Motif ID: TBX4,5.p2

Z-value: 1.180

Transcription factors associated with TBX4,5.p2:

NameEntrezDescription
Tbx4 21387 T-box 4
Tbx5 21388 T-box 5



Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr3_+_126299858 5.379 NM_001025438
NM_001025439
NM_023813
Camk2d


calcium/calmodulin-dependent protein kinase II, delta


chr12_+_89961317 5.029 NM_001198587
Nrxn3
neurexin III
chr5_+_98609872 4.899 NM_029947
Prdm8
PR domain containing 8
chr9_-_107134182 4.403 NM_153413
Dock3
dedicator of cyto-kinesis 3
chr6_+_103460955 3.715 Chl1
cell adhesion molecule with homology to L1CAM
chr10_-_126971614 3.629 NM_183297
Nxph4
neurexophilin 4
chr1_-_127808723 3.446 Lypd1
Ly6/Plaur domain containing 1
chr18_-_43552694 3.443 NM_009468
Dpysl3
dihydropyrimidinase-like 3
chr16_+_91225794 3.381 NM_016967
Olig2
oligodendrocyte transcription factor 2
chr2_+_70312979 3.381 NM_022435
Sp5
trans-acting transcription factor 5
chr11_+_23978110 3.380 Bcl11a
B-cell CLL/lymphoma 11A (zinc finger protein)
chr3_+_75361454 3.321 NM_009250
Serpini1
serine (or cysteine) peptidase inhibitor, clade I, member 1
chrX_+_102315680 3.298 NM_053201
Magee1
melanoma antigen, family E, 1
chr6_+_105627738 3.298 NM_001109749
NM_173004
Cntn4

contactin 4

chr7_-_30066910 3.120 NM_001082548
NM_011464
Spint2

serine protease inhibitor, Kunitz type 2

chr2_+_70400179 3.099 NM_008077
Gad1
glutamic acid decarboxylase 1
chr5_+_31117077 3.032 NM_133350
Mapre3
microtubule-associated protein, RP/EB family, member 3
chr4_+_49072327 2.917 NM_178756
E130309F12Rik
RIKEN cDNA E130309F12 gene
chr6_-_13789847 2.906 NM_145066
Gpr85
G protein-coupled receptor 85
chr19_+_22522646 2.873 NM_177341
Trpm3
transient receptor potential cation channel, subfamily M, member 3
chr17_-_46683249 2.867 NM_001081335
Cul9
cullin 9
chr6_+_54631644 2.773 NM_026629
2410066E13Rik
RIKEN cDNA 2410066E13 gene
chr13_-_100286446 2.767 Mtap1b
microtubule-associated protein 1B
chrX_+_132330678 2.761 Gprasp1
G protein-coupled receptor associated sorting protein 1
chr5_-_139801315 2.724 NM_172723
Adap1
ArfGAP with dual PH domains 1
chr9_-_102256962 2.687 NM_001168296
NM_173447
Ephb1

Eph receptor B1

chr1_-_133141708 2.648 NM_018750
Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chr6_-_90378423 2.602 NM_173775
Ccdc37
coiled-coil domain containing 37
chr5_-_147396407 2.548 Gpr12
G-protein coupled receptor 12
chr6_+_7505070 2.501 NM_009311
Tac1
tachykinin 1
chr1_-_171677653 2.484 NM_009062
Rgs4
regulator of G-protein signaling 4
chr17_-_24306262 2.469 NM_009729
Atp6v0c-ps2
Atp6v0c
ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 2
ATPase, H+ transporting, lysosomal V0 subunit C
chr19_-_46401618 2.436 NM_028627
Psd
pleckstrin and Sec7 domain containing
chr1_-_94998418 2.384 NM_001110315
NM_008440
Kif1a

kinesin family member 1A

chr19_+_54119671 2.364 NM_007417
Adra2a
adrenergic receptor, alpha 2a
chr2_-_33226946 2.359 Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr9_-_56483379 2.349 Lingo1
leucine rich repeat and Ig domain containing 1
chr13_-_34169854 2.338 NM_009450
Tubb2a
tubulin, beta 2A
chr5_-_9725158 2.331 Grm3
glutamate receptor, metabotropic 3
chr12_-_14158843 2.310 NM_029007
Fam84a
family with sequence similarity 84, member A
chr9_+_40076800 2.299 NM_001083917
NM_153522
NM_178227
Scn3b


sodium channel, voltage-gated, type III, beta


chr10_-_24919916 2.252 Akap7
A kinase (PRKA) anchor protein 7
chr2_+_140221165 2.245 NM_001013802
NM_028387
Macrod2

MACRO domain containing 2

chr3_+_82162091 2.245 Mtap9
microtubule-associated protein 9
chr2_-_33226980 2.237 NM_175211
Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr3_+_82162037 2.232 Mtap9
microtubule-associated protein 9
chrX_+_130829929 2.210 Tmem35
transmembrane protein 35
chr10_+_122701051 2.197 NM_182807
Fam19a2
family with sequence similarity 19, member A2
chr12_+_75385267 2.172 1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr1_-_135817945 2.123 NM_054077
Prelp
proline arginine-rich end leucine-rich repeat
chr15_+_100592177 2.075 NM_021530
Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr3_+_36762025 2.065 NM_172679
4932438A13Rik
RIKEN cDNA 4932438A13 gene
chr13_+_54605152 1.955 NM_176987
4732471D19Rik
RIKEN cDNA 4732471D19 gene
chr12_+_71008808 1.919 Atl1
atlastin GTPase 1
chr17_+_24625530 1.909 Caskin1
CASK interacting protein 1
chr5_+_43625165 1.903 Cpeb2
cytoplasmic polyadenylation element binding protein 2
chr1_-_94998392 1.886 Kif1a
kinesin family member 1A
chrX_+_7496899 1.881 NM_013892
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr5_-_99681835 1.880 NM_145839
NM_181318
Rasgef1b

RasGEF domain family, member 1B

chr18_+_38115192 1.866 NM_153793
Rell2
RELT-like 2
chr6_+_114081227 1.825 NM_172890
Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr14_-_56519012 1.818 NM_001082975
Sdr39u1
short chain dehydrogenase/reductase family 39U, member 1
chrX_+_7215705 1.788 NM_009305
Syp
synaptophysin
chr7_-_147268395 1.758 NM_001190385
NM_026769
Caly

calcyon neuron-specific vesicular protein

chr16_-_37385024 1.747 NM_001114611
NM_001114612
NM_001114613
NM_172440
Stxbp5l



syntaxin binding protein 5-like



chr9_+_45714587 1.741 NM_008794
Pcsk7
Rnf214
proprotein convertase subtilisin/kexin type 7
ring finger protein 214
chr15_-_56526052 1.693 NM_008216
Has2
hyaluronan synthase 2
chr18_+_45719101 1.683 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr1_+_87942437 1.665 NM_001144992
NM_001144993
2810459M11Rik

RIKEN cDNA 2810459M11 gene

chr6_+_115084919 1.621 NM_001111015
NM_013681
Syn2

synapsin II

chr19_-_7557678 1.612 Rtn3
reticulon 3
chr16_-_67621054 1.612 NM_001145977
NM_178721
Cadm2

cell adhesion molecule 2

chr1_+_23768764 1.608 NM_172124
B3gat2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr8_+_96676506 1.606 NM_013603
Mt3
metallothionein 3
chr16_+_31428833 1.594 NM_001122683
Bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr7_-_110976439 1.578 Hbb-b1
hemoglobin, beta adult major chain
chr10_+_59568976 1.570 NM_052994
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr1_-_175297778 1.550 NM_053199
Cadm3
cell adhesion molecule 3
chr4_+_58956460 1.532 NM_001099323
Zkscan16
zinc finger with KRAB and SCAN domains 16
chr7_-_26460180 1.521 NM_177102
Tmem91
transmembrane protein 91
chr9_+_86360760 1.516 NM_177208
Dopey1
dopey family member 1
chr3_-_94386449 1.507 Snx27
sorting nexin family member 27
chr11_-_28484265 1.507 NM_001166661
NM_001166662
NM_181577
Ccdc85a


coiled-coil domain containing 85A


chr11_-_3763899 1.503 NM_152818
Osbp2
oxysterol binding protein 2
chr5_-_131783136 1.503 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr16_-_37384915 1.490 Stxbp5l
syntaxin binding protein 5-like
chr2_+_90725895 1.473 NM_026161
C1qtnf4
C1q and tumor necrosis factor related protein 4
chr3_+_126300163 1.468 Camk2d
calcium/calmodulin-dependent protein kinase II, delta
chr2_-_91023004 1.460 Madd
MAP-kinase activating death domain
chr3_-_81949667 1.442 NM_021896
Gucy1a3
guanylate cyclase 1, soluble, alpha 3
chr6_-_85019497 1.439 NM_177077
Exoc6b
exocyst complex component 6B
chrX_-_92391841 1.438 Arhgef9
CDC42 guanine nucleotide exchange factor (GEF) 9
chr6_-_85019480 1.434 Exoc6b
exocyst complex component 6B
chr10_+_78243274 1.421 Slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr5_-_108978950 1.416 NM_007756
Cplx1
complexin 1
chr3_+_75878452 1.366 NM_178673
Fstl5
follistatin-like 5
chr6_-_91757386 1.355 NM_001159507
Grip2
glutamate receptor interacting protein 2
chr11_-_100621034 1.352 NM_001081194
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr16_+_17276384 1.349 NM_177473
Tmem191c
transmembrane protein 191C
chr9_-_110379093 1.338 NM_177771
Klhl18
kelch-like 18 (Drosophila)
chr11_+_77845814 1.334 NM_183286
Dhrs13
dehydrogenase/reductase (SDR family) member 13
chr11_-_77303157 1.333 NM_172945
Ankrd13b
ankyrin repeat domain 13b
chr14_+_122874625 1.333 Zic2
zinc finger protein of the cerebellum 2
chr7_-_134041745 1.328 NM_026827
NM_028389
Tmem219

transmembrane protein 219

chr3_-_126928844 1.325 Ank2
ankyrin 2, brain
chr13_+_20564928 1.313 NM_198093
Elmo1
engulfment and cell motility 1, ced-12 homolog (C. elegans)
chr14_+_66963139 1.305 NM_019675
Stmn4
stathmin-like 4
chr19_+_10463540 1.299 NM_018801
NM_173067
NM_173068
Syt7


synaptotagmin VII


chr11_-_70846926 1.293 6330403K07Rik
RIKEN cDNA 6330403K07 gene
chr10_+_43298969 1.291 NM_009846
Cd24a
CD24a antigen
chr4_+_128560786 1.291 Trim62
tripartite motif-containing 62
chr18_+_36508277 1.280 NM_001081365
0610010O12Rik
RIKEN cDNA 0610010O12 gene
chr18_-_46372017 1.276 NM_178872
Trim36
tripartite motif-containing 36
chr14_+_28435613 1.272 NM_177814
Erc2
ELKS/RAB6-interacting/CAST family member 2
chr17_-_64681166 1.265 NM_001025309
NM_144859
Pja2

praja 2, RING-H2 motif containing

chr19_-_6235784 1.255 NM_198168
Ppp2r5b
protein phosphatase 2, regulatory subunit B (B56), beta isoform
chr11_-_3271326 1.250 Limk2
LIM motif-containing protein kinase 2
chr2_-_91023154 1.248 NM_001177719
NM_145527
Madd

MAP-kinase activating death domain

chr6_+_17015159 1.245 Tes
testis derived transcript
chr8_+_46970814 1.244 NM_016798
Pdlim3
PDZ and LIM domain 3
chr12_-_71212591 1.225 Nin
ninein
chr4_+_5571271 1.219 Fam110b
family with sequence similarity 110, member B
chr15_-_76648532 1.214 NM_001168288
NM_198420
Arhgap39

Rho GTPase activating protein 39

chr8_+_96334452 1.182 NM_001113384
NM_010308
Gnao1

guanine nucleotide binding protein, alpha O

chr11_-_3271367 1.179 NM_173053
Limk2
LIM motif-containing protein kinase 2
chr19_+_6418737 1.165 Nrxn2
neurexin II
chr2_+_113839219 1.162 A530058N18Rik
RIKEN cDNA A530058N18 gene
chr8_-_86118344 1.138 NM_027179
NM_134118
Tecr

trans-2,3-enoyl-CoA reductase

chr2_+_32480924 1.135 NM_001198791
Ak1
adenylate kinase 1
chr4_+_137860641 1.129 NM_007838
Ddost
dolichyl-di-phosphooligosaccharide-protein glycotransferase
chr1_-_135817867 1.107


chrX_+_166123130 1.106 NM_010797
Mid1
midline 1
chr2_+_156246644 1.100 NM_001003815
NM_013510
Epb4.1l1

erythrocyte protein band 4.1-like 1

chr1_-_177422630 1.099 NM_001199003
NM_011880
Rgs7

regulator of G protein signaling 7

chr11_-_95574067 1.097 1110035M17Rik
RIKEN cDNA 1110035M17 gene
chr2_-_12933305 1.089 C1ql3
C1q-like 3
chr2_-_103637795 1.083 NM_001111291
NM_016739
Caprin1

cell cycle associated protein 1

chr19_+_6418755 1.076 Nrxn2
neurexin II
chr9_+_81757308 1.069 NM_175213
Mei4
meiosis-specific, MEI4 homolog (S. cerevisiae)
chr11_-_69373707 1.066 NM_007911
Efnb3
ephrin B3
chr1_-_133421746 1.065 Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chrX_-_131745187 1.062 NM_025355
Tceal6
transcription elongation factor A (SII)-like 6
chr4_+_34011567 1.051 NM_007726
Cnr1
cannabinoid receptor 1 (brain)
chr7_-_91234908 1.050 NM_030728
9930013L23Rik
RIKEN cDNA 9930013L23 gene
chr7_-_148513391 1.047 Deaf1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr10_-_80945445 1.037 NM_176954
Celf5
CUGBP, Elav-like family member 5
chr4_-_129118034 1.026 NM_153541
Zbtb8b
zinc finger and BTB domain containing 8b
chr6_+_103461323 1.009 Chl1
cell adhesion molecule with homology to L1CAM
chr6_-_119280616 1.008 NM_172492
Lrtm2
leucine-rich repeats and transmembrane domains 2
chr5_-_8622882 1.005 NM_198620
Rundc3b
RUN domain containing 3B
chr11_-_69651218 1.001 Nlgn2
neuroligin 2
chr7_-_25101619 0.985 NM_009568
Zfp94
zinc finger protein 94
chr6_+_114081375 0.983 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr10_-_26095736 0.982 L3mbtl3
l(3)mbt-like 3 (Drosophila)
chr2_-_5635547 0.972 NM_177343
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr2_+_155102040 0.968 NM_025735
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr15_-_95358306 0.963 Nell2
NEL-like 2 (chicken)
chr5_-_84846348 0.959 NM_007937
Epha5
Eph receptor A5
chr5_+_36100547 0.958 Ablim2
actin-binding LIM protein 2
chr9_+_95459990 0.954 NM_198414
Paqr9
progestin and adipoQ receptor family member IX
chr7_-_16531098 0.946 Gltscr2
glioma tumor suppressor candidate region gene 2
chr8_+_85913750 0.942 NM_009904
Clgn
calmegin
chr6_+_103460834 0.939 NM_007697
Chl1
cell adhesion molecule with homology to L1CAM
chrX_+_130829763 0.937 NM_026239
Tmem35
transmembrane protein 35
chr3_-_67267727 0.932 Lxn
latexin
chr6_+_53989925 0.925 NM_001163640
Chn2
chimerin (chimaerin) 2
chr19_-_5098498 0.924 Cnih2
cornichon homolog 2 (Drosophila)
chr7_-_120512849 0.923 NM_133700
Btbd10
BTB (POZ) domain containing 10
chr15_+_54402914 0.918 NM_178920
Mal2
mal, T-cell differentiation protein 2
chr19_-_11945703 0.917 NM_001011775
Olfr1419
olfactory receptor 1419
chr13_-_101603189 0.914 Slc30a5
solute carrier family 30 (zinc transporter), member 5
chr5_+_130371592 0.911 NM_183088
Scand3
SCAN domain containing 3
chr10_+_102830353 0.902 NM_175328
Slc6a15
solute carrier family 6 (neurotransmitter transporter), member 15
chr10_+_59569052 0.894 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr11_-_113511366 0.890 Slc39a11
solute carrier family 39 (metal ion transporter), member 11
chr5_-_143668403 0.888 Actb
actin, beta
chr1_-_134638361 0.887 NM_001160317
NM_182716
Nfasc

neurofascin

chr1_-_72921438 0.884 NM_010518
Igfbp5
insulin-like growth factor binding protein 5
chr9_-_99336923 0.883 NM_008624
Mras
muscle and microspikes RAS
chr2_-_5635517 0.875 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr2_+_134611953 0.867 Plcb1
phospholipase C, beta 1
chr1_-_175263540 0.865 NM_010045
Darc
Duffy blood group, chemokine receptor
chr11_+_114536748 0.859 NM_053273
Ttyh2
tweety homolog 2 (Drosophila)
chr5_-_143668398 0.857 NM_007393
Actb
actin, beta
chr10_-_61802889 0.848 NM_001146100
Hk1
hexokinase 1
chr7_-_53069599 0.844 NM_001112701
NM_011181
Cyth2

cytohesin 2

chr6_+_90500776 0.839 NM_027406
Aldh1l1
aldehyde dehydrogenase 1 family, member L1
chr10_+_36226801 0.832 Hs3st5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr3_-_67267776 0.825 NM_016753
Lxn
latexin
chr19_-_7557553 0.823 Rtn3
reticulon 3
chr5_-_92471603 0.815 Cdkl2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr8_+_65430028 0.813 NM_023689
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr4_+_13678443 0.806 NM_001111027
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr13_-_10360048 0.802 NM_033269
Chrm3
cholinergic receptor, muscarinic 3, cardiac
chr18_+_23468585 0.801 Dtna
dystrobrevin alpha
chr14_-_52533039 0.795 Ndrg2
N-myc downstream regulated gene 2
chr7_+_123647881 0.790 NM_001130479
NM_016773
Nucb2

nucleobindin 2

chr17_-_36046961 0.789 NM_001142744
NM_001142745
NM_028476
Atat1


alpha tubulin acetyltransferase 1


chr6_-_124719465 0.789 NM_013509
Eno2
enolase 2, gamma neuronal
chr10_+_105907394 0.786 NM_177373
Ppfia2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
3.12 2.81e-02 GO:0022008 neurogenesis
5.28 2.88e-02 GO:0007268 synaptic transmission
4.64 3.26e-02 GO:0019226 transmission of nerve impulse
4.64 3.26e-02 GO:0035637 multicellular organismal signaling
3.12 4.86e-02 GO:0048699 generation of neurons

Gene overrepresentation in compartment category:

enrichment p-value GO term description
5.08 1.16e-05 GO:0045202 synapse
5.45 2.40e-04 GO:0044456 synapse part
15.12 1.56e-02 GO:0042734 presynaptic membrane
1.71 2.94e-02 GO:0071944 cell periphery
3.28 3.49e-02 GO:0043005 neuron projection
1.39 3.91e-02 GO:0016020 membrane

Nothing significant found in function category.