6_-_136123091 1.007 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr2_-_180891448 1.005 Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr4_+_17780739 1.005 Mmp16
matrix metallopeptidase 16
chr10_+_126515962 1.003 NM_001033263
Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr19_-_61303137 1.003 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr13_+_113078658 0.996 NM_001168403
NM_001168405
NM_029898
NM_001168404
Ankrd55



ankyrin repeat domain 55



chr5_+_144125586 0.994 NM_133355
Grid2ip
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
chr11_+_98603186 0.982 NM_178060
Thra
thyroid hormone receptor alpha
chr2_-_102741483 0.978 Cd44
CD44 antigen
chr8_-_13494457 0.974 NM_019521
Gas6
growth arrest specific 6
chr9_+_51573434 0.968 NM_175535
Arhgap20
Rho GTPase activating protein 20
chr17_-_91492065 0.965 NM_020252
NM_177284
Nrxn1

neurexin I

chr10_-_42893894 0.964 Sobp
sine oculis-binding protein homolog (Drosophila)
chr3_+_145421870 0.960 Ddah1
dimethylarginine dimethylaminohydrolase 1
chr14_-_98568962 0.954 Dach1
dachshund 1 (Drosophila)
chr3_-_84063605 0.954 Trim2
tripartite motif-containing 2
chr4_+_130378728 0.946 Sdc3
syndecan 3
chr12_+_85455277 0.942 NM_028821
Dnalc1
dynein, axonemal, light chain 1
chr8_-_101940218 0.939 NM_001039154
NM_007667
Cdh8

cadherin 8

chr13_-_34169854 0.939 NM_009450
Tubb2a
tubulin, beta 2A
chr8_+_46970814 0.937 NM_016798
Pdlim3
PDZ and LIM domain 3
chr4_+_99768413 0.937 Ror1
receptor tyrosine kinase-like orphan receptor 1
chr2_+_29821079 0.931 NM_001076554
NM_001177667
NM_001177668
Spna2


spectrin alpha 2


chr4_-_82150687 0.925 Nfib
nuclear factor I/B
chr4_+_49072327 0.924 NM_178756
E130309F12Rik
RIKEN cDNA E130309F12 gene
chr19_+_6418737 0.919 Nrxn2
neurexin II
chr8_+_96334879 0.914 Gnao1
guanine nucleotide binding protein, alpha O
chr10_-_108448003 0.912 Syt1
synaptotagmin I
chr11_+_70467599 0.910 Pfn1
profilin 1
chr7_-_112781902 0.908 NM_018880
Trim3
tripartite motif-containing 3
chr14_+_66963139 0.901 NM_019675
Stmn4
stathmin-like 4
chr6_+_77192615 0.901 NM_028880
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr12_+_78339999 0.893 NM_016893
Fut8
fucosyltransferase 8
chrX_-_130223380 0.892 NM_001105245
NM_001105246
Pcdh19

protocadherin 19

chr16_-_45408997 0.889 NM_010818
Cd200
2300009N04Rik
CD200 antigen
RIKEN cDNA 2300009N04 gene
chr10_-_77365164 0.887 NM_145152
Lrrc3
leucine rich repeat containing 3
chr17_+_27792487 0.886 Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr6_-_124719465 0.883 NM_013509
Eno2
enolase 2, gamma neuronal
chrX_+_7496899 0.883 NM_013892
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr10_-_42894259 0.880 NM_175407
Sobp
sine oculis-binding protein homolog (Drosophila)
chr6_+_53523365 0.878 NM_172728
Creb5
cAMP responsive element binding protein 5
chr8_+_59934719 0.872 NM_009136
Scrg1
scrapie responsive gene 1
chr2_+_164773719 0.872 NM_013599
Mmp9
matrix metallopeptidase 9
chr17_+_34766489 0.870 NM_030890
Prrt1
proline-rich transmembrane protein 1
chr10_-_79336973 0.870 BC005764
cDNA sequence BC005764
chr18_-_33623273 0.852 D0H4S114
DNA segment, human D4S114
chr7_+_29237141 0.850 NM_001141921
Lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr4_-_139802683 0.846 NM_198610
Igsf21
immunoglobin superfamily, member 21
chr2_+_158201373 0.845 NM_175692
Snhg11
small nucleolar RNA host gene 11
chr5_+_123093892 0.844 NM_001038839
NM_001038845
NM_001038887
NM_011027
P2rx7



purinergic receptor P2X, ligand-gated ion channel, 7



chr5_+_150214363 0.840 NM_027519
6330406I15Rik
RIKEN cDNA 6330406I15 gene
chr19_-_4615180 0.838 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr11_+_6558494 0.837 NM_019511
Ramp3
receptor (calcitonin) activity modifying protein 3
chr6_-_55631039 0.836 Neurod6
neurogenic differentiation 6
chr10_-_127057998 0.836 Lrp1
low density lipoprotein receptor-related protein 1
chr5_+_117807290 0.834 NM_021539
Wsb2
WD repeat and SOCS box-containing 2
chr5_-_123229335 0.832 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr9_-_91260597 0.831 Zic1
zinc finger protein of the cerebellum 1
chr2_+_131735663 0.826 NM_011170
Prnp
prion protein
chr4_+_147534776 0.823 NM_176848
Fbxo2
F-box protein 2
chr2_-_162486792 0.823 Ptprt
protein tyrosine phosphatase, receptor type, T
chr18_+_66033139 0.821 NM_175012
Grp
gastrin releasing peptide
chr8_-_87297283 0.818 Nfix
nuclear factor I/X
chr4_-_82151657 0.809 Nfib
nuclear factor I/B
chr1_+_23768764 0.808 NM_172124
B3gat2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr4_+_104040160 0.806 NM_010014
NM_177259
Dab1

disabled homolog 1 (Drosophila)

chr5_-_100158034 0.804 A930011G23Rik
RIKEN cDNA A930011G23 gene
chr8_-_30329898 0.803 Unc5d
unc-5 homolog D (C. elegans)
chr17_+_56904162 0.800 NM_144858
Dus3l
dihydrouridine synthase 3-like (S. cerevisiae)
chr4_+_151712739 0.799 NM_001081376
NM_029216
Chd5

chromodomain helicase DNA binding protein 5

chr19_+_6418755 0.794 Nrxn2
neurexin II
chr15_+_73342989 0.787 NM_001081066
Dennd3
DENN/MADD domain containing 3
chr8_+_113245378 0.781 NM_198625
Mtss1l
metastasis suppressor 1-like
chr7_+_29236897 0.780 NM_030562
Lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr12_+_78340039 0.778 Fut8
fucosyltransferase 8
chr15_+_99125666 0.775 Prpf40b
PRP40 pre-mRNA processing factor 40 homolog B (yeast)
chr4_+_151712914 0.774 Chd5
chromodomain helicase DNA binding protein 5
chr4_+_126287109 0.774 5730409E04Rik
RIKEN cDNA 5730409E04Rik gene
chr7_+_4642681 0.771 Brsk1
BR serine/threonine kinase 1
chr4_+_99768456 0.767 Ror1
receptor tyrosine kinase-like orphan receptor 1
chr8_-_89996474 0.766 NM_019626
Cbln1
cerebellin 1 precursor protein
chr7_-_85722668 0.764 NM_008746
NM_182809
Ntrk3

neurotrophic tyrosine kinase, receptor, type 3

chr1_-_156731538 0.762 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr6_+_17256415 0.761 Cav1
caveolin 1, caveolae protein
chr7_+_107855164 0.746 Fam168a
family with sequence similarity 168, member A
chr9_+_34296315 0.744 NM_001190911
NM_001190912
NM_001190913
NM_001190914
NM_026324
Kirrel3




kin of IRRE like 3 (Drosophila)




chr4_+_57447340 0.743 Palm2
paralemmin 2
chr5_-_124875921 0.741 NM_001081203
Sbno1
sno, strawberry notch homolog 1 (Drosophila)
chr4_-_25727109 0.741 NM_010243
Fut9
fucosyltransferase 9
chr10_+_20672352 0.740 NM_026203
Ahi1
Abelson helper integration site 1
chr15_-_37721754 0.739 NM_001170866
Ncald
neurocalcin delta
chr5_+_37259780 0.737 NM_172994
Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr10_+_79630579 0.737 NM_007705
Cirbp
cold inducible RNA binding protein
chr17_+_37210011 0.736 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr9_-_58049765 0.729 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr2_+_10294062 0.726 NM_001198809
NM_177386
Sfmbt2

Scm-like with four mbt domains 2

chr3_-_32515388 0.723 NM_013531
Gnb4
guanine nucleotide binding protein (G protein), beta 4
chr10_-_13588578 0.721 NM_025446
Aig1
androgen-induced 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
8.91 1.77e-03 GO:0043269 regulation of ion transport
79.71 3.08e-03 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
5.80 4.67e-03 GO:0007610 behavior
3.91 1.40e-02 GO:0051049 regulation of transport
13.29 2.05e-02 GO:0030902 hindbrain development
3.08 2.82e-02 GO:0007399 nervous system development
141.70 3.67e-02 GO:2000278 regulation of DNA biosynthetic process
35.43 4.33e-02 GO:0030204 chondroitin sulfate metabolic process
35.43 4.33e-02 GO:0050974 detection of mechanical stimulus involved in sensory perception

Gene overrepresentation in compartment category:

enrichment p-value GO term description
3.82 4.15e-04 GO:0005626 insoluble fraction
10.20 6.69e-04 GO:0030136 clathrin-coated vesicle
12.89 8.46e-04 GO:0008021 synaptic vesicle
8.97 1.55e-03 GO:0030135 coated vesicle
2.59 4.51e-03 GO:0044459 plasma membrane part
3.50 4.79e-03 GO:0005624 membrane fraction
3.00 8.42e-03 GO:0000267 cell fraction
5.27 1.64e-02 GO:0031012 extracellular matrix
14.67 1.90e-02 GO:0005901 caveola
5.73 2.64e-02 GO:0030424 axon
1.87 2.68e-02 GO:0071944 cell periphery
3.84 3.21e-02 GO:0043005 neuron projection
1.85 4.41e-02 GO:0005886 plasma membrane
8.06 4.70e-02 GO:0033267 axon part
4.02 4.73e-02 GO:0045202 synapse

Gene overrepresentation in function category:

enrichment p-value GO term description
35.43 9.72e-03 GO:0005242 inward rectifier potassium channel activity
106.28 1.64e-02 GO:0015467 G-protein activated inward rectifier potassium channel activity
22.78 3.77e-02 GO:0003746 translation elongation factor activity