Motif ID: SPI1.p2

Z-value: 1.191

Transcription factors associated with SPI1.p2:

NameEntrezDescription
Sfpi1 20375 SFFV proviral integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Sfpi1chr2_+_909368450.163.5e-01Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr10_-_119913319 4.416 Hmga2
high mobility group AT-hook 2
chr2_+_92024338 4.404 NM_138755
Phf21a
PHD finger protein 21A
chr16_+_52031704 4.298 Cblb
Casitas B-lineage lymphoma b
chr17_+_34729159 4.187 Pbx2
pre B-cell leukemia transcription factor 2
chr16_+_52031733 4.018 Cblb
Casitas B-lineage lymphoma b
chr4_+_41082861 3.488 Ube2r2
ubiquitin-conjugating enzyme E2R 2
chr12_-_28027541 3.453 NM_009234
Sox11
SRY-box containing gene 11
chrX_+_97972559 3.181 NM_001177780
Dlg3
discs, large homolog 3 (Drosophila)
chr13_-_56353523 3.176 NM_010896
Neurog1
neurogenin 1
chr11_-_97049143 3.033 Kpnb1
karyopherin (importin) beta 1
chr11_+_3190334 3.031 NM_019574
Patz1
POZ (BTB) and AT hook containing zinc finger 1
chr8_-_94325138 2.957 NM_008393
Irx3
Iroquois related homeobox 3 (Drosophila)
chr3_+_133902563 2.952 Cxxc4
CXXC finger 4
chr16_+_24393435 2.797 NM_178665
Lpp
LIM domain containing preferred translocation partner in lipoma
chr2_-_68310324 2.786 Stk39
serine/threonine kinase 39, STE20/SPS1 homolog (yeast)
chr10_-_119913204 2.676 Hmga2
high mobility group AT-hook 2
chr11_-_95867076 2.629 NM_009951
Igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
chr11_+_98902556 2.452 NM_010517
Igfbp4
insulin-like growth factor binding protein 4
chr11_-_97049185 2.412 NM_008379
Kpnb1
karyopherin (importin) beta 1
chr2_+_4480799 2.344 NM_001177844
Frmd4a
FERM domain containing 4A
chr9_+_109778051 2.298 NM_007658
Cdc25a
cell division cycle 25 homolog A (S. pombe)
chr11_+_23978029 2.263 NM_001159289
NM_016707
Bcl11a

B-cell CLL/lymphoma 11A (zinc finger protein)

chr14_+_67853446 2.166 Ebf2
early B-cell factor 2
chr6_-_49164469 2.151 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr9_+_74709673 2.133 NM_008262
Onecut1
one cut domain, family member 1
chr2_+_131012677 2.053 NM_001111075
NM_023117
Cdc25b

cell division cycle 25 homolog B (S. pombe)

chr3_+_133899454 1.996 Cxxc4
CXXC finger 4
chr11_-_69182891 1.959 NM_146019
Chd3
chromodomain helicase DNA binding protein 3
chr15_-_10644312 1.949 NM_001166408
Rai14
retinoic acid induced 14
chr18_+_35278553 1.934 NM_009818
Ctnna1
catenin (cadherin associated protein), alpha 1
chr1_+_174412343 1.910 NM_001145800
NM_033608
Igsf9

immunoglobulin superfamily, member 9

chr8_-_74035629 1.869 Plvap
plasmalemma vesicle associated protein
chr18_+_35278538 1.860 Ctnna1
catenin (cadherin associated protein), alpha 1
chr19_-_58529766 1.838 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr17_+_36003527 1.831 NM_175242
2310014H01Rik
RIKEN cDNA 2310014H01 gene
chr7_-_140315030 1.808 Ctbp2
C-terminal binding protein 2
chr2_+_38206759 1.803 NM_010710
Lhx2
LIM homeobox protein 2
chr18_-_72510670 1.799 NM_007831
Dcc
deleted in colorectal carcinoma
chr6_-_134516799 1.794 Lrp6
low density lipoprotein receptor-related protein 6
chr1_-_173957316 1.740 NM_033509
Vangl2
vang-like 2 (van gogh, Drosophila)
chr10_-_17742931 1.710 NM_028440
3110003A17Rik
RIKEN cDNA 3110003A17 gene
chr17_-_35840931 1.706 NM_007584
NM_172962
Ddr1

discoidin domain receptor family, member 1

chr9_+_7764067 1.705 NM_133739
Tmem123
transmembrane protein 123
chr4_-_123427465 1.670 NM_023423
Akirin1
akirin 1
chr2_-_53937785 1.662 NM_023396
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr11_-_69229653 1.633 Kdm6b
KDM1 lysine (K)-specific demethylase 6B
chr9_-_82868992 1.630 Phip
pleckstrin homology domain interacting protein
chr11_-_86621074 1.619 Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr8_+_108583449 1.582 NM_010901
Nfatc3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr11_+_43342241 1.554 NM_001045530
Ccnjl
cyclin J-like
chr17_+_34729498 1.544 Pbx2
pre B-cell leukemia transcription factor 2
chr13_+_99124196 1.523 NM_008242
Foxd1
forkhead box D1
chr1_-_163181251 1.518 NM_007453
Prdx6
peroxiredoxin 6
chr2_-_92232506 1.514 Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr11_+_32176599 1.497 NM_010405
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr17_+_35035395 1.488 NM_147151
Ehmt2
euchromatic histone lysine N-methyltransferase 2
chr2_+_48805027 1.460 NM_029924
Mbd5
methyl-CpG binding domain protein 5
chr18_+_70727897 1.453 NM_010773
Mbd2
methyl-CpG binding domain protein 2
chr4_+_109349259 1.435 Faf1
Fas-associated factor 1
chr7_-_52308243 1.410 NM_175022
Prr12
proline rich 12
chr3_-_66785692 1.410 NM_013665
Shox2
short stature homeobox 2
chr2_-_113688771 1.402 NM_181416
Arhgap11a
Rho GTPase activating protein 11A
chr5_+_123592177 1.401 Setd1b
SET domain containing 1B
chr7_+_52471161 1.396 Tead2
TEA domain family member 2
chr2_+_152561983 1.394 NM_010495
Id1
inhibitor of DNA binding 1
chr10_-_86956393 1.365 NM_008553
Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr9_-_82869034 1.362 Phip
pleckstrin homology domain interacting protein
chr1_-_157882999 1.357 Tor1aip1
torsin A interacting protein 1
chr2_-_103637096 1.355 NM_001111289
NM_001111290
NM_001111292
Caprin1


cell cycle associated protein 1


chr2_-_129627180 1.350 4932416H05Rik
RIKEN cDNA 4932416H05 gene
chr8_-_74035667 1.343 NM_032398
Plvap
plasmalemma vesicle associated protein
chr4_+_41082993 1.343 NM_026275
Ube2r2
ubiquitin-conjugating enzyme E2R 2
chr5_+_129526383 1.334 Ran
RAN, member RAS oncogene family
chr3_+_5218545 1.330 NM_030708
Zfhx4
zinc finger homeodomain 4
chr4_-_125879832 1.324 NM_146153
Thrap3
thyroid hormone receptor associated protein 3
chr12_-_56087322 1.321 NM_013815
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr6_-_39507593 1.316 Dennd2a
DENN/MADD domain containing 2A
chr9_-_69608633 1.313 NM_022378
Foxb1
forkhead box B1
chr1_+_63319842 1.303 NM_028673
Zdbf2
zinc finger, DBF-type containing 2
chr16_+_22892112 1.299 NM_013465
Ahsg
alpha-2-HS-glycoprotein
chr13_+_98011057 1.286 NM_007930
Enc1
ectodermal-neural cortex 1
chr19_+_21852816 1.268 NM_001033759
NM_031997
Tmem2

transmembrane protein 2

chr18_+_35278585 1.268 Ctnna1
catenin (cadherin associated protein), alpha 1
chr17_-_3114749 1.257 A230045G11Rik
RIKEN cDNA A230045G11 gene
chr1_+_72871060 1.246 NM_008342
Igfbp2
insulin-like growth factor binding protein 2
chr13_-_54788995 1.232 Rnf44
ring finger protein 44
chrX_+_39503858 1.226 NM_021465
Stag2
stromal antigen 2
chr12_+_3960002 1.201 Pomc
pro-opiomelanocortin-alpha
chr11_+_98656807 1.199 Msl1
male-specific lethal 1 homolog (Drosophila)
chr5_+_115879617 1.191 NM_008629
Msi1
Musashi homolog 1(Drosophila)
chr1_-_154749751 1.187 NM_001005507
NM_001160256
Smg7

Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)

chr15_+_102236709 1.187 NM_013672
Sp1
trans-acting transcription factor 1
chr11_-_97048933 1.186 Kpnb1
karyopherin (importin) beta 1
chr4_+_108507258 1.185 NM_025334
Txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr14_+_35487052 1.169 NM_001004436
Wapal
wings apart-like homolog (Drosophila)
chr3_+_16083164 1.167 NM_001145919
NM_172677
Ythdf3

YTH domain family 3

chr2_-_72817311 1.165 NM_001098425
Sp3
trans-acting transcription factor 3
chr2_-_147871630 1.144 Foxa2
forkhead box A2
chr3_-_75760843 1.137 Golim4
golgi integral membrane protein 4
chr17_+_36003000 1.136 NM_001146710
2310014H01Rik
RIKEN cDNA 2310014H01 gene
chr6_+_107479719 1.136 NM_008516
Lrrn1
leucine rich repeat protein 1, neuronal
chr9_+_103014445 1.124 Rab6b
RAB6B, member RAS oncogene family
chr9_-_36954842 1.115 NM_001029838
Pknox2
Pbx/knotted 1 homeobox 2
chr3_+_87775081 1.112 Nes
nestin
chr10_-_75395207 1.112 NM_008606
Mmp11
matrix metallopeptidase 11
chr1_+_153275671 1.110 NM_026876
1190005F20Rik
RIKEN cDNA 1190005F20 gene
chr9_-_65675327 1.110 NM_172536
Zfp609
zinc finger protein 609
chr19_+_55816320 1.103 Tcf7l2
transcription factor 7-like 2, T-cell specific, HMG-box
chr14_+_31832374 1.102 Pbrm1
polybromo 1
chr11_+_87666566 1.101 NM_001039684
Mks1
Meckel syndrome, type 1
chr12_-_58646914 1.100 Foxa1
forkhead box A1
chr1_-_16647097 1.094 Tceb1
transcription elongation factor B (SIII), polypeptide 1
chr5_+_30431701 1.090 NM_001167879
Fam59b
family with sequence similarity 59, member B
chr13_-_78337844 1.087 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr16_+_37777075 1.076 NM_008047
Fstl1
follistatin-like 1
chr5_-_115608153 1.075 NM_175403
Mlec
malectin
chr15_+_98465193 1.069 NM_007581
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr16_+_64851768 1.067 NM_178647
Cggbp1
CGG triplet repeat binding protein 1
chr1_-_153275461 1.065 1200016B10Rik
RIKEN cDNA 1200016B10 gene
chr12_-_28027272 1.063 Sox11
SRY-box containing gene 11
chr13_-_54789064 1.060 Rnf44
ring finger protein 44
chr19_-_10175969 1.055 Fads2
fatty acid desaturase 2
chr10_+_84218792 1.054 NM_001024918
Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr8_-_41597015 1.053 Cnot7
CCR4-NOT transcription complex, subunit 7
chr2_-_127657532 1.051 NM_001113179
NM_009772
Bub1

budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)

chr6_-_125115580 1.046 NM_008084
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr11_+_57917469 1.043 NM_026949
Cnot8
CCR4-NOT transcription complex, subunit 8
chr17_-_47970167 1.041 NM_010783
Mdfi
MyoD family inhibitor
chr5_+_124895400 1.040 Setd8
SET domain containing (lysine methyltransferase) 8
chr2_+_53051140 1.039 Arl6ip6
ADP-ribosylation factor-like 6 interacting protein 6
chr17_+_47730384 1.035 NM_007632
Ccnd3
cyclin D3
chr3_+_88425073 1.032 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr15_-_97661807 1.031 Hdac7
histone deacetylase 7
chr19_+_6363686 1.018 NM_001110791
NM_011750
Sf1

splicing factor 1

chr14_-_71041964 1.012 NM_008004
Fgf17
fibroblast growth factor 17
chr18_-_16966954 1.009 Cdh2
cadherin 2
chr7_+_87171113 1.002 NM_175433
Zfp710
zinc finger protein 710
chr5_-_89104575 1.002 NM_001098476
Grsf1
G-rich RNA sequence binding factor 1
chr11_+_70833066 0.991 NM_025993
Mis12
MIS12 homolog (yeast)
chr8_+_109127245 0.985 NM_009864
Cdh1
cadherin 1
chr1_+_157882793 0.984 NM_172843
NM_001160180
Tor1aip2

torsin A interacting protein 2

chr17_+_88374355 0.975 NM_010830
Msh6
mutS homolog 6 (E. coli)
chr10_-_95026677 0.970 Nudt4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr7_+_134628622 0.964 NM_010183
Fbrs
fibrosin
chr4_+_14791353 0.964 NM_028264
Tmem55a
transmembrane protein 55A
chr9_+_74885420 0.961 NM_001142655
Arpp19
cAMP-regulated phosphoprotein 19
chr1_+_74708306 0.961 NM_001014974
Ttll4
tubulin tyrosine ligase-like family, member 4
chr13_-_78338131 0.959 NM_010151
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr18_+_69505374 0.959 NM_001083967
Tcf4
transcription factor 4
chr19_-_60656627 0.949 NM_001172096
NM_001172097
NM_030197
2700078E11Rik


RIKEN cDNA 2700078E11 gene


chr14_-_55272452 0.948 NM_019567
NM_001085472
Acin1

apoptotic chromatin condensation inducer 1

chr13_-_104124527 0.940 NM_175171
Mast4
microtubule associated serine/threonine kinase family member 4
chr14_-_98568744 0.931 NM_001038610
NM_007826
Dach1

dachshund 1 (Drosophila)

chrX_+_68916841 0.930 NM_010340
Gpr50
G-protein-coupled receptor 50
chr4_-_120498198 0.928 NM_008692
Nfyc
nuclear transcription factor-Y gamma
chr3_-_95021614 0.928 NM_029885
NM_172512
Gabpb2

GA repeat binding protein, beta 2

chr16_-_18248701 0.926 NM_011239
Ranbp1
RAN binding protein 1
chr14_+_73542810 0.926 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr1_+_141351340 0.925 NM_009791
Aspm
asp (abnormal spindle)-like, microcephaly associated (Drosophila)
chr11_+_98219742 0.925 Stard3
START domain containing 3
chr5_-_137592066 0.917 NM_201373
Trim56
tripartite motif-containing 56
chr19_-_6932673 0.915 NM_001081291
Ccdc88b
coiled-coil domain containing 88B
chr11_+_69794546 0.910 NM_026017
Ctdnep1
CTD nuclear envelope phosphatase 1
chr7_-_27981077 0.910 NM_015782
Snrpa
small nuclear ribonucleoprotein polypeptide A
chr2_+_13496013 0.905 Vim
vimentin
chr7_-_97129450 0.905 NM_021876
Eed
embryonic ectoderm development
chr4_+_124479785 0.904 NM_008636
Mtf1
metal response element binding transcription factor 1
chrX_-_101866123 0.903 Zdhhc15
zinc finger, DHHC domain containing 15
chr2_-_71384748 0.900 NM_010054
Dlx2
distal-less homeobox 2
chr5_+_43624701 0.900 NM_001177379
NM_175937
Cpeb2

cytoplasmic polyadenylation element binding protein 2

chr12_+_4924157 0.897 NM_001099628
Atad2b
ATPase family, AAA domain containing 2B
chr16_-_50432421 0.897 NM_027444
Bbx
bobby sox homolog (Drosophila)
chr1_-_171461510 0.892 NM_023284
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr11_+_98657082 0.892 NM_028722
Msl1
male-specific lethal 1 homolog (Drosophila)
chr2_+_72817468 0.892 1700011J10Rik
RIKEN cDNA 1700011J10 gene
chr10_-_82226774 0.890 NM_010914
Nfyb
nuclear transcription factor-Y beta
chr3_+_87710282 0.890 Hdgf
hepatoma-derived growth factor
chr1_+_196446006 0.890 NM_008882
Plxna2
plexin A2
chr10_+_24315247 0.887 NM_010217
Ctgf
connective tissue growth factor
chr6_+_71221670 0.886 Krcc1
lysine-rich coiled-coil 1
chr4_+_108132602 0.880 Zcchc11
zinc finger, CCHC domain containing 11
chr3_-_75760820 0.878 Golim4
golgi integral membrane protein 4
chr3_-_103613211 0.875 Dclre1b
DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)
chr8_+_87493507 0.867 NM_011563
Prdx2
peroxiredoxin 2
chr12_-_119539909 0.854 NM_001166385
NM_009239
Sp4

trans-acting transcription factor 4

chr2_-_30329737 0.853 Ier5l
immediate early response 5-like
chr2_-_121097017 0.850 NM_013735
Trp53bp1
transformation related protein 53 binding protein 1
chr11_-_86621130 0.842 NM_026191
Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr2_+_29921953 0.841 Set
SET nuclear oncogene
chr3_+_34548916 0.825 NM_011443
Sox2
SRY-box containing gene 2
chr6_-_125115619 0.823 Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr4_+_100449375 0.821 Cachd1
cache domain containing 1
chr3_+_90097269 0.820 Gatad2b
GATA zinc finger domain containing 2B
chr7_+_86805081 0.820 NM_029835
5730590G19Rik
RIKEN cDNA 5730590G19 gene
chrX_+_103382432 0.817 NM_008828
Pgk1
phosphoglycerate kinase 1
chr19_-_29880498 0.817 NM_172836
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr10_-_118677059 0.813 NM_027994
Cand1
cullin associated and neddylation disassociated 1
chr10_-_128142007 0.812 NM_016756
NM_183417
Cdk2

cyclin-dependent kinase 2

chr11_+_23978110 0.811 Bcl11a
B-cell CLL/lymphoma 11A (zinc finger protein)
chr2_-_48804672 0.810 NM_001177313
NM_011958
Orc4

origin recognition complex, subunit 4


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
3.77 9.21e-17 GO:2000112 regulation of cellular macromolecule biosynthetic process
3.68 2.87e-16 GO:0010556 regulation of macromolecule biosynthetic process
3.48 3.65e-15 GO:0031326 regulation of cellular biosynthetic process
3.43 6.46e-15 GO:0009889 regulation of biosynthetic process
3.73 6.72e-15 GO:0051252 regulation of RNA metabolic process
3.73 1.70e-14 GO:0006355 regulation of transcription, DNA-dependent
3.43 3.83e-14 GO:0010468 regulation of gene expression
3.37 8.16e-14 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.34 1.28e-13 GO:0051171 regulation of nitrogen compound metabolic process
2.99 1.30e-13 GO:0060255 regulation of macromolecule metabolic process
2.94 1.34e-13 GO:0080090 regulation of primary metabolic process
5.60 1.43e-12 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.82 4.15e-12 GO:0031323 regulation of cellular metabolic process
2.58 5.86e-11 GO:0019222 regulation of metabolic process
3.45 1.24e-10 GO:0048523 negative regulation of cellular process
3.73 5.13e-10 GO:0006351 transcription, DNA-dependent
3.73 5.42e-10 GO:0032774 RNA biosynthetic process
3.22 6.01e-10 GO:0048519 negative regulation of biological process
6.05 6.90e-10 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
5.81 1.62e-09 GO:0010558 negative regulation of macromolecule biosynthetic process
5.62 3.24e-09 GO:0031327 negative regulation of cellular biosynthetic process
5.49 5.33e-09 GO:0009890 negative regulation of biosynthetic process
2.63 2.59e-08 GO:0032502 developmental process
5.61 2.94e-08 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
5.53 3.95e-08 GO:0051172 negative regulation of nitrogen compound metabolic process
3.01 4.06e-08 GO:0016070 RNA metabolic process
2.83 4.47e-08 GO:0048856 anatomical structure development
2.68 7.53e-08 GO:0007275 multicellular organismal development
4.48 1.42e-07 GO:0031324 negative regulation of cellular metabolic process
3.15 1.53e-07 GO:0048869 cellular developmental process
4.46 1.55e-07 GO:0010605 negative regulation of macromolecule metabolic process
5.70 1.94e-07 GO:0045892 negative regulation of transcription, DNA-dependent
2.75 2.09e-07 GO:0090304 nucleic acid metabolic process
5.61 2.53e-07 GO:0051253 negative regulation of RNA metabolic process
1.76 2.66e-07 GO:0050794 regulation of cellular process
6.89 2.77e-07 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
2.84 4.47e-07 GO:0009059 macromolecule biosynthetic process
4.12 8.03e-07 GO:0009892 negative regulation of metabolic process
3.06 1.16e-06 GO:0030154 cell differentiation
3.63 1.17e-06 GO:0009653 anatomical structure morphogenesis
5.14 1.18e-06 GO:0010629 negative regulation of gene expression
2.79 1.33e-06 GO:0034645 cellular macromolecule biosynthetic process
2.79 1.35e-06 GO:0048731 system development
1.69 1.65e-06 GO:0050789 regulation of biological process
2.68 2.40e-06 GO:0010467 gene expression
5.47 3.19e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
7.24 5.77e-06 GO:0035295 tube development
1.64 6.33e-06 GO:0065007 biological regulation
4.60 7.54e-06 GO:0045893 positive regulation of transcription, DNA-dependent
4.53 9.71e-06 GO:0051254 positive regulation of RNA metabolic process
2.37 1.20e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.60 2.49e-05 GO:0007399 nervous system development
4.22 3.14e-05 GO:0010628 positive regulation of gene expression
2.00 4.12e-05 GO:0044260 cellular macromolecule metabolic process
2.42 6.88e-05 GO:0048518 positive regulation of biological process
4.01 7.18e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
5.92 7.23e-05 GO:0060429 epithelium development
1.90 7.53e-05 GO:0043170 macromolecule metabolic process
3.96 9.06e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
3.92 1.08e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
2.66 1.15e-04 GO:0071842 cellular component organization at cellular level
2.47 1.52e-04 GO:0048522 positive regulation of cellular process
2.14 1.64e-04 GO:0006807 nitrogen compound metabolic process
2.14 2.21e-04 GO:0034641 cellular nitrogen compound metabolic process
4.11 2.40e-04 GO:0048699 generation of neurons
2.23 2.52e-04 GO:0009058 biosynthetic process
3.68 2.87e-04 GO:0031328 positive regulation of cellular biosynthetic process
2.80 3.00e-04 GO:0048513 organ development
2.24 3.39e-04 GO:0044249 cellular biosynthetic process
2.53 3.74e-04 GO:0071841 cellular component organization or biogenesis at cellular level
3.61 3.91e-04 GO:0009891 positive regulation of biosynthetic process
6.08 4.72e-04 GO:0051301 cell division
3.26 5.45e-04 GO:0009966 regulation of signal transduction
3.85 6.16e-04 GO:0022008 neurogenesis
10.54 6.54e-04 GO:0048754 branching morphogenesis of a tube
7.38 7.40e-04 GO:0035239 tube morphogenesis
4.85 8.03e-04 GO:0051276 chromosome organization
3.74 9.52e-04 GO:0048468 cell development
5.17 9.80e-04 GO:0048598 embryonic morphogenesis
2.23 1.16e-03 GO:0016043 cellular component organization
5.52 1.29e-03 GO:0051960 regulation of nervous system development
5.49 1.36e-03 GO:0007389 pattern specification process
6.86 1.43e-03 GO:0051101 regulation of DNA binding
5.45 1.48e-03 GO:0006325 chromatin organization
3.61 1.52e-03 GO:2000026 regulation of multicellular organismal development
9.29 1.70e-03 GO:0060541 respiratory system development
5.88 1.96e-03 GO:0051098 regulation of binding
3.00 2.19e-03 GO:0010604 positive regulation of macromolecule metabolic process
5.73 2.50e-03 GO:0016568 chromatin modification
1.80 2.57e-03 GO:0032501 multicellular organismal process
3.66 2.58e-03 GO:0009790 embryo development
2.14 3.26e-03 GO:0071840 cellular component organization or biogenesis
10.47 3.38e-03 GO:0021915 neural tube development
8.46 3.41e-03 GO:0001763 morphogenesis of a branching structure
6.95 4.27e-03 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
6.04 4.45e-03 GO:0002009 morphogenesis of an epithelium
6.79 5.15e-03 GO:0090046 regulation of transcription regulator activity
3.13 6.09e-03 GO:0010646 regulation of cell communication
2.65 6.16e-03 GO:0048583 regulation of response to stimulus
3.39 7.12e-03 GO:0009888 tissue development
7.63 7.26e-03 GO:0060562 epithelial tube morphogenesis
9.22 7.80e-03 GO:0030324 lung development
2.76 8.08e-03 GO:0009893 positive regulation of metabolic process
9.08 8.64e-03 GO:0030323 respiratory tube development
2.81 1.03e-02 GO:0031325 positive regulation of cellular metabolic process
4.91 1.07e-02 GO:0051093 negative regulation of developmental process
5.45 1.10e-02 GO:0045596 negative regulation of cell differentiation
2.71 1.12e-02 GO:0023051 regulation of signaling
8.61 1.22e-02 GO:0061138 morphogenesis of a branching epithelium
7.03 1.32e-02 GO:0048562 embryonic organ morphogenesis
4.37 1.37e-02 GO:0032989 cellular component morphogenesis
3.07 1.41e-02 GO:0050793 regulation of developmental process
4.31 1.59e-02 GO:0009967 positive regulation of signal transduction
4.70 1.61e-02 GO:0060284 regulation of cell development
49.77 1.75e-02 GO:0060487 lung epithelial cell differentiation
5.14 1.79e-02 GO:0050767 regulation of neurogenesis
5.79 1.83e-02 GO:0003002 regionalization
3.89 2.06e-02 GO:0022402 cell cycle process
45.25 2.40e-02 GO:0048596 embryonic camera-type eye morphogenesis
45.25 2.40e-02 GO:0060479 lung cell differentiation
3.38 2.53e-02 GO:0045595 regulation of cell differentiation
1.58 2.53e-02 GO:0044238 primary metabolic process
165.89 2.56e-02 GO:0030219 megakaryocyte differentiation
20.74 2.78e-02 GO:0060425 lung morphogenesis
1.58 2.84e-02 GO:0044237 cellular metabolic process
4.36 3.17e-02 GO:0000902 cell morphogenesis
3.98 3.43e-02 GO:0048646 anatomical structure formation involved in morphogenesis
6.07 3.79e-02 GO:0000280 nuclear division
6.07 3.79e-02 GO:0007067 mitosis
3.93 3.85e-02 GO:0010647 positive regulation of cell communication
3.91 4.07e-02 GO:0023056 positive regulation of signaling
5.93 4.44e-02 GO:0000087 M phase of mitotic cell cycle
4.58 4.79e-02 GO:0048729 tissue morphogenesis
3.19 4.87e-02 GO:0051128 regulation of cellular component organization

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.39 9.12e-13 GO:0005634 nucleus
1.67 6.87e-09 GO:0043229 intracellular organelle
1.67 8.23e-09 GO:0043226 organelle
1.69 1.42e-07 GO:0043231 intracellular membrane-bounded organelle
1.69 1.59e-07 GO:0043227 membrane-bounded organelle
1.51 1.61e-07 GO:0005622 intracellular
1.49 1.39e-06 GO:0044424 intracellular part
3.25 3.83e-06 GO:0031981 nuclear lumen
2.95 4.96e-06 GO:0044428 nuclear part
3.61 2.85e-05 GO:0005654 nucleoplasm
2.82 6.76e-05 GO:0070013 intracellular organelle lumen
2.81 7.02e-05 GO:0043233 organelle lumen
2.75 1.04e-04 GO:0031974 membrane-enclosed lumen
4.09 1.84e-04 GO:0044451 nucleoplasm part
17.47 8.22e-03 GO:0000118 histone deacetylase complex
10.25 1.34e-02 GO:0016585 chromatin remodeling complex
1.20 1.66e-02 GO:0005623 cell
1.20 1.66e-02 GO:0044464 cell part
1.80 3.21e-02 GO:0032991 macromolecular complex
1.89 3.57e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

enrichment p-value GO term description
5.30 2.78e-11 GO:0030528 transcription regulator activity
2.83 1.34e-08 GO:0003676 nucleic acid binding
1.52 2.08e-07 GO:0005488 binding
3.04 1.49e-06 GO:0003677 DNA binding
4.54 1.58e-06 GO:0001071 nucleic acid binding transcription factor activity
4.54 1.58e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
6.54 1.11e-05 GO:0016563 transcription activator activity
1.82 2.08e-05 GO:0005515 protein binding
4.46 2.77e-05 GO:0043565 sequence-specific DNA binding
6.45 4.16e-05 GO:0008134 transcription factor binding
8.18 4.80e-05 GO:0003682 chromatin binding
9.42 2.54e-04 GO:0003690 double-stranded DNA binding
9.22 2.98e-04 GO:0003702 RNA polymerase II transcription factor activity
12.30 1.09e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
5.31 2.28e-03 GO:0016564 transcription repressor activity
49.77 2.92e-03 GO:0045295 gamma-catenin binding
10.27 3.08e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
10.27 3.08e-03 GO:0016566 specific transcriptional repressor activity
6.68 3.19e-03 GO:0043566 structure-specific DNA binding
5.30 1.63e-02 GO:0019901 protein kinase binding
5.90 2.22e-02 GO:0010843 promoter binding
13.28 2.72e-02 GO:0008301 DNA bending activity
5.54 3.28e-02 GO:0000975 regulatory region DNA binding
5.54 3.28e-02 GO:0001067 regulatory region nucleic acid binding
5.54 3.28e-02 GO:0044212 transcription regulatory region DNA binding