Motif ID: SMAD1..7,9.p2

Z-value: 1.582

Transcription factors associated with SMAD1..7,9.p2:

NameEntrezDescription
Smad1 17125 MAD homolog 1 (Drosophila)
Smad2 17126 MAD homolog 2 (Drosophila)
Smad3 17127 MAD homolog 3 (Drosophila)
Smad4 17128 MAD homolog 4 (Drosophila)
Smad5 17129 MAD homolog 5 (Drosophila)
Smad6 17130 MAD homolog 6 (Drosophila)
Smad7 17131 MAD homolog 7 (Drosophila)
Smad9 55994 MAD homolog 9 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Smad3chr9_-_63605917-0.854.1e-11Click!
Smad5chr13_+_56805028-0.726.2e-07Click!
Smad6chr9_-_63869857-0.591.4e-04Click!
Smad4chr18_-_73863381-0.582.1e-04Click!
Smad2chr18_+_76401531-0.582.4e-04Click!
Smad9chr3_+_545595030.446.6e-03Click!
Smad7chr18_+_75527015-0.334.9e-02Click!
Smad1chr8_-_81923366-0.212.1e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr1_+_89160921 8.775 NM_028889
Efhd1
EF hand domain containing 1
chr2_+_70400179 8.599 NM_008077
Gad1
glutamic acid decarboxylase 1
chr7_-_91234908 8.460 NM_030728
9930013L23Rik
RIKEN cDNA 9930013L23 gene
chr9_+_21741435 7.969 BC018242
cDNA sequence BC018242
chr8_+_115093942 7.579 NM_130457
Cntnap4
contactin associated protein-like 4
chr2_+_55288297 7.039 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr10_-_24919916 6.727 Akap7
A kinase (PRKA) anchor protein 7
chr7_-_148615247 6.103 NM_021316
Cend1
cell cycle exit and neuronal differentiation 1
chr11_-_64976408 5.655 NM_001099288
NM_175003
Arhgap44

Rho GTPase activating protein 44

chr16_+_96689322 5.601


chr8_+_59934719 5.487 NM_009136
Scrg1
scrapie responsive gene 1
chr2_-_151458299 5.242 Snph
syntaphilin
chr3_+_28162135 5.081 NM_001163007
NM_001163008
NM_001163009
NM_026910
Tnik



TRAF2 and NCK interacting kinase



chr11_+_16157685 5.051 NM_145967
Vstm2a
V-set and transmembrane domain containing 2A
chr15_+_40486630 4.717 Zfpm2
zinc finger protein, multitype 2
chr2_-_84265422 4.522 NM_018782
Calcrl
calcitonin receptor-like
chr9_-_61970402 4.426 Glce
glucuronyl C5-epimerase
chr5_+_137729501 4.282 NM_009599
Ache
acetylcholinesterase
chr8_+_128519001 4.257 NM_008430
Kcnk1
potassium channel, subfamily K, member 1
chr17_+_79451501 4.226 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr9_+_27598853 4.207 NM_177906
Opcml
opioid binding protein/cell adhesion molecule-like
chr10_-_126971614 4.201 NM_183297
Nxph4
neurexophilin 4
chr6_+_5675638 4.200 NM_001191023
NM_001191025
NM_001191026
NM_001191027
NM_010063
Dync1i1




dynein cytoplasmic 1 intermediate chain 1




chr5_-_135223110 4.086 NM_007925
Eln
elastin
chr9_-_56483379 4.078 Lingo1
leucine rich repeat and Ig domain containing 1
chr8_+_68141935 4.066 NM_001166372
March1
membrane-associated ring finger (C3HC4) 1
chr2_+_136539202 4.035 Snap25
synaptosomal-associated protein 25
chr7_-_135561641 3.999 NM_026418
Rgs10
regulator of G-protein signalling 10
chr3_-_80606500 3.955 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr15_+_78744328 3.753 NM_020271
Pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr2_+_178149238 3.673 NM_001081289
9030418K01Rik
RIKEN cDNA 9030418K01 gene
chr5_+_75971011 3.657 NM_001122733
NM_021099
Kit

kit oncogene

chr5_+_14514975 3.635 Pclo
piccolo (presynaptic cytomatrix protein)
chr1_-_64167952 3.604 NM_033563
Klf7
Kruppel-like factor 7 (ubiquitous)
chr15_+_61817102 3.584 Myc
myelocytomatosis oncogene
chr14_-_122138082 3.575 NM_001128307
NM_001128308
Dock9

dedicator of cytokinesis 9

chr6_+_141472906 3.543 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chr1_-_175297778 3.473 NM_053199
Cadm3
cell adhesion molecule 3
chr8_+_65430028 3.472 NM_023689
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr18_-_33623273 3.470 D0H4S114
DNA segment, human D4S114
chr7_-_31836457 3.439 NM_022007
Fxyd7
FXYD domain-containing ion transport regulator 7
chr11_+_61298923 3.375 NM_029568
Mfap4
microfibrillar-associated protein 4
chr16_+_49855691 3.340 NM_010581
Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chrX_+_93908779 3.329 NM_029536
Gpr165
G protein-coupled receptor 165
chr9_+_95459990 3.320 NM_198414
Paqr9
progestin and adipoQ receptor family member IX
chr15_+_82105322 3.292 NM_011889
Sept3
septin 3
chr5_-_71487013 3.285 NM_008066
Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr5_+_137994744 3.281 NM_031404
Actl6b
actin-like 6B
chr5_+_36100547 3.248 Ablim2
actin-binding LIM protein 2
chr18_+_36508277 3.240 NM_001081365
0610010O12Rik
RIKEN cDNA 0610010O12 gene
chr18_-_33623287 3.235 NM_053078
D0H4S114
DNA segment, human D4S114
chr11_+_77992224 3.197 NM_026708
Tlcd1
TLC domain containing 1
chr17_+_34766489 3.186 NM_030890
Prrt1
proline-rich transmembrane protein 1
chr8_+_128519295 3.174 Kcnk1
potassium channel, subfamily K, member 1
chr7_+_35971403 3.066 NM_017394
Slc7a10
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
chr9_-_112137285 3.051 NM_001177619
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr8_-_17535279 3.043 NM_053171
Csmd1
CUB and Sushi multiple domains 1
chr17_+_23810844 2.990 Hcfc1r1
host cell factor C1 regulator 1 (XPO1-dependent)
chr2_-_163744663 2.968 Rims4
regulating synaptic membrane exocytosis 4
chr11_+_120582777 2.956 NM_133223
Rac3
RAS-related C3 botulinum substrate 3
chr3_+_31048841 2.917 NM_008770
Cldn11
claudin 11
chr5_-_121161656 2.876 NM_008052
Dtx1
deltex 1 homolog (Drosophila)
chr9_-_91259829 2.831 Zic1
zinc finger protein of the cerebellum 1
chr2_+_136539143 2.796 NM_011428
Snap25
synaptosomal-associated protein 25
chr15_-_78034565 2.788 NM_013645
Pvalb
parvalbumin
chr2_+_158201373 2.781 NM_175692
Snhg11
small nucleolar RNA host gene 11
chr2_-_127346987 2.770 Kcnip3
Kv channel interacting protein 3, calsenilin
chr1_-_133421746 2.759 Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr11_-_55233366 2.751 Sparc
secreted acidic cysteine rich glycoprotein
chr2_-_151458281 2.741 Snph
syntaphilin
chrX_-_138740574 2.734 Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr10_-_10802102 2.697 NM_001114333
NM_016976
Grm1

glutamate receptor, metabotropic 1

chr9_+_69137694 2.658 Rora
RAR-related orphan receptor alpha
chr9_-_102256962 2.648 NM_001168296
NM_173447
Ephb1

Eph receptor B1

chr3_+_33699060 2.625 Ttc14
tetratricopeptide repeat domain 14
chr19_-_5510453 2.611 NM_001024560
Snx32
sorting nexin 32
chrX_-_7783571 2.571 NM_016913
NM_023638
NM_145907
NM_145908
Porcn



porcupine homolog (Drosophila)



chr15_-_89026839 2.564 NM_027081
Fam116b
family with sequence similarity 116, member B
chr1_-_175297624 2.558 Cadm3
cell adhesion molecule 3
chr2_+_181255209 2.554 NM_016775
Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr19_-_32462926 2.551 NM_144792
Sgms1
sphingomyelin synthase 1
chr2_-_12933305 2.548 C1ql3
C1q-like 3
chr10_-_76188683 2.546 NM_009933
Col6a1
collagen, type VI, alpha 1
chr18_+_37581071 2.523 NM_053136
Pcdhb11
protocadherin beta 11
chr11_-_55233339 2.519 Sparc
secreted acidic cysteine rich glycoprotein
chr7_+_6367885 2.486 NM_001134752
Gm16532
predicted gene, 16532
chr17_+_43153516 2.450 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr15_+_78673024 2.426 NM_027219
Cdc42ep1
CDC42 effector protein (Rho GTPase binding) 1
chr10_-_108447894 2.424 Syt1
synaptotagmin I
chr5_-_123582394 2.397 Rhof
ras homolog gene family, member f
chr5_-_121161612 2.395 Dtx1
deltex 1 homolog (Drosophila)
chr7_+_139158135 2.394 NM_173410
Gpr26
G protein-coupled receptor 26
chr9_+_51573434 2.387 NM_175535
Arhgap20
Rho GTPase activating protein 20
chr1_-_175266945 2.363 Cadm3
cell adhesion molecule 3
chr11_+_87574041 2.308 NM_172449
Bzrap1
benzodiazepine receptor associated protein 1
chr11_-_75268137 2.303 NM_138950
Wdr81
WD repeat domain 81
chr3_-_58495986 2.296 Siah2
seven in absentia 2
chr16_-_95218980 2.274 Kcnj6
potassium inwardly-rectifying channel, subfamily J, member 6
chr2_-_113057218 2.243 Ryr3
ryanodine receptor 3
chr17_+_8503966 2.222 NM_134114
Sft2d1
SFT2 domain containing 1
chr8_-_125201971 2.218 NM_001109873
NM_177289
Cbfa2t3

core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)

chr5_-_92707164 2.211 NM_001163687
NM_025972
Naaa

N-acylethanolamine acid amidase

chr2_-_93797176 2.210 NM_001145034
Gm13889
predicted gene 13889
chr4_+_117507914 2.199 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr13_+_111185251 2.181 NM_152804
Plk2
polo-like kinase 2 (Drosophila)
chr18_+_37467108 2.179 NM_053129
Pcdhb4
protocadherin beta 4
chr11_-_116515361 2.177 Cygb
cytoglobin
chr5_-_113444509 2.175 NM_001035531
NM_177078
Adrbk2

adrenergic receptor kinase, beta 2

chr19_-_10315199 2.173 NM_001033481
Gm98
predicted gene 98
chr17_-_90487479 2.169 Nrxn1
neurexin I
chrX_-_45388010 2.167 NM_013912
Apln
apelin
chrX_-_61530035 2.141 Slitrk4
SLIT and NTRK-like family, member 4
chr3_-_80606598 2.141 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr7_+_107756292 2.134 Rab6
RAB6, member RAS oncogene family
chr9_-_70504934 2.130 NM_172772
Fam63b
family with sequence similarity 63, member B
chr5_-_128938813 2.109 NM_172885
Tmem132d
transmembrane protein 132D
chr17_+_43526389 2.100 NM_001081178
Gpr116
G protein-coupled receptor 116
chr15_+_94459521 2.084 NM_178789
Tmem117
transmembrane protein 117
chr3_-_50247306 2.079 NM_011990
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr18_+_45719101 2.035 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr1_+_155747072 2.021 NM_008131
Glul
glutamate-ammonia ligase (glutamine synthetase)
chr9_+_82723787 2.003 Irak1bp1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr4_-_8166182 2.002 NM_007592
Car8
carbonic anhydrase 8
chr7_+_53040723 1.994 Lmtk3
lemur tyrosine kinase 3
chr11_+_80290509 1.984 NM_009871
Cdk5r1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr5_+_130620730 1.981 NM_172509
Kctd7
potassium channel tetramerisation domain containing 7
chr10_+_75052084 1.980 NM_011820
Ggt5
gamma-glutamyltransferase 5
chr8_+_85913750 1.964 NM_009904
Clgn
calmegin
chr10_+_13220833 1.959 NM_025799
Fuca2
fucosidase, alpha-L- 2, plasma
chr15_-_101966611 1.935 NM_001033277
Spryd3
SPRY domain containing 3
chr11_-_96805092 1.923 Pnpo
pyridoxine 5'-phosphate oxidase
chr9_+_122481617 1.917 9530059O14Rik
RIKEN cDNA 9530059O14 gene
chr9_+_45178267 1.916 NM_022004
Fxyd6
FXYD domain-containing ion transport regulator 6
chr11_+_3388229 1.909 NM_172791
Pla2g3
phospholipase A2, group III
chrX_-_20527674 1.900 NM_007922
Elk1
ELK1, member of ETS oncogene family
chr7_+_51846254 1.900 NM_008422
Kcnc3
potassium voltage gated channel, Shaw-related subfamily, member 3
chr5_-_121038602 1.885 NM_145853
Tpcn1
two pore channel 1
chr9_-_114842996 1.880 Gpd1l
glycerol-3-phosphate dehydrogenase 1-like
chr11_+_52578152 1.879 NM_177059
Fstl4
follistatin-like 4
chr16_-_28753276 1.869 NM_010199
Fgf12
fibroblast growth factor 12
chr11_-_116515602 1.867 NM_030206
Cygb
cytoglobin
chr11_-_61267383 1.850 NM_009548
Rnf112
ring finger protein 112
chr17_-_79754427 1.835 NM_026514
Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr14_-_37781899 1.828 Gcap14
granule cell antiserum positive 14
chr11_-_28484265 1.827 NM_001166661
NM_001166662
NM_181577
Ccdc85a


coiled-coil domain containing 85A


chr18_+_45719464 1.819 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr2_+_127096432 1.810 Stard7
START domain containing 7
chr5_+_14514906 1.802 NM_001110796
NM_011995
Pclo

piccolo (presynaptic cytomatrix protein)

chr19_-_7292086 1.797 NM_007750
Cox8a
cytochrome c oxidase, subunit VIIIa
chr12_-_73337534 1.793 Rtn1
reticulon 1
chr11_-_69734369 1.787 NM_001166592
NM_001166594
Eif5a

eukaryotic translation initiation factor 5A

chr3_-_80606704 1.765 NM_001039195
NM_001083806
NM_013540
Gria2


glutamate receptor, ionotropic, AMPA2 (alpha 2)


chr3_-_107820705 1.754 Gstm1
glutathione S-transferase, mu 1
chr1_+_60155090 1.750 NM_139150
Carf
calcium response factor
chr12_+_77425836 1.746 NM_001101471
Akap5
A kinase (PRKA) anchor protein 5
chr2_-_147011990 1.745 NM_001077632
NM_010919
Nkx2-2

NK2 transcription factor related, locus 2 (Drosophila)

chr16_-_20621287 1.741 NM_028420
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr15_-_48623520 1.729 NM_001081391
Csmd3
CUB and Sushi multiple domains 3
chr11_+_114536748 1.727 NM_053273
Ttyh2
tweety homolog 2 (Drosophila)
chr12_+_70342818 1.726 NM_178253
Klhdc1
kelch domain containing 1
chr7_+_17529961 1.714 NM_001099636
Pnmal2
PNMA-like 2
chr11_-_101032604 1.703 NM_146030
Plekhh3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr7_-_54387695 1.703 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr2_+_26772222 1.700 Surf2
surfeit gene 2
chr18_-_33623069 1.690 NM_001109990
D0H4S114
DNA segment, human D4S114
chr7_-_104566013 1.688 NM_009381
Thrsp
thyroid hormone responsive SPOT14 homolog (Rattus)
chr2_+_21289168 1.677 NM_001004761
Gpr158
G protein-coupled receptor 158
chr6_-_48395691 1.676 NM_001085417
NM_020589
Zfp467

zinc finger protein 467

chr4_-_150482562 1.675 Camta1
calmodulin binding transcription activator 1
chr13_-_54850954 1.665 NM_012014
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr16_-_4679664 1.664 NM_030205
Coro7
coronin 7
chr7_+_51640108 1.659 Syt3
synaptotagmin III
chr9_-_53822931 1.648 Elmod1
ELMO domain containing 1
chr8_-_124102548 1.647 NM_133765
Fbxo31
F-box protein 31
chr11_-_58768012 1.645 NM_206882
Hist3h2bb-ps
histone cluster 3, H2bb, pseudogene
chr7_+_52897090 1.644 Mamstr
MEF2 activating motif and SAP domain containing transcriptional regulator
chr1_-_64167818 1.632 Klf7
Kruppel-like factor 7 (ubiquitous)
chr19_-_7292009 1.623 Cox8a
cytochrome c oxidase, subunit VIIIa
chr2_+_156301543 1.577 NM_001006664
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr7_+_107756205 1.570 Rab6
RAB6, member RAS oncogene family
chrX_+_132330678 1.568 Gprasp1
G protein-coupled receptor associated sorting protein 1
chr5_-_115722862 1.566 NM_016698
Rnf10
ring finger protein 10
chr11_+_103994128 1.549 Crhr1
corticotropin releasing hormone receptor 1
chr13_-_52626065 1.538 NM_001024474
Diras2
DIRAS family, GTP-binding RAS-like 2
chr17_+_24488985 1.535 NM_001039581
NM_013855
Abca3

ATP-binding cassette, sub-family A (ABC1), member 3

chr15_+_83998239 1.530 NM_054088
Pnpla3
patatin-like phospholipase domain containing 3
chr7_+_52112742 1.527 Pnkp
polynucleotide kinase 3'- phosphatase
chr15_+_20378816 1.516


chr2_-_60801248 1.508 NM_020296
Rbms1
RNA binding motif, single stranded interacting protein 1
chr11_+_61298978 1.507 Mfap4
microfibrillar-associated protein 4
chr4_+_126287086 1.474 NM_001013755
NM_001145950
5730409E04Rik

RIKEN cDNA 5730409E04Rik gene

chr17_+_27070275 1.471 Phf1
PHD finger protein 1
chr11_+_80290571 1.471 Cdk5r1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr1_-_136131399 1.467 Adora1
adenosine A1 receptor
chr10_-_30522912 1.466 NM_172495
Ncoa7
nuclear receptor coactivator 7
chr5_+_9266137 1.461 NM_172706
9330182L06Rik
RIKEN cDNA 9330182L06 gene
chr15_-_81524457 1.459 Chadl
chondroadherin-like
chr11_+_92960603 1.459 NM_028296
Car10
carbonic anhydrase 10
chr2_+_4897196 1.444 Ucma
upper zone of growth plate and cartilage matrix associated
chr12_-_73337707 1.429 NM_001007596
Rtn1
reticulon 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
4.10 8.47e-04 GO:0019226 transmission of nerve impulse
4.10 8.47e-04 GO:0035637 multicellular organismal signaling
1.86 1.25e-03 GO:0006810 transport
2.78 1.41e-03 GO:0006811 ion transport
1.75 1.56e-03 GO:0051179 localization
7.76 1.97e-03 GO:0006836 neurotransmitter transport
1.83 2.14e-03 GO:0051234 establishment of localization
8.26 4.52e-03 GO:0001505 regulation of neurotransmitter levels
4.26 4.91e-03 GO:0007268 synaptic transmission
2.59 1.72e-02 GO:0048699 generation of neurons
2.53 1.73e-02 GO:0022008 neurogenesis
2.20 2.64e-02 GO:0007399 nervous system development
4.19 2.71e-02 GO:0031644 regulation of neurological system process
2.94 3.90e-02 GO:0030001 metal ion transport
5.24 4.83e-02 GO:0050890 cognition

Gene overrepresentation in compartment category:

enrichment p-value GO term description
4.39 8.94e-10 GO:0043005 neuron projection
6.34 3.59e-09 GO:0030424 axon
1.86 8.54e-07 GO:0005886 plasma membrane
1.84 9.77e-07 GO:0071944 cell periphery
2.76 3.41e-06 GO:0042995 cell projection
3.79 9.03e-06 GO:0045202 synapse
1.41 2.45e-05 GO:0016020 membrane
4.39 3.15e-05 GO:0043025 neuronal cell body
4.18 6.44e-05 GO:0044297 cell body
13.74 1.15e-04 GO:0042734 presynaptic membrane
3.64 2.48e-04 GO:0044463 cell projection part
1.17 3.96e-04 GO:0005623 cell
1.17 3.96e-04 GO:0044464 cell part
4.13 7.16e-04 GO:0030425 dendrite
10.18 9.40e-04 GO:0030665 clathrin coated vesicle membrane
1.41 1.30e-03 GO:0044425 membrane part
1.43 3.14e-03 GO:0031224 intrinsic to membrane
3.54 4.55e-03 GO:0044456 synapse part
7.85 5.36e-03 GO:0030662 coated vesicle membrane
5.35 8.77e-03 GO:0033267 axon part
1.41 1.03e-02 GO:0016021 integral to membrane
7.05 1.08e-02 GO:0043679 axon terminus
2.45 1.29e-02 GO:0031982 vesicle
6.54 1.74e-02 GO:0044306 neuron projection terminus
29.43 1.95e-02 GO:0061200 clathrin sculpted gamma-aminobutyric acid transport vesicle
29.43 1.95e-02 GO:0061202 clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
26.16 2.89e-02 GO:0060198 clathrin sculpted vesicle
2.20 3.38e-02 GO:0005626 insoluble fraction
23.55 4.09e-02 GO:0032590 dendrite membrane

Gene overrepresentation in function category:

enrichment p-value GO term description
3.47 1.10e-07 GO:0022891 substrate-specific transmembrane transporter activity
3.23 3.75e-07 GO:0022857 transmembrane transporter activity
4.73 4.04e-07 GO:0005216 ion channel activity
4.63 6.04e-07 GO:0022838 substrate-specific channel activity
3.11 9.24e-07 GO:0022892 substrate-specific transporter activity
3.50 1.06e-06 GO:0015075 ion transmembrane transporter activity
4.49 1.08e-06 GO:0015267 channel activity
4.48 1.13e-06 GO:0022803 passive transmembrane transporter activity
2.86 1.80e-06 GO:0005215 transporter activity
6.11 1.76e-05 GO:0005244 voltage-gated ion channel activity
6.11 1.76e-05 GO:0022832 voltage-gated channel activity
4.80 2.44e-05 GO:0022836 gated channel activity
3.60 5.35e-05 GO:0008324 cation transmembrane transporter activity
4.69 1.85e-04 GO:0005261 cation channel activity
1.46 2.57e-03 GO:0005515 protein binding
5.70 6.69e-03 GO:0005267 potassium channel activity
5.40 1.03e-02 GO:0022843 voltage-gated cation channel activity