Motif ID: T.p2

Z-value: 0.837

Transcription factors associated with T.p2:

NameEntrezDescription
T 20997 brachyury



Activity profile for motif T.p2.

activity profile for motif T.p2


Sorted Z-values histogram for motif T.p2

Sorted Z-values for motif T.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of T.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr2_+_70312979 8.189 NM_022435
Sp5
trans-acting transcription factor 5
chr8_+_46970814 7.853 NM_016798
Pdlim3
PDZ and LIM domain 3
chr10_-_24919916 7.160 Akap7
A kinase (PRKA) anchor protein 7
chr6_+_114081227 5.193 NM_172890
Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr12_+_110783593 4.351 Meg3
maternally expressed 3
chrX_+_133200982 4.324 Tceal3
transcription elongation factor A (SII)-like 3
chr6_-_94650118 3.883 NM_008377
Lrig1
leucine-rich repeats and immunoglobulin-like domains 1
chr17_-_24306262 3.613 NM_009729
Atp6v0c-ps2
Atp6v0c
ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 2
ATPase, H+ transporting, lysosomal V0 subunit C
chr4_-_82151657 3.573 Nfib
nuclear factor I/B
chr8_+_46970860 3.349 Pdlim3
PDZ and LIM domain 3
chr2_-_12933305 2.956 C1ql3
C1q-like 3
chr3_+_75361454 2.791 NM_009250
Serpini1
serine (or cysteine) peptidase inhibitor, clade I, member 1
chr6_-_24905939 2.757 NM_177013
Tmem229a
transmembrane protein 229A
chr14_+_70857227 2.696 NM_145981
Phyhip
phytanoyl-CoA hydroxylase interacting protein
chr7_+_26052714 2.599 Cic
capicua homolog (Drosophila)
chr2_+_138104219 2.438 NM_145534
Btbd3
BTB (POZ) domain containing 3
chr7_-_82453166 2.164 Sv2b
synaptic vesicle glycoprotein 2 b
chrX_-_147091911 2.053 NM_001002272
NM_019548
Tro

trophinin

chr5_-_9725158 2.008 Grm3
glutamate receptor, metabotropic 3
chr6_+_22825464 1.897 NM_001081306
Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr12_+_110783786 1.770 Meg3
maternally expressed 3
chr16_-_37384915 1.389 Stxbp5l
syntaxin binding protein 5-like
chr17_-_90436488 1.265 Nrxn1
neurexin I
chrX_+_133200913 1.198 NM_001029978
Tceal3
transcription elongation factor A (SII)-like 3
chr3_-_107820766 1.141 NM_010358
Gstm1
glutathione S-transferase, mu 1
chr3_-_107820705 1.093 Gstm1
glutathione S-transferase, mu 1
chr6_-_122692526 0.955 Slc2a3
solute carrier family 2 (facilitated glucose transporter), member 3
chr11_+_77845814 0.950 NM_183286
Dhrs13
dehydrogenase/reductase (SDR family) member 13
chr15_+_84493635 0.913 Prr5
proline rich 5 (renal)
chr5_-_143668403 0.889 Actb
actin, beta
chr7_-_25772525 0.850 Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr7_-_107806887 0.845 NM_001163183
NM_001163184
NM_001163185
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr5_-_143668398 0.844 NM_007393
Actb
actin, beta
chr9_-_53418394 0.839 NM_144784
Acat1
acetyl-Coenzyme A acetyltransferase 1
chr4_-_132066370 0.788 NM_144907
Sesn2
sestrin 2
chr8_+_74092790 0.783 NM_011977
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr4_+_53453302 0.759 Slc44a1
solute carrier family 44, member 1
chr1_+_74283325 0.759 Arpc2
actin related protein 2/3 complex, subunit 2
chr18_+_37975071 0.717 Pcdhgc4
protocadherin gamma subfamily C, 4
chr6_-_13789847 0.690 NM_145066
Gpr85
G protein-coupled receptor 85
chr18_+_38456280 0.687 NM_001164622
NM_020012
Rnf14

ring finger protein 14

chr2_-_103637795 0.685 NM_001111291
NM_016739
Caprin1

cell cycle associated protein 1

chr4_-_82151590 0.682 Nfib
nuclear factor I/B
chr14_+_55502261 0.625 NM_007537
Bcl2l2
BCL2-like 2
chr1_-_166368439 0.624 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr12_-_32319353 0.615 NM_007530
NM_001164090
Bcap29

B-cell receptor-associated protein 29

chr9_+_15043488 0.603 NM_026955
2200002K05Rik
RIKEN cDNA 2200002K05 gene
chr10_+_25949512 0.593 NM_001013766
NM_001115154
Samd3

sterile alpha motif domain containing 3

chr11_-_100599413 0.590 NM_024456
Rab5c
RAB5C, member RAS oncogene family
chr7_-_6683113 0.589 NM_008817
Peg3
paternally expressed 3
chr11_+_93905501 0.586 NM_001025428
NM_001025429
NM_001025430
Spag9


sperm associated antigen 9


chr16_-_31314534 0.572 NM_007470
Apod
apolipoprotein D
chr15_-_75397601 0.571 NM_011837
Ly6h
lymphocyte antigen 6 complex, locus H
chr18_+_38456315 0.547 Rnf14
ring finger protein 14
chr4_+_58956460 0.532 NM_001099323
Zkscan16
zinc finger with KRAB and SCAN domains 16
chr1_-_192803077 0.515 Vash2
vasohibin 2
chr5_-_123183537 0.491 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr18_+_45719464 0.483 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr14_+_32842174 0.481 NM_030166
Galntl2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr18_+_45719101 0.472 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr2_+_119698245 0.466 Mga
MAX gene associated
chr3_+_17954500 0.461 Bhlhe22
basic helix-loop-helix family, member e22
chr10_-_88067758 0.448 NM_175418
Mybpc1
myosin binding protein C, slow-type
chr5_-_31395853 0.448 NM_011773
Slc30a3
solute carrier family 30 (zinc transporter), member 3
chr6_-_92164804 0.440 NM_030081
Zfyve20
zinc finger, FYVE domain containing 20
chr2_-_168427037 0.427 NM_001037178
Nfatc2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr14_+_32064648 0.416 NM_027088
Bap1
Brca1 associated protein 1
chr9_+_15043658 0.401 2200002K05Rik
RIKEN cDNA 2200002K05 gene
chr11_+_116938138 0.388 2810008D09Rik
RIKEN cDNA 2810008D09 gene
chr14_+_21527175 0.385 2310021P13Rik
RIKEN cDNA 2310021P13 gene
chr14_+_54878898 0.377 NM_134076
Abhd4
abhydrolase domain containing 4
chr18_-_12394814 0.374 Npc1
Niemann Pick type C1
chr8_+_74092759 0.373 Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr19_+_53214934 0.368 NM_001164099
NM_001164101
Add3

adducin 3 (gamma)

chr1_+_174012641 0.353 NM_009938
Copa
coatomer protein complex subunit alpha
chr19_+_23240506 0.347 Klf9
Kruppel-like factor 9
chr8_-_86671651 0.345 NM_145970
Cc2d1a
coiled-coil and C2 domain containing 1A
chr19_-_20465158 0.344 NM_010730
Anxa1
annexin A1
chr2_-_25079684 0.343 Tubb2c
tubulin, beta 2C
chr10_+_98453513 0.343 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr19_-_59018112 0.342 Hspa12a
heat shock protein 12A
chr10_-_61970481 0.333 NM_011157
Srgn
serglycin
chr2_-_34681707 0.323 NM_001164769
NM_001164770
NM_001164772
NM_013890
Fbxw2



F-box and WD-40 domain protein 2



chr12_-_113749363 0.310 NM_178915
Tmem179
transmembrane protein 179
chr2_+_113839219 0.310 A530058N18Rik
RIKEN cDNA A530058N18 gene
chr4_-_132833514 0.304


chr18_+_37607310 0.301 NM_053139
Pcdhb14
protocadherin beta 14
chr11_-_69479553 0.299 NM_009853
Cd68
CD68 antigen
chr6_-_53018566 0.286 NM_173406
Jazf1
JAZF zinc finger 1
chr16_+_94664089 0.280 Ttc3
tetratricopeptide repeat domain 3
chr3_+_67696141 0.279 NM_001113419
NM_177585
Iqcj-schip1
Iqcj
IQ motif containing J-schwannomin interacting protein 1 read-through transcript
IQ motif containing J
chr16_-_44111760 0.278 Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr12_+_110806715 0.269 Meg3
maternally expressed 3
chr12_+_73543228 0.259 NM_001142729
Lrrc9
leucine rich repeat containing 9
chr3_-_88307024 0.257 Lmna
lamin A
chr7_-_148513391 0.248 Deaf1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr3_-_88307198 0.245 Lmna
lamin A
chr6_+_124254668 0.245 NM_001170395
NM_053094
Cd163

CD163 antigen

chr4_-_132833622 0.238 NM_025667
Tmem222
transmembrane protein 222
chr10_+_101974855 0.236 NM_146240
Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr14_-_34260323 0.234 NM_016700
Mapk8
mitogen-activated protein kinase 8
chr10_+_87922331 0.221 NM_011517
Sycp3
synaptonemal complex protein 3
chr2_-_91802081 0.219


chr12_-_113749313 0.212 Tmem179
transmembrane protein 179
chr2_-_57034164 0.208 BB557941
expressed sequence BB557941
chr10_+_122116022 0.207


chr3_-_50247306 0.207 NM_011990
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr6_+_22238226 0.207 NM_053116
Wnt16
wingless-related MMTV integration site 16
chr11_-_105805442 0.206 NM_007805
Cyb561
cytochrome b-561
chr7_+_150293158 0.192 NM_008434
Kcnq1
potassium voltage-gated channel, subfamily Q, member 1
chrX_+_101678109 0.189 NM_001081189
Uprt
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr7_-_147298872 0.182 Echs1
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
chr2_+_118687703 0.179 NM_019826
Ivd
isovaleryl coenzyme A dehydrogenase
chr17_-_24647423 0.176 Traf7
TNF receptor-associated factor 7
chr5_-_123183255 0.175 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr4_+_102242664 0.169 NM_001177980
Pde4b
phosphodiesterase 4B, cAMP specific
chr2_-_31007762 0.169 D330023K18Rik
RIKEN cDNA D330023K18 gene
chr6_+_83051509 0.167 NM_001081266
Ccdc142
coiled-coil domain containing 142
chr19_-_32177613 0.165 NM_018830
Asah2
N-acylsphingosine amidohydrolase 2
chr6_-_136121885 0.163 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr6_+_48597232 0.159 NM_001077410
NM_212486
Gimap8

GTPase, IMAP family member 8

chr18_-_12464213 0.153 NM_001190371
Ankrd29
ankyrin repeat domain 29
chr6_+_58781846 0.151 Herc3
hect domain and RLD 3
chr6_-_122692754 0.150 NM_011401
Slc2a3
solute carrier family 2 (facilitated glucose transporter), member 3
chr7_+_4971977 0.147 NM_001033383
Zfp865
zinc finger protein 865
chr11_-_58996318 0.147 NM_175452
Gjc2
gap junction protein, gamma 2
chr19_+_7457020 0.146 1700105P06Rik
RIKEN cDNA 1700105P06 gene
chr11_+_77845840 0.145 Dhrs13
dehydrogenase/reductase (SDR family) member 13
chr19_-_8787313 0.138 Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr11_-_83881811 0.135 NM_019819
Dusp14
dual specificity phosphatase 14
chrX_+_130829763 0.134 NM_026239
Tmem35
transmembrane protein 35
chrM_+_7714 0.133 Gm10925
ATP6
predicted gene 10925
ATP synthase F0 subunit 6
chr9_-_58050340 0.132 NM_001161538
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr2_-_80421054 0.129 NM_016965
Nckap1
NCK-associated protein 1
chr6_+_124885783 0.126 Mlf2
myeloid leukemia factor 2
chr14_+_55502291 0.125 Bcl2l2
BCL2-like 2
chr18_-_60908267 0.119 Ndst1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr16_-_95680627 0.119


chr12_+_89961317 0.112 NM_001198587
Nrxn3
neurexin III
chr9_+_107483603 0.112 NM_178020
Hyal3
hyaluronoglucosaminidase 3
chr18_+_38456364 0.110 NM_001164621
Rnf14
ring finger protein 14
chr19_+_20567199 0.108 E030003E18Rik
RIKEN cDNA E030003E18 gene
chr7_-_107805466 0.108 NM_001163186
NM_001163187
Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr11_-_42134509 0.104 Gabra6
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
chr19_+_8915018 0.104 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr14_+_55502433 0.102 Bcl2l2
BCL2-like 2
chr3_-_97628441 0.100 NM_001110163
Pde4dip
phosphodiesterase 4D interacting protein (myomegalin)
chr6_-_139989932 0.098 NM_054066
Plcz1
phospholipase C, zeta 1
chr3_+_102975621 0.097 NM_026602
Bcas2
breast carcinoma amplified sequence 2
chr2_-_66278870 0.097 NM_018733
Scn1a
sodium channel, voltage-gated, type I, alpha
chr18_-_39078304 0.097 NM_010197
Fgf1
fibroblast growth factor 1
chr2_-_155979971 0.093 Rbm39
RNA binding motif protein 39
chr11_+_28753190 0.093 NM_146015
Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr2_+_179759610 0.092 NM_177727
Lsm14b
LSM14 homolog B (SCD6, S. cerevisiae)
chr7_-_148067703 0.088 NM_001127351
NM_001177804
Sirt3

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

chrX_-_147779368 0.086 A230072E10Rik
RIKEN cDNA A230072E10 gene
chr16_-_95680888 0.084 Erg
avian erythroblastosis virus E-26 (v-ets) oncogene related
chr18_-_15471207 0.081 E430002N23Rik
RIKEN cDNA E430002N23 gene
chr18_-_36886051 0.078 Cd14
CD14 antigen
chr17_+_13414053 0.075 NM_013741
Smok2a
sperm motility kinase 2A
chr16_-_5222354 0.072 AU021092
expressed sequence AU021092
chr7_-_4116102 0.071 Cdc42ep5
CDC42 effector protein (Rho GTPase binding) 5
chr7_+_17334480 0.070 Ap2s1
adaptor-related protein complex 2, sigma 1 subunit
chr19_-_6982516 0.069 Prdx5
peroxiredoxin 5
chr16_-_3872273 0.068 NM_001033159
Zfp597
zinc finger protein 597
chr9_+_106073255 0.066 NM_029896
Wdr82
WD repeat domain containing 82
chr11_-_74739449 0.065 Srr
serine racemase
chr9_-_26816373 0.065 Vps26b
vacuolar protein sorting 26 homolog B (yeast)
chrX_+_71542425 0.065 NM_018794
Atp6ap1
ATPase, H+ transporting, lysosomal accessory protein 1
chr2_-_155127037 0.065 Pigu
phosphatidylinositol glycan anchor biosynthesis, class U
chr16_+_56477956 0.064 NM_001014399
NM_001014422
NM_001014423
NM_001014424
NM_178790
Abi3bp




ABI gene family, member 3 (NESH) binding protein




chr8_-_87370656 0.063 Calr
calreticulin
chr8_+_108160437 0.062 NM_181322
Ctcf
CCCTC-binding factor
chr2_+_121134843 0.060 Mtap1a
microtubule-associated protein 1 A
chr7_+_25155455 0.053 Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr4_+_132120098 0.052 Ptafr
platelet-activating factor receptor
chr1_-_36756687 0.052 Actr1b
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr19_-_6982094 0.050 Prdx5
peroxiredoxin 5
chr3_-_62409061 0.048 NM_177346
Gpr149
G protein-coupled receptor 149
chr16_+_37884098 0.047 Lrrc58
leucine rich repeat containing 58
chr5_+_138187390 0.046 Tsc22d4
TSC22 domain family, member 4
chr10_+_41170163 0.046 NM_153398
Zbtb24
zinc finger and BTB domain containing 24
chr12_+_71008808 0.044 Atl1
atlastin GTPase 1
chr15_+_80086643 0.044 Atf4
activating transcription factor 4
chr13_-_74480876 0.044 Sdha
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr16_+_84835573 0.044 Gabpa
GA repeat binding protein, alpha
chr2_+_28368603 0.042 NM_001145834
NM_009058
Ralgds

ral guanine nucleotide dissociation stimulator

chr3_+_129883794 0.040 NM_029838
NM_198711
Col25a1

collagen, type XXV, alpha 1

chr2_-_164008333 0.039 NM_145369
Wfdc5
WAP four-disulfide core domain 5
chr8_+_11834520 0.038 Arhgef7
Rho guanine nucleotide exchange factor (GEF7)
chr1_+_174012909 0.037 Copa
coatomer protein complex subunit alpha
chrX_+_38754568 0.036 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr11_-_55208276 0.036


chr5_-_121822213 0.035 Trafd1
TRAF type zinc finger domain containing 1
chr5_-_33590505 0.034


chr9_+_69843263 0.028 NM_001008238
Bnip2
BCL2/adenovirus E1B interacting protein 2
chr11_-_106163120 0.028 NM_008117
Gh
growth hormone
chr10_+_127832280 0.024


chr10_+_56097078 0.024 NM_010288
Gja1
gap junction protein, alpha 1
chrX_-_130432840 0.022 NM_019656
Tspan6
tetraspanin 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
30.62 1.08e-02 GO:0006836 neurotransmitter transport
25.57 1.84e-02 GO:0023061 signal release
11.94 2.62e-02 GO:0046903 secretion

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment p-value GO term description
115.97 3.48e-03 GO:0005246 calcium channel regulator activity