Motif ID: STAT2,4,6.p2

Z-value: 1.608

Transcription factors associated with STAT2,4,6.p2:

NameEntrezDescription
Stat2 20847 signal transducer and activator of transcription 2
Stat4 20849 signal transducer and activator of transcription 4
Stat6 20852 signal transducer and activator of transcription 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Stat2chr10_+_1277075550.539.7e-04Click!
Stat6chr10_+_1270800130.221.9e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr11_-_117830455 8.632 Socs3
suppressor of cytokine signaling 3
chr11_-_102758340 7.027 Gfap
glial fibrillary acidic protein
chr8_-_127093601 5.918 NM_007428
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr5_+_104864136 5.033 NM_009263
Spp1
secreted phosphoprotein 1
chr7_-_31699850 4.820 NM_010758
Mag
myelin-associated glycoprotein
chr4_+_15808409 4.536 NM_009788
Calb1
calbindin 1
chr2_-_84614976 4.377 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr11_-_102758460 4.365 NM_001131020
NM_010277
Gfap

glial fibrillary acidic protein

chr8_+_96702981 4.228 NM_013602
Mt1
metallothionein 1
chr9_+_107199019 4.138 NM_009895
Cish
cytokine inducible SH2-containing protein
chr11_+_78312621 3.910 NM_011707
Vtn
vitronectin
chr18_-_78320014 3.893 Slc14a1
solute carrier family 14 (urea transporter), member 1
chr5_-_138404150 3.584 NM_080450
Gjc3
gap junction protein, gamma 3
chr11_-_55233366 3.320 Sparc
secreted acidic cysteine rich glycoprotein
chr8_-_87297283 3.010 Nfix
nuclear factor I/X
chr11_-_79317471 2.776 Omg
oligodendrocyte myelin glycoprotein
chr10_-_94879369 2.703 Socs2
suppressor of cytokine signaling 2
chr11_-_117830554 2.688 NM_007707
Socs3
suppressor of cytokine signaling 3
chr15_+_34167908 2.668 Laptm4b
lysosomal-associated protein transmembrane 4B
chr8_+_47825098 2.626 NM_008391
Irf2
interferon regulatory factor 2
chr7_-_31699888 2.622 Mag
myelin-associated glycoprotein
chr15_-_54751515 2.565 NM_001136077
NM_015744
Enpp2

ectonucleotide pyrophosphatase/phosphodiesterase 2

chr14_+_66587319 2.561 NM_013492
Clu
clusterin
chr2_-_84615535 2.502 NM_009776
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr10_-_126507271 2.501 NM_025982
Tspan31
tetraspanin 31
chr1_-_173987681 2.498 NM_010916
Nhlh1
nescient helix loop helix 1
chr16_-_23988680 2.341 NM_009744
Bcl6
B-cell leukemia/lymphoma 6
chr7_-_26022753 2.290 NM_001031667
Gsk3a
glycogen synthase kinase 3 alpha
chr1_-_134036041 2.274 NM_008795
Cdk18
cyclin-dependent kinase 18
chr3_+_101814059 2.204 NM_178777
Nhlh2
nescient helix loop helix 2
chr11_-_114657186 2.155 NM_028055
Btbd17
BTB (POZ) domain containing 17
chr2_+_152673699 2.152 NM_001141975
NM_001141976
NM_001141977
NM_001141978
NM_028109
Tpx2




TPX2, microtubule-associated protein homolog (Xenopus laevis)




chr10_-_27336648 2.139 NM_008481
Lama2
laminin, alpha 2
chr7_+_114710946 2.076 NM_172907
Olfml1
olfactomedin-like 1
chr10_+_127452270 2.073 NM_008921
Prim1
DNA primase, p49 subunit
chr7_-_88851798 2.051 NM_001164086
NM_011983
Homer2

homer homolog 2 (Drosophila)

chr11_-_55233354 2.015 Sparc
secreted acidic cysteine rich glycoprotein
chr3_-_27795287 1.984 NM_001164437
Tmem212
transmembrane protein 212
chr11_+_98209978 1.941 NM_144828
Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr16_-_22657245 1.936 Dgkg
diacylglycerol kinase, gamma
chr7_-_133768983 1.931 NM_019738
Nupr1
nuclear protein 1
chr13_+_23622912 1.893 NM_153173
Hist1h4h
histone cluster 1, H4h
chr19_+_12535536 1.887 Mpeg1
macrophage expressed gene 1
chr4_+_129985957 1.861 NM_010174
Fabp3
fatty acid binding protein 3, muscle and heart
chr18_-_62339609 1.835 NM_007420
Adrb2
adrenergic receptor, beta 2
chr11_+_53333270 1.832 NM_033144
Sept8
septin 8
chr1_-_137584672 1.814 Nav1
neuron navigator 1
chr5_+_89315839 1.788 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chrX_-_7722800 1.751 NM_001166409
NM_001166410
NM_001166411
NM_016809
Rbm3



RNA binding motif protein 3



chr18_-_53577625 1.738 NM_008908
Ppic
peptidylprolyl isomerase C
chr12_+_86814822 1.725 NM_010234
Fos
FBJ osteosarcoma oncogene
chr17_-_45729199 1.688 NM_022880
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr11_-_55233339 1.671 Sparc
secreted acidic cysteine rich glycoprotein
chr8_+_96703145 1.666 Mt1
metallothionein 1
chr19_+_8692485 1.639 NM_008766
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr13_+_20564928 1.596 NM_198093
Elmo1
engulfment and cell motility 1, ced-12 homolog (C. elegans)
chr3_+_121948541 1.591 Gclm
glutamate-cysteine ligase, modifier subunit
chr1_+_59538966 1.576 NM_008057
Fzd7
frizzled homolog 7 (Drosophila)
chr10_+_13685882 1.572 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr14_+_70857227 1.554 NM_145981
Phyhip
phytanoyl-CoA hydroxylase interacting protein
chr3_-_116510948 1.554 NM_001081326
Agl
amylo-1,6-glucosidase, 4-alpha-glucanotransferase
chr2_+_59450123 1.500


chr7_+_104991475 1.489 Pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr18_+_34784589 1.482 NM_009004
NM_001166406
Kif20a

kinesin family member 20A

chr1_+_89160921 1.475 NM_028889
Efhd1
EF hand domain containing 1
chr7_-_87080143 1.471 NM_027420
2610034B18Rik
RIKEN cDNA 2610034B18 gene
chr18_-_78320126 1.470 NM_001171010
NM_028122
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr7_+_104991480 1.456 Pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr3_-_50247306 1.454 NM_011990
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr11_+_78312784 1.450 Vtn
vitronectin
chr7_-_88851662 1.445 Homer2
homer homolog 2 (Drosophila)
chr7_-_24993103 1.440 NM_019940
Zfp111
zinc finger protein 111
chr10_+_127740390 1.421 NM_133992
Pan2
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr14_+_21113911 1.418 NM_026341
Nudt13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr3_+_138190223 1.417 Eif4e
eukaryotic translation initiation factor 4E
chr2_-_73367455 1.410 NM_153138
Wipf1
WAS/WASL interacting protein family, member 1
chr3_-_59147980 1.384 NM_001162884
Igsf10
immunoglobulin superfamily, member 10
chr16_-_10313963 1.372 Emp2
epithelial membrane protein 2
chr15_+_34167780 1.368 NM_033521
Laptm4b
lysosomal-associated protein transmembrane 4B
chr9_+_86636433 1.366 NM_178738
Prss35
protease, serine, 35
chr2_+_153171730 1.365 NM_001039939
Asxl1
additional sex combs like 1 (Drosophila)
chr8_+_96703174 1.358 Mt1
metallothionein 1
chr7_+_29551728 1.345 NM_001122765
NM_001122766
NM_022432
Sirt2


sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)


chr18_-_35374531 1.344 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chrX_+_7455387 1.332 NM_138606
Pim2
proviral integration site 2
chr3_-_51364525 1.325 NM_080793
Setd7
SET domain containing (lysine methyltransferase) 7
chr10_+_79792864 1.321 NM_139292
Reep6
receptor accessory protein 6
chr9_+_107199169 1.309 Cish
cytokine inducible SH2-containing protein
chr10_-_17742931 1.300 NM_028440
3110003A17Rik
RIKEN cDNA 3110003A17 gene
chr1_-_75215798 1.292 NM_009447
Tuba4a
tubulin, alpha 4A
chr11_+_77992224 1.290 NM_026708
Tlcd1
TLC domain containing 1
chr9_+_123060096 1.259 Clec3b
C-type lectin domain family 3, member b
chr10_+_87321789 1.258 NM_001111275
NM_010512
Igf1

insulin-like growth factor 1

chr17_-_46817717 1.251 Klhdc3
kelch domain containing 3
chr18_-_35374663 1.246 NM_178005
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr18_+_35278553 1.232 NM_009818
Ctnna1
catenin (cadherin associated protein), alpha 1
chr19_+_4711220 1.229 NM_021287
Spnb3
spectrin beta 3
chr17_-_88197333 1.218 NM_199251
Kcnk12
potassium channel, subfamily K, member 12
chrX_+_39503858 1.216 NM_021465
Stag2
stromal antigen 2
chr10_-_126725826 1.213 NM_033072
Mbd6
methyl-CpG binding domain protein 6
chr11_+_3388229 1.212 NM_172791
Pla2g3
phospholipase A2, group III
chr9_+_20673069 1.207 NM_175687
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr9_-_123587923 1.200 NM_139142
Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr9_-_61970402 1.186 Glce
glucuronyl C5-epimerase
chrX_+_20265590 1.163 NM_011049
Cdk16
cyclin-dependent kinase 16
chr15_+_101974792 1.162 Igfbp6
insulin-like growth factor binding protein 6
chr1_+_180117815 1.160 Pppde1
PPPDE peptidase domain containing 1
chr6_+_133985988 1.159 Etv6
ets variant gene 6 (TEL oncogene)
chr7_-_20282950 1.156 Apoe
apolipoprotein E
chr5_-_108978950 1.142 NM_007756
Cplx1
complexin 1
chr5_-_138052555 1.131 NM_008788
Pcolce
procollagen C-endopeptidase enhancer protein
chr9_+_72892614 1.131 NM_023635
Rab27a
RAB27A, member RAS oncogene family
chr3_-_96001504 1.128 NM_026975
Bola1
bolA-like 1 (E. coli)
chr8_+_91045232 1.128 NM_027280
Nkd1
naked cuticle 1 homolog (Drosophila)
chr9_+_20820403 1.122 NM_010493
Icam1
intercellular adhesion molecule 1
chr10_-_126959446 1.111 NM_028230
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr15_+_75692745 1.111 NM_026960
Gsdmd
gasdermin D
chr8_-_74061134 1.108 NM_198095
Bst2
bone marrow stromal cell antigen 2
chr1_+_34062720 1.101 Dst
dystonin
chr11_+_100981384 1.100 NM_134024
Tubg1
tubulin, gamma 1
chr6_+_115084919 1.096 NM_001111015
NM_013681
Syn2

synapsin II

chr5_+_124889925 1.084 NM_030241
Setd8
SET domain containing (lysine methyltransferase) 8
chr3_+_19857053 1.083 NM_001042611
NM_007752
Cp

ceruloplasmin

chr10_+_75716647 1.070 S100b
S100 protein, beta polypeptide, neural
chr13_-_46823191 1.052 NM_175749
Nup153
nucleoporin 153
chr8_-_87211726 1.032 NM_025788
Nacc1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr7_-_27966073 1.025 Mia1
melanoma inhibitory activity 1
chr2_-_26883441 1.024 NM_001177627
NM_172659
Slc2a6

solute carrier family 2 (facilitated glucose transporter), member 6

chr9_-_121701480 1.021 NM_029095
Hhatl
hedgehog acyltransferase-like
chr18_-_33623069 1.020 NM_001109990
D0H4S114
DNA segment, human D4S114
chr4_-_116380924 1.011 NM_025962
Mmachc
methylmalonic aciduria cblC type, with homocystinuria
chr11_-_48684659 1.010 NM_008326
Irgm1
immunity-related GTPase family M member 1
chr5_+_107926763 1.005 NM_001007574
NM_001168557
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr19_-_40588193 0.996 Sorbs1
sorbin and SH3 domain containing 1
chr12_+_16660521 0.996 Ntsr2
neurotensin receptor 2
chr1_-_182947585 0.987 NM_010145
Ephx1
epoxide hydrolase 1, microsomal
chr14_-_66452720 0.987 NM_028039
Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr4_-_125879832 0.985 NM_146153
Thrap3
thyroid hormone receptor associated protein 3
chrX_+_131135770 0.980 NM_019868
Hnrnph2
heterogeneous nuclear ribonucleoprotein H2
chr11_+_70514004 0.979 NM_153103
Kif1c
kinesin family member 1C
chr3_-_107563049 0.978 Csf1
colony stimulating factor 1 (macrophage)
chr5_+_31495623 0.977 NM_153680
Snx17
sorting nexin 17
chr12_-_11272479 0.971 NM_177331
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr9_+_43893029 0.970 Usp2
ubiquitin specific peptidase 2
chr9_-_70269326 0.968 NM_007630
Ccnb2
cyclin B2
chr13_-_56397521 0.968 Cxcl14
chemokine (C-X-C motif) ligand 14
chr9_+_5345475 0.966 NM_009808
Casp12
caspase 12
chr7_+_125856066 0.960 NM_182995
6330503K22Rik
RIKEN cDNA 6330503K22 gene
chr7_+_134944168 0.951 Hsd3b7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr6_+_66846377 0.945 NM_001177556
NM_001177557
NM_001177559
NM_001177560
NM_025278
Gng12




guanine nucleotide binding protein (G protein), gamma 12




chr9_+_75623153 0.945 NM_007555
Bmp5
bone morphogenetic protein 5
chr18_+_58038278 0.926 NM_009194
Slc12a2
solute carrier family 12, member 2
chr1_+_141351340 0.923 NM_009791
Aspm
asp (abnormal spindle)-like, microcephaly associated (Drosophila)
chr9_-_21043246 0.922 Keap1
kelch-like ECH-associated protein 1
chr1_-_180267759 0.919 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr10_-_76188683 0.919 NM_009933
Col6a1
collagen, type VI, alpha 1
chr6_-_124861656 0.915 NM_008479
Lag3
lymphocyte-activation gene 3
chr9_+_44142772 0.911 NM_010436
H2afx
H2A histone family, member X
chr3_+_121948693 0.900 Gclm
glutamate-cysteine ligase, modifier subunit
chrX_-_7829333 0.899 NM_133991
Ftsj1
FtsJ homolog 1 (E. coli)
chrX_+_97821403 0.899 NM_008446
Kif4
kinesin family member 4
chr13_-_34094629 0.899 Serpinb6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
chr7_-_88851823 0.896 Homer2
homer homolog 2 (Drosophila)
chr6_-_125263750 0.894 NM_010736
Ltbr
lymphotoxin B receptor
chr10_-_81007727 0.891 NM_010301
Gna11
guanine nucleotide binding protein, alpha 11
chr2_-_181194085 0.891 NM_028125
Zbtb46
zinc finger and BTB domain containing 46
chr7_+_19609771 0.889 Sympk
symplekin
chr5_-_38215607 0.874 NM_010835
Msx1
homeobox, msh-like 1
chr2_-_30758745 0.865 Ptges
prostaglandin E synthase
chr14_+_45949451 0.861 NM_025959
Psmc6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr5_-_135223110 0.856 NM_007925
Eln
elastin
chr2_-_101469142 0.855 NM_026592
B230118H07Rik
RIKEN cDNA B230118H07 gene
chr7_-_135605026 0.850 NM_009383
Tial1
Tia1 cytotoxic granule-associated RNA binding protein-like 1
chr3_+_90052083 0.848 NM_013901
Slc39a1
solute carrier family 39 (zinc transporter), member 1
chr3_+_88004544 0.848 AW047730
expressed sequence AW047730
chr11_-_21471829 0.845 NM_008618
Mdh1
malate dehydrogenase 1, NAD (soluble)
chr17_-_79420125 0.844 NM_001171004
NM_029239
Prkd3

protein kinase D3

chr3_+_68376319 0.831 Schip1
schwannomin interacting protein 1
chr10_+_75716580 0.829 NM_009115
S100b
S100 protein, beta polypeptide, neural
chr7_+_89484203 0.823 NM_001190374
Adamtsl3
ADAMTS-like 3
chr4_+_97248556 0.814 NM_001122952
Nfia
D130039L10Rik
nuclear factor I/A
RIKEN cDNA D130039L10 gene
chr10_+_40069113 0.814 NM_001168304
NM_198164
Cdk19

cyclin-dependent kinase 19

chr12_-_111934580 0.808 NM_010480
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr5_-_147032932 0.801 NM_028774
Rnf6
ring finger protein (C3H2C3 type) 6
chr15_+_25552273 0.798 NM_019472
Myo10
myosin X
chr12_-_71087988 0.797 NM_022028
Sav1
salvador homolog 1 (Drosophila)
chr7_+_28376578 0.796 NM_001110208
Akt2
thymoma viral proto-oncogene 2
chr17_-_80114299 0.789 NM_009994
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
chr11_+_116976506 0.788 Sec14l1
SEC14-like 1 (S. cerevisiae)
chr7_+_51723361 0.787 NM_025368
Josd2
Josephin domain containing 2
chr2_-_120966376 0.786 NM_177846
Lcmt2
leucine carboxyl methyltransferase 2
chr5_-_123439064 0.785 NM_001003953
Kdm2b
lysine (K)-specific demethylase 2B
chr11_-_79317583 0.785 NM_019409
Omg
oligodendrocyte myelin glycoprotein
chr5_-_115223373 0.785 NM_001077360
NM_019834
NM_001077359
Git2


G protein-coupled receptor kinase-interactor 2


chr6_+_108610606 0.783 NM_011498
Bhlhe40
basic helix-loop-helix family, member e40
chr10_+_13686829 0.778 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr7_+_26052714 0.778 Cic
capicua homolog (Drosophila)
chr9_-_63605745 0.777 NM_016769
Smad3
MAD homolog 3 (Drosophila)
chr11_+_3883638 0.776 NM_001177703
NM_016922
Gal3st1

galactose-3-O-sulfotransferase 1

chr17_-_34137221 0.772 NM_001001892
H2-K1
histocompatibility 2, K1, K region

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
21.46 2.50e-03 GO:0031099 regeneration
52.77 1.53e-02 GO:0051929 positive regulation of calcium ion transport via voltage-gated calcium channel activity
2.22 2.44e-02 GO:0048519 negative regulation of biological process
2.26 3.70e-02 GO:0048523 negative regulation of cellular process
2.41 4.20e-02 GO:0065008 regulation of biological quality

Gene overrepresentation in compartment category:

enrichment p-value GO term description
5.56 4.70e-03 GO:0030425 dendrite
3.81 9.62e-03 GO:0043005 neuron projection
2.85 1.13e-02 GO:0042995 cell projection
5.64 1.18e-02 GO:0045177 apical part of cell
3.28 2.12e-02 GO:0005615 extracellular space
2.26 2.88e-02 GO:0005576 extracellular region
22.95 3.87e-02 GO:0043209 myelin sheath

Gene overrepresentation in function category:

enrichment p-value GO term description
1.80 9.34e-05 GO:0005515 protein binding
1.42 2.70e-04 GO:0005488 binding